The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
The Mammalian Basic Helix Loop Helix Protein HES-1 Binds to and Modulates the Transactivating Function of the Runt-related Factor Cbfa1
Open accessAbstract
Drosophila Runt is the founding member of a family of related transcription factors involved in the regulation of a variety of cell-differentiation events in invertebrates and vertebrates. Runt-related proteins act as both transactivators and transcriptional repressors, suggesting that context-dependent mechanisms modulate their transcriptional properties. The aim of this study was to elucidate the molecular mechanisms that contribute to the regulation of the functions of the mammalian Runt-related protein, Cbfa1. Here we provide the first demonstration that Cbfa1 (as well as the related protein, Cbfa2/AML1) physically interacts with the basic helix loop helix transcription factor, HES-1, a mammalian counterpart of the Drosophila Hairy and Enhancer of split proteins. This interaction is mediated by the carboxyl-terminal domains of Cbfa1 and HES-1, but does not require their respective tetrapeptide motifs, WRPY and WRPW. Our studies also show that HES-1 can antagonize the binding of Cbfa1 to mammalian transcriptional corepressors of the Groucho family. Moreover, HES-1 can potentiate Cbfa1-mediated transactivation in transfected cells. Taken together, these findings implicate HES-1 in the transcriptional functions of Cbfa1 and suggest that the concerted activities of Groucho and HES proteins modulate the functions of mammalian Runt-related proteins.
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Metadata
- Authors
- McLarren, K. W., Lo, R., Grbavec, D., Thirunavukkarasu, K., Karsenty, G., & Stifani, S.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2000-01
- Volume
- 275
- Issue
- 1
- Pages
- 530-538
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1972942592
- Cited by
- 177
- References
- 7
- FWCI
- 5.75
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- McLarren, K. W., Lo, R., Grbavec, D., Thirunavukkarasu, K., Karsenty, G., & Stifani, S. (2000). The Mammalian Basic Helix Loop Helix Protein HES-1 Binds to and Modulates the Transactivating Function of the Runt-related Factor Cbfa1. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.275.1.530
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