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Mechano- or Acid Stimulation, Two Interactive Modes of Activation of the TREK-1 Potassium Channel
Open accessAbstract
TREK-1 is a member of the novel structural class of K(+) channels with four transmembrane segments and two pore domains in tandem (1,2). TREK-1 is opened by membrane stretch and arachidonic acid. It is also an important target for volatile anesthetics (2,3). Here we show that internal acidification opens TREK-1. Indeed, lowering pH(i) shifts the pressure-activation relationship toward positive values and leads to channel opening at atmospheric pressure. The pH(i)-sensitive region in the carboxyl terminus of TREK-1 is the same that is critically involved in mechano-gating as well as arachidonic acid activation. A convergence, which is dependent on the carboxyl terminus, occurs between mechanical, fatty acids and acidic stimuli. Intracellular acidosis, which occurs during brain and heart ischemia, will induce TREK-1 opening with subsequent K(+) efflux and hyperpolarization.
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Cited by
Physiology of cell volume regulation in vertebrates
Hoffmann, E. K., Lambert, I. H., & Pedersen, S. F. (2009) · Physiological Reviews · doi:10.1152/physrev.00037.2007 · Cited by 1,441
Molecular Background of Leak K+Currents: Two-Pore Domain Potassium Channels
Enyedi, P., & Czirják, G. (2010) · Physiological Reviews · doi:10.1152/physrev.00029.2009 · Cited by 868
Mechanically Activated Ion Channels
Ranade, S. S., Syeda, R., & Patapoutian, A. (2015) · Neuron · doi:10.1016/j.neuron.2015.08.032 · Cited by 652
Piezos thrive under pressure: mechanically activated ion channels in health and disease
Murthy, S. E., Dubin, A. E., & Patapoutian, A. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.92 · Cited by 582
CNS Distribution of Members of the Two-Pore-Domain (KCNK) Potassium Channel Family
Talley, E. M., Solórzano, G., Lei, Q., Kim, D., & Bayliss, D. A. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-19-07491.2001 · Cited by 573
Metadata
- Authors
- Maingret, F., Patel, A. J., Lesage, F., Lazdunski, M., & Honoré, E.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1999-09
- Volume
- 274
- Issue
- 38
- Pages
- 26691-26696
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1968001136
- Cited by
- 430
- References
- 0
- FWCI
- 4.57
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Maingret, F., Patel, A. J., Lesage, F., Lazdunski, M., & Honoré, E. (1999). Mechano- or Acid Stimulation, Two Interactive Modes of Activation of the TREK-1 Potassium Channel. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.274.38.26691
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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