Correlation between Sustained c-Jun N-terminal Protein Kinase Activation and Apoptosis Induced by Tumor Necrosis Factor-α in Rat Mesangial Cells

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302 · see citing works

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961 · see citing works

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

Xia, Z., Dickens, M., Raingeaud, J., Davis, R. J., & Greenberg, M. E. (1995) · Science · doi:10.1126/science.270.5240.1326 · Cited by 5,290 · see citing works

Apoptosis by Death Factor

Nagata, S. (1997) · Cell · doi:10.1016/s0092-8674(00)81874-7 · Cited by 4,908 · see citing works

Function and Activation of NF-kappaB in the Immune System

Baeuerle, P. A., & Henkel, T. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.001041 · Cited by 4,745 · see citing works

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

Alessi, D. R., Cuenda, A., Cohen, P., Dudley, D. T., & Saltiel, A. R. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.46.27489 · Cited by 3,396 · see citing works

An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death

Beg, A. A., & Baltimore, D. (1996) · Science · doi:10.1126/science.274.5288.782 · Cited by 3,047 · see citing works

The stress-activated protein kinase subfamily of c-Jun kinases

Kyriakis, J. M., Banerjee, P. T., Nikolakaki, E., Dai, T., Rubie, E. A., Ahmad, M. F., Avruch, J., & Woodgett, J. R. (1994) · Nature · doi:10.1038/369156a0 · Cited by 2,601 · see citing works

Suppression of TNF-α-Induced Apoptosis by NF-κB

Antwerp, D. J. V., Martin, S. J., Kafri, T., Green, D. R., & Verma, I. M. (1996) · Science · doi:10.1126/science.274.5288.787 · Cited by 2,581 · see citing works

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

Liu, Z.-G., Hsu, H., Goeddel, D. V., & Karin, M. (1996) · Cell · doi:10.1016/s0092-8674(00)81375-6 · Cited by 1,937 · see citing works

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis

Verheij, M., Bose, R., Lin, X. H., Yao, B., Jarvis, W. D., Grant, S., Birrer, M. J., Szabo, E. M., Zon, L. I., Kyriakis, J. M., et al. (1996) · Nature · doi:10.1038/380075a0 · Cited by 1,767 · see citing works

Recombinant Human Tumor Necrosis Factor-α: Effects on Proliferation of Normal and Transformed Cells in Vitro

Sugarman, B. J., Aggarwal, B. B., Hass, P. E., Figari, I. S., Palladino, M. A., & Shepard, H. M. (1985) · Science · doi:10.1126/science.3933111 · Cited by 1,572 · see citing works

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB

Kauffmann-Zeh, A., Rodriguez‐Viciana, P., Ulrich, E., Gilbert, C. S., Coffer, P. J., Downward, J., & Evan, G. I. (1997) · Nature · doi:10.1038/385544a0 · Cited by 1,148 · see citing works

Sounding the Alarm: Protein Kinase Cascades Activated by Stress and Inflammation

Kyriakis, J. M., & Avruch, J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.40.24313 · Cited by 1,083 · see citing works

Differential Activation of ERK and JNK Mitogen-Activated Protein Kinases by Raf-1 and MEKK

Minden, A., Lin, A., McMahon, M., Lange, C. A., Dérijard, B., Davis, R. J., Johnson, G. L., & Karin, M. (1994) · Science · doi:10.1126/science.7992057 · Cited by 1,069 · see citing works

The Role of c-Jun N-terminal Kinase (JNK) in Apoptosis Induced by Ultraviolet C and γ Radiation

Chen, Y.-R., Wang, X., Templeton, D., Davis, R. J., & Tan, T.-H. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.50.31929 · Cited by 867 · see citing works

Daxx, a Novel Fas-Binding Protein That Activates JNK and Apoptosis

Yang, X., Khosravi‐Far, R., Chang, H. Y., & Baltimore, D. (1997) · Cell · doi:10.1016/s0092-8674(00)80294-9 · Cited by 830 · see citing works

Transcriptional control by protein phosphorylation: signal transmission from the cell surface to the nucleus

Karin, M., & Hunter, T. R. (1995) · Current Biology · doi:10.1016/s0960-9822(95)00151-5 · Cited by 752 · see citing works

Activation of the IκBα Kinase Complex by MEKK1, a Kinase of the JNK Pathway

Lee, F. S., Hagler, J., Chen, Z. J., & Maniatis, T. (1997) · Cell · doi:10.1016/s0092-8674(00)81842-5 · Cited by 710 · see citing works

Protein kinase cascades activated by stress and inflammatory cytokines

Kyriakis, J. M., & Avruch, J. (1996) · BioEssays · doi:10.1002/bies.950180708 · Cited by 709 · see citing works

Apoptosis: Activate NF-κB or die?

Baichwal, V. R., & Baeuerle, P. A. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00046-7 · Cited by 528 · see citing works

Murine hepatocyte apoptosis induced in vitro and in vivo by TNF- alpha requires transcriptional arrest.

