Cited by 149Metabolism, Diabetes, and CancerPI3K/AKT/mTOR signaling in cancerMuscle metabolism and nutrition

The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.

Insulin, but Not Contraction, Activates Akt/PKB in Isolated Rat Skeletal Muscle

Open access

Brozinick, Joseph T., Birnbaum, Morris J.·1998·Journal of Biological Chemistry

Open this paper in CoChat — free account

Abstract

Insulin and muscle contraction potently stimulate glucose uptake in mammalian skeletal muscle. Studies in muscle and adipose tissue have shown that insulin induces its receptor-dependent phosphorylation of insulin receptor substrates 1 and 2, which leads to activation of polyphosphatidylinositol (PI) 3'-kinase. In contrast, muscle contraction stimulates glucose transport via a mechanism that is independent of insulin, but the two pathways may converge downstream at the level of stimulation of GLUT4 translocation. In the present study, we have examined the role of Akt, an insulin-activated serine threonine kinase that has previously been shown to increase glucose transport in adipocytes. Either insulin or in vitro muscle contraction significantly elevated glucose transport in isolated rat epitrochlearis and soleus muscles. However, Akt kinase activity was significantly stimulated by insulin and not contraction. Moreover, wortmannin, an inhibitor of PI 3'-kinase, completely blocked the insulin-stimulated increase in Akt activity and glucose transport but did not alter either of these parameters in contracting muscles. The increases in Akt activity were paralleled by a decrease in the electrophoretic mobility of Akt, indicative of phosphorylation of Akt by an upstream kinase. These changes in Akt mobility appeared to be at least partially because of phosphorylation of Akt on serine 473. A putative downstream target of Akt, p70 S6 kinase, showed similar changes in mobility in response to insulin but not contraction. These data support the view that Akt is a downstream target of PI 3'-kinase and is involved in the signaling pathways involved in insulin but not contraction stimulation of glucose transport in skeletal muscle. These data provide further evidence that two distinct pathways exist for the stimulation of glucose transport in mammalian skeletal muscle.

Integrity signals

Registry

Crossref · 10.1074/jbc.273.24.14679

Cites

32 of 32 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
Cross, D. A. E., Alessi, D. R., Cohen, P., Andjelkovich, M., & Hemmings, B. A. (1995) · Nature · doi:10.1038/378785a0 · Cited by 5,244
Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
Burgering, B. M. T., & Coffer, P. J. (1995) · Nature · doi:10.1038/376599a0 · Cited by 2,076
The insulin signaling system.
White, M. F., & Kahn, C. R. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42297-6 · Cited by 1,707
Expression of a Constitutively Active Akt Ser/Thr Kinase in 3T3-L1 Adipocytes Stimulates Glucose Uptake and Glucose Transporter 4 Translocation
Kohn, A. D., Summers, S. A., Birnbaum, M. J., & Roth, R. A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.49.31372 · Cited by 1,284
Self-citation
Phosphatidylinositol 3-Kinase Activation Is Required for Insulin Stimulation of pp70 S6 Kinase, DNA Synthesis, and Glucose Transporter Translocation
Cheatham, B., Vlahos, C. J., Cheatham, L. A., Wang, L., Blenis, J., & Kahn, C. R. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.7.4902-4911.1994 · Cited by 1,062
Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects.
Goodyear, L. J., Giorgino, F., Sherman, L., Carey, J., Smith, R. J., & Dohm, G. L. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117909 · Cited by 527
Akt Signaling--Linking Membrane Events to Life and Death Decisions
Hemmings, B. A. (1997) · Science · doi:10.1126/science.275.5300.628 · Cited by 514
Contraction stimulates translocation of glucose transporter GLUT4 in skeletal muscle through a mechanism distinct from that of insulin
Lund, S., Holman, G. D., Schmitz, O., & Pedersen, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.13.5817 · Cited by 492
Exercise induces recruitment of the “insulin-responsive glucose transporter”. Evidence for distinct intracellular insulin- and exercise-recruitable transporter pools in skeletal muscle.
Douen, A. G., Ramlal, T., Rastogi, S., Bilan, P. J., Cartee, G. D., Vranić, M., Holloszy, J. O., & Klip, A. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)77362-6 · Cited by 471
Akt, a Pleckstrin Homology Domain Containing Kinase, Is Activated Primarily by Phosphorylation
Kohn, A. D., Takeuchi, F., & Roth, R. A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.36.21920 · Cited by 468

