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CDC55, a Saccharomyces cerevisiae Gene Involved in Cellular Morphogenesis: Identification, Characterization, and Homology to the B Subunit of Mammalian Type 2A Protein Phosphatase

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Structure of the 55-kDa regulatory subunit of protein phosphatase 2A: evidence for a neuronal-specific isoform

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Conservation analysis and structure prediction of the protein serine/threonine phosphatases

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Inactivation of the protein phosphatase 2A regulatory subunit A results in morphological and transcriptional defects in Saccharomyces cerevisiae.

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The catalytic subunit of protein phosphatase 2A is carboxyl-methylated in vivo.

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High Complexity in the Expression of the B′ Subunit of Protein Phosphatase 2A0

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Structure and expression of a 72-kDa regulatory subunit of protein phosphatase 2A. Evidence for different size forms produced by alternative splicing

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Differential methylation and altered conformation of cytoplasmic and nuclear forms of protein phosphatase 2A during cell cycle progression.

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Remarkable similarities between yeast and mammalian protein phosphatases

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Protein phosphatase 2A is reversibly modified by methyl esterification at its C-terminal leucine residue in bovine brain.

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Protein phosphatase 2A positively and negatively regulates Ras1-mediated photoreceptor development in Drosophila.Preprint

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Drosophila mutants in the 55 kDa regulatory subunit of protein phosphatase 2A show strongly reduced ability to dephosphorylate substrates of p34cdc2

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Structure and transcriptional regulation of protein phosphatase 2A catalytic subunit genes

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Functional interaction between a novel protein phosphatase 2A regulatory subunit, PR59, and the retinoblastoma-related p107 protein

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Saccharomyces cerevisiae Homologs of Mammalian B and B′ Subunits of Protein Phosphatase 2A Direct the Enzyme to Distinct Cellular Functions

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Mutations in the Saccharomyces cerevisiae Type 2A Protein Phosphatase Catalytic Subunit Reveal Roles in Cell Wall Integrity, Actin Cytoskeleton Organization and Mitosis

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Analysis of subunit isoforms in protein phosphatase 2A holoenzymes from rabbit and Xenopus.

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A series of yeast shuttle vectors for expression of cDNAs and other DNA sequences

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Rox3 and Rts1 Function in the Global Stress Response Pathway in Baker's Yeast

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An Enzymatic Activity in Bovine Brain That Catalyzes the Reversal of the C-Terminal Methyl Esterification of Protein Phosphatase 2A

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What goes up must come down

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Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling

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Enumeration of the Simian Virus 40 Early Region Elements Necessary for Human Cell Transformation

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Autophosphorylation of ataxia‐telangiectasia mutated is regulated by protein phosphatase 2A

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Carboxyl methylation regulates phosphoprotein phosphatase 2A by controlling the association of regulatory B subunits

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FMRP Phosphorylation Reveals an Immediate-Early Signaling Pathway Triggered by Group I mGluR and Mediated by PP2A

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Raf-1-associated Protein Phosphatase 2A as a Positive Regulator of Kinase Activation

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Reduced protein phosphatase 2A activity induces hyperphosphorylation and altered compartmentalization of tau in transgenic mice

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Curcumin Disrupts the Mammalian Target of Rapamycin-Raptor Complex

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Identification of PP2A Complexes and Pathways Involved in Cell Transformation

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Therapeutic targeting of PP2A

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Carboxyl methylation of the phosphoprotein phosphatase 2A catalytic subunit promotes its functional association with regulatory subunits in vivo

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Activation of the ERK and JNK signaling pathways caused by neuron-specific inhibition of PP2A in transgenic mice

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Protein phosphatase 2A is a negative regulator of IL-2 production in patients with systemic lupus erythematosus

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Regulation of telomerase activity and anti‐apoptotic function by protein–protein interaction and phosphorylation

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Protein phosphatase 1 positively regulates stomatal opening in response to blue light in Vicia faba

