Osteoclasts: What Do They Do and How Do They Do It?

Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation.

Lacey, D. L., Timms, E., Tan, H.-L., Kelley, M. J., Dunstan, C. R., Burgess, T., Elliott, R., Colombero, A., Elliott, G., Scully, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)81569-x · Cited by 5,439 · see citing works

Osteoprotegerin: a novel secreted protein involved in the regulation of bone density.

Simonet, W. S., Lacey, D. L., Dunstan, C. R., Kelley, M., Chang, M.-S., Lüthy, R., Nguyen, H. Q., Wooden, S., Bennett, L., Boone, T., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80209-3 · Cited by 5,130 · see citing works

Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL

Yasuda, H., Shima, N., Nakagawa, N., Yamaguchi, K., Kinosaki, M., Mochizuki, S.-I., Tomoyasu, A., Yano, K., Goto, M., Murakami, A., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.3597 · Cited by 4,224 · see citing works

Induction and Activation of the Transcription Factor NFATc1 (NFAT2) Integrate RANKL Signaling in Terminal Differentiation of Osteoclasts

Takayanagi, H., Kim, S., Koga, T., Nishina, H., Isshiki, M., Yoshida, H., Saiura, A., Isobe, M., Yokochi, T., Inoue, J.-I., et al. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00369-6 · Cited by 2,701 · see citing works

Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

Soriano, P. M., Montgomery, C. A., Geske, R. S., & Bradley, A. (1991) · Cell · doi:10.1016/0092-8674(91)90499-o · Cited by 1,997 · see citing works

Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand.

Kong, Y.-Y., Feige, U., Sarosi, I., Bolon, B., Tafuri, A., Morony, S., Capparelli, C., Li, J., Elliott, R., McCabe, S., et al. (1999) · Nature · doi:10.1038/46303 · Cited by 1,856 · see citing works

The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene

Yoshida, H., Hayashi, S.-I., Kunisada, T., Ogawa, M., Nishikawa, S., Okamura, H., Sudo, T., Shultz, L. D., & Nishikawa, S.-I. (1990) · Nature · doi:10.1038/345442a0 · Cited by 1,789 · see citing works

Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone.

Weinstein, R. S., Jilka, R. L., Parfitt, A. M., & Manolagas, S. C. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2799 · Cited by 1,753 · see citing works

Genetic regulation of osteoclast development and function

Teitelbaum, S. L., & Ross, F. (2003) · Nature reviews genetics · doi:10.1038/nrg1122 · Cited by 1,733 · see citing works

TNF-α induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand

Lam, J., Takeshita, S., Barker, J. E., Kanagawa, O., Ross, F. P., & Teitelbaum, S. L. (2000) · Journal of Clinical Investigation · doi:10.1172/jci11176 · Cited by 1,440 · see citing works

Severely Suppressed Bone Turnover: A Potential Complication of Alendronate Therapy

Odvina, C. V., Zerwekh, J. E., Rao, D. S., Maalouf, N. M., Gottschalk, F., & Pak, C. Y. C. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0952 · Cited by 1,429 · see citing works

c-Fos: a Key Regulator of Osteoclast-Macrophage Lineage Determination and Bone Remodeling

Grigoriadis, A. E., Wang, Z., Cecchini, M. G., Hofstetter, W., Felix, R., Fleisch, H. A., & Wagner, E. F. (1994) · Science · doi:10.1126/science.7939685 · Cited by 1,260 · see citing works

TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signalingPreprint

Lomaga, M. A., Yeh, W., Sarosi, I., Duncan, G. S., Furlonger, C. L., Ho, A. P., Morony, S., Capparelli, C., Van, G. Y., Kaufman, S., et al. (1999) · Genes & Development · doi:10.1101/gad.13.8.1015 · Cited by 1,253 · see citing works

Global Conformational Rearrangements in Integrin Extracellular Domains in Outside-In and Inside-Out Signaling

Takagi, J., Petre, B. M., Walz, T., & Springer, T. A. (2002) · Cell · doi:10.1016/s0092-8674(02)00935-2 · Cited by 1,168 · see citing works

RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis, and regulation of bone mass and calcium metabolism.