Leist, M., Gantner, F., Bohlinger, I., Germann, P., Tiegs, G., & Wendel, A. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.153.4.1778 · Cited by 492 · see citing works

Activation of SAPK/JNK by TNF Receptor 1 Through a Noncytotoxic TRAF2-Dependent Pathway

Natoli, G., Costanzo, A., Ianni, A., Templeton, D. J., Woodgett, J. R., Balsano, C., & Levrero, M. (1997) · Science · doi:10.1126/science.275.5297.200 · Cited by 452 · see citing works

The stress-activated protein kinase pathway mediates cell death following injury induced by cis-platinum, UV irradiation or heat

Zanke, B. W., Boudreau, K., Rubie, E. A., Winnett, E., Tibbles, L. A., Zon, L. I., Kyriakis, J. M., Liu, F., & Woodgett, J. R. (1996) · Current Biology · doi:10.1016/s0960-9822(02)00547-x · Cited by 444 · see citing works

The Dual Specificity Phosphatases M3/6 and MKP-3 Are Highly Selective for Inactivation of Distinct Mitogen-activated Protein Kinases

Muda, M., Theodosiou, A. M., Rodrigues, N. R., Boschert, U., Camps, M., Gilliéron, C., Davies, K. E., Ashworth, A., & Arkinstall, S. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.44.27205 · Cited by 375 · see citing works

Ceramide Activates the Stress-activated Protein Kinases

Westwick, J. K., Bielawska, A. E., Dbaibo, G. S., Hannun, Y. A., & Brenner, D. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.39.22689 · Cited by 369 · see citing works

Role of Mitogen-activated Protein Kinase Phosphatase during the Cellular Response to Genotoxic Stress

Liu, Y., Gorospe, M., Yang, C., & Holbrook, N. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.15.8377 · Cited by 283 · see citing works

Tumor necrosis factor α‐induced activation of c‐jun N‐terminal kinase is mediated by TRAF2

Reinhard, C., Shamoon, B., Shyamala, V., & Williams, L. T. (1997) · The EMBO Journal · doi:10.1093/emboj/16.5.1080 · Cited by 277 · see citing works

An emerging family of dual specificity MAP kinase phosphatases

Keyse, S. M. (1995) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(94)00211-v · Cited by 261 · see citing works

Mitogen-activated protein kinase-mediated Fas apoptotic signaling pathway

Goillot, E., Raingeaud, J., Ranger, A. M., Tepper, R. I., Davis, R. J., Harlow, E., & Sánchez, I. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.7.3302 · Cited by 260 · see citing works

Molecular mechanisms of tumor necrosis factor‐induced cytotoxicity

Beyaert, R., & Fiers, W. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)80163-0 · Cited by 235 · see citing works

Fibroblast Growth Factor-2 Suppression of Tumor Necrosis Factor α-Mediated Apoptosis Requires Ras and the Activation of Mitogen-activated Protein Kinase

Gardner, A. M., & Johnson, G. L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.24.14560 · Cited by 215 · see citing works

Isolation and characterization of rat glomerular epithelial cells in vitro

Kreisberg, J. I., Hoover, R. L., & Karnovsky, M. J. (1978) · Kidney International · doi:10.1038/ki.1978.86 · Cited by 210 · see citing works

Partial Inhibition of Na+/K+-ATPase by Ouabain Induces the Ca2+-dependent Expressions of Early-response Genes in Cardiac Myocytes

Peng, M., Huang, L., Xie, Z., Huang, W.-H., & Askari, A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.17.10372 · Cited by 194 · see citing works

Muscarinic Regulation of Alzheimer's Disease Amyloid Precursor Protein Secretion and Amyloid β-Protein Production in Human Neuronal NT2N Cells

Wolf, B. A., Wertkin, A. M., Jolly, Y. C., Yasuda, R. P., Wolfe, B. B., Konrad, R. J., Manning, D. R., Ravi, S., WILLIAMSON, J. R., & Lee, V. M. ‐. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.9.4916 · Cited by 190 · see citing works

MADD, a Novel Death Domain Protein That Interacts with the Type 1 Tumor Necrosis Factor Receptor and Activates Mitogen-activated Protein Kinase

Schievella, A. R., Chen, J. H., Graham, J. R., & Lin, L. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.18.12069 · Cited by 170 · see citing works

Induction of Mitogen-activated Protein Kinase Phosphatase 1 by the Stress-activated Protein Kinase Signaling Pathway but Not by Extracellular Signal-regulated Kinase in Fibroblasts

Bokemeyer, D., Sorokin, A., Yan, M., Ahn, N. G., Templeton, D. J., & Dunn, M. J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.2.639 · Cited by 157 · see citing works

c-Jun NH2-terminal Kinase Regulation of the Apoptotic Response of Small Cell Lung Cancer Cells to Ultraviolet Radiation

Butterfield, L., Storey, B., Maas, L., & Heasley, L. E. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.15.10110 · Cited by 146 · see citing works

Activation of c-Jun N-terminal Kinase Antagonizes an Anti-apoptotic Action of Bcl-2

Park, J., Kim, I. J., Oh, Y. J., Lee, K.-W., Han, P., & Choi, E. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.27.16725 · Cited by 130 · see citing works

MacMARCKS, a novel member of the MARCKS family of protein kinase C substrates

Li, J., & Aderem, A. A. (1992) · Cell · doi:10.1016/0092-8674(92)90312-z · Cited by 117 · see citing works

Nuclear Factor-κB Is Activated by Hyperoxia but Does Not Protect from Cell Death

Li, Y., Zhang, W., Mantell, L. L., Kazzaz, J. A., Fein, A. M., & Horowitz, S. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.33.20646 · Cited by 104 · see citing works

Mechanism for Biphasic Rel A· NF-κB1 Nuclear Translocation in Tumor Necrosis Factor α-stimulated Hepatocytes

Han, Y., & Brasier, A. R. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.15.9825 · Cited by 101 · see citing works

