Cited by 259Neutrophil, Myeloperoxidase and Oxidative MechanismsInflammation biomarkers and pathwaysImmune Response and Inflammation

Role of neutrophils in innate immunity: A systems biology-level approach

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Kobayashi, Scott D., DeLeo, Frank R.·2009·WIREs Systems Biology and Medicine

Abstract

The innate immune system is the first line of host defense against invading microorganisms. Polymorphonuclear leukocytes (PMNs or neutrophils) are the most abundant leukocyte in humans and essential to the innate immune response against invading pathogens. Compared with the acquired immune response, which requires time to develop and is dependent on previous interaction with specific microbes, the ability of neutrophils to kill microorganisms is immediate, non‐specific, and not dependent on previous exposure to microorganisms. Historically, studies on PMN‐pathogen interaction focused on the events leading to killing of microorganisms, such as recruitment/chemotaxis, transmigration, phagocytosis, and activation, whereas post‐phagocytosis sequelae were infrequently considered. In addition, it was widely accepted that human neutrophils possessed limited capacity for new gene transcription and thus, relatively little biosynthetic capacity. This notion has changed dramatically within the past decade. Further, there is now more effort directed to understand the events occurring in PMNs after killing of microbes. Herein we review the systems biology‐level approaches that have been used to gain an enhanced view of the role of neutrophils during host‐pathogen interaction. We anticipate that these and future systems‐level studies will ultimately provide information critical to our understanding, treatment, and control of diseases caused by pathogenic microorganisms. Copyright © 2009 John Wiley & Sons, Inc. This article is categorized under: Physiology > Organismal Responses to Environment

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  • Neutrophil priming is the ability to increase superoxide anion and also improves adhesion, phagocytosis, cytokine secretion, leukotriene synthesis, degranulation, and bactericidal activity.

    “Neutrophil “priming” is the ability to increase superoxide anion. In fact, this capacity is not limited to •O2− production, but also to improved adhesion, phagocytosis, cytokine secretion, leukotriene synthesis, degranulation, and, ultimately, bactericidal activity.”

    From The Role of Reactive Species on Innate Immunity (2022) · cites this paper as [83]

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Research works printed but not linked: 3

  1. [16]Cline MJ Cline Martin J. Production and distribution of neutrophils The White Cell 1975 22 38 Harvard University Press Cambridge, Massachusetts
  2. [56]Theilgaard-Monch K Knudsen S Follin P Borregaard N The transcriptional activation program of human neutrophils in skin lesions supports their important role in wound healing J. Immunol 6 2004 172 12 7684 7693 15187151
  3. [87]DeLeo FR Renee J Mccormick S Nakamura M Apicella M Weiss JP Nauseef WM Neutrophils exposed to bacterial lipopolysaccharide upregulate NADPH oxidase assembly J. Clin. Invest 1 1998 101 2 455 463 9435318 PMC508585

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Authors
Kobayashi, S. D., & DeLeo, F. R.
Affiliations
National Institutes of Health (US)
Corresponding author
DeLeo, Frank R.
Venue
WIREs Systems Biology and Medicine
Publisher
Wiley
Published
2009-11
Volume
1
Issue
3
Pages
309-333
ISSN
  • 1939-005X (ISSN-L)
  • 1939-5094
OpenAlex
W1979858376
Cited by
259
References
206
Citations by year
2026: 7 · 2025: 11 · 2024: 18 · 2023: 24 · 2022: 24 · 2021: 14 · 2020: 12 · 2019: 13 · 2018: 22 · 2017: 17 · 2016: 18 · 2015: 18 · 2014: 12 · 2013: 18 · 2012: 16
FWCI
0.78
Type
journal article
Language
en
Open access
Locations
  • WIREs Systems Biology and Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute of Allergy and Infectious Diseases (ZIAAI000900)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords
neutrophils, innate immunity, host-pathogen interaction, polymorphonuclear leukocytes, phagocytosis, neutrophil activation, chemotaxis, transmigration, systems biology
MeSH terms
Animals, Humans, Immunity, Innate, Neutrophils, Models, Immunological, Systems Biology, Host-Pathogen Interactions

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