Li, J., Sarosi, I., Yan, X.-Q., Morony, S., Capparelli, C., Tan, H.-L., McCabe, S., Elliott, R., Scully, S., Van, G., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.4.1566 · Cited by 1,119 · see citing works

Origin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells.

Udagawa, N., Takahashi, N., Akatsu, T., Tanaka, H., Sasaki, T., Nishihara, T., Koga, T., Martin, T. J., & Suda, T. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.18.7260 · Cited by 1,048 · see citing works

Pycnodysostosis, a Lysosomal Disease Caused by Cathepsin K Deficiency

Gelb, B. D., Shi, G., Chapman, H. A., & Desnick, R. J. (1996) · Science · doi:10.1126/science.273.5279.1236 · Cited by 1,022 · see citing works

Requirement for NF-κB in osteoclast and B-cell development

Franzoso, G., Carlson, L., Xing, L., Poljak, L., Shores, E. W., Brown, K. D., Leonardi, A., Tran, T., Boyce, B. F., & Siebenlist, U. (1997) · Genes & Development · doi:10.1101/gad.11.24.3482 · Cited by 996 · see citing works

Loss of the ClC-7 Chloride Channel Leads to Osteopetrosis in Mice and Man

Kornak, U., Kasper, D., Bösl, M. R., Kaiser, E., Schweizer, M., Schulz, A., Friedrich, W., Delling, G., & Jentsch, T. J. (2001) · Cell · doi:10.1016/s0092-8674(01)00206-9 · Cited by 995 · see citing works

Osteoclastic Bone Resorption by a Polarized Vacuolar Proton Pump

Blair, H. C., Teitelbaum, S. L., Ghiselli, R. W., & Gluck, S. L. (1989) · Science · doi:10.1126/science.2528207 · Cited by 862 · see citing works

Autoamplification of NFATc1 expression determines its essential role in bone homeostasis

Asagiri, M., Sato, K., Usami, T., Ochi, S., Nishina, H., Yoshida, H., Morita, I., Wagner, E. F., Mak, T. W., Serfling, E., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20051150 · Cited by 849 · see citing works

Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis

Koga, T., Inui, M., Inoue, K., Kim, S., Suematsu, A., Kobayashi, E., Iwata, T., Ohnishi, H., Matozaki, T., Kodama, T., et al. (2004) · Nature · doi:10.1038/nature02444 · Cited by 828 · see citing works

IL-1 mediates TNF-induced osteoclastogenesis.

Wei, S., Kitaura, H., Zhou, P., Ross, F. P., & Teitelbaum, S. L. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23394 · Cited by 813 · see citing works

Mice lacking beta3 integrins are osteosclerotic because of dysfunctional osteoclasts.

McHugh, K. P., Hodivala-Dilke, K., Zheng, M., Namba, N., Lam, J. D., Novack, D., Feng, X., Ross, F., Hynes, R. O., & Teitelbaum, S. L. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8905 · Cited by 786 · see citing works

Defects in TCIRG1 subunit of the vacuolar proton pump are responsible for a subset of human autosomal recessive osteopetrosis

Frattini, A., Orchard, P. J., Sobacchi, C., Giliani, S. C., Abinun, M., Mattsson, J. P., Keeling, D. J., Andersson, A., Wallbrandt, P., Zecca, L., et al. (2000) · Nature Genetics · doi:10.1038/77131 · Cited by 669 · see citing works

Distinct molecular mechanism for initiating TRAF6 signalling

Ye, H., Arron, J. R., Lamothe, B., Cirilli, M., Kobayashi, T., Shevde, N. K., Segal, D., Dzivenu, O. K., Vologodskaia, M., Yim, M., et al. (2002) · Nature · doi:10.1038/nature00888 · Cited by 665 · see citing works

Severe osteopetrosis, defective interleukin‐1 signalling and lymph node organogenesis in TRAF6‐deficient mice

