Superoxide production by mitochondria in the presence of nitric oxide forms peroxynitrite
Abstract
The mitochondrial respiratory chain continually produces superoxide leading to high levels of mitochondrial oxidative stress. This oxidative damage has been attributed to the formation of hydroxyl radicals and hydrogen peroxide from superoxide. Alternatively, mitochondrial superoxide may react with nitric oxide forming the potent oxidant peroxynitrite, thus damaging mitochondrial protein, lipid and DNA. To test this hypothesis we induced mitochondrial superoxide formation in the presence of nitric oxide. Here we demonstrate that mitochondrial superoxide reacts with nitric oxide to form peroxynitrite, suggesting that mitochondria may be a significant intracellular source of peroxynitrite.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Peroxynitrite can nitrate tyrosine or tryptophan residues or oxidise methionine residues.
“In addition, peroxynitrite is capable of nitrating tyrosine or tryptophan residues, or oxidising methionine residues [123,124,125,126,127,128].”
From Superoxide Anion Chemistry—Its Role at the Core of the Innate Immunity (2023) · cites this paper as [124]
Cited by
Sorted by citations
How mitochondria produce reactive oxygen species
Murphy, M. P. (2009) · Biochemical Journal · doi:10.1042/bj20081386 · Cited by 8,207 · see citing works
Self-citationChemical Basis of Reactive Oxygen Species Reactivity and Involvement in Neurodegenerative Diseases
Collin, F. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20102407 · Cited by 822 · see citing works
Al-Gubory, K. H., Fowler, P., & Garrel, C. (2010) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2010.06.001 · Cited by 803 · see citing works
Does nitric oxide modulate mitochondrial energy generation and apoptosis?
Moncada, S., & Erusalimsky, J. D. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm762 · Cited by 789 · see citing works
Role of mitochondria in oxidative stress and ageing
Lenaz, G. (1998) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(98)00120-0 · Cited by 650 · see citing works
Peroxynitrite reactions and formation in mitochondria
Radí, R., Cassina, A., Hodara, R., Quijano, C., & Castro, L. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01111-5 · Cited by 635 · see citing works
Regulation and measurement of oxidative stress in apoptosis
Curtin, J. F., Donovan, M., & Cotter, T. G. (2002) · Journal of Immunological Methods · doi:10.1016/s0022-1759(02)00070-4 · Cited by 581 · see citing works
Nitric oxide and iron proteins
Cooper, C. E. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(99)00021-3 · Cited by 510 · see citing works
Oxidative Stress and Neurodegenerative Disorders
Li, J., Wuliji, O., Li, W., Jiang, Z.-G., & Ghanbari, H. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms141224438 · Cited by 511 · see citing works
Murphy, M. P. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(99)00029-8 · Cited by 455 · see citing works
Self-citationOxidative stress as a pathogenic factor in inflammatory bowel disease — radicals or ridiculous?
Kruidenier, L., & Verspaget, H. W. (2002) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2002.01378.x · Cited by 392 · see citing works
Reactive oxygen species and mitochondrial diseases
Kirkinezos, I. G., & Moraes, C. T. (2001) · Seminars in Cell and Developmental Biology · doi:10.1006/scdb.2001.0282 · Cited by 385 · see citing works
Bench-to-bedside review: Cytopathic hypoxia.
