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Characterization of Rac and Cdc42 Activation in Chemoattractant-stimulated Human Neutrophils Using a Novel Assay for Active GTPases
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“deficiency of Rac2 function results in decreased migration and F-actin generation in multiple differentiated blood cell types (10–13, 18).”
From Rac and Cdc42 GTPases control hematopoietic stem cell shape, adhesion, migration, and mobilization (2001) · cites this paper as [18]
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“As shown in Fig. 4 (lower panel, lane 5), Rac1 activity as measured using the PBD GST pull-down assay (38) in cultured Rac2Ϫ/Ϫ cells increased more than 5-fold compared with in vitro cultured WT cells (lane 1).”
From Biochemical and Biological Characterization of a Human Rac2 GTPase Mutant Associated with Phagocytic Immunodeficiency (2001) · cites this paper as [38]
In the citing paper
“activated (GTP-bound) Cdc42 measured by GST-PAK1 p21-binding domain pull-down (18) was increased by 3- to 20-fold in Rac2−/− cells after exposure to SDF-1, compared with WT cells (Fig. 4A).”
From Rac and Cdc42 GTPases control hematopoietic stem cell shape, adhesion, migration, and mobilization (2001) · cites this paper as [18]
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Cited by
Habas, R., Kato, Y., & He, X. (2001) · Cell · doi:10.1016/s0092-8674(01)00614-6 · Cited by 842
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Martyn, K. D., Frederick, L. M., von Loehneysen, K., Dinauer, M. C., & Knaus, U. G. (2006) · Cellular Signalling · doi:10.1016/j.cellsig.2005.03.023 · Cited by 783
Krendel, M., Zenke, F. T., & Bokoch, G. M. (2002) · Nature Cell Biology · doi:10.1038/ncb773 · Cited by 669
Self-citationCoactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation
Habas, R., Dawid, I. B., & He, X. (2003) · Genes & Development · doi:10.1101/gad.1022203 · Cited by 603
Syk is required for integrin signaling in neutrophils
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Metadata
- Authors
- Benard, V., Bohl, B. P., & Bokoch, G. M.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1999-05
- Volume
- 274
- Issue
- 19
- Pages
- 13198-13204
- ISSN
- 0021-9258
- Cited by
- 645
- References
- 0
- Language
- en
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- CoChat. (2026). Citation check: Characterization of Rac and Cdc42 Activation in Chemoattractant-stimulated Human Neutrophils Using a Novel Assay for Active GTPases. https://app.cochat.ai/papers/10.1074/jbc.274.19.13198
- The paper
- Benard, V., Bohl, B. P., & Bokoch, G. M. (1999). Characterization of Rac and Cdc42 Activation in Chemoattractant-stimulated Human Neutrophils Using a Novel Assay for Active GTPases. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.274.19.13198