Show all 32 references

Research works printed but not linked: 9

Ploug, 1984, Am. J. Physiol., 247, E726
Goodyear, 1990, Am. J. Physiol., 258, E667
Henriksen, 1989, Am. J. Physiol., 256, E662
Etgen, 1996, Am. J. Physiol., 271, E294
Hansen, 1995, J. Biol. Chem., 270, 1679, 10.1016/S0021-9258(18)85410-2 · DOI
Cheatham, 1994, Mol. Cell. Biol., 14, 4902
Goodyear, 1995, Am. J. Physiol., 268, E987
Henriksen, 1990, Am. J. Physiol., 259, E593
Cartee, 1992, Am. J. Physiol., 263, R70

Sorted by citations

Insulin Resistance and a Diabetes Mellitus-Like Syndrome in Mice Lacking the Protein Kinase Akt2 (PKBβ)
Cho, H., Mu, J., Kim, J. K., Thorvaldsen, J. L., Chu, Q., Crenshaw, E. B., Kaestner, K. H., Bartolomei, M. S., Shulman, G. I., & Birnbaum, M. J. (2001) · Science · doi:10.1126/science.292.5522.1728 · Cited by 1,860
Self-citation
Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance
Holland, W. L., Brozinick, J. T., Wang, L.-P., Hawkins, E. D., Sargent, K. M., Liu, Y., Narra, K., Hoehn, K. L., Knotts, T. A., Siesky, A., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.01.002 · Cited by 1,232
Self-citation
Regulated transport of the glucose transporter GLUT4
Bryant, N. J., Govers, R., & James, D. E. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm782 · Cited by 1,183
Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle
Cusi, K., Maezono, K., Osman, A., Pendergrass, M., Patti, M. E., Pratipanawatr, T., DeFronzo, R. A., Kahn, C. R., & Mandarino, L. J. (2000) · Journal of Clinical Investigation · doi:10.1172/jci7535 · Cited by 1,139
A Role for AMP-Activated Protein Kinase in Contraction- and Hypoxia-Regulated Glucose Transport in Skeletal Muscle
Mu, J., Brozinick, J. T., Valladares, O., Bucan, M., & Birnbaum, M. J. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00251-9 · Cited by 924
Self-citation
Hepatitis C virus infection and diabetes: direct involvement of the virus in the development of insulin resistance
Shintani, Y., Fujie, H., Miyoshi, H., Tsutsumi, T., Tsukamoto, K., Kimura, S., Moriya, K., & Koike, K. (2004) · Gastroenterology · doi:10.1053/j.gastro.2003.11.056 · Cited by 761
Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid–induced ceramide biosynthesis in mice
Holland, W. L., Bikman, B. T., Wang, L.-P., Yuguang, G., Sargent, K. M., Bulchand, S., Knotts, T. A., Shui, G., Clegg, D. J., Wenk, M. R., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci43378 · Cited by 705
Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats
Jiang, Z. Y., Lin, Y.-W., Clemont, A., Feener, E. P., Hein, K. D., Igarashi, M., Yamauchi, T., White, M. F., & King, G. L. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5971 · Cited by 604
Insulin regulation of gluconeogenesis
Hatting, M., Tavares, C. D. J., Sharabi, K., Rines, A. K., & Puigserver, P. (2017) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13435 · Cited by 625
Translocation of myocardial GLUT-4 and increased glucose uptake through activation of AMPK by AICAR
Russell, R. R., Bergeron, R., Shulman, G. I., & Young, L. H. (1999) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1999.277.2.h643 · Cited by 553
Signaling Mechanisms That Regulate Glucose Transport
Czech, M., & Corvera, S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.4.1865 · Cited by 519
The cell biology of systemic insulin function
Tokarz, V. L., MacDonald, P. E., & Klip, A. (2018) · Journal of Cell Biology · doi:10.1083/jcb.201802095 · Cited by 471
Skeletal Muscle Glucose Uptake During Exercise: How is it Regulated?
Rose, A. J., & Richter, E. A. (2005) · Physiology · doi:10.1152/physiol.00012.2005 · Cited by 386
Contraction signaling to glucose transport in skeletal muscle
Jessen, N., & Goodyear, L. J. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00175.2005 · Cited by 311
Invited Review: Role of insulin in translational control of protein synthesis in skeletal muscle by amino acids or exercise
Kimball, S. R., Farrell, P. A., & Jefferson, L. S. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00221.2002 · Cited by 304
AMPK and Exercise: Glucose Uptake and Insulin Sensitivity
O'Neill, H. M. (2013) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2013.37.1.1 · Cited by 295
CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK
Watt, M. J., Dzamko, N. L., Thomas, W. G., Rose‐John, S., Ernst, M., Carling, D., Kemp, B. E., Febbraio, M. A., & Steinberg, G. R. (2006) · Nature Medicine · doi:10.1038/nm1383 · Cited by 282
Invited Review: Intracellular signaling in contracting skeletal muscle
Sakamoto, K., & Goodyear, L. J. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00167.2002 · Cited by 260
Divergent effects of exercise on metabolic and mitogenic signaling pathways in human skeletal muscle
Widegren, U., Jiang, X. J., Krook, A., Chibalin, A., Björnholm, M., Tally, M., Roth, R. A., Henriksson, J., Wallberg‐Henriksson, H., & Zierath, J. R. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.13.1379 · Cited by 248
Long-chain fatty acid uptake and FAT/CD36 translocation in heart and skeletal muscle
Koonen, D. P. Y., Glatz, J. F. C., Bonen, A., & Luiken, J. J. F. P. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2005.08.018 · Cited by 243
Glucose transport in the heart
Abel, E. D. (2004) · Frontiers in bioscience · doi:10.2741/1216 · Cited by 240
Akt signaling in skeletal muscle: regulation by exercise and passive stretch
Sakamoto, K., Aschenbach, W. G., Hirshman, M. F., & Goodyear, L. J. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00228.2003 · Cited by 207
Contraction Regulation of Akt in Rat Skeletal Muscle
Sakamoto, K., Hirshman, M. F., Aschenbach, W. G., & Goodyear, L. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m112410200 · Cited by 197
Exercise and insulin cause GLUT-4 translocation in human skeletal muscle
Thorell, A., Hirshman, M. F., Nygren, J., Jorfeldt, L., Wojtaszewski, J. F. P., Dufresne, S. D., Horton, E. S., Ljungqvist, O. H., & Goodyear, L. J. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.277.4.e733 · Cited by 193
Role of Akt substrate of 160 kDa in insulin-stimulated and contraction-stimulated glucose transport
Cartee, G. D., & Wojtaszewski, J. F. P. (2007) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h07-026 · Cited by 184
Selective impairment of insulin signalling in the hypothalamus of obese Zucker rats
Carvalheira, J. B. C., Ribeiro, E. B., Ara�jo, E. P., Guimar�es, R. B., Telles, M. M., Torsoni, M., Gontijo, J. A. R., Velloso, L. A., & Saad, M. J. A. (2003) · Diabetologia · doi:10.1007/s00125-003-1246-x · Cited by 176
Getting ready for building: signaling and autophagosome biogenesis
Abada, A., & Elazar, Z. (2014) · EMBO Reports · doi:10.15252/embr.201439076 · Cited by 178
The role of skeletal muscle Akt in the regulation of muscle mass and glucose homeostasis
Jaiswal, N., Gavin, M. G., Quinn, W. J., Luongo, T. S., Gelfer, R. G., Baur, J. A., & Titchenell, P. M. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.08.001 · Cited by 167
Defective Signaling Through Akt-2 and -3 But Not Akt-1 in Insulin-Resistant Human Skeletal Muscle
Brozinick, J. T., Roberts, B. R., & Dohm, G. L. (2003) · Diabetes · doi:10.2337/diabetes.52.4.935 · Cited by 164
Self-citation
Modulation of autophagy and ubiquitin-proteasome pathways during ultra-endurance running
Jamart, C., Francaux, M., Millet, G. Y., Deldicque, L., Frère, D., & Féasson, L. (2012) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00952.2011 · Cited by 157
Intracellular mechanisms underlying increases in glucose uptake in response to insulin or exercise in skeletal muscle
Ryder, J. W., Chibalin, A., & Zierath, J. R. (2001) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2001.00827.x · Cited by 158
Roles of TBC1D1 and TBC1D4 in insulin- and exercise-stimulated glucose transport of skeletal muscle
Cartee, G. D. (2014) · Diabetologia · doi:10.1007/s00125-014-3395-5 · Cited by 158
Leucine and insulin activate p70 S6 kinase through different pathways in human skeletal muscle
Greiwe, J. S., Kwon, G., McDaniel, M. L., & Semenkovich, C. F. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.281.3.e466 · Cited by 153
Cellular energy sensing and signaling by AMP-activated protein kinase
Winder, W. W., & Thomson, D. M. (2007) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-007-0008-7 · Cited by 142
Insulin and Exercise Decrease Glycogen Synthase Kinase-3 Activity by Different Mechanisms in Rat Skeletal Muscle
