Cited by 73Neutrophil, Myeloperoxidase and Oxidative MechanismsInflammation biomarkers and pathwaysImmune Response and Inflammation

Neutrophils in innate immunity and systems biology‐level approaches

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Rungelrath, Viktoria, Kobayashi, Scott D., DeLeo, Frank R.·2020·WIREs Systems Biology and Medicine

Abstract

The innate immune system is the first line of host defense against invading microorganisms. Polymorphonuclear leukocytes (PMNs or neutrophils) are the most abundant leukocyte in humans and essential to the innate immune response against invading pathogens. Compared to the acquired immune response, which requires time to develop and is dependent on previous interaction with specific microbes, the ability of neutrophils to kill microorganisms is immediate, nonspecific, and not dependent on previous exposure to microorganisms. Historically, studies of PMN‐pathogen interaction focused on the events leading to killing of microorganisms, such as recruitment/chemotaxis, transmigration, phagocytosis, and activation, whereas postphagocytosis sequelae were infrequently considered. In addition, it was widely accepted that human neutrophils possessed limited capacity for new gene transcription and thus, relatively little biosynthetic capacity. This notion has changed dramatically within the past 20 years. Further, there is now more effort directed to understand the events occurring in PMNs after killing of microbes. Herein, we give an updated review of the systems biology‐level approaches that have been used to gain an enhanced view of the role of neutrophils during host‐pathogen interaction and neutrophil‐mediated diseases. We anticipate that these and future systems‐level studies will continue to provide information important for understanding, treatment, and control of diseases caused by pathogenic microorganisms. This article is categorized under: Physiology > Organismal Responses to Environment Physiology > Mammalian Physiology in Health and Disease Biological Mechanisms > Cell Fates

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Authors
Rungelrath, V., Kobayashi, S. D., & DeLeo, F. R.
Affiliations
National Institutes of Health (US)
Corresponding author
DeLeo, Frank R.
Venue
WIREs Systems Biology and Medicine
Publisher
Wiley
Published
2019-06-20
Volume
12
Issue
1
Pages
e1458-e1458
ISSN
  • 1939-005X (ISSN-L)
  • 1939-5094
OpenAlex
W2952808618
Cited by
72
References
246
Citations by year
2026: 9 · 2025: 16 · 2024: 14 · 2023: 7 · 2022: 6 · 2021: 8 · 2020: 11 · 2019: 1
FWCI
2.60
Type
journal article
Language
en
Open access
Locations
  • WIREs Systems Biology and Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
Division of Intramural Research, National Institute of Allergy and Infectious Diseases
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords
neutrophils, innate immunity, host-pathogen interaction, neutrophil activation, phagocytosis, chemotaxis, transmigration
MeSH terms
Humans, Immunity, Innate, Inflammation, Neutrophils, Phagocytosis, Apoptosis, Models, Immunological, Systems Biology, Host-Pathogen Interactions, Transcriptome

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