Insulin, but Not Contraction, Activates Akt/PKB in Isolated Rat Skeletal Muscle

Brozinick, Joseph T.; Birnbaum, Morris J.

doi:10.1074/jbc.273.24.14679

Cited by 149Metabolism, Diabetes, and CancerPI3K/AKT/mTOR signaling in cancerMuscle metabolism and nutrition

Insulin, but Not Contraction, Activates Akt/PKB in Isolated Rat Skeletal Muscle

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Brozinick, Joseph T., Birnbaum, Morris J.·1998·Journal of Biological Chemistry

DOI 10.1074/jbc.273.24.14679

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Abstract

Insulin and muscle contraction potently stimulate glucose uptake in mammalian skeletal muscle. Studies in muscle and adipose tissue have shown that insulin induces its receptor-dependent phosphorylation of insulin receptor substrates 1 and 2, which leads to activation of polyphosphatidylinositol (PI) 3'-kinase. In contrast, muscle contraction stimulates glucose transport via a mechanism that is independent of insulin, but the two pathways may converge downstream at the level of stimulation of GLUT4 translocation. In the present study, we have examined the role of Akt, an insulin-activated serine threonine kinase that has previously been shown to increase glucose transport in adipocytes. Either insulin or in vitro muscle contraction significantly elevated glucose transport in isolated rat epitrochlearis and soleus muscles. However, Akt kinase activity was significantly stimulated by insulin and not contraction. Moreover, wortmannin, an inhibitor of PI 3'-kinase, completely blocked the insulin-stimulated increase in Akt activity and glucose transport but did not alter either of these parameters in contracting muscles. The increases in Akt activity were paralleled by a decrease in the electrophoretic mobility of Akt, indicative of phosphorylation of Akt by an upstream kinase. These changes in Akt mobility appeared to be at least partially because of phosphorylation of Akt on serine 473. A putative downstream target of Akt, p70 S6 kinase, showed similar changes in mobility in response to insulin but not contraction. These data support the view that Akt is a downstream target of PI 3'-kinase and is involved in the signaling pathways involved in insulin but not contraction stimulation of glucose transport in skeletal muscle. These data provide further evidence that two distinct pathways exist for the stimulation of glucose transport in mammalian skeletal muscle.

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PI3 kinase inhibitor wortmannin inhibits insulin but not contraction-stimulated glucose uptake.
“1) PI3 kinase inhibitor wortmannin inhibits insulin but not contraction-stimulated glucose uptake. Contraction does not promote IRS-1 autophosphorylation or increase PI3 kinase activity [103-106].”
From AMPK and Exercise: Glucose Uptake and Insulin Sensitivity (2013) · cites this paper as [106]
Contraction does not promote IRS-1 autophosphorylation or increase PI3 kinase activity.
“1) PI3 kinase inhibitor wortmannin inhibits insulin but not contraction-stimulated glucose uptake. Contraction does not promote IRS-1 autophosphorylation or increase PI3 kinase activity [103-106].”
From AMPK and Exercise: Glucose Uptake and Insulin Sensitivity (2013) · cites this paper as [106]

