The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
The Xeroderma Pigmentosum Group C Protein Complex XPC-HR23B Plays an Important Role in the Recruitment of Transcription Factor IIH to Damaged DNA
Open accessAbstract
The xeroderma pigmentosum group C protein complex XPC-HR23B was first isolated as a factor that complemented nucleotide excision repair defects of XP-C cell extracts in vitro. Recent studies have revealed that this protein complex plays an important role in the early steps of global genome nucleotide excision repair, especially in damage recognition, open complex formation, and repair protein complex formation. However, the precise function of XPC-HR23B in global genome repair is still unclear. Here we demonstrate that XPC-HR23B interacts with general transcription factor IIH (TFIIH) both in vivo and in vitro. This interaction is thought to be mediated through the specific affinity of XPC for the TFIIH subunits XPB and/or p62, which are essential for both basal transcription and nucleotide excision repair. Interestingly, association of TFIIH with DNA was observed in both wild-type and XP-A cell extracts but not in XP-C cell extracts, and XPC-HR23B could restore the association of TFIIH with DNA in XP-C cell extracts. Moreover, we found that XPC-HR23B was necessary for efficient association of TFIIH with damaged DNA in cell-free extracts. We conclude that the XPC-HR23B protein complex plays a crucial role in the recruitment of TFIIH to damaged DNA in global genome repair.
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Cites
Sancar, A. (1996) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.65.070196.000355 · Cited by 1,131
Molecular mechanism of nucleotide excision repair
de Laat, W. L., Jaspers, N. G. J., & Hoeijmakers, J. H. J. (1999) · Genes & Development · doi:10.1101/gad.13.7.768 · Cited by 1,122
Sugasawa, K., Ng, J. M. Y., Masutani, C., Iwai, S., van der Spek, P. J., Eker, A. P. M., Hanaoka, F., Bootsma, D., & Hoeijmakers, J. H. J. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80132-x · Cited by 899
Self-citationMechanism of open complex and dual incision formation by human nucleotide excision repair factors
Evans, E., Moggs, J. G., Hwang, J. R., Egly, J., & Wood, R. D. (1997) · The EMBO Journal · doi:10.1093/emboj/16.21.6559 · Cited by 500
Reconstitution of Human DNA Repair Excision Nuclease in a Highly Defined System
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Self-citationPreferential binding of the xeroderma pigmentosum group A complementing protein to damaged DNA
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HHR23B, a Human Rad23 Homolog, Stimulates XPC Protein in Nucleotide Excision Repair In Vitro
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Cited by
Mechanisms of DNA damage, repair, and mutagenesis
Chatterjee, N., & Walker, G. C. (2017) · Environmental and Molecular Mutagenesis · doi:10.1002/em.22087 · Cited by 2,039
Understanding nucleotide excision repair and its roles in cancer and ageing
Marteijn, J. A., Lans, H., Vermeulen, W., & Hoeijmakers, J. H. J. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3822 · Cited by 1,192
Molecular Mechanisms of Mammalian Global Genome Nucleotide Excision Repair
Gillet, L. C. J., & Schärer, O. D. (2006) · Chemical Reviews · doi:10.1021/cr040483f · Cited by 642
A multistep damage recognition mechanism for global genomic nucleotide excision repair
Sugasawa, K., Okamoto, T., Shimizu, Y., Masutani, C., Iwai, S., & Hanaoka, F. (2001) · Genes & Development · doi:10.1101/gad.866301 · Cited by 435
Self-citationThe eukaryotic nucleotide excision repair pathway
Costa, R. (2003) · Biochimie · doi:10.1016/j.biochi.2003.10.017 · Cited by 373
Metadata
- Authors
- Yokoi, M., Masutani, C., Maekawa, T., Sugasawa, K., Ohkuma, Y., & Hanaoka, F.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2000-03
- Volume
- 275
- Issue
- 13
- Pages
- 9870-9875
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2070184329
- Cited by
- 280
- References
- 9
- FWCI
- 4.28
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: The Xeroderma Pigmentosum Group C Protein Complex XPC-HR23B Plays an Important Role in the Recruitment of Transcription Factor IIH to Damaged DNA. https://app.cochat.ai/papers/10.1074/jbc.275.13.9870
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- Yokoi, M., Masutani, C., Maekawa, T., Sugasawa, K., Ohkuma, Y., & Hanaoka, F. (2000). The Xeroderma Pigmentosum Group C Protein Complex XPC-HR23B Plays an Important Role in the Recruitment of Transcription Factor IIH to Damaged DNA. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.275.13.9870
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