The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
A Newly Identified Member of the Tumor Necrosis Factor Receptor Superfamily with a Wide Tissue Distribution and Involvement in Lymphocyte Activation
Open accessAbstract
The tumor necrosis factor receptor (TNFR) superfamily consists of approximately 10 characterized members of human proteins. We have identified a new member of the TNFR superfamily, TR2, from a search of an expressed sequence tag data base. cDNA cloning and Northern blot hybridization demonstrated multiple mRNA species, of which a 1.7-kilobase form was most abundant. However, TR2 is encoded by a single gene which, maps to chromosome 1p36.22-36.3, in the same region as several other members of the TNFR superfamily. The most abundant TR2 open reading frame encodes a 283-amino acid single transmembrane protein with a 36-residue signal sequence, two perfect and two imperfect TNFR-like cysteine-rich domains, and a short cytoplasmic tail with some similarity to 4-1BB and CD40. TR2 mRNA is expressed in multiple human tissues and cell lines and shows a constitutive and relatively high expression in peripheral blood T cells, B cells, and monocytes. A TR2-Fc fusion protein inhibited a mixed lymphocyte reaction-mediated proliferation suggesting that the receptor and/or its ligand play a role in T cell stimulation.
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Metadata
- Authors
- Kwon, B. S., Tan, K. B., Ni, J., Lee, K.-O.-O., Kim, K. K., Kim, Y.-J., Wang, S., Gentz, R., Yu, G.-L., Harrop, J., Lyn, S. D., Silverman, C., Porter, T. G., Truneh, A., & Young, P. R.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1997-05
- Volume
- 272
- Issue
- 22
- Pages
- 14272-14276
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2165910525
- Cited by
- 300
- References
- 41
- FWCI
- 5.70
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Kwon, B. S., Tan, K. B., Ni, J., Lee, K.-O.-O., Kim, K. K., Kim, Y.-J., Wang, S., Gentz, R., Yu, G.-L., Harrop, J., Lyn, S. D., Silverman, C., Porter, T. G., Truneh, A., & Young, P. R. (1997). A Newly Identified Member of the Tumor Necrosis Factor Receptor Superfamily with a Wide Tissue Distribution and Involvement in Lymphocyte Activation. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.272.22.14272
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