Naito, A., Azuma, S., Tanaka, S., Miyazaki, T., Takaki, S., Takatsu, K., Nakao, K., Nakamura, K., Katsuki, M., Yamamoto, T. S., et al. (1999) · Genes to Cells · doi:10.1046/j.1365-2443.1999.00265.x · Cited by 626 · see citing works

Role of receptor activator of nuclear factor-κB ligand and osteoprotegerin in bone cell biology

Hofbauer, L. C., & Heufelder, A. E. (2001) · Journal of Molecular Medicine · doi:10.1007/s001090100226 · Cited by 586 · see citing works

Osteopetrosis in mice lacking haematopoietic transcription factor PU.1

Tondravi, M. M., McKercher, S. R., Anderson, K., Erdmann, J. M., Quiroz, M. E., Maki, R. A., & Teitelbaum, S. L. (1997) · Nature · doi:10.1038/386081a0 · Cited by 537 · see citing works

Selective inhibition of NF-κB blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo

Jimi, E., Aoki, K., Saito, H., D’Acquisto, F., May, M. J., Nakamura, I., Sudo, T., Kojima, T., Okamoto, F., Fukushima, H., et al. (2004) · Nature Medicine · doi:10.1038/nm1054 · Cited by 500 · see citing works

Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-regulated osteoclast differentiation

Ikeda, F., Nishimura, R., Matsubara, T., Tanaka, S., Inoue, J., Reddy, S. V., Hata, K., Yamashita, K., Hiraga, T., Watanabe, T., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200419657 · Cited by 461 · see citing works

Successful Bone-Marrow Transplantation for Infantile Malignant Osteopetrosis

Coccia, P. F., Krivit, W. A., Červenka, J., Clawson, C., Kersey, J. H., Kim, T. H., Nesbit, M. E., Ramsay, N. K. C., Warkentin, P. I., Teitelbaum, S. L., et al. (1980) · New England Journal of Medicine · doi:10.1056/nejm198003273021301 · Cited by 450 · see citing works

Bisphosphonate-Induced Osteopetrosis

Whyte, M. P., Wenkert, D., Clements, K. L., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa023110 · Cited by 449 · see citing works

Osteoprotegerin Deficiency and Juvenile Paget's Disease

Whyte, M. P., Obrecht, S. E., Finnegan, P. M., Jones, J. L., Podgornik, M. N., McAlister, W. H., & Mumm, S. R. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa013096 · Cited by 446 · see citing works

Glucocorticoids suppress bone formation via the osteoclast.

Kim, H.-J. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28084 · Cited by 384 · see citing works

Large Scale Gene Expression Analysis of Osteoclastogenesisin Vitro and Elucidation of NFAT2 as a Key Regulator

Ishida, N., Hayashi, K., Hoshijima, M., Ogawa, T., Koga, S., Miyatake, Y., Kumegawa, M., Kimura, T., & Takeya, T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205063200 · Cited by 377 · see citing works

Osteoclast differentiation independent of the TRANCE–RANK–TRAF6 axis

Kim, N., Kadono, Y., Takami, M., Lee, J., Lee, S.-H., Okada, F., Kim, J. H., Kobayashi, T., Odgren, P. R., Nakano, H., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050978 · Cited by 371 · see citing works

Bone Resorption Restored in Osteopetrotic Mice by Transplants of Normal Bone Marrow and Spleen Cells

Walker, D. G. (1975) · Science · doi:10.1126/science.1105786 · Cited by 346 · see citing works

JNK1 modulates osteoclastogenesis through both c-Jun phosphorylation-dependent and -independent mechanisms

David, J., Sabapathy, K., Hoffmann, O., Idarraga, M. H., & Wagner, E. F. (2002) · Journal of Cell Science · doi:10.1242/jcs.00082 · Cited by 334 · see citing works

TNFα Potently Activates Osteoclasts, through a Direct Action Independent of and Strongly Synergistic with RANKL.

