Two Kinesin Light Chain Genes in Mice
Open accessAbstract
Native kinesin consists of two light chains and two heavy chains in a 1:1 stoichiometric ratio. To date, only one gene for kinesin light chain has been characterized, while a second gene was identified in a genomic sequencing study but not analyzed biochemically. Here we describe new genes encoding kinesin light chains in mouse. One of these light chains is neuronally enriched, while another shows ubiquitous expression. The presence of multiple kinesin light chain genes in mice is especially interesting, since there are two kinesin heavy chain genes in humans (Niclas, J., Navone, F., Hom-Booher, N., and Vale, R. D. (1994) Neuron 12, 1059-1072). To assess the selectivity of kinesin light chain interaction with the heavy chains, we performed immunoprecipitation experiments. The data suggested that the light chains form homodimers with no specificity in their interaction with the two heavy chains. Immunofluorescence and biochemical subfractionation suggested differences in the subcellular localization of the two kinesin light chain gene products. Although both kinesin light chains are distributed throughout the central and peripheral nervous systems, there is enrichment of one in sciatic nerve axons, while the other shows elevated levels in olfactory bulb glomeruli. These results indicate that the mammalian nervous system contains multiple kinesin light chain gene products with potentially distinct functions.
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KLC1 is predominant in neuronal tissues.
“KLC1 is predominant in neuronal tissues (Rahman et al., 1998).”
From Microtubule motors transport phagosomes in the RPE, and lack of KLC1 leads to AMD-like pathogenesis (2015) · cites this paper as Rahman et al., 1998
There is no specificity in the interaction of KLCs with KHCs.
“Recent data suggest that while KHC and KLC only form homodimers amongst themselves, there is no specificity in the interaction of KLCs with KHCs (Rahman et al. 1998).”
From Defective kinesin heavy chain behavior in mouse kinesin light chain mutants (1999) · cites this paper as Rahman et al. 1998
In mammals, kinesin-I polypeptide components are encoded by three KHC genes (KIF5A, KIF5B, KIF5C) and three KLC genes (KLC1, KLC2, KLC3).
“In mammals, the polypeptide components of kinesin-I are encoded by three KHC genes, KIF5A, KIF5B, and KIF5C (Gudkov et al. 1994; Niclas et al. 1994; Nakagawa et al. 1997; Xia et al. 1998), and three KLC genes, KLC1, KLC2, and KLC3 (Lamerdin et al. 1996; Rahman et al. 1998).”
From Defective kinesin heavy chain behavior in mouse kinesin light chain mutants (1999) · cites this paper as Rahman et al. 1998
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Cites
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961 · see citing works
Molecular Cloning: A Laboratory Manual
Sambrook, J., Fritsch, E., & Maniatis, T. (1989) · UCLA - Biblioteca de Ciencias de la Salud · Cited by 133,589 · see citing works
Molecular cloning: A laboratory manual
Deininger, P. L. (1990) · Analytical Biochemistry · doi:10.1016/0003-2697(90)90595-z · Cited by 84,684 · see citing works
A comprehensive set of sequence analysis programs for the VAX
Devereux, J., Haeberli, P. E., & Smithies, O. (1984) · Nucleic Acids Research · doi:10.1093/nar/12.1part1.387 · Cited by 14,222 · see citing works
Cleavage of structural proteins during the assemble of the head of bacterio-phage T4
Laemmli, U. K. (1970) · Nature · Cited by 5,673 · see citing works
Altering the Genome by Homologous Recombination
Capecchi, M. R. (1989) · Science · doi:10.1126/science.2660260 · Cited by 2,037 · see citing works
Identification of a novel force-generating protein, kinesin, involved in microtubule-based motility
VALE, R., REESE, T., & SHEETZ, M. (1985) · Cell · doi:10.1016/s0092-8674(85)80099-4 · Cited by 1,993 · see citing works
Guan, K., & Dixon, J. (1991) · Analytical Biochemistry · doi:10.1016/0003-2697(91)90534-z · Cited by 1,735 · see citing works
Sternberger, L. A., & Sternberger, N. H. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.19.6126 · Cited by 1,158 · see citing works
Okada, Y., Yamazaki, H., Sekine‐Aizawa, Y., & Hirokawa, N. (1995) · Cell · doi:10.1016/0092-8674(95)90538-3 · Cited by 679 · see citing works
Tetratrico peptide repeat interactions: to TPR or not to TPR?
Lamb, J. R., Tugendreich, S., & Hieter, P. (1995) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)89037-4 · Cited by 626 · see citing works
A novel brain ATPase with properties expected for the fast axonal transport motor
Brady, S. T. (1985) · Nature · doi:10.1038/317073a0 · Cited by 618 · see citing works
KIF1B, a novel microtubule plus end-directed monomeric motor protein for transport of mitochondria
Nangaku, M., Sato-Yoshitake, R., Okada, Y., Noda, Y., Takemura, R., Yamazaki, H., & Hirokawa, N. (1994) · Cell · doi:10.1016/0092-8674(94)90012-4 · Cited by 598 · see citing works
Hirokawa, N., Pfister, K. K., Yorifuji, H., Wagner, M. C., Brady, S. T., & Bloom, G. S. (1989) · Cell · doi:10.1016/0092-8674(89)90691-0 · Cited by 477 · see citing works
Yang, J. T., Laymon, R. A., & Goldstein, L. S. B. (1989) · Cell · doi:10.1016/0092-8674(89)90692-2 · Cited by 395 · see citing works
Kinesin family in murine central nervous system.
