The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Bcl-2 Prevents Caspase-independent Cell Death
Open accessAbstract
Nitric oxide (NO) is implicated in apoptosis and has both cytotoxic and cytoprotective effects. Exogenous NO induced the death of PC12 and HeLa cells via a process showing features of both apoptosis and necrosis, with chromatin condensation, nuclear compaction, and mitochondrial swelling. Activation of caspases was not observed during NO-induced cell death. In addition, cell death was not inhibited by peptide caspase inhibitors or by expression of p35, a baculovirus-encoded caspase inhibitor, indicating that NO-induced cell death was independent of caspases. NO-induced cell death was enhanced by Bax expression in a caspase-independent manner and prevented by the anti-cell death protein Bcl-2. Although Bcl-2 has previously been shown to prevent cell death by inhibiting caspase activation, these results indicate that it can also prevent cell death via a caspase-independent mechanism.
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Lipton, S. A., Choi, Y.-B., Pan, Z.-H., Lei, S. Z., Chen, H.-S. V., Sucher, N. J., Loscalzo, J., Singel, D. J., & Stamler, J. S. (1993) · Nature · doi:10.1038/364626a0 · Cited by 2,433
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The regulatory role of nitric oxide in apoptosis
Kim, P. K. M., Zamora, R., Petrosko, P., & Billiar, T. R. (2001) · International Immunopharmacology · doi:10.1016/s1567-5769(01)00088-1 · Cited by 391
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Goldberg, J. L., & Barres, B. A. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.579 · Cited by 338
Apoptotic and necrotic cell death induced by death domain receptors
Denecker, G., Vercammen, D., Declercq, W., & Vandenabeele, P. (2001) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000863 · Cited by 279
Marine cyanobacteria compounds with anticancer properties: A review on the implication of apoptosis
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Metadata
- Authors
- Okuno, S.-I., Shimizu, S., Ito, T., Nomura, M., Hamada, E., Tsujimoto, Y., & Matsuda, H.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1998-12
- Volume
- 273
- Issue
- 51
- Pages
- 34272-34277
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1971602494
- Cited by
- 160
- References
- 1
- FWCI
- 7.32
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Okuno, S.-I., Shimizu, S., Ito, T., Nomura, M., Hamada, E., Tsujimoto, Y., & Matsuda, H. (1998). Bcl-2 Prevents Caspase-independent Cell Death. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.273.51.34272
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
