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The Many Faces of G Protein Signaling

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Hamm, Heidi E.·1998·Journal of Biological Chemistry
DOI 10.1074/jbc.273.2.669
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Abstract

Progress in areas of research that once might have seemed distant from the field of G protein signaling now shows that G proteins are involved in a broad range of cellular regulatory activities. The understanding of how the proteins interact (receptors, G proteins, and effectors, as well as other regulatory proteins) thus has enormous implications for physiology. The rapid progress in determining three-dimensional structures of G proteins, and more recently their regulators and effectors, has illuminated the search for mechanisms of activation and regulation and has allowed structure-based mutagenesis to test these ideas. The structural and mechanistic studies will in the future also hopefully provide opportunities to alter those interactions in pathological situations.

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Metadata

Authors
Hamm, H. E.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1998-01
Volume
273
Issue
2
Pages
669-672
ISSN
0021-9258 (ISSN-L)
DOI
10.1074/jbc.273.2.669
OpenAlex
W2066109743
Cited by
1,132
References
0
FWCI
29.38
Type
journal article
Language
en
Open access
hybrid
Licence

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Hamm, H. E. (1998). The Many Faces of G Protein Signaling. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.273.2.669

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