Fuller, K., Murphy, C., Kirstein, B., Fox, S., & Chambers, T. (2002) · Endocrinology · doi:10.1210/endo.143.3.8701 · Cited by 322 · see citing works

Single and combined inhibition of tumor necrosis factor, interleukin‐1, and RANKL pathways in tumor necrosis factor–induced arthritis: Effects on synovial inflammation, bone erosion, and cartilage destruction

Zwerina, J., Hayer, S., Tohidast-Akrad, M., Bergmeister, H., Redlich, K., Feige, U., Dunstan, C. R., Kollias, G., Steiner, G. E., Smolen, J. S., et al. (2004) · Arthritis & Rheumatism · doi:10.1002/art.11487 · Cited by 308 · see citing works

Vav3 regulates osteoclast function and bone mass

Faccio, R., Teitelbaum, S., Fujikawa, K., Chappel, J., Zallone, A., Tybulewicz, V., Ross, F., & Swat, W. (2005) · Nature Medicine · doi:10.1038/nm1194 · Cited by 304 · see citing works

M-CSF mediates TNF-induced inflammatory osteolysis.

Kitaura, H., Zhou, P., Kim, H.-J., Novack, D., Ross, F. P., & Teitelbaum, S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci26132 · Cited by 301 · see citing works

Lipopolysaccharide-stimulated osteoclastogenesis is mediated by tumor necrosis factor via its P55 receptor.

Abu‐Amer, Y., Ross, F. P., Edwards, J. C., & Teitelbaum, S. L. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119679 · Cited by 291 · see citing works

A peptidomimetic antagonist of the alpha(v)beta3 integrin inhibits bone resorption in vitro and prevents osteoporosis in vivo.

Engleman, V. W., Nickols, G. A., Ross, F. P., Horton, M. A., Griggs, D. W., Settle, S. L., Ruminski, P., & Teitelbaum, S. L. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119404 · Cited by 285 · see citing works

Isolated osteoclasts resorb the organic and inorganic components of bone.

Blair, H. C., Kahn, A. J., Crouch, E. C., Jeffrey, J. J., & Teitelbaum, S. L. (1986) · The Journal of Cell Biology · doi:10.1083/jcb.102.4.1164 · Cited by 281 · see citing works

Src Kinase Activity Is Essential for Osteoclast Function

Miyazaki, T., Sanjay, A., Neff, L., Tanaka, S., Horne, W. C., & Baron, R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311032200 · Cited by 275 · see citing works

The IκB Function of NF-κB2 p100 Controls Stimulated Osteoclastogenesis

Novack, D., Yin, L., Hagen-Stapleton, A., Schreiber, R. D., Goeddel, D., Ross, F. P., & Teitelbaum, S. L. (2003) · Journal of Experimental Medicine · doi:10.1084/jem.20030116 · Cited by 275 · see citing works

Rescue of osteoclast function by transgenic expression of kinase-deficient Src insrc−/− mutant micePreprint

Schwartzberg, P. L., Xing, L., Hoffmann, O., Lowell, C. A., Garrett, L. J., Boyce, B. F., & Varmus, H. E. (1997) · Genes & Development · doi:10.1101/gad.11.21.2835 · Cited by 268 · see citing works

SHIP-deficient mice are severely osteoporotic due to increased numbers of hyper-resorptive osteoclasts

Takeshita, S., Namba, N., Zhao, J. J., Jiang, Y., Genant, H. K., Silva, M. J., Brodt, M. D., Helgason, C. D., Kalesnikoff, J., Rauh, M. J., et al. (2002) · Nature Medicine · doi:10.1038/nm752 · Cited by 250 · see citing works

RANK‐mediated amplification of TRAF6 signaling leads to NFATc1 induction during osteoclastogenesis

Gohda, J., Akiyama, T., Koga, T., Takayanagi, H., Tanaka, S., & Inoue, J. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600564 · Cited by 226 · see citing works

Crystal structure of the TRANCE/RANKL cytokine reveals determinants of receptor-ligand specificity.

