The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
A Protein Kinase C Translocation Inhibitor as an Isozyme-selective Antagonist of Cardiac Function
Open accessAbstract
Protein kinase C (PKC) isozymes translocate to unique subcellular sites following activation. We previously suggested that translocation of activated isozymes is required for their function and that in addition to binding to lipids, translocation involves binding of the activated isozymes to specific anchoring proteins (receptors for activated protein kinase C. Using cultured cardiomyocytes we identified inhibitors, the V1 fragment of epsilonPKC (epsilonV1), and an 8-amino acid peptide derived from it that selectively inhibited the translocation of epsilonPKC. Inhibition of epsilonPKC translocation but not inhibition of delta or betaPKC translocation specifically blocked phorbol ester- or norepinephrine-mediated regulation of contraction. These isozyme-selective translocation inhibitors provide novel tools to determine the function of individual PKC isozymes in intact cells.
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Cites
Protein kinase C and lipid signaling for sustained cellular responses
Nishizuka, Y. (1995) · The FASEB Journal · doi:10.1096/fasebj.9.7.7737456 · Cited by 2,499
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YELLON, D. M., & DOWNEY, J. M. (2003) · Physiological Reviews · doi:10.1152/physrev.00009.2003 · Cited by 1,062
Opposing cardioprotective actions and parallel hypertrophic effects of δPKC and ɛPKC
Chen, L., Hahn, H., Wu, G., Chen, C.-H., Liron, T., Schechtman, D., Cavallaro, G., Banci, L., Guo, Y., Bolli, R., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191369098 · Cited by 538
Self-citationProtein Kinase G Transmits the Cardioprotective Signal From Cytosol to Mitochondria
Costa, A. D. T., Garlid, K. D., West, I. C., Lincoln, T. M., Downey, J. M., Cohen, M. V., & Critz, S. D. (2005) · Circulation Research · doi:10.1161/01.res.0000178451.08719.5b · Cited by 307
Intramitochondrial signaling: interactions among mitoKATP, PKCε, ROS, and MPT
Costa, A. D. T., & Garlid, K. D. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01189.2007 · Cited by 238
Lineage-restricted expression of protein kinase C isoforms in hematopoiesis
Bassini, A., Zauli, G., Migliaccio, G., Migliaccio, A. R., Pascuccio, M., Pierpaoli, S., Guidotti, L., Capitani, S., & Vitale, M. (1999) · Blood · doi:10.1182/blood.v93.4.1178 · Cited by 41
Metadata
- Authors
- Johnson, J. A., Gray, M. O., Chen, C.-H., & Mochly-Rosen, D.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1996-10
- Volume
- 271
- Issue
- 40
- Pages
- 24962-24966
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2061052988
- Cited by
- 377
- References
- 1
- FWCI
- 6.18
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- The paper
- Johnson, J. A., Gray, M. O., Chen, C.-H., & Mochly-Rosen, D. (1996). A Protein Kinase C Translocation Inhibitor as an Isozyme-selective Antagonist of Cardiac Function. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.271.40.24962
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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