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
Cross, D. A. E., Alessi, D. R., Cohen, P., Andjelkovich, M., & Hemmings, B. A. (1995) · Nature · doi:10.1038/378785a0 · Cited by 5,244 · see citing works
Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
Burgering, B. M. T., & Coffer, P. J. (1995) · Nature · doi:10.1038/376599a0 · Cited by 2,113 · see citing works
The insulin signaling system.
White, M. F., & Kahn, C. R. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42297-6 · Cited by 1,723 · see citing works
Expression of a Constitutively Active Akt Ser/Thr Kinase in 3T3-L1 Adipocytes Stimulates Glucose Uptake and Glucose Transporter 4 Translocation
Kohn, A. D., Summers, S. A., Birnbaum, M. J., & Roth, R. A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.49.31372 · Cited by 1,284 · see citing works
Self-citation
Phosphatidylinositol 3-Kinase Activation Is Required for Insulin Stimulation of pp70 S6 Kinase, DNA Synthesis, and Glucose Transporter Translocation
Cheatham, B., Vlahos, C. J., Cheatham, L. A., Wang, L., Blenis, J., & Kahn, C. R. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.7.4902-4911.1994 · Cited by 1,067 · see citing works
Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects.
Goodyear, L. J., Giorgino, F., Sherman, L., Carey, J., Smith, R. J., & Dohm, G. L. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117909 · Cited by 525 · see citing works
Akt Signaling--Linking Membrane Events to Life and Death Decisions
Hemmings, B. A. (1997) · Science · doi:10.1126/science.275.5300.628 · Cited by 517 · see citing works
Contraction stimulates translocation of glucose transporter GLUT4 in skeletal muscle through a mechanism distinct from that of insulin
Lund, S., Holman, G. D., Schmitz, O., & Pedersen, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.13.5817 · Cited by 492 · see citing works
Akt, a Pleckstrin Homology Domain Containing Kinase, Is Activated Primarily by Phosphorylation
Kohn, A. D., Takeuchi, F., & Roth, R. A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.36.21920 · Cited by 476 · see citing works
Exercise induces recruitment of the “insulin-responsive glucose transporter”. Evidence for distinct intracellular insulin- and exercise-recruitable transporter pools in skeletal muscle.
Douen, A. G., Ramlal, T., Rastogi, S., Bilan, P. J., Cartee, G. D., Vranić, M., Holloszy, J. O., & Klip, A. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)77362-6 · Cited by 473 · see citing works
Physiological Role of Akt in Insulin-Stimulated Translocation of GLUT4 in Transfected Rat Adipose Cells
Cong, L.-N., Chen, H., Li, Y., Zhou, L., McGibbon, M. A., Taylor, S. I., & Quon, M. J. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.13.0027 · Cited by 383 · see citing works
The Effects of Wortmannin on Rat Skeletal Muscle
Yeh, J., Gulve, E. A., Rameh, L. E., & Birnbaum, M. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.5.2107 · Cited by 313 · see citing works
Self-citation
Potential Role of Protein Kinase B in Glucose Transporter 4 Translocation in Adipocytes
Tanti, J., Grillo, S., Grémeaux, T., Coffer, P. J., OBBERGHEN, E. V., & MARCHAND‐BRUSTEL, Y. L. (1997) · Endocrinology · doi:10.1210/endo.138.5.5136 · Cited by 261 · see citing works
Dissociation of effects of insulin and contraction on glucose transport in rat epitrochlearis muscle
Нешер, Р., Karl, I. E., & KIPNIS, D. M. (1985) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1985.249.3.c226 · Cited by 255 · see citing works
Regulation of Protein Kinase B and Glycogen Synthase Kinase-3 by Insulin and β-Adrenergic Agonists in Rat Epididymal Fat Cells
MOULE, S. K., Welsh, G. I., EDGELL, N. J., Foulstone, E. J., Proud, C. G., & Denton, R. M. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.12.7713 · Cited by 242 · see citing works
Insulin activates protein kinase B, inhibits glycogen synthase kinase‐3 and activates glycogen synthase by rapamycin‐insensitive pathways in skeletal muscle and adipose tissue
Cross, D. A. E., Watt, P., Shaw, M., KAAY, J. V. D., Downes, C. P., Holder, J. C., & Cohen, P. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00240-8 · Cited by 220 · see citing works
Identification and Characterization of an Exercise-sensitive Pool of Glucose Transporters in Skeletal Muscle
Coderre, L., Kandror, K. V., Vallega, G., & Pilch, P. F. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.46.27584 · Cited by 195 · see citing works
Activation of RAC-protein kinase by heat shock and hyperosmolarity stress through a pathway independent of phosphatidylinositol 3-kinase.
Konishi, H., Matsuzaki, H., Tanaka, M., Ono, Y., Tokunaga, C., Kuroda, S., & Kikkawa, U. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.15.7639 · Cited by 192 · see citing works
cAMP stimulates protein kinase B in a Wortmannin‐insensitive manner
Sable, C. L., Filippa, N., Hemmings, B. A., & OBBERGHEN, E. V. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00518-8 · Cited by 166 · see citing works
Skeletal Muscle Glucose Transport and Metabolism Are Enhanced in Transgenic Mice Overexpressing the Glut4 Glucose Transporter
Gulve, E. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.5.1679 · Cited by 165 · see citing works
Regulation of glucose transport into skeletal muscle
Holloszy, J. O., & Hansen, P. A. (1996) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/3-540-61343-9_8 · Cited by 151 · see citing works
Improved Glucose Tolerance Restores Insulin-Stimulated Akt Kinase Activity and Glucose Transport in Skeletal Muscle From Diabetic Goto-Kakizaki Rats
Krook, A., Kawano, Y., Song, X. M., Efendić, S., Roth, R. A., Wallberg‐Henriksson, H., & Zierath, J. R. (1997) · Diabetes · doi:10.2337/diab.46.12.2110 · Cited by 143 · see citing works
Osmotic Shock Stimulates GLUT4 Translocation in 3T3L1 Adipocytes by a Novel Tyrosine Kinase Pathway
Chen, D., Elmendorf, J. S., Olson, A. L., Li, X., Earp, H. S., & Pessin, J. E. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.43.27401 · Cited by 141 · see citing works
Phosphoinositide 3-Kinase Is Required for Insulin-Induced but Not for Growth Hormone- or Hyperosmolarity-Induced Glucose Uptake in 3T3-L1 Adipocytes
Sakaue, H., Ogawa, W., Takata, M., Kuroda, S., Kotani, K., Matsumoto, M., Sakaue, M., Nishio, S., Ueno, H., & Kasuga, M. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.10.9986 · Cited by 125 · see citing works
Acute exercise increases the number of plasma membrane glucose transporters in rat skeletal muscle
Hirshman, M. F., Wallberg‐Henriksson, H., Wardzala, L. J., Horton, E. D., & Horton, E. S. (1988) · FEBS Letters · doi:10.1016/0014-5793(88)80486-1 · Cited by 113 · see citing works
Regulation of calcium mobilization and entry in human platelets by endothelium-derived factors
Geiger, J., Nolte, C., & Walter, U. (1994) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1994.267.1.c236 · Cited by 99 · see citing works
Effect of diffusion distance on measurement of rat skeletal muscle glucose transport in vitro
Henriksen, E. J., & Holloszy, J. O. (1991) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1991.tb09249.x · Cited by 79 · see citing works
Regulation of Protein Kinase B in Rat Adipocytes by Insulin, Vanadate, and Peroxovanadate
Wijkander, J., Holst, L. S., Landström, T. R., Resjö, S., Castan‐Laurell, I., Manganiello, V. C., Belfrage, P., & Degerman, E. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.34.21520 · Cited by 75 · see citing works
Update: PtdIns(3,4,5)P 3 Gets Its Message Across
Hemmings, B. A. (1997) · Science · doi:10.1126/science.277.5325.534 · Cited by 74 · see citing works
Involvement of phosphoinositide 3-kinase in insulin stimulation of MAP-kinase and phosphorylation of protein kinase-B in human skeletal muscle: implications for glucose metabolism
Shepherd, P. R., NAVÉ, B. T., Rincón, J., Haigh, R. J., Foulstone, E. J., Proud, C. G., Zierath, J. R., Siddle, K., & Wallberg‐Henriksson, H. (1997) · Diabetologia · doi:10.1007/s001250050803 · Cited by 62 · see citing works
Skeletal Muscle Glucose Transport and Metabolism Are Enhanced in Transgenic Mice Overexpressing the Glut4 Glucose Transporter.
Hansen, P. A., Gulve, E. A., Marshall, B. A., et al. (1995) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)85410-2 · Cited by 62 · see citing works
Treadmill Running Increases Phosphatidylinostol 3-Kinase Activity in Rat Skeletal Muscle
Zhou, Q., & Dohm, G. L. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7028 · Cited by 57 · see citing works
A Novel, Rapid, and Highly Sensitive Mass Assay for Phosphatidylinositol 3,4,5-Trisphosphate (PtdIns(3,4,5)P3) and Its Application to Measure Insulin-stimulated PtdIns(3,4,5)P3 Production in Rat Skeletal Muscle in Vivo
KAAY, J. V. D., Batty, I. H., Cross, D. A. E., Watt, P., & Downes, C. P. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.9.5477 · Cited by 48 · see citing works