Fink, M. P. (2002) · Critical Care · doi:10.1186/cc1824 · Cited by 387 · see citing works
Superoxide Anion Chemistry—Its Role at the Core of the Innate Immunity
Andrés, C. M. C., Pérez de la Lastra, J. M., Andrés Juan, C., Plou, F. J., & Pérez-Lebeña, E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24031841 · Cited by 342 · see citing works
Biology of nitric oxide signaling
Liaudet, L., Soriano, F. G., & Szabó, C. (2000) · Critical Care Medicine · doi:10.1097/00003246-200004001-00005 · Cited by 326 · see citing works
Fink, M. P. (2001) · Critical Care Clinics · doi:10.1016/s0749-0704(05)70161-5 · Cited by 302 · see citing works
Mitochondria: regulators of signal transduction by reactive oxygen and nitrogen species
Brookes, P. S., Levonen, A.-L., Shiva, S., Sarti, P., & Darley-Usmar, V. M. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00901-2 · Cited by 298 · see citing works
Mitochondrial Approaches for Neuroprotection
Chaturvedi, R. K., & Beal, M. F. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1427.027 · Cited by 294 · see citing works
Nitric Oxide and Peroxynitrite Interactions with Mitochondria
Radí, R., Cassina, A., & Hodara, R. (2002) · Biological Chemistry · doi:10.1515/bc.2002.044 · Cited by 293 · see citing works
Mantena, S. K., Vaughn, D. P., Andringa, K. K., Eccleston, H. B., King, A. L., Abrams, G. A., Doeller, J. E., Kraus, D. W., Darley-Usmar, V. M., & Bailey, S. M. (2009) · Biochemical Journal · doi:10.1042/bj20080868 · Cited by 265 · see citing works
Ischemia/reperfusion injury: A review in relation to free tissue transfers
Siemionow, M., & Arslan, E. (2004) · Microsurgery · doi:10.1002/micr.20060 · Cited by 263 · see citing works
Nitric Oxide in Macrophage Immunometabolism: Hiding in Plain Sight
Palmieri, E. M., McGinity, C., Wink, D. A., & McVicar, D. W. (2020) · Metabolites · doi:10.3390/metabo10110429 · Cited by 237 · see citing works
NO way to live; the various roles of nitric oxide in plant–pathogen interactions
Mur, L. A. J., Carver, T. L. W., & Prats, E. (2005) · Journal of Experimental Botany · doi:10.1093/jxb/erj052 · Cited by 232 · see citing works
The role of mitochondria in ischemia/reperfusion injury
Jassem, W., Fuggle, S. V., Rela, M., Koo, D. D. H., & Heaton, N. D. (2002) · Transplantation · doi:10.1097/00007890-200202270-00001 · Cited by 231 · see citing works
Shiva, S., Brookes, P. S., Patel, R. P., Anderson, P. G., & Darley-Usmar, V. M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.131128898 · Cited by 212 · see citing works
Carriedo, S. G., Yin, H. Z., Sensi, S. L., & Weiss, J. H. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-19-07727.1998 · Cited by 196 · see citing works
Dahm, C. C., Moore, K., & Murphy, M. P. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m512203200 · Cited by 194 · see citing works
Self-citationNitric oxide-induced mitochondrial dysfunction: implications for neurodegeneration
Stewart, V. C., & Heales, S. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01327-8 · Cited by 191 · see citing works
Interactions of zinc- and redox-signaling pathways
Hübner, C., & Haase, H. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101916 · Cited by 183 · see citing works
Poderoso, J. J., Lisdero, C. L., Schopfer, F. J., Galdo, N. A. R., Carreras, M. C., Cadenas, E., & Boveris, A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.53.37709 · Cited by 183 · see citing works
Murphy, M. P., Packer, M. A., Scarlett, J. L., & Martin, S. W. (1998) · General Pharmacology The Vascular System · doi:10.1016/s0306-3623(97)00418-7 · Cited by 180 · see citing works
Self-citationLi, R., Kou, X., Geng, H., Xie, J., Tian, J., Cai, Z., & Dong, C. (2015) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2015.02.006 · Cited by 158 · see citing works
Melatonin role in the mitochondrial function