Cell growth and apoptosis: a practical approach

(1997) · General Pharmacology The Vascular System · doi:10.1016/s0306-3623(97)84212-7 · Cited by 93 · see citing works

The mesangial cell: A tissue culture view

Davies, M. (1994) · Kidney International · doi:10.1038/ki.1994.41 · Cited by 90 · see citing works

[35] Methods for analyzing c-Jun kinase

Westwick, J. K., & Brenner, D. A. (1995) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(95)55037-2 · Cited by 51 · see citing works

Independent effects of platelet-derived growth factor isoforms on mitogen-activated protein kinase activation and mitogenesis in human dermal fibroblasts

Lubinus, M., Meier, K. E., Smith, E. A., Gause, K. C., LeRoy, E. C., & Trojanowska, M. E. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36957-0 · Cited by 47 · see citing works

TNF-alpha and IL-1 alpha induce mannose receptors and apoptosis in glomerular mesangial but not endothelial cells

Liu, Z., Striker, G. E., Stetler-Stevenson, M. A., Fukushima, P. I., Patel, A. D., & Striker, L. J. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.270.6.c1595 · Cited by 45 · see citing works

Apoptosis: Does stress kill?

Cosulich, S. C., & Clarke, P. R. (1996) · Current Biology · doi:10.1016/s0960-9822(02)70779-3 · Cited by 44 · see citing works

Partial Purification and Characterization of a Ca2+-Dependent Protein Kinase from the Green Alga, Dunaliella salina

Guo, Y., & Roux, S. J. (1990) · PLANT PHYSIOLOGY · doi:10.1104/pp.94.1.143 · Cited by 39 · see citing works

Tyrosine kinase growth factor receptors but not seven-membrane-spanning receptors or phorbol esters activate mitogen-activated protein kinase in rat hepatocytes

Ginès, P., Li, X., Zamarripa, J., Brown, S. E., Wieder, E., Nakamura, T., Guzelian, P. S., Schrier, R. W., Heasley, L. E., & Nemenoff, R. A. (1995) · Hepatology · doi:10.1002/hep.1840220440 · Cited by 32 · see citing works

Signaling to NF-κB

Hayden, M. S., & Ghosh, S. (2004) · Genes & Development · doi:10.1101/gad.1228704 · Cited by 3,842 · see citing works

Tumor necrosis factor signaling

Wajant, H., Pfizenmaier, K., & Scheurich, P. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401189 · Cited by 2,353 · see citing works

Oxidative stress: the mitochondria-dependent and mitochondria-independent pathways of apoptosis

Sinha, K., Das, J., Pal, P. B., & Sil, P. C. (2013) · Archives of Toxicology · doi:10.1007/s00204-013-1034-4 · Cited by 1,622 · see citing works

TUMOR NECROSIS FACTOR RECEPTOR AND Fas SIGNALING MECHANISMS

Wallach, D., Varfolomeev, E. E., Malinin, N. L., Goltsev, Y. V., Kovalenko, A. V., & Boldin, M. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.331 · Cited by 1,299 · see citing works

ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis

Tobiume, K., Matsuzawa, A., Takahashi, T., Nishitoh, H., Morita, K., Takeda, K., Minowa, O., Miyazono, K., Noda, T., & Ichijo, H. (2001) · EMBO Reports · doi:10.1093/embo-reports/kve046 · Cited by 1,213 · see citing works

A Family of Stress-Inducible GADD45-like Proteins Mediate Activation of the Stress-Responsive MTK1/MEKK4 MAPKKK

Takekawa, M., & Saito, H. (1998) · Cell · doi:10.1016/s0092-8674(00)81619-0 · Cited by 746 · see citing works

Induction of gadd45β by NF-κB downregulates pro-apoptotic JNK signalling

De Smaele, E., Zazzeroni, F., Papa, S., Nguyen, D. U., Jin, R., Jones, J., Cong, R., & Franzoso, G. (2001) · Nature · doi:10.1038/35104560 · Cited by 732 · see citing works

Inhibition of JNK activation through NF-κB target genes

Tang, G., Minemoto, Y., Dibling, B., Purcell, N. H., Li, Z., Karin, M., & Lin, A. (2001) · Nature · doi:10.1038/35104568 · Cited by 721 · see citing works

Redox regulation of mitochondrial function

Handy, D. E., & Loscalzo, J. (2012) · Antioxidants & Redox Signaling · doi:10.1089/ars.2011.4123 · Cited by 588 · see citing works

Redox control of cell fate by MAP kinase: physiological roles of ASK1-MAP kinase pathway in stress signaling

Matsuzawa, A., & Ichijo, H. (2008) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2007.12.011 · Cited by 502 · see citing works

NF‐κB inhibits TNF‐induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death

Sakon, S., Xue, X., Takekawa, M., Sasazuki, T., Okazaki, T., Kojima, Y., Piao, J., Yagita, H., Okumura, K., Doi, T., et al. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg379 · Cited by 497 · see citing works

TNF-Induced Signaling in Apoptosis

Rath, P., & Aggarwal, B. (1999) · Journal of Clinical Immunology · doi:10.1023/a:1020546615229 · Cited by 454 · see citing works

Protective effect of curcumin against heavy metals-induced liver damage

García‐Niño, W. R., & Pedraza‐Chaverrí, J. (2014) · Food and Chemical Toxicology · doi:10.1016/j.fct.2014.04.016 · Cited by 388 · see citing works

Reactive oxygen species mediate crosstalk between NF-κB and JNK

Nakano, H., Nakajima, A., Sakon-Komazawa, S., Piao, J.-H., Xue, X., & Okumura, K. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401830 · Cited by 368 · see citing works