Aizawa, H., Sekine, Y., Takemura, R., Zhang, Z., Nangaku, M., & Hirokawa, N. (1992) · The Journal of Cell Biology · doi:10.1083/jcb.119.5.1287 · Cited by 321 · see citing works
Radial extension of macrophage tubular lysosomes supported by kinesin
Hollenbeck, P. J., & Swanson, J. A. (1990) · Nature · doi:10.1038/346864a0 · Cited by 295 · see citing works
Yamazaki, H., Nakata, T., Okada, Y., & Hirokawa, N. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.130.6.1387 · Cited by 293 · see citing works
Bloom, G. S., Wagner, M. C., Pfister, K. K., & Brady, S. T. (1988) · Biochemistry · doi:10.1021/bi00409a043 · Cited by 284 · see citing works
Kinesin associates with anterogradely transported membranous organelles in vivo.
Hirokawa, N., Sato-Yoshitake, R., Kobayashi, N., Pfister, K. K., Bloom, G. S., & Brady, S. T. (1991) · The Journal of Cell Biology · doi:10.1083/jcb.114.2.295 · Cited by 260 · see citing works
Pfister, K. K., Wagner, M. C., Stenoien, D. L., Brady, S. T., & Bloom, G. S. (1989) · The Journal of Cell Biology · doi:10.1083/jcb.108.4.1453 · Cited by 258 · see citing works
Brady, S. T., Pfister, K. K., & Bloom, G. S. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.3.1061 · Cited by 237 · see citing works
KIF3A is a new microtubule-based anterograde motor in the nerve axon.
Kondo, S., Sato-Yoshitake, R., Noda, Y., Aizawa, H., Nakata, T., Matsuura, Y., & Hirokawa, N. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.125.5.1095 · Cited by 237 · see citing works
Evidence that the Head of Kinesin Is Sufficient for Force Generation and Motility in Vitro
Yang, J. T., Saxton, W. M., Stewart, R. J., Raff, E. C., & Goldstein, L. S. B. (1990) · Science · doi:10.1126/science.2142332 · Cited by 225 · see citing works
Kinesin- and Myosin-driven Steps of Vesicle Recruitment for Ca2+-regulated Exocytosis
Bi, G., Morris, R. L., Liao, G., Alderton, J. M., Scholey, J. M., & Steinhardt, R. A. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.138.5.999 · Cited by 207 · see citing works
Suppression of kinesin expression in cultured hippocampal neurons using antisense oligonucleotides.
Ferreira, A., Niclas, J., Vale, R. D., Banker, G. A., & Kosik, K. S. (1992) · The Journal of Cell Biology · doi:10.1083/jcb.117.3.595 · Cited by 190 · see citing works
The quaternary structure of bovine brain kinesin.
Kuznetsov, S., Vaisberg, E. A., Shanina, N. A., Magretova, N. N., Chernyak, V. Y., & Gelfand, V. I. (1988) · The EMBO Journal · doi:10.1002/j.1460-2075.1988.tb02820.x · Cited by 183 · see citing works
WITH APOLOGIES TO SCHEHERAZADE: TAILS OF 1001 KINESIN MOTORS
Goldstein, L. S. B. (1993) · Annual Review of Genetics · doi:10.1146/annurev.ge.27.120193.001535 · Cited by 181 · see citing works
Inhibition of kinesin-driven microtubule motility by monoclonal antibodies to kinesin heavy chains.
Ingold, A. L., Cohn, S. A., & Scholey, J. M. (1988) · The Journal of Cell Biology · doi:10.1083/jcb.107.6.2657 · Cited by 175 · see citing works
Kinesin is responsible for centrifugal movement of pigment granules in melanophores.
Rodionov, V., Gyoeva, F. K., & Gelfand, V. I. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.11.4956 · Cited by 170 · see citing works
Hoshimaru, M., Ray, J., Sah, D. W. Y., & Gage, F. H. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.4.1518 · Cited by 165 · see citing works
Cloning and localization of a conventional kinesin motor expressed exclusively in neurons
Niclas, J., Navone, F., Hom-Booker, N., & Vale, R. D. (1994) · Neuron · doi:10.1016/0896-6273(94)90314-x · Cited by 153 · see citing works
Immunochemical analysis of kinesin light chain function
Stenoien, D. L., & Brady, S. T. (1997) · Molecular Biology of the Cell · doi:10.1091/mbc.8.4.675 · Cited by 143 · see citing works
Gudkov, A. V., Kazarov, A. R., Thimmapaya, R., Axenovich, S. A., Mazo, I. A., & Roninson, I. B. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.9.3744 · Cited by 122 · see citing works
Molecular genetics of kinesin light chains: generation of isoforms by alternative splicing.
