Protein kinase C and lipid signaling for sustained cellular responses
Abstract
Since the second messenger role was proposed for the products of inositol phospholipid hydrolysis, considerable progress has been made in our understanding of the biochemical mechanism of the intracellular signaling network. It is now becoming evident that stimulation of a cell surface receptor initiates a degradation cascade of various membrane lipid constituents. Many of their metabolites have potential to induce, intensify, and prolong the activation of protein kinase C that is needed for sustained cellular responses.
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PLCγ2 is a critical signaling molecule activated downstream from cell surface receptors containing an intracellular immunoreceptor tyrosine-based activation motif.
“Phosphatidylinositol-specific phospholipase Cγ2 (PLCγ2) is a critical signaling molecule activated downstream from a variety of cell surface receptors that contain an intracellular immunoreceptor tyrosine-based activation motif.”
From The role of PLCγ2 in immunological disorders, cancer, and neurodegeneration (2021) · cites this paper as [2]
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- Authors
- Nishizuka, Y.
- Affiliations
- Biosignal Research Center, Kobe University (JP)
- Corresponding author
- Nishizuka, Yasutomi
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 1995-04
- Volume
- 9
- Issue
- 7
- Pages
- 484-496
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W1576671418
- Cited by
- 2,499
- References
- 0
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 8 · 2023: 23 · 2022: 26 · 2021: 23 · 2020: 23 · 2019: 22 · 2018: 32 · 2017: 32 · 2016: 34 · 2015: 42 · 2014: 51 · 2013: 61 · 2012: 75
- FWCI
- 66.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The FASEB Journal (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- protein kinase C, lipid signaling, inositol phospholipid hydrolysis, second messengers, intracellular signaling cascades
- MeSH terms
- Animals, Cell Physiological Phenomena, Cells, Enzyme Activation, Isoenzymes, Lipids, Mammals, Phospholipases, Protein Kinase C, Signal Transduction, Lipid Metabolism
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