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Cloning of AIP1, a Novel Protein That Associates with the Apoptosis-linked Gene ALG-2 in a Ca2+-dependent Reaction
Open accessAbstract
ALG-2 is a 22-kDa calcium-binding protein necessary for cell death induced by different stimuli in 3DO T-cell hybridoma. 3DO cell clones depleted of ALG-2 protein exhibit normal caspases activation, suggesting that ALG-2 function is required downstream or is independent of caspase proteases activity for apoptosis to occur. Using the yeast two-hybrid screening system, we have isolated and characterized the mouse cDNA encoding for ALG-2 interacting protein 1 (AIP1), a novel protein that interacts with ALG-2. ALG-2 and AIP1 colocalize in the cytosol and the presence of calcium is an indispensable requisite for their association. Sequence alignment shows that AIP1 is highly similar to BRO1, a yeast protein related to components of the Pkc1p-MAP kinase cascade. Overexpression of a truncated form of AIP1 protects two different cell types from death induced by trophic factors withdrawal; thus, our data indicate that AIP1 cooperates with ALG-2 in executing the calcium-dependent requirements along the cell death pathway.
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Cited by
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Nixon, R. A. (2017) · The FASEB Journal · doi:10.1096/fj.201700359 · Cited by 400
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Calpains — An elaborate proteolytic system
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Metadata
- Authors
- Vito, P., Pellegrini, L., Guiet, C., & D'Adamio, L.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1999-01
- Volume
- 274
- Issue
- 3
- Pages
- 1533-1540
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1986394736
- Cited by
- 234
- References
- 0
- FWCI
- 4.35
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Vito, P., Pellegrini, L., Guiet, C., & D'Adamio, L. (1999). Cloning of AIP1, a Novel Protein That Associates with the Apoptosis-linked Gene ALG-2 in a Ca2+-dependent Reaction. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.274.3.1533
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