The DOI matches its Crossref record; 101 of the 101 references it cites were found in a registry or an index.
Regulation of Gene Expression by Ambient pH in Filamentous Fungi and Yeasts
Open accessAbstract
SUMMARY: Life, as we know it, is water based. Exposure to hydroxonium and hydroxide ions is constant and ubiquitous, and the evolutionary pressure to respond appropriately to these ions is likely to be intense. Fungi respond to their environments by tailoring their output of activities destined for the cell surface or beyond to the ambient pH. We are beginning to glimpse how they sense ambient pH and transmit this information to the transcription factor, whose roles ensure that a suitable collection of gene products will be made. Although relatively little is known about pH signal transduction itself, its consequences for the cognate transcription factor are much clearer. Intriguingly, homologues of components of this system mediating the regulation of fungal gene expression by ambient pH are to be found in the animal kingdom. The potential applied importance of this regulatory system lies in its key role in fungal pathogenicity of animals and plants and in its control of fungal production of toxins, antibiotics, and secreted enzymes.
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Cites
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Cited by
O'Connell, R. J., Thon, M. R., Hacquard, S., Amyotte, S. G., Kleemann, J., Torres, M. F., Damm, U., Buiate, E. A., Epstein, L., Alkan, N., et al. (2012) · Nature Genetics · doi:10.1038/ng.2372 · Cited by 1,047
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Fusarium oxysporum : exploring the molecular arsenal of a vascular wilt fungus
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Proton transport and pH control in fungi
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Metadata
- Authors
- Peñalva, M. A., & Arst, H. N.
- Venue
- Microbiology and Molecular Biology Reviews
- Publisher
- American Society for Microbiology
- Published
- 2002-09
- Volume
- 66
- Issue
- 3
- Pages
- 426-446
- ISSN
- 1092-2172 (ISSN-L)
- 1098-5557
- OpenAlex
- W2106001253
- Cited by
- 320
- References
- 101
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- green
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- Peñalva, M. A., & Arst, H. N. (2002). Regulation of Gene Expression by Ambient pH in Filamentous Fungi and Yeasts. Microbiology and Molecular Biology Reviews. https://doi.org/10.1128/mmbr.66.3.426-446.2002
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