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Cho, H., Mu, J., Kim, J. K., Thorvaldsen, J. L., Chu, Q., Crenshaw, E. B., Kaestner, K. H., Bartolomei, M. S., Shulman, G. I., & Birnbaum, M. J. (2001) · Science · doi:10.1126/science.292.5522.1728 · Cited by 1,837 · see citing works
Self-citation
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Holland, W. L., Brozinick, J. T., Wang, L.-P., Hawkins, E. D., Sargent, K. M., Liu, Y., Narra, K., Hoehn, K. L., Knotts, T. A., Siesky, A., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.01.002 · Cited by 1,232 · see citing works
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Bryant, N. J., Govers, R., & James, D. E. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm782 · Cited by 1,183 · see citing works
Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle
Cusi, K., Maezono, K., Osman, A., Pendergrass, M., Patti, M. E., Pratipanawatr, T., DeFronzo, R. A., Kahn, C. R., & Mandarino, L. J. (2000) · Journal of Clinical Investigation · doi:10.1172/jci7535 · Cited by 1,139 · see citing works
A Role for AMP-Activated Protein Kinase in Contraction- and Hypoxia-Regulated Glucose Transport in Skeletal Muscle
Mu, J., Brozinick, J. T., Valladares, O., Bucan, M., & Birnbaum, M. J. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00251-9 · Cited by 924 · see citing works
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Hepatitis C virus infection and diabetes: direct involvement of the virus in the development of insulin resistance
Shintani, Y., Fujie, H., Miyoshi, H., Tsutsumi, T., Tsukamoto, K., Kimura, S., Moriya, K., & Koike, K. (2004) · Gastroenterology · doi:10.1053/j.gastro.2003.11.056 · Cited by 761 · see citing works
Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid–induced ceramide biosynthesis in mice
Holland, W. L., Bikman, B. T., Wang, L.-P., Yuguang, G., Sargent, K. M., Bulchand, S., Knotts, T. A., Shui, G., Clegg, D. J., Wenk, M. R., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci43378 · Cited by 705 · see citing works
Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats
Jiang, Z. Y., Lin, Y.-W., Clemont, A., Feener, E. P., Hein, K. D., Igarashi, M., Yamauchi, T., White, M. F., & King, G. L. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5971 · Cited by 604 · see citing works
Insulin regulation of gluconeogenesis
Hatting, M., Tavares, C. D. J., Sharabi, K., Rines, A. K., & Puigserver, P. (2017) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13435 · Cited by 589 · see citing works
Translocation of myocardial GLUT-4 and increased glucose uptake through activation of AMPK by AICAR
Russell, R. R., Bergeron, R., Shulman, G. I., & Young, L. H. (1999) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1999.277.2.h643 · Cited by 553 · see citing works
Signaling Mechanisms That Regulate Glucose Transport
Czech, M., & Corvera, S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.4.1865 · Cited by 514 · see citing works
The cell biology of systemic insulin function
Tokarz, V. L., MacDonald, P. E., & Klip, A. (2018) · Journal of Cell Biology · doi:10.1083/jcb.201802095 · Cited by 471 · see citing works
Skeletal Muscle Glucose Uptake During Exercise: How is it Regulated?
Rose, A. J., & Richter, E. A. (2005) · Physiology · doi:10.1152/physiol.00012.2005 · Cited by 371 · see citing works
Contraction signaling to glucose transport in skeletal muscle
Jessen, N., & Goodyear, L. J. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00175.2005 · Cited by 311 · see citing works
Invited Review: Role of insulin in translational control of protein synthesis in skeletal muscle by amino acids or exercise
Kimball, S. R., Farrell, P. A., & Jefferson, L. S. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00221.2002 · Cited by 296 · see citing works
AMPK and Exercise: Glucose Uptake and Insulin Sensitivity
O'Neill, H. M. (2013) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2013.37.1.1 · Cited by 295 · see citing works
CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK
Watt, M. J., Dzamko, N. L., Thomas, W. G., Rose‐John, S., Ernst, M., Carling, D., Kemp, B. E., Febbraio, M. A., & Steinberg, G. R. (2006) · Nature Medicine · doi:10.1038/nm1383 · Cited by 275 · see citing works
Invited Review: Intracellular signaling in contracting skeletal muscle
Sakamoto, K., & Goodyear, L. J. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00167.2002 · Cited by 260 · see citing works
Divergent effects of exercise on metabolic and mitogenic signaling pathways in human skeletal muscle
Widegren, U., Jiang, X. J., Krook, A., Chibalin, A., Björnholm, M., Tally, M., Roth, R. A., Henriksson, J., Wallberg‐Henriksson, H., & Zierath, J. R. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.13.1379 · Cited by 242 · see citing works
Long-chain fatty acid uptake and FAT/CD36 translocation in heart and skeletal muscle
Koonen, D. P. Y., Glatz, J. F. C., Bonen, A., & Luiken, J. J. F. P. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2005.08.018 · Cited by 238 · see citing works
Glucose transport in the heart
Abel, E. D. (2004) · Frontiers in bioscience · doi:10.2741/1216 · Cited by 234 · see citing works
Akt signaling in skeletal muscle: regulation by exercise and passive stretch
Sakamoto, K., Aschenbach, W. G., Hirshman, M. F., & Goodyear, L. J. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00228.2003 · Cited by 206 · see citing works
Contraction Regulation of Akt in Rat Skeletal Muscle
Sakamoto, K., Hirshman, M. F., Aschenbach, W. G., & Goodyear, L. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m112410200 · Cited by 192 · see citing works
Exercise and insulin cause GLUT-4 translocation in human skeletal muscle
Thorell, A., Hirshman, M. F., Nygren, J., Jorfeldt, L., Wojtaszewski, J. F. P., Dufresne, S. D., Horton, E. S., Ljungqvist, O. H., & Goodyear, L. J. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.277.4.e733 · Cited by 190 · see citing works
Role of Akt substrate of 160 kDa in insulin-stimulated and contraction-stimulated glucose transport
Cartee, G. D., & Wojtaszewski, J. F. P. (2007) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h07-026 · Cited by 183 · see citing works