Lam, J. D., Nelson, C. A., Ross, F. P., Teitelbaum, S., & Fremont, D. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13890 · Cited by 205 · see citing works

The IκB Kinase (IKK) Inhibitor, NEMO-binding Domain Peptide, Blocks Osteoclastogenesis and Bone Erosion in Inflammatory Arthritis

Dai, S., Hirayama, T., Abbas, S., & Abu‐Amer, Y. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.c400258200 · Cited by 196 · see citing works

Tumor Necrosis Factor Receptors Types 1 and 2 Differentially Regulate Osteoclastogenesis

Abu‐Amer, Y., Erdmann, J. M., Alexopoulou, L., Kollias, G. A., Ross, F. P., & Teitelbaum, S. L. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003886200 · Cited by 195 · see citing works

c-Fms and the αvβ3 integrin collaborate during osteoclast differentiation

Faccio, R., Takeshita, S., Zallone, A. Z., Ross, F. P., & Teitelbaum, S. L. (2003) · Journal of Clinical Investigation · doi:10.1172/jci16924 · Cited by 195 · see citing works

Characterization of the Osteoclast Ruffled Border Chloride Channel and Its Role in Bone Resorption

Schlesinger, P. H., Blair, H. C., Teitelbaum, S. L., & Edwards, J. C. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.30.18636 · Cited by 194 · see citing works

Tumor Necrosis Factor-α Increases Circulating Osteoclast Precursor Numbers by Promoting Their Proliferation and Differentiation in the Bone Marrow through Up-regulation of c-Fms Expression

Yao, Z., Li, P., Zhang, Q., Schwarz, E. M., Keng, P., Arbini, A., Boyce, B. F., & Xing, L. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m512624200 · Cited by 192 · see citing works

Marrow Stromal Cells and Osteoclast Precursors Differentially Contribute to TNF-α-Induced Osteoclastogenesis In Vivo

Kitaura, H., Sands, M. S., Aya, K., Zhou, P., Hirayama, T., Uthgenannt, B., Wei, S., Takeshita, S., Novack, D. V., Silva, M. J., et al. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.8.4838 · Cited by 190 · see citing works

The role of T lymphocytes in bone metabolism

Weitzmann, M. N., & Pacifici, R. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00324.x · Cited by 188 · see citing works

Changing RANKL/OPG mRNA expression in differentiating murine primary osteoblasts

Thomas, G. P., Baker, S., Eisman, J. A., & Gardiner, E. M. (2001) · Journal of Endocrinology · doi:10.1677/joe.0.1700451 · Cited by 184 · see citing works

Dynamic changes in the osteoclast cytoskeleton in response to growth factors and cell attachment are controlled by β3 integrin

Faccio, R., Novack, D. V., Zallone, A. Z., Ross, F. P., & Teitelbaum, S. L. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200212082 · Cited by 178 · see citing works

c-Fms and the αvβ3 integrin collaborate during osteoclast differentiation

Faccio, R., Takeshita, S., Zallone, A. Z., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200316924 · Cited by 171 · see citing works

Immediate Fall of Bone Formation and Transient Increase of Bone Resorption in the Course of High-Dose, Short-Term Glucocorticoid Therapy in Young Patients with Multiple Sclerosis

Dovio, A., Perazzolo, L., Osella, G., Ventura, M., Termine, A., Milano, E., Bertolotto, A., & Angeli, A. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0164 · Cited by 161 · see citing works

Osteoclasts; culprits in inflammatory osteolysis

Teitelbaum, S. (2005) · Arthritis Research & Therapy · doi:10.1186/ar1857 · Cited by 150 · see citing works

Effect of L-000845704, an αVβ3 Integrin Antagonist, on Markers of Bone Turnover and Bone Mineral Density in Postmenopausal Osteoporotic Women

Murphy, M. G., Cerchio, K., Stoch, S. A., et al. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-2126 · Cited by 137 · see citing works

A TNF receptor loop peptide mimic blocks RANK ligand-induced signaling, bone resorption, and bone loss.

Aoki, K., Saito, H., Itzstein, C., Ishiguro, M., Shibata, T., Blanqué, R., Mian, A. H., Takahashi, M., Suzuki, Y., Yoshimatsu, M., et al. (2006) · Journal of Clinical Investigation · doi:10.1172/jci22513 · Cited by 135 · see citing works

A Glanzmann’s mutation in β3 integrin specifically impairs osteoclast function

Feng, X., Novack, D. V., Faccio, R., Ory, D. S., Aya, K., Boyer, M. I., McHugh, K. P., Ross, F. P., & Teitelbaum, S. L. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12040 · Cited by 134 · see citing works

Cytoplasmic pH regulation and chloride/bicarbonate exchange in avian osteoclasts.

