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The Many Faces of G Protein Signaling
Open accessAbstract
Progress in areas of research that once might have seemed distant from the field of G protein signaling now shows that G proteins are involved in a broad range of cellular regulatory activities. The understanding of how the proteins interact (receptors, G proteins, and effectors, as well as other regulatory proteins) thus has enormous implications for physiology. The rapid progress in determining three-dimensional structures of G proteins, and more recently their regulators and effectors, has illuminated the search for mechanisms of activation and regulation and has allowed structure-based mutagenesis to test these ideas. The structural and mechanistic studies will in the future also hopefully provide opportunities to alter those interactions in pathological situations.
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Metadata
- Authors
- Hamm, H. E.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1998-01
- Volume
- 273
- Issue
- 2
- Pages
- 669-672
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2066109743
- Cited by
- 1,132
- References
- 0
- FWCI
- 29.38
- Type
- journal article
- Language
- en
- Open access
- hybrid
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- creativecommons.org/licenses/by/4.0/ (vor, 8331 d)
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