Selective impairment of insulin signalling in the hypothalamus of obese Zucker rats
Carvalheira, J. B. C., Ribeiro, E. B., Ara�jo, E. P., Guimar�es, R. B., Telles, M. M., Torsoni, M., Gontijo, J. A. R., Velloso, L. A., & Saad, M. J. A. (2003) · Diabetologia · doi:10.1007/s00125-003-1246-x · Cited by 176 · see citing works
Getting ready for building: signaling and autophagosome biogenesis
Abada, A., & Elazar, Z. (2014) · EMBO Reports · doi:10.15252/embr.201439076 · Cited by 171 · see citing works
The role of skeletal muscle Akt in the regulation of muscle mass and glucose homeostasis
Jaiswal, N., Gavin, M. G., Quinn, W. J., Luongo, T. S., Gelfer, R. G., Baur, J. A., & Titchenell, P. M. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.08.001 · Cited by 167 · see citing works
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Self-citation
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Jamart, C., Francaux, M., Millet, G. Y., Deldicque, L., Frère, D., & Féasson, L. (2012) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00952.2011 · Cited by 157 · see citing works
Intracellular mechanisms underlying increases in glucose uptake in response to insulin or exercise in skeletal muscle
Ryder, J. W., Chibalin, A., & Zierath, J. R. (2001) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2001.00827.x · Cited by 155 · see citing works
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Leucine and insulin activate p70 S6 kinase through different pathways in human skeletal muscle
Greiwe, J. S., Kwon, G., McDaniel, M. L., & Semenkovich, C. F. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.281.3.e466 · Cited by 151 · see citing works
Cellular energy sensing and signaling by AMP-activated protein kinase
Winder, W. W., & Thomson, D. M. (2007) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-007-0008-7 · Cited by 141 · see citing works
Insulin and Exercise Decrease Glycogen Synthase Kinase-3 Activity by Different Mechanisms in Rat Skeletal Muscle
Markuns, J. F., Wojtaszewski, J. F. P., & Goodyear, L. J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.35.24896 · Cited by 141 · see citing works
Regulation of mTOR by amino acids and resistance exercise in skeletal muscle
Deldicque, L., Theisen, D., & Francaux, M. (2005) · European Journal of Applied Physiology · doi:10.1007/s00421-004-1255-6 · Cited by 139 · see citing works
The B Cell Antigen Receptor Activates the Akt (Protein Kinase B)/Glycogen Synthase Kinase-3 Signaling Pathway Via Phosphatidylinositol 3-Kinase
Gold, M. R., Scheid, M. P., Santos, L., Dang-Lawson, M., Roth, R. A., Matsuuchi, L., Duronio, V., & Krebs, D. L. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.4.1894 · Cited by 133 · see citing works
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Prior exercise increases phosphorylation of Akt substrate of 160 kDa (AS160) in rat skeletal muscle
Arias, E. B., Kim, J., Funai, K., & Cartee, G. D. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00602.2006 · Cited by 118 · see citing works
Insulin and Contraction Stimulate Exocytosis, but Increased AMP-activated Protein Kinase Activity Resulting from Oxidative Metabolism Stress Slows Endocytosis of GLUT4 in Cardiomyocytes
Yang, J., & Holman, G. D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m410213200 · Cited by 118 · see citing works
Decrease in Akt/PKB signalling in human skeletal muscle by resistance exercise
Deldicque, L., Atherton, P. J., Patel, R. S., Theisen, D., Nielens, H., Rennie, M. J., & Francaux, M. (2008) · European Journal of Applied Physiology · doi:10.1007/s00421-008-0786-7 · Cited by 117 · see citing works
Signaling Pathways Mediating Insulin‐Stimulated Glucose Transport
Summers, S. A., Yin, V. P., Whiteman, E. L., Garza, L. A., Cho, H., Tuttle, R. L., & Birnbaum, M. J. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb07795.x · Cited by 104 · see citing works
Self-citation
Mechanisms underlying impaired GLUT-4 translocation in glycogen-supercompensated muscles of exercised rats
Kawanaka, K., Nolte, L. A., Han, D., Hansen, P. A., & Holloszy, J. O. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.6.e1311 · Cited by 98 · see citing works
Differential regulation of MAP kinase, p70S6K, and Akt by contraction and insulin in rat skeletal muscle
Sherwood, D. J., Dufresne, S. D., Markuns, J. F., Cheatham, B., Moller, D. E., Aronson, D., & Goodyear, L. J. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.276.5.e870 · Cited by 98 · see citing works
Cross‐talk mechanisms in the development of insulin resistance of skeletal muscle cells
Störz, P., Döppler, H. R., Wernig, A., Pfizenmaier, K., & Müller, G. I. (1999) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1999.00809.x · Cited by 95 · see citing works
Activation of AMPK is essential for AICAR-induced glucose uptake by skeletal muscle but not adipocytes
Sakoda, H., Ogihara, T., Anai, M., Fujishiro, M., Ono, H., Onishi, Y., Katagiri, H., Abe, M., Fukushima, Y., Shojima, N., et al. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00455.2001 · Cited by 95 · see citing works
The HIV Protease Inhibitor Indinavir Decreases Insulin- and Contraction-Stimulated Glucose Transport in Skeletal Muscle
Nolte, L. A., Yarasheski, K. E., Kawanaka, K., Fisher, J. S., Le, N., & Holloszy, J. O. (2001) · Diabetes · doi:10.2337/diabetes.50.6.1397 · Cited by 92 · see citing works
Endoplasmic Reticulum Stress Markers and Ubiquitin-Proteasome Pathway Activity in Response to a 200-km Run
Kim, H. J., Jamart, C., Deldicque, L., An, G.-L., Lee, Y. H., Kim, C. K., Raymackers, J., & Francaux, M. (2010) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181e4c5d1 · Cited by 91 · see citing works
Preconditioning Enhanced Glucose Uptake Is Mediated by p38 MAP Kinase Not by Phosphatidylinositol 3-Kinase
Tong, H., Chen, W., London, R. E., Murphy, E., & Steenbergen, C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.16.11981 · Cited by 91 · see citing works
Role of plasma membrane transporters in muscle metabolism
Zorzano, A., Fandos, C., & Palacı́n, M. (2000) · Biochemical Journal · doi:10.1042/bj3490667 · Cited by 77 · see citing works
