Nutrient Deprivation of Cultured Rat Hepatocytes Increases the Desferrioxamine-available Iron Pool and Augments the Sensitivity to Hydrogen Peroxide
Open accessAbstract
Primary cultures of rat hepatocytes were subjected to amino acid and serum deprivation for 4 h. This treatment augmented the sensitivity to ensuing hydrogen peroxide exposure for 30 min. The by nutrient deprivation-increased autophagocytosis was confirmed by transmission electron microscopy and uptake of the lysosomotropic weak base acridine orange within the intracellular acidic vacuolar apparatus. The desferrioxamine-available pool of iron increased 2.5-fold during deprivation, compared with control cells. Furthermore, amino acid deprivation increased the cellular protein turnover, measured by radioactive labeling with -3H-Leu. Exposure to 40 microM ascorbic acid specifically decreased the turnover of ferritin, as estimated by enzyme-linked immunosorbent assay, and prevented an increase of the desferrioxamine-available iron pool, resulting in protection against hydrogen peroxide-induced cell killing. Thus, hepatocytes with nutrient deprivation-enhanced autophagocytosis contain a larger pool of catalytically active iron than control cells. This iron pool is mainly derived from the turnover (autophagocytosis) of cytosolic ferritin and is probably situated in the lysosomes. Furthermore, nutrient-deprived cells show augmented sensitivity to hydrogen peroxide-induced oxidative stress, since the enhanced availability of iron in low molecular weight form results in an increased potential of intralysosomal Fenton chemistry, that may cause lysosomal rupture with release of potent hydrolytic enzymes.
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HFE2 is expressed mainly in skeletal muscle, cardiac tissue, and liver.
“HFE2 is expressed mainly in skeletal muscle, cardiac tissue, and liver.”
From Intracellular iron transport and storage: from molecular mechanisms to health implications (2008) · cites this paper as [230]
HFE2 is a GPI-anchored protein that appears to be a sensor of dietary iron levels.
“HFE2 is a GPI-anchored protein that appears to be a sensor of dietary iron levels (230).”
From Intracellular iron transport and storage: from molecular mechanisms to health implications (2008) · cites this paper as [230]
Type 2 HH is associated with a mutation mapped via positional cloning to chromosome 1q in a gene encoding hemojuvelin (HFE2).
“This particular type of HH is associated with a mutation that was mapped via positional cloning to chromosome 1q (230). The mutation occurs in a gene encoding hemojuvelin (HFE2).”
From Intracellular iron transport and storage: from molecular mechanisms to health implications (2008) · cites this paper as [230]
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- Authors
- Öllinger, K., & Roberg, K.
- Affiliations
- Linköping University (SE)
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1997-09
- Volume
- 272
- Issue
- 38
- Pages
- 23707-23711
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2046663690
- Cited by
- 65
- References
- 35
- Citations by year
- 2025: 1 · 2023: 1 · 2021: 3 · 2020: 2 · 2019: 2 · 2017: 1 · 2015: 2 · 2014: 2 · 2013: 3 · 2012: 1
- FWCI
- 3.12
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Ferroptosis and cancer prognosis
- Keywords
- nutrient deprivation, hepatocytes, amino acid starvation, serum deprivation, hydrogen peroxide sensitivity, oxidative stress, autophagy, lysosomes, Fenton reaction, vitamin C, lysosomal rupture, protein turnover
- MeSH terms
- Animals, Autophagy, Cells, Cultured, Culture Media, Deferoxamine, Hydrogen Peroxide, Liver, Microscopy, Electron, Oxidation-Reduction, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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