Cyr, J. L., Pfister, K. K., Bloom, G. S., Slaughter, C. A., & Brady, S. T. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.22.10114 · Cited by 120 · see citing works
Effects of kinesin mutations on neuronal functions
Gho, M., McDonald, K., Ganetzky, B., & Saxton, W. M. (1992) · Science · doi:10.1126/science.1384131 · Cited by 120 · see citing works
Elluru, R. G., Bloom, G. S., & Brady, S. T. (1995) · Molecular Biology of the Cell · doi:10.1091/mbc.6.1.21 · Cited by 119 · see citing works
The carboxyl-terminal domain of kinesin heavy chain is important for membrane binding
Skoufias, D. A., Cole, D. G., Wedaman, K. P., & Scholey, J. M. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42281-2 · Cited by 110 · see citing works
The Drosophila kinesin light chain. Primary structure and interaction with kinesin heavy chain
Gauger, A. K., & Goldstein, L. S. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)38698-3 · Cited by 105 · see citing works
Steinberg, G., & Schliwa, M. (1995) · Molecular Biology of the Cell · doi:10.1091/mbc.6.11.1605 · Cited by 102 · see citing works
Characterization of the KIF3C Neural Kinesin-like Motor from Mouse
Yang, Z., & Goldstein, L. S. B. (1998) · Molecular Biology of the Cell · doi:10.1091/mbc.9.2.249 · Cited by 102 · see citing works
Evidence that the stalk of Drosophila kinesin heavy chain is an alpha-helical coiled coil.
de Cuevas, M., Tao, T., & Goldstein, L. S. B. (1992) · The Journal of Cell Biology · doi:10.1083/jcb.116.4.957 · Cited by 100 · see citing works
Characterization of KIFC2, a Neuronal Kinesin Superfamily Member in Mouse
Hanlon, D., Yang, Z., & Goldstein, L. S. B. (1997) · Neuron · doi:10.1016/s0896-6273(00)81244-1 · Cited by 97 · see citing works
Neurofilament protein phosphorylation - where, when and why
Matus, A. I. (1988) · Trends in Neurosciences · doi:10.1016/0166-2236(88)90086-0 · Cited by 88 · see citing works
A Collection of cDNA Clones with Specific Expression Patterns in Mouse Brain
Kato, K. (1990) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1990.tb00460.x · Cited by 84 · see citing works
Tetratrico peptide repeats are present in the kinesin light chain
Gindhart, J. G., & Goldstein, L. S. B. (1996) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(96)80180-0 · Cited by 76 · see citing works
Amaratunga, A., Morin, P. J., Kosik, K. S., & Fine, R. E. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)85352-8 · Cited by 67 · see citing works
Sequence Analysis of theERCC2Gene Regions in Human, Mouse, and Hamster Reveals Three Linked Genes
Lamerdin, J. E., Stilwagen, S. A., Ramirez, M., Stubbs, L. J., & Carrano, A. V. (1996) · Genomics · doi:10.1006/geno.1996.0303 · Cited by 54 · see citing works
Sequences of Sea Urchin Kinesin Light Chain Isoforms
Wedaman, K. P., Knight, A. E., Kendrick‐Jones, J., & Scholey, J. M. (1993) · Journal of Molecular Biology · doi:10.1006/jmbi.1993.1267 · Cited by 47 · see citing works
Motor activity and mitotic spindle localization of the Drosophila kinesin-like protein KLP61F.
Barton, N. R., Pereira, A., & Goldstein, L. S. B. (1995) · Molecular Biology of the Cell · doi:10.1091/mbc.6.11.1563 · Cited by 45 · see citing works
Beushausen, S. A., Kladakis, A., & Jaffe, H. (1993) · DNA and Cell Biology · doi:10.1089/dna.1993.12.901 · Cited by 36 · see citing works
Kinesin Light Chain Isoforms in Caenorhabditis elegans
Fan, J., & Amos, L. (1994) · Journal of Molecular Biology · doi:10.1006/jmbi.1994.1465 · Cited by 26 · see citing works
Cloning and Genetic Characterization of the Human Kinesin Light-Chain (KLC) Gene
Cabeza-Arvelaiz, Y., SHIH, L.-C. N., Hardman, N., ASSELBERGS, F., Bilbe, G., Schmitz, A., WHITE, B., Siciliano, M. J., & Lachman, L. B. (1993) · DNA and Cell Biology · doi:10.1089/dna.1993.12.881 · Cited by 23 · see citing works
Subcellular localization of the F5 protein to the neuronal membrane‐associated cytoskeleton
Arai, M., & Cohen, J. A. (1994) · Journal of Neuroscience Research · doi:10.1002/jnr.490380313 · Cited by 11 · see citing works
Goedert, M., Marsh, S. G. E., & Carter, N. (1996) · Genomics · doi:10.1006/geno.1996.0102 · Cited by 8 · see citing works
Flagged first, then by citations
Research works printed but not linked: 6
- Brady, S. T., Pfister, K. K., and Bloom, G. S. (1990) Proc. Natl. Acad. Sci.
- Rodionov, V. I., Gyoeva, F. K., and Gelfand, V. I. (1991) Proc. Natl. Acad. Sci.