Concerted redox modulation by sulforaphane alleviates diabetes and cardiometabolic syndrome
Patel, B., Mann, G. E., & Chapple, S. J. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.02.004 · Cited by 74 · see citing works
Munc18c Regulates Insulin-stimulated GLUT4 Translocation to the Transverse Tubules in Skeletal Muscle
Khan, A. H., Thurmond, D. C., Yang, C., Ceresa, B. P., Sigmund, C. D., & Pessin, J. E. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007419200 · Cited by 74 · see citing works
Intracellular Segregation of Phosphatidylinositol-3,4,5-Trisphosphate by Insulin-Dependent Actin Remodeling in L6 Skeletal Muscle Cells
Patel, N., Rudich, A., Khayat, Z. A., Garg, R. R., & Klip, A. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.13.4611-4626.2003 · Cited by 73 · see citing works
Is REDD1 a metabolic double agent? Lessons from physiology and pathology
Britto, F. A., Dumas, K., Giorgetti‐Peraldi, S., Ollendorff, V., & Favier, F. B. (2020) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00340.2020 · Cited by 70 · see citing works
Push/pull mechanisms of GLUT4 traffic in muscle cells
Rudich, A., & Klip, A. (2003) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2003.01163.x · Cited by 67 · see citing works
G α 11 Signaling through ARF6 Regulates F-Actin Mobilization and GLUT4 Glucose Transporter Translocation to the Plasma Membrane
Bose, A., Cherniack, A. D., Langille, S. E., Nicoloro, S. M. C., Buxton, J. M., Park, J. G., Chawla, A., & Czech, M. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.15.5262-5275.2001 · Cited by 66 · see citing works
Statin modulates insulin signaling and insulin resistance in liver and muscle of rats fed a high-fat diet
Lalli, C. A., Pauli, J. R., Prada, P. O., Cintra, D. E., Ropelle, E. R., Velloso, L. A., & Saad, M. J. A. (2007) · Metabolism · doi:10.1016/j.metabol.2007.07.021 · Cited by 65 · see citing works
Akt kinases and 2-deoxyglucose uptake in rat skeletal muscles in vivo: study with insulin and exercise
Turinsky, J., & Damrau-Abney, A. (1999) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1999.276.1.r277 · Cited by 64 · see citing works
In Vivo Adenoviral Delivery of Recombinant Human Protein Kinase C-ζ Stimulates Glucose Transport Activity in Rat Skeletal Muscle
Etgen, G. J., Valasek, K. M., Broderick, C. L., & Miller, A. R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.32.22139 · Cited by 64 · see citing works
Role of Akt2 in contraction-stimulated cell signaling and glucose uptake in skeletal muscle
Sakamoto, K., Arnolds, D. E., Fujii, N., Kramer, H. F., Hirshman, M. F., & Goodyear, L. J. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00204.2006 · Cited by 63 · see citing works
Elovl5 regulates the mTORC2-Akt-FOXO1 pathway by controlling hepatic cis-vaccenic acid synthesis in diet-induced obese mice
Tripathy, S., & Jump, D. Β. (2012) · Journal of Lipid Research · doi:10.1194/jlr.m028787 · Cited by 61 · see citing works
Secretion of Annexin II via Activation of Insulin Receptor and Insulin-like Growth Factor Receptor
Zhao, W., Chen, G. H., Chen, H., Pascale, A., Ravindranath, L., Quon, M. J., & Alkon, D. L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210545200 · Cited by 61 · see citing works
A comprehensive view of muscle glucose uptake: regulation by insulin, contractile activity, and exercise
Richter, E. A., Bilan, P. J., & Klip, A. (2025) · Physiological Reviews · doi:10.1152/physrev.00033.2024 · Cited by 64 · see citing works
Homozygous staggerer (sg/sg) mice display improved insulin sensitivity and enhanced glucose uptake in skeletal muscle
Lau, P., Fitzsimmons, R. L., Pearen, M. A., Watt, M. J., & Muscat, G. E. O. (2011) · Diabetologia · doi:10.1007/s00125-011-2046-3 · Cited by 58 · see citing works
Phenylmethimazole blocks palmitate-mediated induction of inflammatory cytokine pathways in 3T3L1 adipocytes and RAW 264.7 macrophages
McCall, K. D., Holliday, D. K., Dickerson, E., Wallace, B., Schwartz, A. L., Schwartz, C., Lewis, C. J., Kohn, L. D., & Schwartz, F. (2010) · Journal of Endocrinology · doi:10.1677/joe-09-0370 · Cited by 57 · see citing works
Identification and validation of the pathways and functions regulated by the orphan nuclear receptor, ROR alpha1, in skeletal muscle
Raichur, S., Fitzsimmons, R. L., Myers, S., Pearen, M. A., Lau, P., Eriksson, N. A., Wang, S.-C., & Muscat, G. E. O. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq180 · Cited by 57 · see citing works
Increased insulin receptor signaling and glycogen synthase activity contribute to the synergistic effect of exercise on insulin action
Christ-Roberts, C. Y., Pratipanawatr, T., Pratipanawatr, W., Berria, R., Belfort, R., & Mandarino, L. J. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00605.2003 · Cited by 54 · see citing works
A novel PKB/Akt inhibitor, MK-2206, effectively inhibits insulin-stimulated glucose metabolism and protein synthesis in isolated rat skeletal muscle
Lai, Y., Liu, Y., Jacobs, R., & Rider, M. H. (2012) · Biochemical Journal · doi:10.1042/bj20120772 · Cited by 55 · see citing works
Contraction inhibits insulin-stimulated insulin receptor substrate-1/2-associated phosphoinositide 3-kinase activity, but not protein kinase B activation or glucose uptake, in rat muscle
WHITEHEAD, J. P., SOOS, M. A., ASLESEN, R., O'RAHILLY, S., & JENSEN, J. (2000) · Biochemical Journal · doi:10.1042/bj3490775 · Cited by 48 · see citing works
Leucine modulates contraction- and insulin-stimulated glucose transport and upstream signaling events in rat skeletal muscle
Iwanaka, N., Egawa, T., Satoubu, N., Karaike, K., Ma, X., Masuda, S., & Hayashi, T. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00420.2009 · Cited by 45 · see citing works
Regulation of MAP kinase pathway activity in vivo in human skeletal muscle
Osman, A. A., Pendergrass, M., Koval, J., Maezono, K., Cusi, K. J., Pratipanawatr, T., & Mandarino, L. J. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.278.6.e992 · Cited by 42 · see citing works
Insulin, Muscle Glucose Uptake, and Hexokinase: Revisiting the Road Not Taken
