The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
A Protein Encoded within the Down Syndrome Critical Region Is Enriched in Striated Muscles and Inhibits Calcineurin Signaling
Open accessAbstract
Here we describe a small family of proteins, termed MCIP1 and MCIP2 (for myocyte-enriched calcineurin interacting protein), that are expressed most abundantly in striated muscles and that form a physical complex with calcineurin A. MCIP1 is encoded by DSCR1, a gene located in the Down syndrome critical region. Expression of the MCIP family of proteins is up-regulated during muscle differentiation, and their forced overexpression inhibits calcineurin signaling to a muscle-specific target gene in a myocyte cell background. Binding of MCIP1 to calcineurin A requires sequence motifs that resemble calcineurin interacting domains found in NFAT proteins. The inhibitory action of MCIP1 involves a direct association with the catalytic domain of calcineurin, rather than interference with the function of downstream components of the calcineurin signaling pathway. The interaction between MCIP proteins and calcineurin may modulate calcineurin-dependent pathways that control hypertrophic growth and selective programs of gene expression in striated muscles.
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TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function
Rao, A., Luo, C., & Hogan, P. G. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.707 · Cited by 2,603
A Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy
Molkentin, J. D., Lu, J.-R., Antos, C. L., Markham, B., Richardson, J., Robbins, J., Grant, S. R., & Olson, E. N. (1998) · Cell · doi:10.1016/s0092-8674(00)81573-1 · Cited by 2,566
Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation
Clipstone, N. A., & Crabtree, G. R. (1992) · Nature · doi:10.1038/357695a0 · Cited by 1,637
Molecular diversity of myofibrillar proteins: gene regulation and functional significance
Schiaffino, S., & Reggiani, C. (1996) · Physiological Reviews · doi:10.1152/physrev.1996.76.2.371 · Cited by 1,545
Ca 2+ -Induced Apoptosis Through Calcineurin Dephosphorylation of BAD
Wang, H.-G., Pathan, N., Ethell, I. M., Krajewski, S., Yamaguchi, Y., Shibasaki, F., McKeon, F., Bobo, T., Franke, T. F., & Reed, J. C. (1999) · Science · doi:10.1126/science.284.5412.339 · Cited by 1,132
A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type
Chin, E. R., Olson, E. N., Richardson, J. A., Yang, Q., Humphries, C., Shelton, J. M., Wu, H., Zhu, W., Bassel-Duby, R., & Williams, R. S. (1998) · Genes & Development · doi:10.1101/gad.12.16.2499 · Cited by 1,011
Self-citationRegulation of the Calmodulin-stimulated Protein Phosphatase, Calcineurin
Klee, C. B., Ren, H., & Wang, X. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.22.13367 · Cited by 898
FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin
O'Keefe, S. J., Tamura, J., Kincaid, R. L., Tocci, M. J., & O'Neill, E. A. (1992) · Nature · doi:10.1038/357692a0 · Cited by 841
Generic Signals and Specific Outcomes
Crabtree, G. R. (1999) · Cell · doi:10.1016/s0092-8674(00)80571-1 · Cited by 731
The Proto-Oncogene c-maf Is Responsible for Tissue-Specific Expression of Interleukin-4
Ho, I.-C., Hodge, M. R., Rooney, J. W., & Glimcher, L. H. (1996) · Cell · doi:10.1016/s0092-8674(00)81299-4 · Cited by 667
Cited by
Fiber Types in Mammalian Skeletal Muscles
Schiaffino, S., & Reggiani, C. (2011) · Physiological Reviews · doi:10.1152/physrev.00031.2010 · Cited by 3,022
Transcriptional regulation by calcium, calcineurin, and NFAT
Hogan, P. G., Chen, L., Nardone, J., & Rao, A. (2003) · Genes & Development · doi:10.1101/gad.1102703 · Cited by 1,991
Crabtree, G. R., & Olson, E. N. (2002) · Cell · doi:10.1016/s0092-8674(02)00699-2 · Cited by 1,323
NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21
Arron, J. R., Winslow, M. M., Polleri, A., Chang, C.-P., Wu, H., Gao, X., Neilson, J. R., Chen, L., Heit, J. J., Kim, S. K., et al. (2006) · Nature · doi:10.1038/nature04678 · Cited by 698
Self-citationCommunication Between the Synapse and the Nucleus in Neuronal Development, Plasticity, and Disease
Cohen, S., & Greenberg, M. E. (2008) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.24.110707.175235 · Cited by 400
Metadata
- Authors
- Rothermel, B., Vega, R. B., Yang, J., Wu, H., Bassel-Duby, R., & Williams, R. S.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2000-03
- Volume
- 275
- Issue
- 12
- Pages
- 8719-8725
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1992967227
- Cited by
- 414
- References
- 49
- FWCI
- 8.90
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Rothermel, B., Vega, R. B., Yang, J., Wu, H., Bassel-Duby, R., & Williams, R. S. (2000). A Protein Encoded within the Down Syndrome Critical Region Is Enriched in Striated Muscles and Inhibits Calcineurin Signaling. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.275.12.8719
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