Acuña-Castroviejo, D. (2006) · Frontiers in bioscience · doi:10.2741/2116 · Cited by 155 · see citing works
Interaction of Peroxynitrite with Mitochondrial Cytochrome Oxidase
Sharpe, M. A., & Cooper, C. E. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.47.30961 · Cited by 133 · see citing works
Fink, M. P. (2002) · Critical Care Clinics · doi:10.1016/s0749-0704(03)00071-x · Cited by 133 · see citing works
Peroxynitrite and Brain Mitochondria: Evidence for Increased Proton Leak
Brookes, P. S., Land, J. M., Clark, J. B., & Heales, S. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.70052195.x · Cited by 125 · see citing works
NO-mediated apoptosis in yeast
Almeida, B., Büttner, S., Ohlmeier, S., Silva, A., Mesquita, A., Sampaio‐Marques, B., Osório, N. S., Kollau, A., Mayer, B., Leão, C., et al. (2007) · Journal of Cell Science · doi:10.1242/jcs.010926 · Cited by 121 · see citing works
Protective Effects of Arginine on Saccharomyces cerevisiae Against Ethanol Stress
Cheng, Y., Du, Z., Zhu, H., Guo, X., & He, X. (2016) · Scientific Reports · doi:10.1038/srep31311 · Cited by 119 · see citing works
Nitric oxide synthesis in the kidney: isoforms, biosynthesis, and functions in health
Kone, B. C. (2004) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2004.04.002 · Cited by 112 · see citing works
Li, R., Yuan, C., Dong, C., Shuang, S., & Choi, M. M. F. (2011) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-011-0613-2 · Cited by 93 · see citing works
The assumption that nitric oxide inhibits mitochondrial ATP synthesis is correct
Brookes, P. S., Bolaños, J. P., & Heales, S. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00217-3 · Cited by 93 · see citing works
Li, L., Zhang, B., Tao, Y., Wang, Y., Wei, H., Zhao, J., Huang, R., & Pei, Z. (2009) · Brain Research · doi:10.1016/j.brainres.2009.07.020 · Cited by 92 · see citing works
Garrel, C., Alessandri, J., Guesnet, P., & Al-Gubory, K. H. (2011) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2011.10.007 · Cited by 87 · see citing works
Nitric oxide and calcium together inactivate mitochondrial complex I and induce cytochrome c release
Jekabsone, A. (2003) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(03)00137-8 · Cited by 85 · see citing works
Borutaitė, V., Morkūnienė, R., & Brown, G. C. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01140-6 · Cited by 77 · see citing works
Interactions of Mitochondrial Thiols with Nitric Oxide
Costa, N. J., Dahm, C., Hurrell, F., Taylor, E. R., & Murphy, M. (2003) · Antioxidants and Redox Signaling · doi:10.1089/152308603322110878 · Cited by 71 · see citing works
Self-citationNavarro, A. (2001) · Frontiers in bioscience · doi:10.2741/navarro · Cited by 75 · see citing works
Heales, S. (2002) · Neurochemistry International · doi:10.1016/s0197-0186(01)00117-6 · Cited by 73 · see citing works
The temporal architecture of eukaryotic growth
Lloyd, D., & Murray, D. B. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.02.066 · Cited by 70 · see citing works
Armas, M. I. D., Esteves, R., Viera, N., Reyes, A. M., Mastrogiovanni, M., Alegria, T. G. P., Netto, L. E. S., Tórtora, V., Radí, R., & Trujillo, M. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.10.451 · Cited by 64 · see citing works
Wheeler, M. D., Katuna, M., Smutney, O. M., Froh, M., Dikalova, A., Mason, R. P., Samulski, R. J., & Thurman, R. G. (2001) · Human Gene Therapy · doi:10.1089/10430340152710513 · Cited by 63 · see citing works
Ileal V o 2–D o 2 Alterations Induced by Endotoxin Correlate with Severity of Mitochondrial Injury
Crouser, E. D., JULIAN, M. W., & Dorinsky, P. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.160.4.9810116 · Cited by 63 · see citing works
Nitric oxide and hypercholesterolemia: a matter of oxidation and reduction?