Wasserman, D. H. (2021) · Physiology · doi:10.1152/physiol.00034.2021 · Cited by 41 · see citing works
The effect of exercise induced cytokines on insulin stimulated glucose transport in C2C12 cells
Gray, S. R., & Kamolrat, T. (2011) · Cytokine · doi:10.1016/j.cyto.2011.04.019 · Cited by 40 · see citing works
Signal-transduction networks and the regulation of muscle protein degradation
Szewczyk, N. J., & Jacobson, L. A. (2005) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2005.02.020 · Cited by 39 · see citing works
Passive stretching produces Akt- and MAPK-dependent augmentations of GLUT4 translocation and glucose uptake in skeletal muscles of mice
Ito, Y., Obara, K., Ikeda, R., Ishii, M., Tanabe, Y., Ishikawa, T., & Nakayama, K. (2006) · Pflügers Archiv · doi:10.1007/s00424-005-1512-5 · Cited by 40 · see citing works
The Akt1 isoform is an essential mediator of ischaemic preconditioning
Kunuthur, S. P., Mocanu, M. M., Hemmings, B. A., Hausenloy, D. J., & Yellon, D. M. (2011) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2011.01491.x · Cited by 38 · see citing works
Management of phosphatidylinositol-3-kinase inhibitor-associated hyperglycemia
Goncalves, M. D., & Farooki, A. (2022) · Integrative Cancer Therapies · doi:10.1177/15347354211073163 · Cited by 37 · see citing works
Assessing Effects of Alcohol Consumption on Protein Synthesis in Striated Muscles
Vary, T. C., & Lang, C. H. (2008) · Methods in molecular biology · doi:10.1007/978-1-59745-242-7_22 · Cited by 37 · see citing works
Triiodothyronine Acutely Stimulates Glucose Transport into L6 Muscle Cells Without Increasing Surface GLUT4, GLUT1, or GLUT3
Teixeira, S. D. S., Tamrakar, A. K., Goulart-Silva, F., Serrano‐Nascimento, C., Klip, A., & Nunes, M. T. (2012) · Thyroid · doi:10.1089/thy.2011.0422 · Cited by 35 · see citing works
Contraction activates glucose uptake and glycogen synthase normally in muscles from dexamethasone-treated rats
Ruzzin, J., & Jensen, J. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00587.2004 · Cited by 33 · see citing works
Potentiation of neuronal insulin signaling and glucose uptake by resveratrol: the involvement of AMPK
Patel, M. I., Gupta, A. K., & Dey, C. S. (2011) · Pharmacological Reports · doi:10.1016/s1734-1140(11)70635-1 · Cited by 32 · see citing works
Epigallocatechin Gallate Stimulates Glucose Uptake Through the Phosphatidylinositol 3-Kinase-Mediated Pathway in L6 Rat Skeletal Muscle Cells
Jung, K. H., Choi, H. S., Kim, D. H., Han, M. Y., Chang, U. J., Yim, S., Song, B. C., Kim, C., & Kang, S. A. (2008) · Journal of Medicinal Food · doi:10.1089/jmf.2007.0107 · Cited by 31 · see citing works
A multidisciplinary approach to optimizing care of patients treated with alpelisib
Rugo, H. S., Lacouture, M. E., Goncalves, M. D., Masharani, U. B., Aapro, M., & O’Shaughnessy, J. (2021) · The Breast · doi:10.1016/j.breast.2021.12.016 · Cited by 30 · see citing works
Muscle contractions, AICAR, and insulin cause phosphorylation of an AMPK-related kinase
Fisher, J. S., Ju, J.-S., Oppelt, P. J., Smith, J. L., Suzuki, A., & Esumi, H. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00335.2004 · Cited by 26 · see citing works
Lengthening contractions differentially affect p70s6k phosphorylation compared to isometric contractions in rat skeletal muscle
Burry, M. E., Hawkins, D., & Spangenburg, E. E. (2007) · European Journal of Applied Physiology · doi:10.1007/s00421-007-0444-5 · Cited by 25 · see citing works
Molecular mechanisms of contraction-regulated cardiac glucose transport
Till, M., Ouwens, D. M., Kessler, A., & Eckel, J. (2000) · Biochemical Journal · doi:10.1042/bj3460841 · Cited by 24 · see citing works
Antioxidant supplemention in the treatment of skeletal muscle insulin resistance: potential mechanisms and clinical relevance
Wright, D. C., & Sutherland, L. (2008) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h07-155 · Cited by 23 · see citing works
The effect of interleukin‐6 and the interleukin‐6 receptor on glucose transport in mouse skeletal muscle
Gray, S. R., Ratkevičius, A., Wackerhage, H., Coats, P., & Nimmo, M. A. (2009) · Experimental Physiology · doi:10.1113/expphysiol.2009.048173 · Cited by 21 · see citing works
Concentrations of signal transduction proteins mediating exercise and insulin responses in rat extensor digitorum longus and soleus muscles
Atherton, P. J., Higginson, J. M., Singh, J., & Wackerhage, H. (2004) · Molecular and Cellular Biochemistry · doi:10.1023/b:mcbi.0000028745.58567.81 · Cited by 21 · see citing works
Contraction-mediated glucose uptake is increased in men with impaired glucose tolerance
Skov-Jensen, C., Skovbro, M., Flint, A., Helge, J. W., & Dela, F. (2007) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h06-098 · Cited by 21 · see citing works
Mechanical stretch activates mammalian target of rapamycin and AMP-activated protein kinase pathways in skeletal muscle cells
Nakai, N., Kawano, F., & Nakata, K. (2015) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-015-2446-7 · Cited by 21 · see citing works
The insulin receptor and metabolic signaling
Gustafson, T. A., Moodie, S. A., & Lavan, B. E. (1999) · Springer eBooks · doi:10.1007/3-540-65362-7_5 · Cited by 21 · see citing works
Peroxiredoxin 2 mediates insulin sensitivity of skeletal muscles through regulation of protein tyrosine phosphatase oxidation
Kim, J., Park, S.-J., Chae, U., Seong, J., Lee, H., Lee, S., Lee, S., & Lee, D. (2018) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2018.03.019 · Cited by 20 · see citing works
Involvement of the extracellular matrix and integrin signalling proteins in skeletal muscle glucose uptake
Draicchio, F., Behrends, V., Tillin, N. A., Hurren, N. M., Sylow, L., & Mackenzie, R. (2022) · The Journal of Physiology · doi:10.1113/jp283039 · Cited by 21 · see citing works
Effects of exercise on muscle glycogen synthesis signalling and enzyme activities in pigs carrying the PRKAG3 mutation
Granlund, A., Kotova, O., Benziane, B., Galuska, D., Jensen‐Waern, M., Chibalin, A., & Essén-Gustavsson, B. (2009) · Experimental Physiology · doi:10.1113/expphysiol.2009.051326 · Cited by 19 · see citing works