Chemical Genetic Analysis of the Time Course of Signal Transduction by JNK

Ventura, J., Hübner, A., Zhang, C., Flavell, R. A., Shokat, K. M., & Davis, R. J. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.01.018 · Cited by 323 · see citing works

JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species

Ventura, J.-J., Cogswell, P., Flavell, R. A., Baldwin, A. S., & Davis, R. J. (2004) · Genes & Development · doi:10.1101/gad.1223004 · Cited by 303 · see citing works

An Inhibitor of p38 Mitogen-activated Protein Kinase Protects Neonatal Cardiac Myocytes from Ischemia

Mackay, K., & Mochly‐Rosen, D. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.10.6272 · Cited by 296 · see citing works

Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress

Morita, K., Saitoh, M., Tobiume, K., Matsuura, H., Enomoto, S., Nishitoh, H., & Ichijo, H. (2001) · The EMBO Journal · doi:10.1093/emboj/20.21.6028 · Cited by 293 · see citing works

Silymarin suppresses TNF-induced activation of NF-kappa B, c-Jun N-terminal kinase, and apoptosis.

Manna, S. K., Mukhopadhyay, A., Van, N. T., & Aggarwal, B. B. (1999) · PubMed · Cited by 293 · see citing works

Homocysteine Induces Programmed Cell Death in Human Vascular Endothelial Cells through Activation of the Unfolded Protein Response

Zhang, C., Cai, Y., Adachi, M. T., Oshiro, S., Aso, T., Kaufman, R. J., & Kitajima, S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100747200 · Cited by 288 · see citing works

The c-Jun N-terminal protein kinase family of mitogen-activated protein kinases (JNK MAPKs)

Barr, R. K., & Bogoyevitch, M. A. (2001) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(01)00093-0 · Cited by 285 · see citing works

Stress-Responsive Protein Kinases in Redox-Regulated Apoptosis Signaling

Matsuzawa, A., & Ichijo, H. (2005) · Antioxidants and Redox Signaling · doi:10.1089/ars.2005.7.472 · Cited by 283 · see citing works

Silymarin Suppresses TNF-Induced Activation of NF-κB, c-Jun N-Terminal Kinase, and Apoptosis

Manna, S. K., Mukhopadhyay, A., Van, N. T., & Aggarwal, B. B. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.12.6800 · Cited by 277 · see citing works

Protein Kinase C δ Is Essential for Etoposide-induced Apoptosis in Salivary Gland Acinar Cells

Reyland, M. E., Anderson, S. M., Matassa, A. A., Barzen, K. A., & Quissell, D. O. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.27.19115 · Cited by 269 · see citing works

JunD Mediates Survival Signaling by the JNK Signal Transduction Pathway

Lamb, J. A., Ventura, J., Hess, P., Flavell, R. A., & Davis, R. J. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00203-x · Cited by 261 · see citing works

Roles of JNK, p38 and ERK mitogen-activated protein kinases in the growth inhibition and apoptosis induced by cadmium

Chuang, S., Wang, I., & Yang, J. (2000) · Carcinogenesis · doi:10.1093/carcin/21.7.1423 · Cited by 252 · see citing works

Physiological Roles of ASK1-Mediated Signal Transduction in Oxidative Stress- and Endoplasmic Reticulum Stress-Induced Apoptosis: Advanced Findings from ASK1 Knockout Mice

Matsuzawa, A., Nishitoh, H., Tobiume, K., Takeda, K., & Ichijo, H. (2002) · Antioxidants and Redox Signaling · doi:10.1089/15230860260196218 · Cited by 249 · see citing works

Deletion of Apoptosis Signal-Regulating Kinase 1 Attenuates Acetaminophen-Induced Liver Injury by Inhibiting c-Jun N-Terminal Kinase Activation

Nakagawa, H., Maeda, S., Hikiba, Y., Ohmae, T., Shibata, W., Yanai, A., Sakamoto, K., Ogura, K., Noguchi, T., Karin, M., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.07.006 · Cited by 253 · see citing works

Role of Hsp70 in regulation of stress‐kinase JNK: implications in apoptosis and aging

Gabai, V. L., Meriin, A. B., Yaglom, J. A., Volloch, V., & Sherman, M. Y. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)01242-3 · Cited by 240 · see citing works

Preconditioning with erythropoietin protects against subsequent ischemia‐reperfusion injury in rat kidney

Yang, C. W., Li, C., Jung, J., Shin, S. J., Choi, B. S., Lim, S. W., Sun, B., Kim, Y., Kim, J., Chang, Y. S., et al. (2003) · The FASEB Journal · doi:10.1096/fj.02-1191fje · Cited by 237 · see citing works

Roles of MAPKKK ASK1 in Stress-Induced Cell Death.