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Dephosphorylation of endothelial nitric oxide synthase contributes to the anti‐angiogenic effects of endostatin

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Planar cell polarization requires Widerborst, a B′ regulatory subunit of protein phosphatase 2A

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Toll-like receptor activation suppresses ER stress factor CHOP and translation inhibition through activation of eIF2B

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Loss of PPP2R2A Inhibits Homologous Recombination DNA Repair and Predicts Tumor Sensitivity to PARP Inhibition

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Physiologic functions of PP2A: Lessons from genetically modified mice

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The Protein Phosphatase 2A Phosphatase Activator Is a Novel Peptidyl-Prolyl cis/trans-Isomerase

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A STRIPAK complex mediates axonal transport of autophagosomes and dense core vesicles through PP2A regulation

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An inactive protein phosphatase 2A population is associated with methylesterase and can be re-activated by the phosphotyrosyl phosphatase activator

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SIK1 is part of a cell sodium-sensing network that regulates active sodium transport through a calcium-dependent process

Sjöström, M., Stenström, K., Eneling, K., Zwiller, J., Katz, A. I., Takemori, H., & Bertorello, A. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706838104 · Cited by 94 · see citing works

Distinct role of protein phosphatase 2A subunit Cα in the regulation of E-cadherin and β-catenin during development

Götz, J., Probst, A., Mistl, C., Nitsch, R. M., & Ehler, E. (2000) · Mechanisms of Development · doi:10.1016/s0925-4773(00)00267-7 · Cited by 88 · see citing works

Dephosphorylation of Carma1 by PP2A negatively regulates T‐cell activation

Eitelhuber, A. C., Warth, S. C., Schimmack, G., Düwel, M., Hadian, K., Demski, K., Beisker, W., Shinohara, H., Kurosaki, T., Heissmeyer, V., et al. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.331 · Cited by 80 · see citing works

Protein Phosphatase 2A Facilitates Axonogenesis by Dephosphorylating CRMP2

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A Wheat ( Triticum aestivum ) Protein Phosphatase 2A Catalytic Subunit Gene Provides Enhanced Drought Tolerance in Tobacco

Xu, C., Jing, R., Mao, X., Jia, X., & Chang, X. (2007) · Annals of Botany · doi:10.1093/aob/mcl285 · Cited by 75 · see citing works

Abolition of Cyclin-Dependent Kinase Inhibitor p16 ^<i>Ink4a</i> and p21 ^{<i>Cip1/Waf1</i>} Functions Permits Ras-Induced Anchorage-Independent Growth in Telomerase-Immortalized Human Fibroblasts

Wei, W., Jobling, W. A., Chen, W., Hahn, W. C., & Sedivy, J. M. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.8.2859-2870.2003 · Cited by 68 · see citing works

The Protein Phosphatases ATUNIS1 and ATUNIS2 Regulate Cell Wall Integrity in Tip-Growing Cells

Franck, C. M., Westermann, J., Bürssner, S., Lentz, R., Lituiev, D., & Boisson‐Dernier, A. (2018) · The Plant Cell · doi:10.1105/tpc.18.00284 · Cited by 63 · see citing works

De Novo Mutations Affecting the Catalytic Cα Subunit of PP2A, PPP2CA, Cause Syndromic Intellectual Disability Resembling Other PP2A-Related Neurodevelopmental Disorders

Reynhout, S., Jansen, S., Haesen, D., Belle, S. V., de Munnik, S. A., Bongers, E. M. H. F., Schieving, J., Marcelis, C., Amiel, J., Rio, M., et al. (2018) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2018.12.002 · Cited by 60 · see citing works

Transcriptional Activation of the cAMP-responsive Modulator Promoter in Human T Cells Is Regulated by Protein Phosphatase 2A-mediated Dephosphorylation of SP-1 and Reflects Disease Activity in Patients with Systemic Lupus Erythematosus