- Cyr, J. L., Pfister, K. K., Bloom, G. S., Slaughter, C. A., and Brady, S. T. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 10114 -10118
- Hoshimaru, M., Ray, J., Sah, D. W., and Gage, F. H. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 1518 -1523
- Sternberger, L. A., and Sternberger, N. H. (1983) Proc. Natl. Acad. Sci. U. S. A. 80, 6126 -6130
- Gudkov, A. V., Kazarov, A. R., Thimmapaya, R., Axenovich, S. A., Mazo, I. A., and Roninson, I. B. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 3744 -3748
Cited by
Sorted by citations
The Molecular Motor Toolbox for Intracellular Transport
Vale, R. D. (2003) · Cell · doi:10.1016/s0092-8674(03)00111-9 · Cited by 1,982 · see citing works
Microtubule-Based Transport Systems in Neurons: The Roles of Kinesins and Dyneins
Goldstein, L. S. B., & Yang, Z. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.39 · Cited by 552 · see citing works
Kamal, A., Stokin, G. B., Yang, Z., Xia, C.-H., & Goldstein, L. S. B. (2000) · Neuron · doi:10.1016/s0896-6273(00)00124-0 · Cited by 544 · see citing works
Intracellular Transport and Kinesin Superfamily Proteins, KIFs: Structure, Function, and Dynamics
Hirokawa, N., & Noda, Y. (2008) · Physiological Reviews · doi:10.1152/physrev.00023.2007 · Cited by 510 · see citing works
Arl8 and SKIP Act Together to Link Lysosomes to Kinesin-1
Rosa-Ferreira, C., & Munro, S. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.10.007 · Cited by 361 · see citing works
Kinesin-Dependent Axonal Transport Is Mediated by the Sunday Driver (SYD) Protein
Bowman, A. B., Kamal, A., Ritchings, B. W., Philp, A. V., McGrail, M. A., Gindhart, J. G., & Goldstein, L. S. B. (2000) · Cell · doi:10.1016/s0092-8674(00)00162-8 · Cited by 331 · see citing works
Interaction of Huntingtin-associated Protein-1 with Kinesin Light Chain
McGuire, J. R., Rong, J., Li, X., & Li, X. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509806200 · Cited by 282 · see citing works
Kinesin-dependent movement on microtubules precedes actin-based motility of vaccinia virus
Rietdorf, J., Ploubidou, A., Reckmann, I., Holmström, A., Frischknecht, F., Zettl, M., Zimmermann, T., & Way, M. (2001) · Nature Cell Biology · doi:10.1038/ncb1101-992 · Cited by 279 · see citing works
The Road Less Traveled: Emerging Principles of Kinesin Motor Utilization
Goldstein, L. S. B., & Philp, A. V. (1999) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.15.1.141 · Cited by 269 · see citing works
Tau Protein Interaction Partners and Their Roles in Alzheimer’s Disease and Other Tauopathies
Sinsky, J., Pichlerova, K., & Hanes, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179207 · Cited by 220 · see citing works
Tubulin and CRMP‐2 complex is transported via Kinesin‐1
Toshihide, N., Watanabe, H., Iwamatsu, A., & Kaibuchi, K. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03063.x · Cited by 218 · see citing works
Stable kinesin and dynein assemblies drive the axonal transport of mammalian prion protein vesicles
Encalada, S. E., Szpankowski, L., Xia, C.-H., & Goldstein, L. S. B. (2011) · Cell · doi:10.1016/j.cell.2011.01.021 · Cited by 206 · see citing works
A Direct Interaction between Cytoplasmic Dynein and Kinesin I May Coordinate Motor Activity
Ligon, L. A., Tokito, M. K., Finklestein, J. M., Grossman, F. E., & Holzbaur, E. L. F. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313472200 · Cited by 164 · see citing works
Conventional kinesin KIF5B mediates insulin‐stimulated GLUT4 movements on microtubules
Semiz, S., Park, J. G., Nicoloro, S. M. C., Furcinitti, P. S., Zhang, C., Chawla, A., Leszyk, J., & Czech, M. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg237 · Cited by 160 · see citing works
Molecular motors implicated in the axonal transport of tau and α-synuclein
Utton, M. A., Noble, W. J., Hill, J. E., Anderton, B. H., & Hanger, D. P. (2005) · Journal of Cell Science · doi:10.1242/jcs.02558 · Cited by 158 · see citing works
Regulation of motor proteins, axonal transport deficits and adult-onset neurodegenerative diseases
Brady, S. T., & Morfini, G. A. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.04.010 · Cited by 152 · see citing works
Calsyntenin-1 Docks Vesicular Cargo to Kinesin-1
Konecna, A., Frischknecht, R., Kinter, J., Ludwig, A., Steuble, M., Meskenaïte, V., Indermühle, M., Engel, M., Cen, C., Mateos, J. M., et al. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-02-0112 · Cited by 148 · see citing works
Gunawardena, S., & Goldstein, L. S. B. (2003) · Journal of Neurobiology · doi:10.1002/neu.10319 · Cited by 147 · see citing works