Takeda, K., Matsuzawa, A., Nishitoh, H., & Ichijo, H. (2003) · Cell Structure and Function · doi:10.1247/csf.28.23 · Cited by 224 · see citing works

Extracellular Signal-regulated Protein Kinase/Jun Kinase Cross-talk Underlies Vascular Endothelial Cell Growth Factor-induced Endothelial Cell Proliferation

Pedram, A., Razandi, M., & Levin, E. R. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.41.26722 · Cited by 214 · see citing works

NF-κB inhibition sensitizes hepatocytes to TNF-induced apoptosis through a sustained activation of JNK and c-Jun

Liu, H., Lo, C. R., & Czaja, M. J. (2002) · Hepatology · doi:10.1053/jhep.2002.32534 · Cited by 199 · see citing works

Role of Gadd45 in apoptosis

Sheikh, M. S., Hollander, M. C., & Fornace, A. J. (2000) · Biochemical Pharmacology · doi:10.1016/s0006-2952(99)00291-9 · Cited by 196 · see citing works

MAPK activation determines renal epithelial cell survival during oxidative injury

Mari, J. F. D., Davis, R. J., & Safirstein, R. L. (1999) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1999.277.2.f195 · Cited by 195 · see citing works

Role of 4-hydroxynonenal in stress-mediated apoptosis signaling

Awasthi, S., Sharma, R., Cheng, J. Z., Yang, Y., Sharma, A., Singhal, S. S., & Awasthi, S. (2003) · Molecular Aspects of Medicine · doi:10.1016/s0098-2997(03)00017-7 · Cited by 192 · see citing works

Role of p53 family members in apoptosis

Sheikh, M. S., & Fornace, A. J. (2000) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(200002)182:2 · Cited by 182 · see citing works

Homocysteine-responsive ATF3 gene expression in human vascular endothelial cells: activation of c-Jun NH2-terminal kinase and promoter response element

Cai, Y., Zhang, C., Nawa, T., Aso, T., Tanaka, M. R., Oshiro, S., Ichijo, H., & Kitajima, S. (2000) · Blood · doi:10.1182/blood.v96.6.2140 · Cited by 181 · see citing works

Identification of NF-κB-regulated genes induced by TNFα utilizing expression profiling and RNA interference

Zhou, A., Scoggin, S. O., Gaynor, R. B., & Williams, N. S. (2003) · Oncogene · doi:10.1038/sj.onc.1206262 · Cited by 177 · see citing works

MAPK signaling and the kidney

Tian, W., Zhang, Z., & Cohen, D. (2000) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.2000.279.4.f593 · Cited by 174 · see citing works

Molecular Mechanisms of the Decision between Life and Death: Regulation of Apoptosis by Apoptosis Signal-Regulating Kinase 1

Matsuzawa, A., & Ichijo, H. (2001) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a002947 · Cited by 171 · see citing works

c-Jun N-terminal kinase (JNK) is required for survival and proliferation of B-lymphoma cells

Gururajan, M., Chui, R., Karuppannan, A. K., Ke, J., JENNINGS, C. D., & Bondada, S. (2005) · Blood · doi:10.1182/blood-2004-10-3819 · Cited by 156 · see citing works

Negative Regulation of JNK Signaling by the Tumor Suppressor CYLD

Reiley, W. W., Zhang, M., & Sun, S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411049200 · Cited by 148 · see citing works

Ectopic Expression of Hepatitis C Virus Core Protein Differentially Regulates Nuclear Transcription Factors

Shrivastava, A., Manna, S. K., Ray, R., & Aggarwal, B. B. (1998) · Journal of Virology · doi:10.1128/jvi.72.12.9722-9728.1998 · Cited by 145 · see citing works

Overexpression of γ-glutamylcysteine synthetase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor-kappa B and activator protein-1

Manna, S. K., Kuo, M. T., & Aggarwal, B. B. (1999) · Oncogene · doi:10.1038/sj.onc.1202811 · Cited by 144 · see citing works

Cellular and molecular mechanisms of sex differences in renal ischemia–reperfusion injury

Kher, A., Meldrum, K. K., Wang, M., Tsai, B. M., Pitcher, J. M., & Meldrum, D. R. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.05.005 · Cited by 136 · see citing works

Chrysin induces G1 phase cell cycle arrest in C6 glioma cells through inducing p21Waf1/Cip1 expression: Involvement of p38 mitogen-activated protein kinase

Weng, M., Ho, Y., & Lin, J.-K. (2005) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.03.011 · Cited by 131 · see citing works

Dominant negative EGFR-CD533 and inhibition of MAPK modify JNK1 activation and enhance radiation toxicity of human mammary carcinoma cells

Reardon, D., Contessa, J., Mikkelsen, R., Valerie, K., Amir, C., Dent, P., & Schmidt-Ullrich, R. (1999) · Oncogene · doi:10.1038/sj.onc.1202849 · Cited by 143 · see citing works

Mitogen-activated Protein Kinase Phosphatase-1 (MKP-1) Expression Is Induced by Low Oxygen Conditions Found in Solid Tumor Microenvironments

Laderoute, K. R., Mendonca, H. L., Calaoagan, J. M., Knapp, A. M., Giaccia, A. J., & Stork, P. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.18.12890 · Cited by 126 · see citing works

NF-κB activation results in rapid inactivation of JNK in TNFα-treated Ewing sarcoma cells: a mechanism for the anti-apoptotic effect of NF-κB

Javelaud, D., & Besançon, F. (2001) · Oncogene · doi:10.1038/sj.onc.1204570 · Cited by 124 · see citing works

Regulation of c-Jun-NH2 Terminal Kinase and Extracellular-Signal Regulated Kinase in Human Platelets

Bugaud, F., Nadal-Wollbold, F., Levy-Toledano, S., Rosa, J., & Bryckaert, M. (1999) · Blood · doi:10.1182/blood.v94.11.3800 · Cited by 123 · see citing works

Transfection of mGSTA4 in HL-60 Cells Protects against 4-Hydroxynonenal-Induced Apoptosis by Inhibiting JNK-Mediated Signaling

Cheng, J., Singhal, S. S., Sharma, A., Saini, M. K., Yang, Y., Awasthi, S., Zimniak, P., & Awasthi, S. (2001) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2001.2452 · Cited by 121 · see citing works

