Delineating the Mechanism of Alzheimer’s Disease Aβ Peptide Neurotoxicity

The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics

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Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy

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Control of inositol 1,4,5-trisphosphate-induced Ca2+ release by cytosolic Ca2+

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The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

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Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo

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Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

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Mutation of the mouse klotho gene leads to a syndrome resembling ageing

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Diffusible, nonfibrillar ligands derived from Aβ _1–42 are potent central nervous system neurotoxins

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Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β

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Hydrogen peroxide mediates amyloid β protein toxicity

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The carboxy terminus of the .beta. amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease

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RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease

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Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides

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Amyloid β-peptide is produced by cultured cells during normal metabolism

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Reducing Endogenous Tau Ameliorates Amyloid ß-Induced Deficits in an Alzheimer's Disease Mouse Model

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Natural oligomers of the amyloid-β protein specifically disrupt cognitive function

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Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP

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Regulation of NMDA receptor trafficking by amyloid-β

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Soluble Amyloid β Peptide Concentration as a Predictor of Synaptic Change in Alzheimer's Disease

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Formation of Neurofibrillary Tangles in P301L Tau Transgenic Mice Induced by Aβ42 Fibrils

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Treatment with a Copper-Zinc Chelator Markedly and Rapidly Inhibits β-Amyloid Accumulation in Alzheimer's Disease Transgenic Mice

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Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

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Clearance of Alzheimer’s amyloid-β1-40 peptide from brain by LDL receptor–related protein-1 at the blood-brain barrier

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ABAD Directly Links Aß to Mitochondrial Toxicity in Alzheimer's Disease

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Correlation Between Elevated Levels of Amyloid β-Peptide in the Brain and Cognitive Decline

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The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction

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Mitochondria are a direct site of Aβ accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression

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Calcium Dysregulation and Membrane Disruption as a Ubiquitous Neurotoxic Mechanism of Soluble Amyloid Oligomers*♦

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Metal-Protein Attenuation With Iodochlorhydroxyquin (Clioquinol) Targeting Aβ Amyloid Deposition and Toxicity in Alzheimer Disease: A Pilot Phase 2 Clinical Trial

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Aβ Oligomers Induce Neuronal Oxidative Stress through an N-Methyl-D-aspartate Receptor-dependent Mechanism That Is Blocked by the Alzheimer Drug Memantine

De Felice, F. G., Velasco, P. T., Lambert, M. P., Viola, K., Fernandez, S. J., Ferreira, S. T., & Klein, W. L. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m607483200 · Cited by 882 · see citing works

In vitro aging of ß-amyloid protein causes peptide aggregation and neurotoxicity

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LRP/Amyloid β-Peptide Interaction Mediates Differential Brain Efflux of Aβ Isoforms

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Tau is essential to β-amyloid-induced neurotoxicity

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Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction

Devi, L., Prabhu, B. M., Galati, D. F., Avadhani, N. G., & Anandatheerthavarada, H. K. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1469-06.2006 · Cited by 792 · see citing works

Cu(II) Potentiation of Alzheimer Aβ Neurotoxicity

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Mitochondrial Aβ: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease

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Alzheimer's Disease Amyloid-β Binds Copper and Zinc to Generate an Allosterically Ordered Membrane-penetrating Structure Containing Superoxide Dismutase-like Subunits

Curtain, C. C., Ali, F. E. A., Volitakis, I., Cherny, R. A., Norton, R. S., Beyreuther, K. T., Barrow, C. J., Masters, C. L., Bush, A. I., & Barnham, K. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100175200 · Cited by 653 · see citing works

Amyloid β protein forms ion channels: implications for Alzheimer's disease pathophysiology

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Metalloenzyme-like Activity of Alzheimer's Disease β-Amyloid

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The Levels of Soluble versus Insoluble Brain Aβ Distinguish Alzheimer's Disease from Normal and Pathologic Aging

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Metal Binding and Oxidation of Amyloid-β within Isolated Senile Plaque Cores: Raman Microscopic Evidence

Dong, J., Atwood, C., Anderson, V. E., Siedlak, S. L., Smith, M. A., Perry, G. L., & CAREY, P. R. (2003) · Biochemistry · doi:10.1021/bi0272151 · Cited by 560 · see citing works

Globular amyloid β‐peptide ₁₋₄₂ oligomer − a homogenous and stable neuropathological protein in Alzheimer's disease

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Soluble oligomers of β amyloid (1-42) inhibit long-term potentiation but not long-term depression in rat dentate gyrus

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Amyloid β protein immunotherapy neutralizes Aβ oligomers that disrupt synaptic plasticity in vivo

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Relative Abundance of Alzheimer A Beta Amyloid Peptide Variants in Alzheimer Disease and normal Aging

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Block of Long-Term Potentiation by Naturally Secreted and Synthetic Amyloid β-Peptide in Hippocampal Slices Is Mediated via Activation of the Kinases c-Jun N-Terminal Kinase, Cyclin-Dependent Kinase 5, and p38 Mitogen-Activated Protein Kinase as well as Metabotropic Glutamate Receptor Type 5

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Massive CA1/2 Neuronal Loss with Intraneuronal and N-Terminal Truncated Aβ42 Accumulation in a Novel Alzheimer Transgenic Model

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Evidence that the β-Amyloid Plaques of Alzheimer's Disease Represent the Redox-silencing and Entombment of Aβ by Zinc

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Alzheimer's disease and Aβ toxicity: from top to bottom

