The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
CYP26, a Novel Mammalian Cytochrome P450, Is Induced by Retinoic Acid and Defines a New Family
Open accessAbstract
A novel member of the cytochrome P450 superfamily, CYP26, which represents a new family of cytochrome P450 enzymes, has been cloned. CYP26 mRNA is up-regulated during the retinoic acid (RA)-induced neural differentiation of mouse embryonic stem cells in vitro and is transiently expressed by embryonic stem cells undergoing predominantly non-neural differentiation. CYP26 transcript is detectable as early as embryonic day 8.5 in mouse embryos, suggesting a function for the gene in early development. CYP26 is expressed in mouse and human liver, as expected for a cytochrome P450, and is also expressed in regions of the brain and the placenta. Acute administration of 100 mg/kg all-trans-RA increases steady-state levels of transcript in the adult liver, but not in the brain. CYP26 is highly homologous to a Zebrafish gene, CYPRA1, which has been proposed to participate in the degradation of RA, but is minimally homologous to other mammalian cytochrome P450 proteins. Thus, we report the cloning of a member of a novel cytochrome P450 family that is expressed in mammalian embryos and in brain and is induced by RA in the liver.
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Cites
Molecular Cloning: A Laboratory Manual
Sambrook, J., Fritsch, E., & Maniatis, T. (1989) · UCLA - Biblioteca de Ciencias de la Salud · Cited by 133,589
Molecular cloning: A laboratory manual
Deininger, P. (1990) · Analytical Biochemistry · doi:10.1016/0003-2697(90)90595-z · Cited by 84,682
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1016/0003-2697(87)90021-2 · Cited by 46,426
Establishment in culture of pluripotential cells from mouse embryos
Evans, M. J., & Kaufman, M. H. (1981) · Nature · doi:10.1038/292154a0 · Cited by 8,607
Martin, G. R. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.12.7634 · Cited by 5,746
An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs
Kozak, M. (1987) · Nucleic Acids Research · doi:10.1093/nar/15.20.8125 · Cited by 5,087
P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature
Nelson, D. R., Koymans, L., Kamataki, T., Stegeman, J. J., Feyereisen, R., Waxman, D. J., Waterman, M. R., Gotoh, O., Coon, M. J., Estabrook, R. W., et al. (1996) · Pharmacogenetics · doi:10.1097/00008571-199602000-00002 · Cited by 2,945
P450 GENES: STRUCTURE, EVOLUTION, AND REGULATION
Nebert, D. W., & Gonzalez, F. J. (1987) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.56.070187.004501 · Cited by 1,585
A Method for Isolation of Intact, Translationally Active Ribonucleic Acid
CATHALA, G., SAVOURET, J.-F., MENDEZ, B., WEST, B. L., KARIN, M., MARTIAL, J. A., & BAXTER, J. D. (1983) · DNA · doi:10.1089/dna.1983.2.329 · Cited by 1,447
Embryonic Stem Cells Express Neuronal Properties in Vitro
Bain, G., Kitchens, D., Yao, M., Huettner, J. E., & Gottlieb, D. I. (1995) · Developmental Biology · doi:10.1006/dbio.1995.1085 · Cited by 1,168
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Ross, S. A., McCaffery, P. J., Drager, U. C., & De Luca, L. M. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.3.1021 · Cited by 866
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Compagnone, N. A., & Mellon, S. H. (2000) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1999.0188 · Cited by 820
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Metadata
- Authors
- Ray, W. J., Bain, G., Yao, M., & Gottlieb, D. I.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1997-07
- Volume
- 272
- Issue
- 30
- Pages
- 18702-18708
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2089189711
- Cited by
- 305
- References
- 38
- FWCI
- 16.81
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Ray, W. J., Bain, G., Yao, M., & Gottlieb, D. I. (1997). CYP26, a Novel Mammalian Cytochrome P450, Is Induced by Retinoic Acid and Defines a New Family. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.272.30.18702
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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