Cross-Talk between Phosphatidylinositol 3-Kinase/AKT and c-Jun NH2-Terminal Kinase Mediates Survival of Isolated Human Islets

Aikin, R. A., Maysinger, D., & Rosenberg, L. C. (2004) · Endocrinology · doi:10.1210/en.2004-0488 · Cited by 119 · see citing works

Inhibition of C-Jun N-Terminal Kinase 1, but Not c-Jun N-Terminal Kinase 2, Suppresses Apoptosis Induced by Ischemia/Reoxygenation in Rat Cardiac Myocytes

Hreniuk, D., Garay, M., Gaarde, W. A., Monia, B. P., McKay, R. A., & Cioffi, C. L. (2001) · Molecular Pharmacology · doi:10.1124/mol.59.4.867 · Cited by 119 · see citing works

Suppressed NF- B and sustained JNK activation contribute to the sensitization effect of parthenolide to TNF- -induced apoptosis in human cancer cells

Zhang, S. (2004) · Carcinogenesis · doi:10.1093/carcin/bgh234 · Cited by 113 · see citing works

Activation of JNK and Transcriptional Repressor ATF3/LRF1 through the IRE1/TRAF2 Pathway Is Implicated in Human Vascular Endothelial Cell Death by Homocysteine

Zhang, C., Kawauchi, J., Adachi, M. T., Hashimoto, Y., Oshiro, S., Aso, T., & Kitajima, S. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.6044 · Cited by 111 · see citing works

Lipopolysaccharide Signals an Endothelial Apoptosis Pathway Through TNF Receptor-Associated Factor 6-Mediated Activation of c-Jun NH2-Terminal Kinase

Hull, C. M., McLean, G. W., Wong, F., Duriez, P. J., & Karsan, A. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.5.2611 · Cited by 107 · see citing works

Akt, MAPK (Erk1/2), and p38 Act in Concert to Promote Apoptosis in Response to ErbB Receptor Family Inhibition

Nelson, J. M., & Fry, D. W. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008786200 · Cited by 102 · see citing works

Taurolithocholic acid-3 sulfate induces CD95 trafficking and apoptosis in a c-Jun N-terminal kinase–dependent manner

Graf, D., Kurz, A. K., Fischer, R., Reinehr, R., & Häussinger, D. (2002) · Gastroenterology · doi:10.1053/gast.2002.32976 · Cited by 97 · see citing works

JNK and p38 are activated by erythropoietin (EPO) but are not induced in apoptosis following EPO withdrawal in EPO-dependent HCD57 cells

Jacobs-Helber, S. M., Ryan, J. J., & Sawyer, S. T. (2000) · Blood · doi:10.1182/blood.v96.3.933 · Cited by 96 · see citing works

An antiapoptotic protein, c‐FLIPL, directly binds to MKK7 and inhibits the JNK pathway

Nakajima, A., Komazawa‐Sakon, S., Takekawa, M., Sasazuki, T., Yeh, W., Yagita∥, H., Okumura, K., & Nakano, H. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601423 · Cited by 94 · see citing works

Squamous cell carcinoma antigen suppresses radiation-induced cell death

Murakami, A., Suminami, Y., Hirakawa, H., Nawata, S., Numa, F., & Kato, H. (2001) · British Journal of Cancer · doi:10.1054/bjoc.2000.1683 · Cited by 95 · see citing works

An initial phase of JNK activation inhibits cell death early in the endoplasmic reticulum stress response

Brown, M., Strudwick, N., Suwara, M., Sutcliffe, L. K., Mihai, A. D., Ali, A. A., Watson, J. N., & Schröder, M. (2016) · Journal of Cell Science · doi:10.1242/jcs.179127 · Cited by 96 · see citing works

Activation of JNK, p38 and ERK mitogen-activated protein kinases by chromium(VI) is mediated through oxidative stress but does not affect cytotoxicity

Chuang, S., Liou, G., & Yang, J. (2000) · Carcinogenesis · doi:10.1093/carcin/21.5.491 · Cited by 93 · see citing works

JNK Activation Is Required for JB6 Cell Transformation Induced by Tumor Necrosis Factor-α but Not by 12-O-Tetradecanoylphorbol-13-Acetate

Huang, C., Li, J., Ma, W., & Dong, Z. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.42.29672 · Cited by 93 · see citing works

Hepatitis B Virus X Protein Differentially Activates RAS-RAF-MAPK and JNK Pathways in X-transforming Versus Non-transforming AML12 Hepatocytes

Tarn, C., Lee, S., Hu, Y., Ashendel, C. L., & ANDRISANI, O. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104105200 · Cited by 92 · see citing works

The Novel Triterpenoid 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) Potently Enhances Apoptosis Induced by Tumor Necrosis Factor in Human Leukemia Cells

Stadheim, T. A., Suh, N., Ganju, N., Sporn, M. B., & Eastman, A. R. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m108974200 · Cited by 91 · see citing works

COX-2 contributes to P-glycoprotein-mediated multidrug resistance via phosphorylation of c-Jun at Ser63/73 in colorectal cancer

Sui, H. X., Zhou, S., Wang, Y., Liu, X., Zhou, L., Yin, P., Fan, Z., & Li, Q. (2011) · Carcinogenesis · doi:10.1093/carcin/bgr016 · Cited by 90 · see citing works