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Huntingtin aggregates may not predict neuronal death in Huntington's disease

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Copper Mediates Dityrosine Cross-Linking of Alzheimer's Amyloid-β

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Oxidative stress in Alzheimer's disease brain: New insights from redox proteomics

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Different Mechanisms of Oxidative Stress and Neurotoxicity for Alzheimer‘s Aβ(1−42) and Aβ(25−35)

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RAGE potentiates Aβ‐induced perturbation of neuronal function in transgenic mice

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Copper-Dependent Inhibition of Human Cytochrome<i>c</i>Oxidase by a Dimeric Conformer of Amyloid-β_1-42

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Degradation of the Alzheimer Disease Amyloid β-Peptide by Metal-dependent Up-regulation of Metalloprotease Activity

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Aggregation-related toxicity of synthetic β-amyloid protein in hippocampal cultures

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Decreased glutathione transferase activity in brain and ventricular fluid in Alzheimer's disease

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Tyrosine gated electron transfer is key to the toxic mechanism of Alzheimer's disease β‐amyloid

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Amyloid β‐peptide interactions with neuronal and glial cell plasma membrane: binding sites and implications for Alzheimer's disease

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ABAD enhances Aβ‐induced cell stress via mitochondrial dysfunction

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Comparative Analysis of Amyloid-β Chemical Structure and Amyloid Plaque Morphology of Transgenic Mouse and Alzheimer's Disease Brains

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Molecular mechanisms for Alzheimer's disease: implications for neuroimaging and therapeutics

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Fresh and globular amyloid β protein (1–42) induces rapid cellular degeneration: evidence for AβP channel‐mediated cellular toxicity

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Concentration Dependent Cu2+Induced Aggregation and Dityrosine Formation of the Alzheimer's Disease Amyloid-β Peptide

Smith, D. P., Ciccotosto, G. D., Tew, D. J., Fodero‐Tavoletti, M. T., Johanssen, T., Masters, C. L., Barnham, K. J., & Cappai, R. (2007) · Biochemistry · doi:10.1021/bi0620961 · Cited by 193 · see citing works

The lipophilic metal chelator DP-109 reduces amyloid pathology in brains of human β-amyloid precursor protein transgenic mice

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Neurotoxic, Redox-competent Alzheimer's β-Amyloid Is Released from Lipid Membrane by Methionine Oxidation

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Surface Behavior and Lipid Interaction of Alzheimer β-Amyloid Peptide 1–42: A Membrane-Disrupting Peptide

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Amyloid β-peptide and amyloid pathology are central to the oxidative stress and inflammatory cascades under which Alzheimer's disease brain exists

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ERK1/2 Activation Mediates Aβ Oligomer-induced Neurotoxicity via Caspase-3 Activation and Tau Cleavage in Rat Organotypic Hippocampal Slice Cultures

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β-Amyloid Induces Local Neurite Degeneration in Cultured Hippocampal Neurons: Evidence for Neuritic Apoptosis

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Amyloid-β Peptide Disruption of Lipid Membranes and the Effect of Metal Ions

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Fyn Kinase Modulates Synaptotoxicity, But Not Aberrant Sprouting, in Human Amyloid Precursor Protein Transgenic Mice

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Role of p75 Neurotrophin Receptor in the Neurotoxicity by β-amyloid Peptides and Synergistic Effect of Inflammatory Cytokines

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Hydroxyl radical generation during exercise increases mitochondrial protein oxidation and levels of urinary dityrosine

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Cross Dimerization of Amyloid-β and αSynuclein Proteins in Aqueous Environment: A Molecular Dynamics Simulations Study

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Metals, Membranes, and Amyloid-β Oligomers: Key Pieces in the Alzheimer's Disease Puzzle?

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Challenges in Designing Therapeutic Agents for Treating Alzheimer’s Disease-from Serendipity to Rationality

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APP involvement in retinogenesis of mice

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Anti-Aβ drug candidates in clinical trials and plasmonic nanoparticle-based drug-screen for Alzheimer's disease

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Protective effect and mechanism of docosahexaenoic acid on the cognitive function in female APP/PS1 mice

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Herpes Simplex Virus Type 1 Enhances Expression of the Synaptic Protein Arc for Its Own Benefit

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Copper(II) Coordination to Amyloid β: Murine versus Human Peptide

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[18F]ROStrace detects oxidative stress in vivo and predicts progression of Alzheimer’s disease pathology in APP/PS1 mice

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Oligomer Formation and Cross‐Seeding: The New Frontier

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Huprines — an insight into the synthesis and biological properties

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Photodynamic and Photothermal Therapies using Nanotechnology Approach in Alzheimer's Disease

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Modelling Copper Binding to the Amyloid-ß Peptide in Alzheimer’s Disease

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Alzheimer's Disease: Clinical Trials and Future Perspectives

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Computational Approaches

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Prospects for Neural Stem Cell Therapy of Alzheimer Disease

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Amyloid Hypothesis: Molecular and Cellular Aspects of Toxicity

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Ferulago angulata Methanolic Extract Protects PC12 Cells Against Beta-amyloid-induced Toxicity

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Copper and Alzheimer Disease: The Good, the Bad and the Ugly

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[18F]ROStrace detects oxidative stress in vivo and predicts progression of Alzheimer’s disease pathology in APP/PS1 micePreprint

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Structural and Computational Studies of Interactions of Metals with Amyloid Beta

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Gonadotropin effects

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The Current Status of Alzheimer's Disease Treatment

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