Molecular motors and their functions in plants
Reddy, A. S. N. (2001) · International review of cytology · doi:10.1016/s0074-7696(01)04004-9 · Cited by 127 · see citing works
Kurowska, M., Goudin, N., Nehme, N. T., Court, M., Garin, J., Fischer, A., Basile, G. D. S., & Ménasché, G. (2012) · Blood · doi:10.1182/blood-2011-09-382556 · Cited by 124 · see citing works
Rong, J., McGuire, J. R., Fang, Z.-H., Sheng, G., Shin, J., Li, S., & Li, X. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1251-06.2006 · Cited by 124 · see citing works
Vos, K. J. D., Severin, F. F., Herreweghe, F. V., Vancompernolle, K., Goossens, V., Hyman, A. A., & Grooten, J. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.149.6.1207 · Cited by 117 · see citing works
Manning, B. D., Barrett, J. G., Wallace, J. A., Granok, H., & Snyder, M. P. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.144.6.1219 · Cited by 111 · see citing works
Dumont, A., Boucrot, E., Drevensek, S., Daire, V., Gorvel, J., Poüs, C., Holden, D. W., & Méresse, S. (2010) · Traffic · doi:10.1111/j.1600-0854.2010.01069.x · Cited by 107 · see citing works
Sunday Driver/JIP3 binds kinesin heavy chain directly and enhances its motility
Sun, F., Zhu, C., Dixit, R., & Cavalli, V. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.229 · Cited by 107 · see citing works
Defective kinesin heavy chain behavior in mouse kinesin light chain mutants
Rahman, A., Kamal, A., Roberts, E. A., & Goldstein, L. S. B. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.146.6.1277 · Cited by 102 · see citing works
A kinesin‐1 binding motif in vaccinia virus that is widespread throughout the human genome
Dodding, M. P., Mitter, R., Humphries, A. C., & Way, M. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.326 · Cited by 102 · see citing works
Chang, R., & Wang, E. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20969 · Cited by 100 · see citing works
Cargo selection by specific kinesin light chain 1 isoforms
Wozniak, M. J., & Allan, V. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601427 · Cited by 96 · see citing works
Role of neuronal activity and kinesin on tract tracing by manganese-enhanced MRI (MEMRI)
Bearer, E. L., Falzone, T. L., Zhang, X., Biris, O., Rasin, A., & Jacobs, R. E. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.04.053 · Cited by 88 · see citing works
Microtubule motors transport phagosomes in the RPE, and lack of KLC1 leads to AMD-like pathogenesis
Jiang, M., Esteve-Rudd, J., Lopes, V. S., Diemer, T., Lillo, C., Rump, A., & Williams, D. S. (2015) · Journal of Cell Biology · doi:10.1083/jcb.201410112 · Cited by 85 · see citing works
Conventional Kinesin Holoenzymes Are Composed of Heavy and Light Chain Homodimers
DeBoer, S. R., You, Y., Szodorai, A., Kamińska, A., Pigino, G. F., Nwabuisi, E., Wang, B., Estrada-Hernandez, T., Kins, S., Brady, S. T., et al. (2008) · Biochemistry · doi:10.1021/bi702445j · Cited by 83 · see citing works
Vagnoni, A., Rodríguez, L. C. D. L. C., Manser, C., Vos, K. J. D., & Miller, C. C. J. (2011) · Journal of Cell Science · doi:10.1242/jcs.075168 · Cited by 73 · see citing works
Synergistic autoinhibition and activation mechanisms control kinesin-1 motor activity
Chiba, K., Ori-McKenney, K. M., Niwa, S., & McKenney, R. J. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110900 · Cited by 70 · see citing works
Kinesin Light-Chain KLC3 Expression in Testis Is Restricted to Spermatids1
Junco, A., Bhullar, B., Tarnasky, H. A., & van der Hoorn, F. A. (2001) · Biology of Reproduction · doi:10.1095/biolreprod64.5.1320 · Cited by 68 · see citing works
Nath, S., Bananis, E., Sarkar, S., Stockert, R. J., Sperry, A. O., Murray, J. W., & Wolkoff, A. W. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-06-0524 · Cited by 68 · see citing works
JLP Associates with Kinesin Light Chain 1 through a Novel Leucine Zipper-like Domain
Nguyen, Q., Lee, C. M., Le, A., & Reddy, E. P. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505499200 · Cited by 66 · see citing works
Conventional kinesin: Biochemical heterogeneity and functional implications in health and disease
Morfini, G. A., Schmidt, N., Weissmann, C., Pigino, G. F., & Kins, S. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.06.009 · Cited by 63 · see citing works
Insights into Kinesin-1 Activation from the Crystal Structure of KLC2 Bound to JIP3
Cockburn, J. J. B., Hesketh, S. J., Mulhair, P. O., Thomsen, M., O’Connell, M. J., & Way, M. (2018) · Structure · doi:10.1016/j.str.2018.07.011 · Cited by 57 · see citing works