Wever, R. M. F., Stroes, E. S. G., & Rabelink, T. J. (1998) · Atherosclerosis · doi:10.1016/s0021-9150(97)00304-3 · Cited by 58 · see citing works
Nitric Oxide Signaling Is Disrupted in the Yeast Model for Batten Disease
Osório, N. S., Carvalho, A., Almeida, A. J., Padilla-Lopez, S., Leão, C., Laranjinha, J., Ludovico, P., Pearce, D. A., & Rodrigues, F. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-11-1053 · Cited by 57 · see citing works
Kolli, V. K., Natarajan, K., Isaac, B. T. J., Selvakumar, D., & Abraham, P. (2013) · Human & Experimental Toxicology · doi:10.1177/0960327113515503 · Cited by 57 · see citing works
Cai, T., & Cai, Y. (2011) · Chemistry & Biodiversity · doi:10.1002/cbdv.201100013 · Cited by 53 · see citing works
Falak, N., Imran, Q. M., Hussain, A., & Yun, B. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020522 · Cited by 52 · see citing works
Gas Signaling Molecules and Mitochondrial Potassium Channels
Walewska, A., Szewczyk, A. M., & Koprowski, P. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103227 · Cited by 45 · see citing works
Nitric oxide signaling in yeast
Astuti, R. I., Nasuno, R., & Takagi, H. (2016) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-016-7827-7 · Cited by 40 · see citing works
Altup, S., Demiryürek, A. T., Doğrukol‐Ak, D., Tungel, M., & Kanzık, ⋖. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)00843-3 · Cited by 39 · see citing works
Ambrosi, N., Guerrieri, D., Caro, F., Sánchez, F., Haeublein, G., Casadei, D. H., Incardona, C., & Chuluyán, E. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19010102 · Cited by 38 · see citing works
Genius, J., & Fandrey, J. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00343-9 · Cited by 39 · see citing works
Diffusion barriers evoked in the rat cortex by reactive astrogliosis
Roitbak, T., & Sykov�, E. (1999) · Glia · doi:10.1002/(sici)1098-1136(199910)28:1 · Cited by 208 · see citing works
Photoreceptor Mitochondrial Tyrosine Nitration in Experimental Uveitis
Wu, G., Lee, T. D., Moore, R. E., & Rao, N. A. (2005) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.04-1525 · Cited by 31 · see citing works
Pathophysiological Roles of Nitric Oxide in Inflammation
Szabó, C. (2000) · Elsevier eBooks · doi:10.1016/b978-012370420-7/50053-8 · Cited by 31 · see citing works
Li, R., Zhou, Y., Ji, J., & Wang, L. (2010) · Aquaculture Research · doi:10.1111/j.1365-2109.2010.02646.x · Cited by 29 · see citing works
Galaup, C., Picard, C., Couderc, F., Gilard, V., & Collin, F. (2021) · FEBS Journal · doi:10.1111/febs.15859 · Cited by 28 · see citing works
Silibinin induces the generation of nitric oxide in human breast cancer MCF-7 cells
Wang, H., Wei, X., Jiang, Y., Huang, H., Yang, Y., Fan, S., Zang, L., Tashiro, S., Onodera, S., & Ikejima, T. (2010) · Free Radical Research · doi:10.3109/10715761003692495 · Cited by 27 · see citing works
Barone, M. C., Darley-Usmar, V. M., & Brookes, P. S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304129200 · Cited by 27 · see citing works
Nitric Oxide Signalling in Yeast
Astuti, R. I., Nasuno, R., & Takagi, H. (2018) · Advances in microbial physiology/Advances in Microbial Physiology · doi:10.1016/bs.ampbs.2018.01.003 · Cited by 25 · see citing works
