The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
Two Kinesin Light Chain Genes in Mice
Open accessAbstract
Native kinesin consists of two light chains and two heavy chains in a 1:1 stoichiometric ratio. To date, only one gene for kinesin light chain has been characterized, while a second gene was identified in a genomic sequencing study but not analyzed biochemically. Here we describe new genes encoding kinesin light chains in mouse. One of these light chains is neuronally enriched, while another shows ubiquitous expression. The presence of multiple kinesin light chain genes in mice is especially interesting, since there are two kinesin heavy chain genes in humans (Niclas, J., Navone, F., Hom-Booher, N., and Vale, R. D. (1994) Neuron 12, 1059-1072). To assess the selectivity of kinesin light chain interaction with the heavy chains, we performed immunoprecipitation experiments. The data suggested that the light chains form homodimers with no specificity in their interaction with the two heavy chains. Immunofluorescence and biochemical subfractionation suggested differences in the subcellular localization of the two kinesin light chain gene products. Although both kinesin light chains are distributed throughout the central and peripheral nervous systems, there is enrichment of one in sciatic nerve axons, while the other shows elevated levels in olfactory bulb glomeruli. These results indicate that the mammalian nervous system contains multiple kinesin light chain gene products with potentially distinct functions.
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“KLC1 is predominant in neuronal tissues (Rahman et al., 1998).”
From Microtubule motors transport phagosomes in the RPE, and lack of KLC1 leads to AMD-like pathogenesis (2015) · cites this paper as Rahman et al., 1998
In the citing paper
“Recent data suggest that while KHC and KLC only form homodimers amongst themselves, there is no specificity in the interaction of KLCs with KHCs (Rahman et al. 1998).”
From Defective kinesin heavy chain behavior in mouse kinesin light chain mutants (1999) · cites this paper as Rahman et al. 1998
In the citing paper
“In mammals, the polypeptide components of kinesin-I are encoded by three KHC genes, KIF5A, KIF5B, and KIF5C (Gudkov et al. 1994; Niclas et al. 1994; Nakagawa et al. 1997; Xia et al. 1998), and three KLC genes, KLC1, KLC2, and KLC3 (Lamerdin et al. 1996; Rahman et al. 1998).”
From Defective kinesin heavy chain behavior in mouse kinesin light chain mutants (1999) · cites this paper as Rahman et al. 1998
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Metadata
- Authors
- Rahman, A., Friedman, D. S., & Goldstein, L. S. B.
- Affiliations
- Howard Hughes Medical Institute (US)
- University of California, San Francisco (US)
- Corresponding author
- Goldstein, Lawrence S.B.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1998-06
- Volume
- 273
- Issue
- 25
- Pages
- 15395-15403
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1983362841
- Cited by
- 123
- References
- 55
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 1 · 2023: 8 · 2022: 3 · 2021: 6 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 7 · 2016: 6 · 2015: 5 · 2014: 4 · 2013: 1 · 2012: 4
- FWCI
- 2.16
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- University of California, San Francisco
- Lawrence Livermore National Laboratory
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Hereditary Neurological Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
- Keywords
- kinesin light chain, kinesin heavy chain, gene duplication, neuronal expression, subcellular localization, olfactory bulb glomeruli
- MeSH terms
- Amino Acid Sequence, Animals, Brain Chemistry, Chromosome Mapping, Cloning, Molecular, Humans, Microtubule-Associated Proteins, Microtubules, Molecular Sequence Data, Sciatic Nerve, Kinesins, Sequence Analysis, DNA, Mice
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