GBP binds kinesin light chain and translocates during cortical rotation inXenopuseggs
Weaver, C. I., Farr, G. H., Pan, W., Rowning, B. A., Wang, J., Mao, J., Wu, D., Li, L., Larabell, C. A., & Kimelman, D. (2003) · Development · doi:10.1242/dev.00737 · Cited by 62 · see citing works
Cytoskeletal regulation guides neuronal trafficking to effectively supply the synapse
Aiken, J., & Holzbaur, E. L. F. (2021) · Current Biology · doi:10.1016/j.cub.2021.02.024 · Cited by 61 · see citing works
Bracale, A., Cesca, F., Neubrand, V. E., Newsome, T. P., Way, M., & Schiavo, G. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-05-0453 · Cited by 60 · see citing works
An isoform of kinesin light chain specific for the Golgi complex
Gyoeva, F. K., Bybikova, E. M., & Minin, A. А. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.11.2047 · Cited by 57 · see citing works
Autoinhibited kinesin-1 adopts a hierarchical folding pattern
Tan, Z., Yue, Y., Leprevost, F., Haynes, S., Basrur, V., Nesvizhskii, A. I., Verhey, K. J., & Cianfrocco, M. A. (2023) · eLife · doi:10.7554/elife.86776 · Cited by 48 · see citing works
Kins, S., Lauther, N., Szodorai, A., & Beyreuther, K. T. (2006) · Neurodegenerative Diseases · doi:10.1159/000095259 · Cited by 54 · see citing works
Behrends, U., Schneider, I., Rössler, S., Frauenknecht, H., Golbeck, A., Lechner, B., Eigenstetter, G., Zobywalski, C., Müller-Weihrich, S., Graubner, U. B., et al. (2003) · International Journal of Cancer · doi:10.1002/ijc.11208 · Cited by 54 · see citing works
YANG, J., & Li, T. (2005) · Experimental Cell Research · doi:10.1016/j.yexcr.2005.05.026 · Cited by 53 · see citing works
Manser, C., Guillot, F., Vagnoni, A., Davies, J., Lau, K., McLoughlin, D. M., Vos, K. J. D., & Miller, C. C. J. (2011) · Oncogene · doi:10.1038/onc.2011.437 · Cited by 51 · see citing works
Ishida, M., Ohbayashi, N., & Fukuda, M. (2015) · Scientific Reports · doi:10.1038/srep08238 · Cited by 49 · see citing works
14-3-3 Protein Interacts with Huntingtin-associated Protein 1 and Regulates Its Trafficking
Rong, J., Li, S., Sheng, G., Wu, M., Coblitz, B., Li, M., Fu, H., & Li, X. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m609057200 · Cited by 46 · see citing works
Deficiency of Klc2 Induces Low-Frequency Sensorineural Hearing Loss in C57BL/6 J Mice and Human
Fu, X., An, Y., Wang, H., Li, P., Lin, J., Yuan, J. Y., Yue, R., Jin, Y., Gao, J., & Chai, R. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02422-w · Cited by 45 · see citing works
One axon, many kinesins: What's the logic?
Mureşan, V. (2000) · Journal of Neurocytology · doi:10.1023/a:1010943424272 · Cited by 44 · see citing works
Morel, M., Héraud, C., Nicaise, C., Suain, V., & Brion, J. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0901-4 · Cited by 43 · see citing works
Overexpression of KLC2 due to a homozygous deletion in the non-coding region causes SPOAN syndrome
Melo, U. S., Macedo‐Souza, L. I., Figueiredo, T., Muotri, A. R., Gleeson, J. G., Coux, G., Armas, P., Calcaterra, N. B., Kitajima, J. P., de Amorim, S. C., et al. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv388 · Cited by 43 · see citing works
Drivers and passengers wanted! The role of kinesin-associated proteins
Manning, B. D., & Snyder, M. P. (2000) · Trends in Cell Biology · doi:10.1016/s0962-8924(00)01774-8 · Cited by 42 · see citing works
Macedo‐Souza, L. I., Kok, F., Santos, S., Licínio, L., Lezirovitz, K., Cavaçana, N., Bueno, C., de Amorim, S. C., Pessoa, A. L. S., Graciani, Z., et al. (2009) · Annals of Human Genetics · doi:10.1111/j.1469-1809.2009.00507.x · Cited by 41 · see citing works
Axonal Transport and Mitochondrial Dysfunction in Alzheimer's Disease
Riemer, J., & Kins, S. (2012) · Neurodegenerative Diseases · doi:10.1159/000342020 · Cited by 39 · see citing works
A Novel Chimeric Mitochondrial RNA Localized in the Nucleus of Mouse Sperm
Villegas, J., Zárraga, A. M., Müller, I., Montecinos, L., Werner, E., Brito, M., Meneses, A. M., & Burzio, L. O. (2000) · DNA and Cell Biology · doi:10.1089/104454900439809 · Cited by 38 · see citing works
Alternatively Spliced Products of the Human Kinesin Light Chain 1 (KNS2) Gene
Reed, A. E. M., Mahony, D., & Rothnagel, J. A. (2003) · Traffic · doi:10.1034/j.1600-0854.2003.00113.x · Cited by 35 · see citing works
Selvarasu, K., Singh, A. K., Iyaswamy, A., Sreenivasmurthy, S. G., Krishnamoorthi, S., Bera, A. K., Huang, J., & Durairajan, S. S. K. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.1050768 · Cited by 33 · see citing works
Rat kinesin light chain 3 associates with spermatid mitochondria