Juang, Y., Rauen, T., Wang, Y., Ichinose, K., Benedyk, K., Tenbrock, K., & Tsokos, G. C. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.166785 · Cited by 59 · see citing works

Inactivation of Mammalian Target of Rapamycin Increases STAT1 Nuclear Content and Transcriptional Activity in α4- and Protein Phosphatase 2A-dependent Fashion

Fielhaber, J. A., Han, Y.-S., Tan, J. J.-S., Xing, S., Biggs, C. M., Joung, K.-B., & Kristof, A. S. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.033530 · Cited by 48 · see citing works

Relevance of Dopamine Signals Anchoring Dynamin-2 to the Plasma Membrane during Na+,K+-ATPase Endocytosis

Efendiev, R., Yudowski, G. A., Zwiller, J., Leibiger, B., Katz, A. I., Berggren, P., Pedemonte, C. H., Leibiger, I. B., & Bertorello, A. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205173200 · Cited by 42 · see citing works

Protein Phosphatase 2A Mediates YAP Activation in Endothelial Cells Upon VEGF Stimulation and Matrix Stiffness

Jiang, X. M., Hu, J., Wu, Z., Cafarello, S. T., Matteo, M. D., Shen, Y. H., Dong, X., Adler, H., Mazzone, M., de Almodóvar, C. R., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.675562 · Cited by 41 · see citing works

Rapamycin Inhibits IGF-1 Stimulated Cell Motility through PP2A Pathway

Liu, L., Chen, L., Luo, Y., Chen, W., Zhou, H., Xu, B., Han, X., Shen, T., & Huang, S. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010578 · Cited by 40 · see citing works

Active-site mutations impairing the catalytic function of the catalytic subunit of human protein phosphatase 2A permit baculovirus-mediated overexpression in insect cells

Myles, T., SCHMIDT, K., Evans, D. R., Cron, P. D., & Hemmings, B. A. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3570225 · Cited by 40 · see citing works

Essential Role of Protein Phosphatase 2A in Metaphase II Arrest and Activation of Mouse Eggs Shown by Okadaic Acid, Dominant Negative Protein Phosphatase 2A, and FTY720

Chang, H.-Y., Jennings, P. C., Stewart, J., Verrills, N. M., & Jones, K. T. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.193227 · Cited by 39 · see citing works

Altered phosphorylation of cytoskeletal proteins in mutant protein phosphatase 2A transgenic mice

Schild, A., Ittner, L. M., & Götz, J. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.03.066 · Cited by 38 · see citing works

Baculovirus expression, purification, and characterization of human protein phosphatase 2A catalytic subunits α and β

Ikehara, T., Shinjo, F., Ikehara, S., Imamura, S., & Yasumoto, T. (2005) · Protein Expression and Purification · doi:10.1016/j.pep.2005.06.002 · Cited by 37 · see citing works

A protein phosphatase feedback mechanism regulates the basal phosphorylation of Chk2 kinase in the absence of DNA damage

Carlessi, L., Buscemi, G., Fontanella, E., & Delia, D. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2010.06.002 · Cited by 36 · see citing works

How it all Started: Tau and Protein Phosphatase 2A

Liu, C., & Götz, J. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130503 · Cited by 35 · see citing works

Transgenic and Knockout Models of PP2A

Götz, J., & Schild, A. (2003) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(03)66029-5 · Cited by 29 · see citing works

Protein Phosphatase Methyltransferase 1 (Ppm1p) Is the Sole Activity Responsible for Modification of the Major Forms of Protein Phosphatase 2A in Yeast

Kalhor, H. R., Luk, K., Ramos, A., Zobel-Thropp, P. A., & Clarke, S. G. (2001) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2001.2558 · Cited by 29 · see citing works

The Scaffolding A/Tpd3 Subunit and High Phosphatase Activity Are Dispensable for Cdc55 Function in the Saccharomyces cerevisiae Spindle Checkpoint and in Cytokinesis

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In Vivo Analysis of Wild‐type and FTDP‐17 Tau Transgenic Mice