Teti, A. M., Blair, H. C., Teitelbaum, S. L., et al. (1989) · Journal of Clinical Investigation · doi:10.1172/jci113863 · Cited by 132 · see citing works

Spleen Cells Transmit Osteopetrosis in Mice

Walker, D. G. (1975) · Science · doi:10.1126/science.1198094 · Cited by 129 · see citing works

The HIV protease inhibitor ritonavir blocks osteoclastogenesis and function by impairing RANKL-induced signaling

Wang, M. W.-H., Shi, W., Faccio, R., Takeshita, S., Tebas, P., Powderly, W. G., Teitelbaum, S. L., & Ross, F. P. (2004) · Journal of Clinical Investigation · doi:10.1172/jci15797 · Cited by 121 · see citing works

Rab3D Regulates a Novel Vesicular Trafficking Pathway That Is Required for Osteoclastic Bone Resorption

Pavlos, N., Xu, J.-K., Riedel, D., Yeoh, J. S. G., Teitelbaum, S., Papadimitriou, J., Jahn, R., Ross, F., & Zheng, M. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.12.5253-5269.2005 · Cited by 105 · see citing works

Substrate Recognition by Osteoclast Precursors Induces C-src/Microtubule Association

Abu‐Amer, Y., Ross, F. P., Schlesinger, P. H., et al. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.137.1.247 · Cited by 96 · see citing works

Direct Inhibition of NF-κB Blocks Bone Erosion Associated with Inflammatory Arthritis

Clohisy, J. C. F., Roy, B. C., Biondo, C., Frazier, E. P., Willis, D., Teitelbaum, S. L., & Abu‐Amer, Y. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.10.5547 · Cited by 90 · see citing works

FHL2 inhibits the activated osteoclast in a TRAF6-dependent manner

Bai, S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24921 · Cited by 89 · see citing works

Murine Osteoclast Formation and Function: Differential Regulation by Humoral Agents

Fuller, K., Kirstein, B., & Chambers, T. J. (2005) · Endocrinology · doi:10.1210/en.2005-1340 · Cited by 88 · see citing works

Strength of TRAF6 signalling determines osteoclastogenesis

Kadono, Y., Okada, F., Perchonock, C. E., Jang, H. D., Lee, S. Y., Kim, N., & Choi, Y. (2005) · EMBO Reports · doi:10.1038/sj.embor.7400345 · Cited by 87 · see citing works

Sustained In Vitro Expansion of Bone Progenitors Is Cell Density Dependent

Purpura, K. A., Aubin, J. E., & Zandstra, P. W. (2004) · Stem Cells · doi:10.1634/stemcells.22-1-39 · Cited by 85 · see citing works

TAT Fusion Proteins Containing Tyrosine 42-deleted IκBα Arrest Osteoclastogenesis

Abu‐Amer, Y., Dowdy, S. F., Ross, F. P., Clohisy, J. C. F., & Teitelbaum, S. L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104725200 · Cited by 85 · see citing works

Unoccupied αvβ3Integrin Regulates Osteoclast Apoptosis by Transmitting a Positive Death Signal

Zhao, H., Ross, F. P., & Teitelbaum, S. L. (2004) · Molecular Endocrinology · doi:10.1210/me.2004-0161 · Cited by 83 · see citing works

Osteoclast Differentiation Is Impaired in the Absence of Inhibitor of κB Kinase α*

Chaisson, M., Branstetter, D., Derry, J., Armstrong, A., Tometsko, M., Takeda, K., Akira, S., & Dougall, W. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406392200 · Cited by 83 · see citing works

Isolation and reconstitution of a vacuolar-type proton pump of osteoclast membranes.