Markuns, J. F., Wojtaszewski, J. F. P., & Goodyear, L. J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.35.24896 · Cited by 140
Regulation of mTOR by amino acids and resistance exercise in skeletal muscle
Deldicque, L., Theisen, D., & Francaux, M. (2005) · European Journal of Applied Physiology · doi:10.1007/s00421-004-1255-6 · Cited by 147
The B Cell Antigen Receptor Activates the Akt (Protein Kinase B)/Glycogen Synthase Kinase-3 Signaling Pathway Via Phosphatidylinositol 3-Kinase
Gold, M. R., Scheid, M. P., Santos, L., Dang-Lawson, M., Roth, R. A., Matsuuchi, L., Duronio, V., & Krebs, D. L. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.4.1894 · Cited by 135
PI3K and Btk differentially regulate B cell antigen receptor-mediated signal transduction
Suzuki, H., Matsuda, S., Terauchi, Y., Fujiwara, M., Ohteki, T., Asano, T., Behrens, T. W., Kouro, T., Takatsu, K., Kadowaki, T., et al. (2003) · Nature Immunology · doi:10.1038/ni890 · Cited by 132
Fenretinide Prevents Lipid-induced Insulin Resistance by Blocking Ceramide Biosynthesis
Bikman, B. T., Guan, Y., Shui, G., Siddique, M. M., Holland, W. L., Kim, J. Y., Fabriàs, G., Wenk, M. R., & Summers, S. A. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.359950 · Cited by 137
Exercise-Induced Phosphorylation of the Novel Akt Substrates AS160 and Filamin A in Human Skeletal Muscle
Deshmukh, A. S., Coffey, V. G., Zhong, Z., Chibalin, A., Hawley, J. A., & Zierath, J. R. (2006) · Diabetes · doi:10.2337/db05-1419 · Cited by 126
Regulation of glucose transport in human skeletal muscle
Koistinen, H. A., & Zierath, J. R. (2002) · Annals of Medicine · doi:10.1080/078538902321012351 · Cited by 124
Disruption of Cortical Actin in Skeletal Muscle Demonstrates an Essential Role of the Cytoskeleton in Glucose Transporter 4 Translocation in Insulin-sensitive Tissues
Brozinick, J. T., Hawkins, E. D., Strawbridge, A. B., & Elmendorf, J. S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402697200 · Cited by 120
Self-citation
Protein Kinase B Stimulates the Translocation of GLUT4 but Not GLUT1 or Transferrin Receptors in 3T3-L1 Adipocytes by a Pathway Involving SNAP-23, Synaptobrevin-2, and/or Cellubrevin
Foran, P., Fletcher, L. M., Oatey, P. B., Mohammed, N., Dolly, J. O., & Tavaré, J. M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.40.28087 · Cited by 117
Prior exercise increases phosphorylation of Akt substrate of 160 kDa (AS160) in rat skeletal muscle
Arias, E. B., Kim, J., Funai, K., & Cartee, G. D. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00602.2006 · Cited by 118
Insulin and Contraction Stimulate Exocytosis, but Increased AMP-activated Protein Kinase Activity Resulting from Oxidative Metabolism Stress Slows Endocytosis of GLUT4 in Cardiomyocytes
Yang, J., & Holman, G. D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m410213200 · Cited by 115
Decrease in Akt/PKB signalling in human skeletal muscle by resistance exercise
Deldicque, L., Atherton, P. J., Patel, R. S., Theisen, D., Nielens, H., Rennie, M. J., & Francaux, M. (2008) · European Journal of Applied Physiology · doi:10.1007/s00421-008-0786-7 · Cited by 117
Signaling Pathways Mediating Insulin‐Stimulated Glucose Transport
Summers, S. A., Yin, V. P., Whiteman, E. L., Garza, L. A., Cho, H., Tuttle, R. L., & Birnbaum, M. J. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb07795.x · Cited by 104
Self-citation
Mechanisms underlying impaired GLUT-4 translocation in glycogen-supercompensated muscles of exercised rats
Kawanaka, K., Nolte, L. A., Han, D., Hansen, P. A., & Holloszy, J. O. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.6.e1311 · Cited by 99
Differential regulation of MAP kinase, p70S6K, and Akt by contraction and insulin in rat skeletal muscle
Sherwood, D. J., Dufresne, S. D., Markuns, J. F., Cheatham, B., Moller, D. E., Aronson, D., & Goodyear, L. J. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.276.5.e870 · Cited by 98
Cross‐talk mechanisms in the development of insulin resistance of skeletal muscle cells
Störz, P., Döppler, H. R., Wernig, A., Pfizenmaier, K., & Müller, G. I. (1999) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1999.00809.x · Cited by 95