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The predicted β12–β13 loop is important for inhibition of PP2Acα by the antitumor drug fostriecin

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Important Role for Phylogenetically Invariant PP2Acα Active Site and C-Terminal Residues Revealed by Mutational Analysis in Saccharomyces cerevisiae

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Development of a gene therapy strategy to target hepatocellular carcinoma based inhibition of protein phosphatase 2A using the α-fetoprotein promoter enhancer and pgk promoter: an in vitro and in vivo study

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Protein phosphatase 2A promotes the transition to G0 during terminal differentiation in Drosophila

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CaMKII phosphorylates serine 10 of p27 and confers apoptosis resistance to HeLa cells

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Impaired development of the Harderian gland in mutant protein phosphatase 2A transgenic mice

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Biochemical characterization of recombinant subunits of type 2A protein phosphatase overexpressed in Pichia pastoris

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Protein phosphatase 2A regulation of GABAB receptors normalizes ischemia-induced aberrant receptor trafficking and provides neuroprotection

Hleihil, M., Balakrishnan, K. R., & Benke, D. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.1015906 · Cited by 12 · see citing works

11 Reversible methylation of protein phosphatase 2A

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Reduction of protein phosphatase 2A Cα promotes in vivo bone formation and adipocyte differentiation

Yoshida, K., Teramachi, J., Uchibe, K., Ikegame, M., Qiu, L., Yang, D., & Okamura, H. (2018) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.11.005 · Cited by 7 · see citing works

A Protein Phosphatase 2A-Based Assay to Detect Okadaic Acids and Microcystins

Ikehara, T., & Oshiro, N. (2024) · Journal of Marine Science and Engineering · doi:10.3390/jmse12020244 · Cited by 6 · see citing works

Characterization and Activity Determination of the Human Protein Phosphatase 2A Catalytic Subunit α Expressed in Insect Larvae

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A PP2A active site mutant impedes growth and causes misregulation of native catalytic subunit expression

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Instrumental Methods for Detection of Lipophilic Marine Toxins in Endemic Species from Pacific Austral Fjords

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Bioengineered protein phosphatase 2A

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Analysis of the structure and function of protein phosphatase 2A

Schmidt, K. (2004) · edoc (University of Basel) · doi:10.5451/unibas-003209151 · Cited by 2 · see citing works

Protein phosphatase 2A: A multifunctional regulator of cell signaling

Mumby, M. C. (2003) · Topics in current genetics · doi:10.1007/978-3-540-40035-6_3 · Cited by 1 · see citing works

A Dual Role for the PP2A Phosphatase in Hippo Signalling RegulationPreprint

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PP2A phosphatase regulates Hippo signalling in dual manner

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Important Role for Phylogenetically Invariant PP2Acα Active Site and C-Terminal Residues Revealed by Mutational Analysis in Saccharomyces cerevisiae

Evans, D. R., & Hemmings, B. A. (2000) · Genetics · doi:10.1093/genetics/156.1.21 · Cited by 20 · see citing works

Functional expression of human and Arabidopsis protein phosphatase 2A in Saccharomyces cerevisiae and isolation of dominant-defective mutants

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Analysis of the structure and function of protein phosphatase 2A

Schmidt, K. (2004) · edoc (University of Basel) · doi:10.5451/unibas-003209151 · Cited by 2 · see citing works

Protein Phosphatase Methyltransferase 1 (Ppm1p) Is the Sole Activity Responsible for Modification of the Major Forms of Protein Phosphatase 2A in Yeast

Kalhor, H. R., Luk, K., Ramos, A., Zobel-Thropp, P. A., & Clarke, S. G. (2001) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2001.2558 · Cited by 29 · see citing works

Function of Protein Phosphatase 2A in Control of Proliferation: Isolation and Analysis of Dominant-Defective Mutants

DeLong, A. (2000) · doi:10.21236/ada391692 · Cited by 1 · see citing works