Mattsson, J. P., Schlesinger, P. H., Keeling, D. J., et al. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31485-0 · Cited by 75 · see citing works

Mice Lacking the Integrin β5 Subunit Have Accelerated Osteoclast Maturation and Increased Activity in the Estrogen-Deficient State

Lane, N. E., Yao, W., Nakamura, M. C., Humphrey, M. B., Kimmel, D. B., Huang, X., Sheppard, D., Ross, F. P., & Teitelbaum, S. L. (2005) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.041017 · Cited by 62 · see citing works

Critical Role of β3 Integrin in Experimental Postmenopausal Osteoporosis

Zhao, H., Kitaura, H., Sands, M. S., Ross, F. P., Teitelbaum, S. L., & Novack, D. V. (2005) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.050724 · Cited by 60 · see citing works

Granulocyte Macrophage-Colony Stimulating Factor Reciprocally Regulates αv-Associated Integrins on Murine Osteoclast Precursors

Inoue, M., Namba, N., Chappel, J. C., Teitelbaum, S. L., & Ross, F. P. (1998) · Molecular Endocrinology · doi:10.1210/mend.12.12.0213 · Cited by 58 · see citing works

Upregulation of human heme oxygenase gene expression by Ets-family proteins

Deramaudt, B. M. J. ‐., Rémy, P., & Abraham, N. G. (1999) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(19990301)72:3 · Cited by 55 · see citing works

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Feng, X., Takeshita, S., Namba, N., Wei, S., Teitelbaum, S., & Ross, F. (2002) · Endocrinology · doi:10.1210/en.2002-220467 · Cited by 43 · see citing works

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Lane, N. E., Yao, W., Nakamura, M. C., Humphrey, M. B., Kimmel, D. B., Huang, X., Sheppard, D., Ross, F. P., & Teitelbaum, S. L. (2005) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2005.20.1.58 · Cited by 39 · see citing works

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Teitelbaum, S. L. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0338 · Cited by 30 · see citing works

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Rocha, L. A., Higa, A., Barreto, F. C., et al. (2006) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2006.05.028 · Cited by 20 · see citing works

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Florencio-Silva, R., Sasso, G. R. D. S., Sasso-Cerri, E., Simões, M. J., & Cerri, P. S. (2015) · BioMed Research International · doi:10.1155/2015/421746 · Cited by 2,044 · see citing works

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Chung, H. Y., Cesari, M., Anton, S., Marzetti, E., Giovannini, S., Seo, A. Y., Carter, C., Yu, B. P., & Leeuwenburgh, C. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2008.07.002 · Cited by 1,203 · see citing works

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Nakamura, T., Imai, Y., Matsumoto, T., Sato, S., Takeuchi, K., Igarashi, K., Harada, Y., Azuma, Y., Krust, A., Yamamoto, Y., et al. (2007) · Cell · doi:10.1016/j.cell.2007.07.025 · Cited by 1,013 · see citing works

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Bahney, C. S., Zondervan, R. L., Allison, P., Theologis, A., Ashley, J. W., Ahn, J., Miclau, T., Marcucio, R. S., & Hankenson, K. D. (2019) · Journal of Orthopaedic Research · doi:10.1002/jor.24170 · Cited by 577 · see citing works

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Britton, R. A., Irwin, R., Quach, D., Schaefer, L., Zhang, J., Lee, T., Parameswaran, N., & McCabe, L. R. (2014) · Journal of Cellular Physiology · doi:10.1002/jcp.24636 · Cited by 499 · see citing works

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Capulli, M., Paone, R., & Rucci, N. (2014) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2014.05.003 · Cited by 413 · see citing works

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Tilg, H., Moschen, A. R., Kaser, A., Pines, A., & Dotan, I. (2008) · Gut · doi:10.1136/gut.2006.117382 · Cited by 292 · see citing works

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Tuckermann, J., & Adams, R. H. (2021) · Nature Reviews Rheumatology · doi:10.1038/s41584-021-00682-3 · Cited by 258 · see citing works

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Mazziotti, G., Frara, S., & Giustina, A. (2018) · Endocrine Reviews · doi:10.1210/er.2018-00005 · Cited by 181 · see citing works

