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A Direct Role for the Macrophage Low Density Lipoprotein Receptor in Atherosclerotic Lesion Formation

Linton, MacRae F., Babaev, Vladimir R., Gleaves, Linda A., Fazio, Sergio·1999·Journal of Biological Chemistry
DOI 10.1074/jbc.274.27.19204
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  • LDLR has a major role in cholesterol and ApoE homeostasis in the periphery.

    “Although the LDLR has been shown to have a major role in cholesterol and ApoE homeostasis in the periphery [15], [16] its role in the CNS remains unclear [17].”

    From Lack of LDL receptor enhances amyloid deposition and decreases glial response in an Alzheimer's disease mouse model (2011) · cites this paper as [15]

    The Results and Discussion report that macrophage LDLR expression can influence serum cholesterol levels in diet-challenged mice, supporting a role in peripheral cholesterol regulation under those conditions. The paper does not establish a major role in ApoE homeostasis; its mention of apoE-deficient mice concerns atherosclerotic lesion area, not ApoE regulation. Page numbers are unavailable in our copy. (LLM, conf=0.86)

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Research works printed but not linked: 34

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Metadata

Authors
Linton, M. F., Babaev, V. R., Gleaves, L. A., & Fazio, S.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1999-07
Volume
274
Issue
27
Pages
19204-19210
ISSN
0021-9258
DOI
10.1074/jbc.274.27.19204
Cited by
77
References
0
Language
en
Licence

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