Sun, C., Zhang, X., Sheard, P. W., MABUCHI, A., & WHEATLEY, A. (2005) · Microvascular Research · doi:10.1016/j.mvr.2005.04.003 · Cited by 23 · see citing works
Nitric Oxide‐mediated Liver Injury in the Presence of Experimental Bile Duct Obstruction
Engin, A., Bozkurt, B. Ş., Altan, N., Memış, L., & Bukan, N. C. (2003) · World Journal of Surgery · doi:10.1007/s00268-002-6710-0 · Cited by 23 · see citing works
Redox regulation in diabetic kidney disease
Daehn, I. S., Ekperikpe, U. S., & Stadler, K. (2023) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00047.2023 · Cited by 22 · see citing works
Mitochondrial nitric oxide inhibits ATP synthesis Effect of free calcium in rat heart
Saavedra‐Molina, A., Ramı́rez-Emiliano, J., Clemente‐Guerrero, M., Pérez‐Vázquez, V., Aguilera-Aguirre, L., & González‐Hernández, J. C. (2003) · Amino Acids · doi:10.1007/s00726-002-0331-7 · Cited by 20 · see citing works
Biological Systems Relevant for Redox Signaling and Control
Hurd, T. R., & Murphy, M. P. (2009) · Wiley eBooks · doi:10.1002/9783527627585.ch2 · Cited by 19 · see citing works
Self-citationGrancara, S., Zonta, F., Ohkubo, S., Brunati, A. M., Agostinelli, E., & Toninello, A. (2015) · Amino Acids · doi:10.1007/s00726-015-1964-7 · Cited by 19 · see citing works
Reactive Oxygen Species and Apoptosis
Bauer, G., Dormann, S., Engelmann, I., Schulz, A., & Sarán, M. (2000) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-57075-9_11 · Cited by 19 · see citing works
Sensing Hypoxia by Mitochondria: A Unifying Hypothesis Involving S-Nitrosation
Ullrich, V., & Schildknecht, S. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4788 · Cited by 18 · see citing works
Zhou, G., Hu, R., Gui-cheng, X., Yan, S., Ren, Q., Zhao, J., Wang, F., Huang, C., Yao, Q., Tan, Y., et al. (2019) · Aging · doi:10.18632/aging.101964 · Cited by 18 · see citing works
Andrei, S. R., Ghosh, M., Sinharoy, P., & Damron, D. S. (2019) · Channels · doi:10.1080/19336950.2019.1623591 · Cited by 18 · see citing works
The Regulation of Cell Energetics and Mitochondrial Signaling by Nitric Oxide
BOVERIS, A., Carreras, M. C., & Poderoso, J. J. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-373866-0.00013-7 · Cited by 18 · see citing works
Respiratory Oscillations in Yeasts
Lloyd, D. (2008) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-09794-7_9 · Cited by 18 · see citing works
Regulation of Oxygen Metabolism by Nitric Oxide
Boveris, A., & Poderoso, J. J. (2000) · Elsevier eBooks · doi:10.1016/b978-012370420-7/50024-1 · Cited by 18 · see citing works
Din, R. M. U., Eman, S., Zafar, M. H., Zhang, C., Saleh, A. A., Husien, H. M., & Wang, M. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1615349 · Cited by 17 · see citing works
Research: advances in cell biology relevant to critical illness
Fink, M. P. (2004) · Current Opinion in Critical Care · doi:10.1097/01.ccx.0000130150.33814.71 · Cited by 15 · see citing works
Kim, S., Hwang, J. S., & Lee, D. G. (2020) · IUBMB Life · doi:10.1002/iub.2284 · Cited by 14 · see citing works
El‐Sehrawy, A. A. M. A., Mohammed, A. N., Gupta, J., Mohammed, J. S., Roopashree, R., Kashyap, A., Janney, J. B., Sahoo, S., Al-Hasnaawei, S., & Nasr, Y. M. (2025) · Pathology - Research and Practice · doi:10.1016/j.prp.2025.156053 · Cited by 13 · see citing works
Oxidative Metabolic Bioactivation of Xenobiotics