Signal transduction pathways regulated by arsenate and arsenite

Porter, A. C., Fanger, G. R., & Vaillancourt, R. R. (1999) · Oncogene · doi:10.1038/sj.onc.1203214 · Cited by 89 · see citing works

Role of MAPK pathways in light chain-induced cytokine production in human proximal tubule cells

Şengül, Ş., Zwizinski, C. W., & Batuman, V. (2003) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00350.2002 · Cited by 88 · see citing works

Hyperosmolality activates Akt and regulates apoptosis in renal tubular cells

Terada, Y., Inoshita, S., Hanada, S., Shimamura, H., Kuwahara, M., Ogawa, W., Kasuga, M., Sasaki, S., & Marumo, F. (2001) · Kidney International · doi:10.1046/j.1523-1755.2001.060002553.x · Cited by 87 · see citing works

Increased cytochromeP-450 2E1 expression sensitizes hepatocytes to c-Jun-mediated cell death from TNF-α

Liu, H., Jones, B., Bradham, C. A., & Czaja, M. J. (2002) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00304.2001 · Cited by 87 · see citing works

Lipopolysaccharide Inhibits TNF-Induced Apoptosis: Role of Nuclear Factor-κB Activation and Reactive Oxygen Intermediates

Manna, S. K., & Aggarwal, B. B. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.3.1510 · Cited by 103 · see citing works

Microglia-derived IGF-2 prevents TNFα induced death of mature oligodendrocytes in vitro

Nicholas, R. S., Stevens, S. C. W., Wing, M. G., & Compston, D. A. S. (2002) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(02)00011-5 · Cited by 86 · see citing works

Lipopolysaccharide inhibits TNF-induced apoptosis: role of nuclear factor-kappaB activation and reactive oxygen intermediates.

Manna, S. K., & Aggarwal, B. B. (1999) · PubMed · Cited by 86 · see citing works

PP2C family members play key roles in regulation of cell survival and apoptosis

Tamura, S., Toriumi, S., Saito, J., Awano, K., Kudo, T., & Kobayashi, T. (2006) · Cancer Science · doi:10.1111/j.1349-7006.2006.00219.x · Cited by 85 · see citing works

Apoptotic regulatory proteins in renal injury

Ortíz, A. (2000) · Kidney International · doi:10.1046/j.1523-1755.2000.00188.x · Cited by 83 · see citing works

Inhibition of the Expression of Mitogen-activated Protein Phosphatase-1 Potentiates Apoptosis Induced by Tumor Necrosis Factor-α in Rat Mesangial Cells

Guo, Y., Kang, B., & WILLIAMSON, J. R. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.17.10362 · Cited by 83 · see citing works

Hyperosmolarity triggers CD95 membrane trafficking and sensitizes rat hepatocytes toward CD95L-induced apoptosis

Reinehr, R., Graf, D., Fischer, R., Schliess, F., & Häussinger, D. (2002) · Hepatology · doi:10.1053/jhep.2002.35447 · Cited by 80 · see citing works

Apoptosis and extracellular matrix–cell interactions in kidney disease

Makino, H., Sugiyama, H., & Kashihara, N. (2000) · Kidney International · doi:10.1046/j.1523-1755.2000.07711.x · Cited by 75 · see citing works

Differential MAP kinase activation and Na+/H+exchanger phosphorylation by H2O2 in rat cardiac myocytes

Wei, S., Rothstein, E. C., Fliegel, L., Dell’Italia, L. J., & Lucchesi, P. A. (2001) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2001.281.5.c1542 · Cited by 74 · see citing works

Signaling crosstalk between NF-κB and JNK

Nakano, H. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.05.007 · Cited by 73 · see citing works

Genipin Induced Apoptosis Associated with Activation of the c-Jun NH2-Terminal Kinase and p53 Protein in HeLa Cells

Cao, H., Feng, Q., Xu, W., Li, X., Kang, Z., Ren, Y., & Du, L. (2010) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.33.1343 · Cited by 73 · see citing works

Roles of p38 and JNK mitogen-activated protein kinase pathways during cantharidin-induced apoptosis in U937 cells

Huh, J., Kang, K., Chae, C., Kim, H., Ahn, K.-S., & Kim, S. (2004) · Biochemical Pharmacology · doi:10.1016/j.bcp.2003.12.025 · Cited by 72 · see citing works

TNF‐induced death of adult human oligodendrocytes is mediated by c‐jun NH2‐terminal kinase‐3

Jurewicz, A., Matysiak, M., Tybor, K., & Selmaj, K. (2003) · Brain · doi:10.1093/brain/awg146 · Cited by 70 · see citing works

TNF-α AND IL-1α INDUCE APOPTOSIS IN SUBCONFLUENT RAT MESANGIAL CELLS. EVIDENCE FOR THE INVOLVEMENT OF HYDROGEN PEROXIDE AND LIPID PEROXIDATION AS SECOND MESSENGERS

Böhler, T., Waiser, J., Hepburn, H., Gaedeke, J., Lehmann, C., Hambach, P., Budde, K., & Neumayer, H. (2000) · Cytokine · doi:10.1006/cyto.1999.0633 · Cited by 68 · see citing works

Sequential Activation of ERK and Repression of JNK by Scatter Factor/Hepatocyte Growth Factor in Madin-Darby Canine Kidney Epithelial Cells

Paumelle, R., Tulasne, D., Leroy, C., Coll, J., Vandenbunder, B., & Fafeur, V. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.11.3751 · Cited by 67 · see citing works

Biglycan, a Nitric Oxide-regulated Gene, Affects Adhesion, Growth, and Survival of Mesangial Cells