Contraction inhibits insulin-stimulated insulin receptor substrate-1/2-associated phosphoinositide 3-kinase activity, but not protein kinase B activation or glucose uptake, in rat muscle
WHITEHEAD, J. P., SOOS, M. A., ASLESEN, R., O'RAHILLY, S., & JENSEN, J. (2000) · Biochemical Journal · doi:10.1042/bj3490775 · Cited by 48 · see citing works
Evidence against protein kinase B as a mediator of contraction‐induced glucose transport and GLUT4 translocation in rat skeletal muscle
Lund, S. A., Pryor, P. R., Østergaard, S. D., Schmitz, O., Pedersen, O. B., & Holman, G. D. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00293-2 · Cited by 67 · see citing works
The interrelation between aPKC and glucose uptake in the skeletal muscle during contraction and insulin stimulation
dos Santos, J. M., Benite‐Ribeiro, S. A., Queiróz, G., & Duarte, J. A. (2014) · Cell Biochemistry and Function · doi:10.1002/cbf.3081 · Cited by 18 · see citing works
Mechanisms by Which Insulin and Muscle Contraction Stimulate Glucose Transport
Cortright, R. N., & Dohm, G. L. (1997) · Canadian Journal of Applied Physiology · doi:10.1139/h97-033 · Cited by 57 · see citing works
Activation of p38 mitogen-activated protein kinase alpha and beta by insulin and contraction in rat skeletal muscle: potential role in the stimulation of glucose transport.
Somwar, R., Perreault, M., Kapur, S., Taha, C., Sweeney, G., Ramlal, T., Kim, D., Keen, J., Cote, C. H., Klip, A., et al. (2000) · Diabetes · doi:10.2337/diabetes.49.11.1794 · Cited by 170 · see citing works

