The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Characterization of the Osteoclast Ruffled Border Chloride Channel and Its Role in Bone Resorption
Open accessAbstract
Bone resorption by osteoclasts requires massive transcellular acid transport, which is accomplished by the parallel action of a V-type proton pump and a chloride channel in the osteoclast ruffled border. We have studied the molecular basis for the appearance of acid transport as avian bone marrow mononuclear cells acquire a bone resorptive phenotype in vitro. We demonstrate a critical role for regulated expression of a ruffled border chloride channel as the cells become competent to resorb bone. Molecular characterization of the chloride channel shows that it is related to the renal microsomal chloride channel, p64. In planar bilayers, the ruffled border channel is a stilbene sulfonate-inhibitable, outwardly rectifying chloride channel. A mechanism by which outward rectification of the single channel chloride current could allow efficient regulation of acidification by the channel is discussed.
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Cites
THE CHEMICAL DYNAMICS OF BONE MINERAL
NEUMAN, W. F., & NEUMAN, M. W. (1959) · The American Journal Of The Medical Sciences · doi:10.1097/00000441-195912000-00030 · Cited by 1,032
Ross, F. P., Chappel, J., Alvarez, J. I., Sander, D., Butler, W. T., Farach-Carson, M. C., Mintz, K. A., Robey, P. G., Teitelbaum, S. L., & Cheresh, D. A. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98430-9 · Cited by 537
Self-citation
Cited by
Bone Resorption by Osteoclasts
Teitelbaum, S. L. (2000) · Science · doi:10.1126/science.289.5484.1504 · Cited by 3,962
Self-citationMolecular Structure and Physiological Function of Chloride Channels
Jentsch, T. J., Stein, V., Weinreich, F., & Zdebik, A. A. (2002) · Physiological Reviews · doi:10.1152/physrev.00029.2001 · Cited by 1,256
Loss of the ClC-7 Chloride Channel Leads to Osteopetrosis in Mice and Man
Kornak, U., Kasper, D., Bösl, M. R., Kaiser, E., Schweizer, M., Schulz, A., Friedrich, W., Delling, G., & Jentsch, T. J. (2001) · Cell · doi:10.1016/s0092-8674(01)00206-9 · Cited by 995
Osteoclasts: What Do They Do and How Do They Do It?
Teitelbaum, S. L. (2007) · The American Journal of Pathology · doi:10.2353/ajpath.2007.060834 · Cited by 730
Self-citationCharacterization of osteoclasts derived from CD14+ monocytes isolated from peripheral blood
Sørensen, M. G., Henriksen, K., Schaller, S., Henriksen, D. B., Nielsen, F. C., Dziegiel, M. H., & Karsdal, M. A. (2006) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-006-0725-9 · Cited by 143
Metadata
- Authors
- Schlesinger, P. H., Blair, H. C., Teitelbaum, S. L., & Edwards, J. C.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1997-07
- Volume
- 272
- Issue
- 30
- Pages
- 18636-18643
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2079270852
- Cited by
- 194
- References
- 2
- FWCI
- 1.91
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Schlesinger, P. H., Blair, H. C., Teitelbaum, S. L., & Edwards, J. C. (1997). Characterization of the Osteoclast Ruffled Border Chloride Channel and Its Role in Bone Resorption. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.272.30.18636
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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