Activation of AMPK is essential for AICAR-induced glucose uptake by skeletal muscle but not adipocytes
Sakoda, H., Ogihara, T., Anai, M., Fujishiro, M., Ono, H., Onishi, Y., Katagiri, H., Abe, M., Fukushima, Y., Shojima, N., et al. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00455.2001 · Cited by 95
The HIV Protease Inhibitor Indinavir Decreases Insulin- and Contraction-Stimulated Glucose Transport in Skeletal Muscle
Nolte, L. A., Yarasheski, K. E., Kawanaka, K., Fisher, J. S., Le, N., & Holloszy, J. O. (2001) · Diabetes · doi:10.2337/diabetes.50.6.1397 · Cited by 92
Endoplasmic Reticulum Stress Markers and Ubiquitin-Proteasome Pathway Activity in Response to a 200-km Run
Kim, H. J., Jamart, C., Deldicque, L., An, G.-L., Lee, Y. H., Kim, C. K., Raymackers, J., & Francaux, M. (2010) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181e4c5d1 · Cited by 94
Preconditioning Enhanced Glucose Uptake Is Mediated by p38 MAP Kinase Not by Phosphatidylinositol 3-Kinase
Tong, H., Chen, W., London, R. E., Murphy, E., & Steenbergen, C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.16.11981 · Cited by 91
Role of plasma membrane transporters in muscle metabolism
Antonio Zorzano, A., Fandos, C., & Palacı́n, M. (2000) · Biochemical Journal · doi:10.1042/bj3490667 · Cited by 78
Concerted redox modulation by sulforaphane alleviates diabetes and cardiometabolic syndrome
Patel, B., Mann, G. E., & Chapple, S. J. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.02.004 · Cited by 77
Munc18c Regulates Insulin-stimulated GLUT4 Translocation to the Transverse Tubules in Skeletal Muscle
Khan, A. H., Thurmond, D. C., Yang, C., Ceresa, B. P., Sigmund, C. D., & Pessin, J. E. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007419200 · Cited by 74
Intracellular Segregation of Phosphatidylinositol-3,4,5-Trisphosphate by Insulin-Dependent Actin Remodeling in L6 Skeletal Muscle Cells
Patel, N., Rudich, A., Khayat, Z. A., Garg, R. R., & Klip, A. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.13.4611-4626.2003 · Cited by 73
Is REDD1 a metabolic double agent? Lessons from physiology and pathology
Britto, F. A., Dumas, K., Giorgetti‐Peraldi, S., Ollendorff, V., & Favier, F. B. (2020) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00340.2020 · Cited by 72
Push/pull mechanisms of GLUT4 traffic in muscle cells
Rudich, A., & Klip, A. (2003) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2003.01163.x · Cited by 67
G α 11 Signaling through ARF6 Regulates F-Actin Mobilization and GLUT4 Glucose Transporter Translocation to the Plasma Membrane
Bose, A., Cherniack, A. D., Langille, S. E., Nicoloro, S. M. C., Buxton, J. M., Park, J. G., Chawla, A., & Czech, M. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.15.5262-5275.2001 · Cited by 66
Statin modulates insulin signaling and insulin resistance in liver and muscle of rats fed a high-fat diet
Lalli, C. A., Pauli, J. R., Prada, P. O., Cintra, D. E., Ropelle, E. R., Velloso, L. A., & Saad, M. J. A. (2007) · Metabolism · doi:10.1016/j.metabol.2007.07.021 · Cited by 67
Akt kinases and 2-deoxyglucose uptake in rat skeletal muscles in vivo: study with insulin and exercise
Turinsky, J., & Damrau-Abney, A. (1999) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1999.276.1.r277 · Cited by 65
In Vivo Adenoviral Delivery of Recombinant Human Protein Kinase C-ζ Stimulates Glucose Transport Activity in Rat Skeletal Muscle
Etgen, G. J., Valasek, K. M., Broderick, C. L., & Miller, A. R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.32.22139 · Cited by 65
Role of Akt2 in contraction-stimulated cell signaling and glucose uptake in skeletal muscle
Sakamoto, K., Arnolds, D. E., Fujii, N., Kramer, H. F., Hirshman, M. F., & Goodyear, L. J. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00204.2006 · Cited by 63
Elovl5 regulates the mTORC2-Akt-FOXO1 pathway by controlling hepatic cis-vaccenic acid synthesis in diet-induced obese mice
Tripathy, S., & Jump, D. Β. (2012) · Journal of Lipid Research · doi:10.1194/jlr.m028787 · Cited by 62
Secretion of Annexin II via Activation of Insulin Receptor and Insulin-like Growth Factor Receptor
Zhao, W., Chen, G. H., Chen, H., Pascale, A., Ravindranath, L., Quon, M. J., & Alkon, D. L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210545200 · Cited by 61
