The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
The Regulation of Mitochondrial Oxygen Uptake by Redox Reactions Involving Nitric Oxide and Ubiquinol
Open accessAbstract
The reversible inhibitory effects of nitric oxide (.NO) on mitochondrial cytochrome oxidase and O(2) uptake are dependent on intramitochondrial.NO utilization. This study was aimed at establishing the mitochondrial pathways for.NO utilization that regulate O-(2) generation via reductive and oxidative reactions involving ubiquinol oxidation and peroxynitrite (ONOO(-)) formation. For this purpose, experimental models consisting of intact mitochondria, ubiquinone-depleted/reconstituted submitochondrial particles, and ONOO(-)-supplemented mitochondrial membranes were used. The results obtained from these experimental approaches strongly suggest the occurrence of independent pathways for.NO utilization in mitochondria, which effectively compete with the binding of.NO to cytochrome oxidase, thereby releasing this inhibition and restoring O(2) uptake. The pathways for.NO utilization are discussed in terms of the steady-state levels of.NO and O-(2) and estimated as a function of O(2) tension. These calculations indicate that mitochondrial.NO decays primarily by pathways involving ONOO(-) formation and ubiquinol oxidation and, secondarily, by reversible binding to cytochrome oxidase.
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Cites
Cadenas, E., Boveris, A., Ragan, C. I., & Stoppani, A. O. M. (1977) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(77)90035-2 · Cited by 855
Self-citationPoderoso, J. J., Carreras, M. C., Lisdero, C., Riobó, N., Schöpfer, F., & Boveris, A. (1996) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1996.0146 · Cited by 726
Nitric oxide synthase activity in mitochondria
Ghafourifar, P., & Richter, C. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01397-5 · Cited by 567
Superoxide production by mitochondria in the presence of nitric oxide forms peroxynitrite
Packer, M. A., Porteous, C. M., & Murphy, M. P. (1996) · IUBMB Life · doi:10.1080/15216549600201103 · Cited by 118
Cited by
Mitochondrial free radical generation, oxidative stress, and aging
Cadenas, E., & Davies, K. J. A. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00317-8 · Cited by 3,010
Self-citationReactive species mechanisms of cellular hypoxia-reoxygenation injury
Li, C., & Jackson, R. M. (2002) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00112.2001 · Cited by 1,043
The mitochondrial energy transduction system and the aging process
Navarro, A., & Boveris, A. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00213.2006 · Cited by 646
Self-citationRegulation of mitochondrial respiration by nitric oxide inhibition of cytochrome c oxidase
Brown, G. C. (2001) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(00)00238-3 · Cited by 602
Mitochondrial Regulation of Cell Cycle and Proliferation
Antico Arciuch, V. G., Elguero, M. E., Poderoso, J. J., & Carreras, M. C. (2012) · Antioxidants & Redox Signaling · doi:10.1089/ars.2011.4085 · Cited by 434
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Metadata
- Authors
- Poderoso, J. J., Lisdero, C., Schöpfer, F., Riobó, N., Carreras, M. C., Cadenas, E., & Boveris, A.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1999-12
- Volume
- 274
- Issue
- 53
- Pages
- 37709-37716
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2018740639
- Cited by
- 183
- References
- 4
- FWCI
- 4.02
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Poderoso, J. J., Lisdero, C., Schöpfer, F., Riobó, N., Carreras, M. C., Cadenas, E., & Boveris, A. (1999). The Regulation of Mitochondrial Oxygen Uptake by Redox Reactions Involving Nitric Oxide and Ubiquinol. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.274.53.37709
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
