The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
A Caspase-9 Variant Missing the Catalytic Site Is an Endogenous Inhibitor of Apoptosis
Open accessAbstract
It is likely that endogenous inhibitors of the apical caspases such as caspase-9 exist to prevent undesirable activation of caspase cascades. A naturally occurring variant of caspase-9 named caspase-9S was cloned from human liver. Caspase-9S is missing most of the large subunit of caspase-9, including the catalytic site, but has the intact prodomain and small subunit. Caspase-9S did not show apoptotic activity in transfection analysis. Overexpression of caspase-9S inhibited apoptosis induced by caspase-9, indicating that caspase-9S is an endogenous dominant-negative of caspase-9. Moreover, caspase-9S inhibited apoptosis induced by tumor necrosis factor(TNF)-alpha, TNF factor-related apoptosis-inducing ligand (TRAIL), Bax, or Fas-associated death domain-containing protein (FADD) as well as the combination of Apaf-1 and caspase-9. In vitro binding assays demonstrated that caspase-9S binds to Apaf-1 and blocks the binding of caspase-9 to Apaf-1. Coexpression of caspase-9 and caspase-9S mRNA was identified in various cell lines. Thus, caspase-9S acts as a dominant-negative inhibitor of caspase-9 activation, at least in part, by blocking Apaf-1-caspase-9 interaction.
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Cites
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Cited by
Chalfant, C. E., Rathman, K., Pinkerman, R. L., Wood, R. E., Obeid, L. M., Ogretmen, B., & Hannun, Y. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m112010200 · Cited by 337
Caspase-9: structure, mechanisms and clinical application
Li, P., Zhou, L., Zhao, T., Liu, X., Zhang, P., Liu, Y., Zheng, X., & Li, Q. (2017) · Oncotarget · doi:10.18632/oncotarget.15098 · Cited by 319
Mechanisms of liver cell injury
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Regulation of death receptor-mediated apoptosis pathways
Schmitz, I., Kirchhoff, S., & Krammer, P. H. (2000) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(00)00048-0 · Cited by 288
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Metadata
- Authors
- Seol, D.-W., & Billiar, T. R.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1999-01
- Volume
- 274
- Issue
- 4
- Pages
- 2072-2076
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2076502151
- Cited by
- 179
- References
- 5
- FWCI
- 7.29
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Seol, D.-W., & Billiar, T. R. (1999). A Caspase-9 Variant Missing the Catalytic Site Is an Endogenous Inhibitor of Apoptosis. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.274.4.2072
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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