Zhang, Y., Oko, R. J., & van der Hoorn, F. A. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2004.07.014 · Cited by 33 · see citing works
Association of Kinesin Light Chain with Outer Dense Fibers in a Microtubule-independent Fashion
Bhullar, B., Zhang, Y., Junco, A., Oko, R. J., & van der Hoorn, F. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m213126200 · Cited by 32 · see citing works
Sato, S., Ito, M., Ito, T., & Yoshioka, K. (2004) · Gene · doi:10.1016/j.gene.2003.12.034 · Cited by 29 · see citing works
Kinesin-1 promotes post-Golgi trafficking of NCAM140 and NCAM180 to the cell surface
Wobst, H., Schmitz, B., Schachner, M., Diestel, S., Leshchyns’ka, I., & Sytnyk, V. (2015) · Journal of Cell Science · doi:10.1242/jcs.169391 · Cited by 25 · see citing works
Carpentier, D. C. J., Gao, W. N. D., Ewles, H. A., Morgan, G. W., & Smith, G. L. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1004723 · Cited by 25 · see citing works
Unraveling the Function of Lemur Tyrosine Kinase 2 Network
Cruz, D. F., Farinha, C. M., & Swiatecka‐Urban, A. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00024 · Cited by 21 · see citing works
Sehgal, L., Mukhopadhyay, A., Rajan, A., Khapare, N., Sawant, M., Vishal, S. S., Bhatt, K., Ambatipudi, S., Antao, N. V., Alam, H., et al. (2014) · Journal of Cell Science · doi:10.1242/jcs.125807 · Cited by 20 · see citing works
Cui, J., Pang, J., Lin, Y., Gong, H., Wang, Z., Li, Y., Li, J., Wang, Z., Jiang, P., Dai, D., et al. (2017) · The FASEB Journal · doi:10.1096/fj.201601103r · Cited by 20 · see citing works
Mouse cathepsin F: cDNA cloning, genomic organization and chromosomal assignment of the gene
Deussing, J. M., Tisljar, K., Papazoglou, A., & Peters, C. (2000) · Gene · doi:10.1016/s0378-1119(00)00196-7 · Cited by 20 · see citing works
Kinesins in the nervous system
Martin, M., Hurd, D. D., & Saxton, W. M. (1999) · Cellular and Molecular Life Sciences · doi:10.1007/s000180050422 · Cited by 20 · see citing works
Baek, J.-H., Lee, J. S., Yun, H. S., Lee, C., Song, J. Y., Um, H., Park, J. K., Park, I., Kim, J., Kim, E. H., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0549-2 · Cited by 19 · see citing works
Molecular mechanism for kinesin-1 direct membrane recognition
Antón, Z., Weijman, J. F., Williams, C., Moody, E. R. R., Mantell, J., Yip, Y. Y., Cross, J. A., Williams, T. A., Steiner, R. A., Crump, M. P., et al. (2021) · Science Advances · doi:10.1126/sciadv.abg6636 · Cited by 18 · see citing works
Kinesin-1 transports morphologically distinct intracellular virions during vaccinia infection
Xu, A., Basant, A., Schleich, S., Newsome, T. P., & Way, M. (2022) · Journal of Cell Science · doi:10.1242/jcs.260175 · Cited by 18 · see citing works
Sobu, Y., Furukori, K., Chiba, K., Nairn, A. C., Kinjo, M., Hata, S., & Suzuki, T. (2017) · Molecular Biology of the Cell · doi:10.1091/mbc.e17-05-0301 · Cited by 18 · see citing works
Takazawa, K., Noguchi, T., Hosooka, T., Yoshioka, T., Tobimatsu, K., & Kasuga, M. (2008) · PubMed · doi:10.24546/81000139 · Cited by 17 · see citing works
Medina, C. S., Biris, O., Falzone, T. L., Zhang, X., Zimmerman, A. J., & Bearer, E. L. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.09.035 · Cited by 16 · see citing works
Axonal transport and neurodegenerative disease: vesicle-motor complex formation and their regulation
Gunawardena, S., Anderson, E. N., & White, J. (2014) · Degenerative Neurological and Neuromuscular Disease · doi:10.2147/dnnd.s57502 · Cited by 15 · see citing works
Kinesin-1 plays a role in transport of SNAP-25 to the plasma membrane
Morton, A. M., Cunningham, A. L., & Diefenbach, R. J. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.11.068 · Cited by 14 · see citing works
Cyrus, B. F., & Müller, W. A. (2016) · American Journal Of Pathology · doi:10.1016/j.ajpath.2016.01.011 · Cited by 14 · see citing works
Killian, R. L., Flippin, J. D., Herrera, C. M., Almenar‐Queralt, A., & Goldstein, L. S. B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029755 · Cited by 14 · see citing works
Biedler, J. K., & Tu, Z. J. (2010) · BMC Evolutionary Biology · doi:10.1186/1471-2148-10-206 · Cited by 12 · see citing works
Cheng, H., Burroughs-Garcìa, J., Birkness-Gartman, J. E., Trinidad, J. C., & Deans, M. R. (2016) · PLoS ONE · doi:10.1371/journal.pone.0165519 · Cited by 12 · see citing works
Gao, W. N. D., Carpentier, D. C. J., Ewles, H. A., Lee, S., & Smith, G. L. (2017) · Traffic · doi:10.1111/tra.12494 · Cited by 12 · see citing works