Mabie, S., Castagnoli, K., & Castagnoli, N. (1999) · CRC Press eBooks · doi:10.1201/b13995-3 · Cited by 13 · see citing works
Forceville, X., Antwerpen, P. V., & Preiser, J. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8063 · Cited by 12 · see citing works
Coordination of physiologic and toxic pathways in hippocampus by nitric oxide and mitochondria
Laranjinha, J. A. N. (2006) · Frontiers in bioscience · doi:10.2741/2129 · Cited by 12 · see citing works
Prooxidant effects of melatonin: a brief review
MUNIK, M. S., & Ekmekçioğlu, C. (2015) · TURKISH JOURNAL OF BIOLOGY · doi:10.3906/biy-1504-24 · Cited by 12 · see citing works
Júnior, A. L. G., Tchekalarova, J. D., Machado, K. D. C., Silva, S. W. C., Paz, M. F. C. J., Nogueira, T. R., Lira, B. S. D. M. M., Zihad, S. M. N. K., Islam, M. T., Ali, E. S., et al. (2019) · Phytotherapy Research · doi:10.1002/ptr.6407 · Cited by 10 · see citing works
Fine particulate matter‑induced cardiac developmental toxicity (Review)
Meng, X., Du, W., & Sun, Z. (2024) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2024.12756 · Cited by 10 · see citing works
[Nitric oxide participation during amoebic liver abscess development].
Ramı́rez-Emiliano, J., Villavicencio, L. L. F., Segovia, J., & Arias‐Negrete, S. (2007) · PubMed · Cited by 9 · see citing works
Al-Gubory, K. H. (2019) · Journal of Biophotonics · doi:10.1002/jbio.201900146 · Cited by 8 · see citing works
Noack, H., Possel, H., Chatterjee, S., Keilhoff, G., & Wolf, G. L. (2000) · Toxicology · doi:10.1016/s0300-483x(00)00204-3 · Cited by 8 · see citing works
Mitochondria and oxidative damage in amyotrophic lateral sclerosis.
Beal, M. F. (2001) · PubMed · Cited by 7 · see citing works
5.3 Mitochondrial Production of Oxidants and Their Role in the Regulation of Cellular Processes
Brookes, P. S. (2007) · Springer eBooks · doi:10.1007/978-0-387-30411-3_19 · Cited by 7 · see citing works
Estresse oxidativo e envelhecimento: papel do exercício físico
de Moraes, C., & Sampaio, R. C. (2010) · Motriz Revista de Educação Física · doi:10.5016/1980-6574.2010v16n2p506 · Cited by 6 · see citing works
Functions and significance of nitric oxide in patho-physiological processes
Gautam, P., & Jain, S. K. (2007) · Cited by 2 · see citing works
- Authors
- Packer, M. A., Porteous, C. M., & Murphy, M. P.
- Affiliations
- University of Otago (NZ)
- Corresponding author
- Murphy, Michael P.
- Venue
- IUBMB Life
- Publisher
- Wiley
- Published
- 1996-10
- Volume
- 40
- Issue
- 3
- Pages
- 527-534
- ISSN
- 1521-6543 (ISSN-L)
- 1521-6551
- OpenAlex
- W2060263803
- Cited by
- 118
- References
- 0
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 3 · 2019: 5 · 2018: 4 · 2017: 1 · 2016: 2 · 2015: 3 · 2014: 1 · 2013: 2 · 2012: 2
- FWCI
- 1.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- IUBMB Life (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Keywords
- superoxide, nitric oxide, peroxynitrite, mitochondria, mitochondrial respiratory chain, oxidative stress, nitrosative stress, mitochondrial DNA damage, lipid peroxidation
- MeSH terms
- Animals, Antimycin A, Cattle, Cell Membrane, DNA Damage, DNA, Mitochondrial, Mitochondria, Heart, Nitrates, Nitric Oxide, Superoxides, Oxidative Stress
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
