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Priming of Human Neutrophil Respiratory Burst by Granulocyte/Macrophage Colony-stimulating Factor (GM-CSF) Involves Partial Phosphorylation of p47

Dang, Pham My-Chan, Dewas, Cedric, Gaudry, Murielle, Fay, Michèle, Pedruzzi, Eric, Gougerot-Pocidalo, Marie-Anne, El Benna, Jamel·1999·Journal of Biological Chemistry
DOI 10.1074/jbc.274.29.20704
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Abstract

Neutrophil superoxide production can be potentiated by prior exposure to "priming" agents such as granulocyte/macrophage colony stimulating factor (GM-CSF). Because the mechanism underlying GM-CSF-dependent priming is not understood, we investigated the effects of GM-CSF on the phosphorylation of the cytosolic NADPH oxidase components p47(phox) and p67(phox). Preincubation of neutrophils with GM-CSF alone increased the phosphorylation of p47(phox) but not that of p67(phox). Addition of formyl-methionyl-leucyl-phenylalanine (fMLP) to GM-CSF-pretreated neutrophils resulted in more intense phosphorylation of p47(phox) than with GM-CSF alone and fMLP alone. GM-CSF-induced p47(phox) phosphorylation was time- and concentration-dependent and ran parallel to the priming effect of GM-CSF on superoxide production. Two-dimensional tryptic peptide mapping of p47(phox) showed that GM-CSF induced phosphorylation of one major peptide. fMLP alone induced phosphorylation of several peptides, an effect enhanced by GM-CSF pretreatment. In contrast to fMLP and phorbol 12-myristate 13-acetate, GM-CSF-induced phosphorylation of p47(phox) was not inhibited by the protein kinase C inhibitor GF109203X. The protein-tyrosine kinase inhibitor genistein and the phosphatidylinositol 3-kinase inhibitor wortmannin inhibited the phosphorylation of p47(phox) induced by GM-CSF and by fMLP but not that induced by phorbol 12-myristate 13-acetate. GM-CSF alone did not induce p47(phox) or p67(phox) translocation t…

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Metadata

Authors
Dang, P. M.-C., Dewas, C., Gaudry, M., Fay, M., Pedruzzi, E., Gougerot-Pocidalo, M.-A., & El Benna, J.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1999-07
Volume
274
Issue
29
Pages
20704-20708
ISSN
0021-9258
DOI
10.1074/jbc.274.29.20704
Cited by
104
References
1
Language
en
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CoChat. (2026). Citation check: Priming of Human Neutrophil Respiratory Burst by Granulocyte/Macrophage Colony-stimulating Factor (GM-CSF) Involves Partial Phosphorylation of p47. https://app.cochat.ai/papers/10.1074/jbc.274.29.20704
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Dang, P. M.-C., Dewas, C., Gaudry, M., Fay, M., Pedruzzi, E., Gougerot-Pocidalo, M.-A., & El Benna, J. (1999). Priming of Human Neutrophil Respiratory Burst by Granulocyte/Macrophage Colony-stimulating Factor (GM-CSF) Involves Partial Phosphorylation of p47. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.274.29.20704