Schaefer, L., Beck, K., Raslik, I., Walpen, S., Mihálik, D., Micegova, M., Mačáková, K., Schönherr, E., Seidler, D. G., Varga, G., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210574200 · Cited by 66 · see citing works

Preparation andin vitrocharacterization of vascular endothelial growth factor (VEGF)-loaded poly( D,L -lactic-co-glycolic acid) microspheres using a double emulsion/solvent evaporation technique

Karal‐Yılmaz, O., Serhatlı, M., Baysal, K., & Baysal, B. M. (2010) · Journal of Microencapsulation · doi:10.3109/02652048.2010.523795 · Cited by 65 · see citing works

Bcl-w is expressed in a majority of infiltrative gastric adenocarcinomas and suppresses the cancer cell death by blocking stress-activated protein kinase/c-Jun NH2-terminal kinase activation.

Lee, H. W., Lee, S., Lee, S. J., & Um, H. (2003) · PubMed · Cited by 65 · see citing works

Cellular N-Ras Promotes Cell Survival by Downregulation of Jun N-Terminal Protein Kinase and p38

Wolfman, J. C., Palmby, T. R., Der, C. J., & Wolfman, A. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.5.1589-1606.2002 · Cited by 64 · see citing works

Antioxidants Differentially Regulate Activation of Nuclear Factor- κ B, Activator Protein-1, c-Jun Amino-Terminal Kinases, and Apoptosis Induced by Tumor Necrosis Factor: Evidence that JNK and NF- κ B Activation Are Not Linked to Apoptosis

Shrivastava, A., & Aggarwal, B. B. (1999) · Antioxidants and Redox Signaling · doi:10.1089/ars.1999.1.2-181 · Cited by 65 · see citing works

Coordination of MAPK and p53 dynamics in the cellular responses to DNA damage and oxidative stress

Hanson, R. L., & Batchelor, E. (2022) · Molecular Systems Biology · doi:10.15252/msb.202211401 · Cited by 60 · see citing works

Apoptosis-inducing Agents Cause Rapid Shedding of Tumor Necrosis Factor Receptor 1 (TNFR1)

Madge, L. A., Sierra-Honigmann, M. R., & Pober, J. S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.19.13643 · Cited by 64 · see citing works

p38 Mitogen-Activated Protein Kinase Mediates Tumor Necrosis Factor-α-Induced Apoptosis in Rat Fetal Brown Adipocytes*

Valladares, A., Alvarez, A. M., Ventura, J., Roncero, C., Benito, M., & Porrás, A. (2000) · Endocrinology · doi:10.1210/endo.141.12.7843 · Cited by 64 · see citing works

Regulation of glomerular cell number by apoptosis

Savill, J. (1999) · Kidney International · doi:10.1046/j.1523-1755.1999.00707.x · Cited by 64 · see citing works

Tumor necrosis factor–induced signal transduction and left ventricular remodeling

Mann, D. L. (2002) · Journal of Cardiac Failure · doi:10.1054/jcaf.2002.129253 · Cited by 62 · see citing works

Increased Expression and Activation of c-Jun Contributes to Human Amylin-induced Apoptosis in Pancreatic Islet β-Cells

Zhang, S., Liu, J., MacGibbon, G. A., Dragunow, M., & Cooper, G. J. S. (2002) · Journal of Molecular Biology · doi:10.1016/s0022-2836(02)01044-6 · Cited by 62 · see citing works

Lead exposure activates nuclear factor kappa B, activator protein-1, c-Jun N-terminal kinase and caspases in the rat brain

Ramesh, G. T., Manna, S. K., Aggarwal, B. B., & Jadhav, A. L. (2001) · Toxicology Letters · doi:10.1016/s0378-4274(01)00395-2 · Cited by 57 · see citing works

Kininostatin, an Angiogenic Inhibitor, Inhibits Proliferation and Induces Apoptosis of Human Endothelial Cells

Guo, Y., Wang, S., & Colman, R. W. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq0901.095277 · Cited by 55 · see citing works

Inhibition of the Expression of Mitogen-activated Protein Phosphatase-1 Potentiates Apoptosis Induced by Tumor Necrosis Factor-α in Rat Mesangial Cells

Guo, Y., Kang, B., & WILLIAMSON, J. R. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.17.10362 · Cited by 83 · see citing works

Resistance to TNF-α cytotoxicity can be achieved through different signaling pathways in rat mesangial cells

Guo, Y., Kang, B., & WILLIAMSON, J. R. (1999) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1999.276.2.c435 · Cited by 47 · see citing works

Early Activation of c-Jun N-terminal Kinase and p38 Kinase Regulate Cell Survival in Response to Tumor Necrosis Factor α

Roulston, A., Reinhard, C., Amiri, P., & Williams, L. T. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.17.10232 · Cited by 371 · see citing works

Prologation of c-Jun N-Terminal Kinase is Associated with Cell Death Induced by Tumor Necrosis Factor Alpha in Human Chondrocytes

Yoon, H. S., & Kim, H. A. (2004) · Journal of Korean Medical Science · doi:10.3346/jkms.2004.19.4.567 · Cited by 21 · see citing works

The Absence of NF-κB-Mediated Inhibition of c-Jun N-Terminal Kinase Activation Contributes to Tumor Necrosis Factor Alpha-Induced Apoptosis

Tang, F., Tang, G., Xiang, J., Dai, Q., Rosner, M. R., & Lin, A. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.24.8571-8579.2002 · Cited by 145 · see citing works