Richards, A. L., Berth, S. H., Brady, S. T., & Morfini, G. A. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.684762 · Cited by 11 · see citing works
Encalada, S. E., Moya, K. L., Lehmann, S., & Zahn, R. (2007) · Journal of Molecular Neuroscience · doi:10.1007/s12031-007-0011-x · Cited by 10 · see citing works
Approaches to Kinesin-1 Phosphorylation
Morfini, G. A., Pigino, G. F., & Brady, S. T. (2007) · Methods in molecular biology · doi:10.1007/978-1-59745-490-2_4 · Cited by 10 · see citing works
How kinesins walk, assemble and transport: A birds-eye-view of some unresolved questions
Ray, K. (2006) · Physica A Statistical Mechanics and its Applications · doi:10.1016/j.physa.2006.05.007 · Cited by 10 · see citing works
Wang, Z., Xue, W., Li, X., Lin, R., Cui, J., & Huang, J. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.02.006 · Cited by 8 · see citing works
JSAP1 Interacts with Kinesin Light Chain 1 through Conserved Binding Segments
Kim, S., Lee, C.-H., Park, H.-Y., Yea, S.-S., Jang, W.-H., Lee, S.-K., Park, Y.-H., Cha, O.-S., Moon, I.-S., & Seog, D. (2007) · Journal of Life Science · doi:10.5352/jls.2007.17.7.889 · Cited by 8 · see citing works
Autoinhibited kinesin-1 adopts a hierarchical folding patternPreprint
Tan, Z., Yue, Y., Leprevost, F. D. V., Haynes, S. E., Basrur, V., Nesvizhskii, A. I., Verhey, K. J., & Cianfrocco, M. A. (2023) · eLife · doi:10.7554/elife.86776.1 · Cited by 8 · see citing works
Jang, W. H., Jeong, Y. J., Choi, S. H., Kim, S.-J., Urm, S.-H., & Seog, D. (2014) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2014.943652 · Cited by 7 · see citing works
Jang, W. H., Jeong, Y. J., Choi, S. H., Urm, S.-H., & Seog, D. (2016) · Biomedical Reports · doi:10.3892/br.2016.818 · Cited by 6 · see citing works
Gümüşderelioğlu, S., Resch, L., Brock, T., Undiagnosed Diseases Network, Luxton, G. W. G., Cope, H., Tan, Q. K. ‐., Hopkins, C. E., & Starr, D. A. (2023) · Disease Models & Mechanisms · doi:10.1242/dmm.050076 · Cited by 6 · see citing works
Reconstitution of Kinesin-1 ActivationPreprint
Chiba, K., Ori-McKenney, K. M., Niwa, S., & McKenney, R. J. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.03.12.434960 · Cited by 6 · see citing works
Autoinhibited kinesin-1 adopts a hierarchical folding pattern
Tan, Z., Yue, Y., Leprevost, F., Haynes, S., Basrur, V., Nesvizhskii, A. I., Verhey, K. J., & Cianfrocco, M. A. (2023) · eLife · doi:10.7554/elife.86776.3 · Cited by 5 · see citing works
The Kinesin Superfamily Handbook
Friel, C. T. (2020) · CRC Press eBooks · doi:10.1201/9780429491559 · Cited by 5 · see citing works
Hafezparast, M., Witherden, A. S., Nicholson, S. J., Bermingham, N. A., Mackin, J., ten Asbroek, A. L. M. A., Ball, S., Peters, J., Baas, F., Martin, J. E., et al. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00620-5 · Cited by 3 · see citing works
Jang, W. H., Kim, S.-J., Jeong, Y. J., Jun, H.-J., Moon, I. S., & Seog, D. (2012) · Journal of Life Science · doi:10.5352/jls.2012.22.12.1608 · Cited by 2 · see citing works
Conventional kinesin KIF5B mediates adiponectin secretion in 3T3-L1 adipocytes
Cui, J., Pang, J., Lin, Y., Jiang, P., Gong, H., Wang, Z., Li, J., Cai, J., Huang, J., & Zhang, T. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.06.008 · Cited by 2 · see citing works
- Authors
- Rahman, A., Friedman, D. S., & Goldstein, L. S. B.
- Affiliations
- Howard Hughes Medical Institute (US)
- University of California, San Francisco (US)
- Corresponding author
- Goldstein, Lawrence S.B.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1998-06
- Volume
- 273
- Issue
- 25
- Pages
- 15395-15403
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1983362841
- Cited by
- 123
- References
- 55
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 1 · 2023: 8 · 2022: 3 · 2021: 6 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 7 · 2016: 6 · 2015: 5 · 2014: 4 · 2013: 1 · 2012: 4
- FWCI
- 2.16
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- University of California, San Francisco
- Lawrence Livermore National Laboratory
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Hereditary Neurological Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
- Keywords
- kinesin light chain, kinesin heavy chain, gene duplication, neuronal expression, subcellular localization, olfactory bulb glomeruli
- MeSH terms
- Amino Acid Sequence, Animals, Brain Chemistry, Chromosome Mapping, Cloning, Molecular, Humans, Microtubule-Associated Proteins, Microtubules, Molecular Sequence Data, Sciatic Nerve, Kinesins, Sequence Analysis, DNA, Mice
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