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Cited by 105

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Quantitation of the Pool of Cholesterol Associated with Acyl-CoA:Cholesterol Acyltransferase in Human Fibroblasts

Lange, Yvonne, Steck, Theodore L.·1997·Journal of Biological Chemistry
DOI 10.1074/jbc.272.20.13103
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Crossref · 10.1074/jbc.272.20.13103

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  • Increases in plasma membrane cholesterol beyond a threshold, or liberation of plasma membrane cholesterol from sequestration, result in transient expansions in the accessible pool of plasma membrane cholesterol.

    “Increases in the level of PM cholesterol beyond a certain threshold (or liberation of PM cholesterol from sequestration) result in transient expansions in the accessible pool of PM cholesterol.”

    From Molecular basis of accessible plasma membrane cholesterol recognition by the GRAM domain of GRAMD1b (2021) · cites this paper as Lange & Steck, 1997

    The passage labeled Abstract (page unavailable) says that large changes in the ER-associated run-off pool with little change in total cell cholesterol support a threshold mechanism; it also reports that sphingomyelinase treatment increased cholesterol esterification. The paper does not establish that either treatment transiently expands an accessible pool in the plasma membrane: the measured pool is associated with the ER, not identified as a plasma-membrane pool. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

  • Cells respond to expanded accessible plasma membrane cholesterol by rapidly transporting it to the endoplasmic reticulum to suppress SREBPs, shutting down cholesterol biosynthesis and uptake.

    “Cells respond by rapidly transporting the newly expanded pool of accessible cholesterol to the ER to suppress the activities of SREBPs, shutting down cholesterol biosynthesis and uptake, thereby avoiding cholesterol overaccumulation and maintaining PM cholesterol levels”

    From Molecular basis of accessible plasma membrane cholesterol recognition by the GRAM domain of GRAMD1b (2021) · cites this paper as Lange & Steck, 1997

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Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 40

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Metadata

Authors
Lange, Y., & Steck, T. L.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1997-05
Volume
272
Issue
20
Pages
13103-13108
ISSN
0021-9258
DOI
10.1074/jbc.272.20.13103
Cited by
105
References
4
Language
en
Licence

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