Regulated transport of the glucose transporter GLUT4
Abstract
In muscle and fat cells, insulin stimulates the delivery of the glucose transporter GLUT4 from an intracellular location to the cell surface, where it facilitates the reduction of plasma glucose levels. Understanding the molecular mechanisms that mediate this translocation event involves integrating our knowledge of two fundamental processes--the signal transduction pathways that are triggered when insulin binds to its receptor and the membrane transport events that need to be modified to divert GLUT4 from intracellular storage to an active plasma membrane shuttle service.
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GLUT4 depends on general exocytic and endocytic pathways to regulate its surface levels.
“The reporter is based on the glucose transporter GLUT4 (Fig. 1A), which depends on general exocytic and endocytic pathways to regulate its surface levels (3, 19–21).”
From Regulation of cargo exocytosis by a Reps1-Ralbp1-RalA module (2023) · cites this paper as [3]
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- Authors
- Bryant, N. J., Govers, R., & James, D. E.
- Affiliations
- Garvan Institute of Medical Research (AU)
- Corresponding author
- James, David E.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2002-04
- Volume
- 3
- Issue
- 4
- Pages
- 267-277
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W2009181620
- Cited by
- 1,183
- References
- 2
- Citations by year
- 2026: 20 · 2025: 30 · 2024: 30 · 2023: 48 · 2022: 46 · 2021: 39 · 2020: 42 · 2019: 48 · 2018: 48 · 2017: 48 · 2016: 42 · 2015: 65 · 2014: 54 · 2013: 62 · 2012: 54
- FWCI
- 4.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- HAL AMU (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Keywords
- GLUT4, glucose transporters, insulin signaling, insulin receptor, translocation, glucose uptake, signal transduction, membrane transport, skeletal muscle, adipocytes, glucose homeostasis
- MeSH terms
- Animals, Biological Transport, Active, Golgi Apparatus, Humans, Insulin, Membrane Proteins, Models, Biological, Monosaccharide Transport Proteins, Muscle Proteins, Muscles, Endosomes, Signal Transduction, Adipocytes, Vesicular Transport Proteins, SNARE Proteins, Glucose Transporter Type 4
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