A comprehensive view of muscle glucose uptake: regulation by insulin, contractile activity, and exercise
Richter, E. A., Bilan, P. J., & Klip, A. (2025) · Physiological Reviews · doi:10.1152/physrev.00033.2024 · Cited by 64
Homozygous staggerer (sg/sg) mice display improved insulin sensitivity and enhanced glucose uptake in skeletal muscle
Lau, P., Fitzsimmons, R. L., Pearen, M. A., Watt, M. J., & Muscat, G. E. O. (2011) · Diabetologia · doi:10.1007/s00125-011-2046-3 · Cited by 58
Phenylmethimazole blocks palmitate-mediated induction of inflammatory cytokine pathways in 3T3L1 adipocytes and RAW 264.7 macrophages
McCall, K. D., Holliday, D. K., Dickerson, E., Wallace, B., Schwartz, A. L., Schwartz, C., Lewis, C. J., Kohn, L. D., & Schwartz, F. (2010) · Journal of Endocrinology · doi:10.1677/joe-09-0370 · Cited by 59
Identification and validation of the pathways and functions regulated by the orphan nuclear receptor, ROR alpha1, in skeletal muscle
Raichur, S., Fitzsimmons, R. L., Myers, S., Pearen, M. A., Lau, P., Eriksson, N. A., Wang, S.-C., & Muscat, G. E. O. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq180 · Cited by 57
Increased insulin receptor signaling and glycogen synthase activity contribute to the synergistic effect of exercise on insulin action
Christ-Roberts, C. Y., Pratipanawatr, T., Pratipanawatr, W., Berria, R., Belfort, R., & Mandarino, L. J. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00605.2003 · Cited by 55
A novel PKB/Akt inhibitor, MK-2206, effectively inhibits insulin-stimulated glucose metabolism and protein synthesis in isolated rat skeletal muscle
Lai, Y., Liu, Y., Jacobs, R., & Rider, M. H. (2012) · Biochemical Journal · doi:10.1042/bj20120772 · Cited by 57
Contraction inhibits insulin-stimulated insulin receptor substrate-1/2-associated phosphoinositide 3-kinase activity, but not protein kinase B activation or glucose uptake, in rat muscle
WHITEHEAD, J. P., SOOS, M. A., ASLESEN, R., O'RAHILLY, S., & JENSEN, J. (2000) · Biochemical Journal · doi:10.1042/bj3490775 · Cited by 48
Leucine modulates contraction- and insulin-stimulated glucose transport and upstream signaling events in rat skeletal muscle
Iwanaka, N., Egawa, T., Satoubu, N., Karaike, K., Ma, X., Masuda, S., & Hayashi, T. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00420.2009 · Cited by 45
Regulation of MAP kinase pathway activity in vivo in human skeletal muscle
Osman, A. A., Pendergrass, M., Koval, J., Maezono, K., Cusi, K. J., Pratipanawatr, T., & Mandarino, L. J. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.278.6.e992 · Cited by 42
Insulin, Muscle Glucose Uptake, and Hexokinase: Revisiting the Road Not Taken
Wasserman, D. H. (2021) · Physiology · doi:10.1152/physiol.00034.2021 · Cited by 44
The effect of exercise induced cytokines on insulin stimulated glucose transport in C2C12 cells
Gray, S. R., & Kamolrat, T. (2011) · Cytokine · doi:10.1016/j.cyto.2011.04.019 · Cited by 41
Signal-transduction networks and the regulation of muscle protein degradation
Szewczyk, N. J., & Jacobson, L. A. (2005) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2005.02.020 · Cited by 39
Passive stretching produces Akt- and MAPK-dependent augmentations of GLUT4 translocation and glucose uptake in skeletal muscles of mice
Ito, Y., Obara, K., Ikeda, R., Ishii, M., Tanabe, Y., Ishikawa, T., & Nakayama, K. (2005) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-005-1512-5 · Cited by 39
The Akt1 isoform is an essential mediator of ischaemic preconditioning
Kunuthur, S. P., Mocanu, M. M., Hemmings, B. A., Hausenloy, D. J., & Yellon, D. M. (2011) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2011.01491.x · Cited by 38
Management of phosphatidylinositol-3-kinase inhibitor-associated hyperglycemia
Goncalves, M. D., & Farooki, A. (2022) · Integrative Cancer Therapies · doi:10.1177/15347354211073163 · Cited by 37
Assessing Effects of Alcohol Consumption on Protein Synthesis in Striated Muscles
Vary, T. C., & Lang, C. H. (2008) · Methods in molecular biology · doi:10.1007/978-1-59745-242-7_22 · Cited by 37
Triiodothyronine Acutely Stimulates Glucose Transport into L6 Muscle Cells Without Increasing Surface GLUT4, GLUT1, or GLUT3