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Xiu, Y., Xu, H., Zhao, C., Li, J., Morita, Y., Yao, Z., Xing, L., & Boyce, B. F. (2014) · Journal of Clinical Investigation · doi:10.1172/jci66947 · Cited by 164 · see citing works

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Guntur, A. R., & Rosen, C. J. (2012) · Endocrine Practice · doi:10.4158/ep12141.ra · Cited by 150 · see citing works

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Grigoriadis, A. E., Kennedy, M., Bozec, A., Brunton, F., Stenbeck, G., Park, I.-H., Wagner, E. F., & Keller, G. M. (2010) · Blood · doi:10.1182/blood-2009-07-234690 · Cited by 151 · see citing works

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Crockett, J. C., Mellis, D. J., Scott, D. I., & Helfrich, M. H. (2011) · Osteoporosis International · doi:10.1007/s00198-010-1272-8 · Cited by 143 · see citing works

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Mansoorifar, A., Gordon, R., Bergan, R. C., & Bertassoni, L. E. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202006796 · Cited by 142 · see citing works

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McNally, A. K., Jones, J. A., MacEwan, S. R., Colton, E., & Anderson, J. M. (2008) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.31658 · Cited by 139 · see citing works

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Ding, K., Hua, F., & Ding, W. (2020) · Aging and disease · doi:10.14336/ad.2019.0523 · Cited by 134 · see citing works

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Sprangers, S., & Everts, V. (2019) · Matrix Biology · doi:10.1016/j.matbio.2017.11.008 · Cited by 102 · see citing works

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Elson, A., Anuj, A., Barnea-Zohar, M., & Reuven, N. (2022) · Bone · doi:10.1016/j.bone.2022.116538 · Cited by 95 · see citing works

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Henriksen, K., Flores, C., Thomsen, J. S., Brüel, A.-M., Thudium, C. S., Neutzsky-Wulff, A. V., Langenbach, G. E. J., Sims, N., Askmyr, M., Martin, T. J., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027482 · Cited by 77 · see citing works

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Izawa, T., Arakaki, R., Mori, H., Tsunematsu, T., Kudo, Y., Tanaka, E., & Ishimaru, N. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600822 · Cited by 64 · see citing works

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Iseme, R. A., Mcevoy, M., Kelly, B., Agnew, L., Walker, F. R., & Attia, J. (2017) · Bone Reports · doi:10.1016/j.bonr.2017.10.003 · Cited by 56 · see citing works

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Shen, W.-R., Kimura, K., Ishida, M., Sugisawa, H., Kishikawa, A., Shima, K., Ogawa, S., Qi, J., & Kitaura, H. (2018) · Journal of Immunology Research · doi:10.1155/2018/5783639 · Cited by 45 · see citing works

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Ishida, M., Shen, W.-R., Kimura, K., Kishikawa, A., Shima, K., Ogawa, S., Qi, J., Ohori, F., Noguchi, T., Marahleh, A., et al. (2019) · Biomedicine &amp; Pharmacotherapy · doi:10.1016/j.biopha.2018.10.052 · Cited by 36 · see citing works

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Department of Trauma and Reconstructive Surgery, E. K. U. T., Menger, M., Merscher, B., Scheuer, C., Braun, B., Herath, S., Rollmann, M., Stenger, D., Später, T., Pohlemann, T., et al. (2021) · European Cells and Materials · doi:10.22203/ecm.v041a38 · Cited by 16 · see citing works

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Mustafa, N. H., Kelesbayev, D., & Alibekova, Z. D. (2018) · The Journal of Economic Research & Business Administration · doi:10.26577/be-2018-2-2141

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Hawkins, D. (2017)

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Cross, R. (2018) · C&EN Global Enterprise · doi:10.1021/cen-09635-buscon15

Enxerto livre de arteria epigastrica inferior: avaliacao hemodinamica e angiografica pre e pos-operatoria

Dib, A., Puig, L. B., Salvadori, D., et al. (1988) · Arquivos Brasileiros de Cardiologia

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Ceccon, M. E. J. R. (2003) · Jornal de Pediatria · doi:10.1590/s0021-75572003000400002 · Cited by 14 · see citing works