Production of superoxide radicals and hydrogen peroxide by NADH-ubiquinone reductase and ubiquinol-cytochrome c reductase from beef-heart mitochondria
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ROS can damage TCA-cycle enzymes, especially aconitase and α-ketoglutarate dehydrogenase.
“ROS can damage TCA-cycle enzymes, especially aconitase and α-ketoglutarate dehydrogenase (62, 168, 249, 250, 277).”
From Mitochondrial reactive oxygen species production in excitable cells: Modulators of mitochondrial and cell function (2009) · cites this paper as [62]
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- Authors
- Cadenas, E., Boveris, A., Ragan, C. I., & Stoppani, A. O. M.
- Affiliations
- Universidad de Buenos Aires (AR)
- ORCID
- Cadenas, Enrique
- Venue
- Archives of Biochemistry and Biophysics
- Publisher
- Elsevier BV
- Published
- 1977-04
- Volume
- 180
- Issue
- 2
- Pages
- 248-257
- ISSN
- 0003-9861 (ISSN-L)
- OpenAlex
- W2050357506
- Cited by
- 855
- References
- 34
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 10 · 2023: 10 · 2022: 18 · 2021: 21 · 2020: 13 · 2019: 16 · 2018: 19 · 2017: 18 · 2016: 16 · 2015: 16 · 2014: 26 · 2013: 27 · 2012: 42
- FWCI
- 4.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Biochemistry and Biophysics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- superoxide, hydrogen peroxide, NADH-ubiquinone reductase, cytochrome bc1 complex, complex I, beef heart mitochondria, coenzyme Q10, superoxide dismutase, rotenone, electron acceptors, oxygen intermediates
- MeSH terms
- Animals, Cattle, Cytochrome c Group, Cytochrome Reductases, Hydrogen Peroxide, Kinetics, Mitochondria, Muscle, Myocardium, NADH, NADPH Oxidoreductases, Oxygen, Quinone Reductases, Rotenone, Superoxides, Superoxide Dismutase, Ubiquinone, Xanthine Oxidase
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