Cited by 769Alzheimer's disease research and treatmentsTrace Elements in HealthDementia and Cognitive Impairment Research

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Cu(II) Potentiation of Alzheimer Aβ Neurotoxicity

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Huang, Xudong, Cuajungco, Math P., Atwood, Craig S., Hartshorn, Mariana A., Tyndall, Joel D.A., Hanson, Graeme R., Stokes, Karen C., Leopold, Michael, Multhaup, Gerd, Goldstein, Lee E., Scarpa, Richard C., Saunders, Aleister J., Lim, James, Moir, Robert D., Glabe, Charles, Bowden, Edmond F., Masters, Colin L., Fairlie, David P., Tanzi, Rudolph E., Bush, Ashley I.·1999·Journal of Biological Chemistry

DOI 10.1074/jbc.274.52.37111

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Abstract

Oxidative stress markers as well as high concentrations of copper are found in the vicinity of Abeta amyloid deposits in Alzheimer's disease. The neurotoxicity of Abeta in cell culture has been linked to H(2)O(2) generation by an unknown mechanism. We now report that Cu(II) markedly potentiates the neurotoxicity exhibited by Abeta in cell culture. The potentiation of toxicity is greatest for Abeta1-42 > Abeta1-40 >> mouse/rat Abeta1-40, corresponding to their relative capacities to reduce Cu(II) to Cu(I), form H(2)O(2) in cell-free assays and to exhibit amyloid pathology. The copper complex of Abeta1-42 has a highly positive formal reduction potential ( approximately +500-550 mV versus Ag/AgCl) characteristic of strongly reducing cuproproteins. These findings suggest that certain redox active metal ions may be important in exacerbating and perhaps facilitating Abeta-mediated oxidative damage in Alzheimer's disease.

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Authors: Huang, X., Cuajungco, M. P., Atwood, C. S., Hartshorn, M. A., Tyndall, J. D. A., Hanson, G. R., Stokes, K. C., Leopold, M., Multhaup, G., Goldstein, L. E., Scarpa, R. C., Saunders, A. J., Lim, J., Moir, R. D., Glabe, C., Bowden, E. F., Masters, C. L., Fairlie, D. P., Tanzi, R. E., & Bush, A. I.
Affiliations: Harvard University (US)
The University of Queensland (AU)
North Carolina State University (US)
Heidelberg University (DE)
University of California, Irvine (US)
Mental Health Research Institute (AU)
Corresponding author: Bush, Ashley I.
ORCID: Huang, Xudong
Cuajungco, Math P.
Atwood, Craig S.
Tyndall, Joel D.A.
Leopold, Michael
Multhaup, Gerd
Goldstein, Lee E.
Saunders, Aleister J.
Moir, Robert D.
Glabe, Charles
Bowden, Edmond F.
Masters, Colin L.
Fairlie, David P.
Tanzi, Rudolph E.
Bush, Ashley I.
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 1999-12
Volume: 274
Issue: 52
Pages: 37111-37116
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1074/jbc.274.52.37111
OpenAlex: W2131633241
Cited by: 762
References: 40
Citations by year: 2026: 9 · 2025: 9 · 2024: 13 · 2023: 14 · 2022: 14 · 2021: 10 · 2020: 15 · 2019: 30 · 2018: 16 · 2017: 19 · 2016: 26 · 2015: 27 · 2014: 33 · 2013: 28 · 2012: 42
FWCI: 14.38
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 7617 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: Massachusetts General Hospital
Commonwealth of Massachusetts
National Institutes of Health
Medical Research Council
Australian Research Council
National Health and Medical Research Council
National Institute on Aging
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: Alzheimer's disease, amyloid-beta, copper(II), neurotoxicity, oxidative stress, hydrogen peroxide production, amyloid-beta 42, Aβ40, copper proteins, metal ions, redox-active metals, oxidative damage
MeSH terms: Animals, Brain, Cells, Cultured, Computer Simulation, Copper, Electron Spin Resonance Spectroscopy, Hydrogen Peroxide, Oxidation-Reduction, Amyloid beta-Peptides, Rats

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