Teixeira, S. D. S., Tamrakar, A. K., Goulart-Silva, F., Serrano‐Nascimento, C., Klip, A., & Nunes, M. T. (2012) · Thyroid · doi:10.1089/thy.2011.0422 · Cited by 35
Contraction activates glucose uptake and glycogen synthase normally in muscles from dexamethasone-treated rats
Ruzzin, J., & Jensen, J. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00587.2004 · Cited by 33
Potentiation of neuronal insulin signaling and glucose uptake by resveratrol: the involvement of AMPK
Patel, M. I., Gupta, A. K., & Dey, C. S. (2011) · Pharmacological Reports · doi:10.1016/s1734-1140(11)70635-1 · Cited by 33
Epigallocatechin Gallate Stimulates Glucose Uptake Through the Phosphatidylinositol 3-Kinase-Mediated Pathway in L6 Rat Skeletal Muscle Cells
Jung, K. H., Choi, H. S., Kim, D. H., Han, M. Y., Chang, U. J., Yim, S., Song, B. C., Kim, C., & Kang, S. A. (2008) · Journal of Medicinal Food · doi:10.1089/jmf.2007.0107 · Cited by 31
A multidisciplinary approach to optimizing care of patients treated with alpelisib
Rugo, H. S., Lacouture, M. E., Goncalves, M. D., Masharani, U. B., Aapro, M., & O’Shaughnessy, J. (2021) · The Breast · doi:10.1016/j.breast.2021.12.016 · Cited by 31
Muscle contractions, AICAR, and insulin cause phosphorylation of an AMPK-related kinase
Fisher, J. S., Ju, J.-S., Oppelt, P. J., Smith, J. L., Suzuki, A., & Esumi, H. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00335.2004 · Cited by 26
Lengthening contractions differentially affect p70s6k phosphorylation compared to isometric contractions in rat skeletal muscle
Burry, M. E., Hawkins, D., & Spangenburg, E. E. (2007) · European Journal of Applied Physiology · doi:10.1007/s00421-007-0444-5 · Cited by 25
Molecular mechanisms of contraction-regulated cardiac glucose transport
Till, M., Ouwens, D. M., Kessler, A., & Eckel, J. (2000) · Biochemical Journal · doi:10.1042/bj3460841 · Cited by 24
Antioxidant supplemention in the treatment of skeletal muscle insulin resistance: potential mechanisms and clinical relevance
Wright, D. C., & Sutherland, L. (2008) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h07-155 · Cited by 23
The effect of interleukin‐6 and the interleukin‐6 receptor on glucose transport in mouse skeletal muscle
Gray, S. R., Ratkevičius, A., Wackerhage, H., Coats, P., & Nimmo, M. A. (2009) · Experimental Physiology · doi:10.1113/expphysiol.2009.048173 · Cited by 22
Concentrations of signal transduction proteins mediating exercise and insulin responses in rat extensor digitorum longus and soleus muscles
Atherton, P. J., Higginson, J. M., Singh, J., & Wackerhage, H. (2004) · Molecular and Cellular Biochemistry · doi:10.1023/b:mcbi.0000028745.58567.81 · Cited by 20
Contraction-mediated glucose uptake is increased in men with impaired glucose tolerance
Skov-Jensen, C., Skovbro, M., Flint, A., Helge, J. W., & Dela, F. (2007) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h06-098 · Cited by 20
Mechanical stretch activates mammalian target of rapamycin and AMP-activated protein kinase pathways in skeletal muscle cells
Nakai, N., Kawano, F., & Nakata, K. (2015) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-015-2446-7 · Cited by 22
The insulin receptor and metabolic signaling
Gustafson, T. A., Moodie, S. A., & Lavan, B. E. (1999) · Springer eBooks · doi:10.1007/3-540-65362-7_5 · Cited by 21
Peroxiredoxin 2 mediates insulin sensitivity of skeletal muscles through regulation of protein tyrosine phosphatase oxidation
Kim, J., Park, S.-J., Chae, U., Seong, J., Lee, H., Lee, S., Lee, S., & Lee, D. (2018) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2018.03.019 · Cited by 20
Involvement of the extracellular matrix and integrin signalling proteins in skeletal muscle glucose uptake
Draicchio, F., Behrends, V., Tillin, N. A., Hurren, N. M., Sylow, L., & Mackenzie, R. (2022) · The Journal of Physiology · doi:10.1113/jp283039 · Cited by 23
Effects of exercise on muscle glycogen synthesis signalling and enzyme activities in pigs carrying the PRKAG3 mutation
Granlund, A., Kotova, O., Benziane, B., Galuska, D., Jensen‐Waern, M., Chibalin, A., & Essén-Gustavsson, B. (2009) · Experimental Physiology · doi:10.1113/expphysiol.2009.051326 · Cited by 19