Authors: Brozinick, J. T., & Birnbaum, M. J.
Affiliations: Howard Hughes Medical Institute (US)
Corresponding author: Brozinick, Joseph T.
Birnbaum, Morris J.
ORCID: Brozinick, Joseph T.
Birnbaum, Morris J.
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 1998-06
Volume: 273
Issue: 24
Pages: 14679-14682
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1074/jbc.273.24.14679
OpenAlex: W2040466763
Cited by: 149
References: 32
Citations by year: 2025: 2 · 2022: 5 · 2021: 3 · 2020: 4 · 2019: 2 · 2018: 6 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 3 · 2013: 2 · 2012: 8
FWCI: 4.25
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 8164 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01dk039615-03)
National Institute of Diabetes and Digestive and Kidney Diseases (DK 39615)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Keywords: insulin signaling, Akt, skeletal muscle glucose transport, muscle contraction, PI3-kinase, wortmannin, GLUT4 translocation, p70 S6 kinase, epitrochlearis muscle, soleus muscle
MeSH terms: Wortmannin, Phosphoinositide-3 Kinase Inhibitors, Androstadienes, Animals, Biological Transport, Enzyme Activation, Enzyme Inhibitors, Glucose, Insulin, Male, Muscle Contraction, Phosphorylation, Phosphoserine, Proto-Oncogene Proteins, Signal Transduction, Rats, Wistar, Protein Serine-Threonine Kinases, Muscle, Skeletal, Ribosomal Protein S6 Kinases, Proto-Oncogene Proteins c-akt, Rats

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Insulin, but Not Contraction, Activates Akt/PKB in Isolated Rat Skeletal Muscle

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