Authors: Brozinick, J. T., & Birnbaum, M. J.
Affiliations: Howard Hughes Medical Institute (US)
Corresponding author: Brozinick, Joseph T.
Birnbaum, Morris J.
ORCID: Brozinick, Joseph T.
Birnbaum, Morris J.
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 1998-06
Volume: 273
Issue: 24
Pages: 14679-14682
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1074/jbc.273.24.14679
OpenAlex: W2040466763
Cited by: 149
References: 32
Citations by year: 2025: 2 · 2022: 5 · 2021: 3 · 2020: 4 · 2019: 2 · 2018: 6 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 3 · 2013: 2 · 2012: 8
FWCI: 4.25
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 8164 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01dk039615-03)
National Institute of Diabetes and Digestive and Kidney Diseases (DK 39615)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Keywords: insulin signaling, Akt, skeletal muscle glucose transport, muscle contraction, PI3-kinase, wortmannin, GLUT4 translocation, p70 S6 kinase, epitrochlearis muscle, soleus muscle
MeSH terms: Wortmannin, Phosphoinositide-3 Kinase Inhibitors, Androstadienes, Animals, Biological Transport, Enzyme Activation, Enzyme Inhibitors, Glucose, Insulin, Male, Muscle Contraction, Phosphorylation, Phosphoserine, Proto-Oncogene Proteins, Signal Transduction, Rats, Wistar, Protein Serine-Threonine Kinases, Muscle, Skeletal, Ribosomal Protein S6 Kinases, Proto-Oncogene Proteins c-akt, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Insulin, but Not Contraction, Activates Akt/PKB in Isolated Rat Skeletal Muscle

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks