The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Effects of Aging on Mitochondrial DNA Copy Number and Cytochromec Oxidase Gene Expression in Rat Skeletal Muscle, Liver, and Heart
Open accessAbstract
Mitochondrial DNA (mtDNA) deletions and mutations have been reported to occur with aging in various tissues. To determine the functional impact of these changes, we measured mtDNA copy number, mitochondria-encoded cytochrome c oxidase (COX) subunit I and III transcript levels, and COX enzyme activity in skeletal muscles (medial and lateral gastrocnemius and soleus), liver, and heart in 6- and 27-month-old rats. Substantial age-related reductions of mtDNA copy number occurred in skeletal muscle groups (-23-40%, p < 0.03) and liver (-50%, p < 0.01) but not in the heart. The decline in mtDNA was not associated with reduced COX transcript levels in tissues with high oxidative capacities such as red soleus muscle or liver, while transcript levels were reduced with aging in the less oxidative mixed fiber gastrocnemius muscle (-17-22%, p < 0.05). Consistent with transcript levels, COX activity also remained unchanged in aging liver and heart but declined with age in the lateral gastrocnemius (-32%, p < 0.05). Thus, the effects of aging on mitochondrial gene expression are tissue-specific. A substantial age-related decline in mtDNA copy number proportional to tissue oxidative capacities is demonstrated in skeletal muscle and liver. mtDNA levels are in contrast preserved in the aging heart muscle, presumably due to its incessant aerobic activity. Reduced mtDNA copy number has no major effects on mitochondrial encoded transcript levels and enzyme activities in various tissues under these base-line study conditions. In contrast, maintenance of mitochondrial transcript levels that may be linked to oxidative metabolism and energy demand appears to be the main determinant of mitochondrial oxidative capacity in aging tissues.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Age-associated alterations have been reported in skeletal muscle at both transcriptional and functional levels of mitochondrial gene expression (27).”
From Discovering pathways of sarcopenia in older adults: a role for insulin resistance on mitochondria dysfunction (2011) · cites this paper as [27]
In the citing paper
“Multiple groups have reported a decrease in skeletal muscle mitochondrial content and function with age.126-128”
From Hormonal and Metabolic Changes of Aging and the Influence of Lifestyle Modifications (2021) · cites this paper as [127]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Molecular cloning: A laboratory manual
Deininger, P. L. (1990) · Analytical Biochemistry · doi:10.1016/0003-2697(90)90595-z · Cited by 84,684
tRNA punctuation model of RNA processing in human mitochondria
Ojala, D., Montoya, J., & Attardi, G. M. (1981) · Nature · doi:10.1038/290470a0 · Cited by 2,561
Adaptations of skeletal muscle to endurance exercise and their metabolic consequences
Holloszy, J. O., & Coyle, E. F. (1984) · Journal of Applied Physiology · doi:10.1152/jappl.1984.56.4.831 · Cited by 1,985
Harman, D. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.11.7124 · Cited by 1,915
Mitochondrial Genetics: A Paradigm for Aging and Degenerative Diseases?
Wallace, D. C. (1992) · Science · doi:10.1126/science.1533953 · Cited by 1,262
Muscle fiber type composition of the rat hindlimb
Armstrong, R. B., & Phelps, R. O. (1984) · American Journal of Anatomy · doi:10.1002/aja.1001710303 · Cited by 1,004
Cardiovascular regulatory mechanisms in advanced age.
Lakatta, E. G. (1993) · Physiological Reviews · doi:10.1152/physrev.1993.73.2.413 · Cited by 791
Decline in skeletal muscle mitochondrial respiratory chain function: possible factor in ageing
Trounce, I., Byrne, E., & Marzuki, S. (1989) · The Lancet · doi:10.1016/s0140-6736(89)92143-0 · Cited by 730
Effect of age on in vivo rates of mitochondrial protein synthesis in human skeletal muscle
Rooyackers, O. E., Adey, D. B., Ades, P. A., & Nair, K. S. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.26.15364 · Cited by 564
Self-citationKarlson, P. (1974) · Biochemical Education · doi:10.1016/0307-4412(74)90015-6 · Cited by 541
Flagged first, then by citations
Research works printed but not linked: 4
- Murakami, 1994, Am. J. Physiol., 267, E388
- Ji, 1990, Am. J. Physiol., 258, R918
- Ji, 1991, Am. J. Physiol., 261, R386
- Fu, 1998, Am. J. Physiol., 275, E1023
Cited by
Sorted by citations
Items 101–200 of 368
Endangered species mitochondrial DNA loss as a mechanism of human disease
Gilkerson, R. (2011) · Frontiers in Bioscience-Scholar · doi:10.2741/428 · Cited by 77
Mitochondrial DNA involvement in human longevity
Santoro, A., Salvioli, S., Raule, N., Capri, M., Sevini, F., Valensin, S., Monti, D., Bellizzi, D., Passarino, G., Rose, G., et al. (2006) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2006.05.040 · Cited by 76
In vivo measurement of synthesis rate of individual skeletal muscle mitochondrial proteins
Jaleel, A., Short, K. R., Asmann, Y. W., Klaus, K. A., Morse, D. M., Ford, G. C., & Nair, K. S. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90586.2008 · Cited by 77
Self-citationMitophagy in maintaining skeletal muscle mitochondrial proteostasis and metabolic health with ageing
Drake, J. C., & Yan, Z. (2017) · The Journal of Physiology · doi:10.1113/jp274337 · Cited by 76
Choksi, K. B., & Papaconstantinou, J. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.01.032 · Cited by 70
Chou, Y.-F., Yu, C.-C., & Huang, R.-F. S. (2007) · Journal of Nutrition · doi:10.1093/jn/137.9.2036 · Cited by 72
Mitochondrial DNA damage and the aging process–facts and imaginations
Wiesner, R. J., Zsurka, G., & Kunz, W. S. (2006) · Free Radical Research · doi:10.1080/10715760600913168 · Cited by 69
Impact of aging on mitochondrial function in cardiac and skeletal muscle
Hepple, R. T. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.03.017 · Cited by 71
Chow, L. S., Greenlund, L. J., Asmann, Y. W., Short, K. R., McCrady, S. K., Levine, J. A., & Nair, K. S. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00791.2006 · Cited by 87
Self-citationImpact of Lifelong Sedentary Behavior on Mitochondrial Function of Mice Skeletal Muscle
Figueiredo, P., Powers, S. K., Ferreira, R. M., Amado, F. M. L., Appell, H.-J., & Duarte, J. A. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/glp066 · Cited by 71
Huang, J. H., & Hood, D. A. (2009) · IUBMB Life · doi:10.1002/iub.164 · Cited by 71
Changes in uncoupling protein-2 and -3 expression in aging rat skeletal muscle, liver, and heart
Barazzoni, R., & Nair, K. S. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.280.3.e413 · Cited by 66
Self-citationHoeks, J., Briedé, J. J., de Vogel, J., Schaart, G., Nabben, M., Moonen-Kornips, E., Hesselink, M. K. C., & Schrauwen, P. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.01.013 · Cited by 63
Muscle Protein Metabolism and the Sarcopenia of Aging
Short, K. R., & Nair, K. S. (2001) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.11.s1.s119 · Cited by 63
Self-citationHarper, C., Gopalan, V., & Goh, J. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-02737-1 · Cited by 68
Age- and calorie restriction-related changes in rat brain mitochondrial DNA and TFAM binding
Picca, A., Fracasso, F., Pesce, V., Cantatore, P., Joseph, A.-M., Leeuwenburgh, C., Gadaleta, M. N., & Lezza, A. M. S. (2012) · AGE · doi:10.1007/s11357-012-9465-z · Cited by 63
Androgen Therapy Induces Muscle Protein Anabolism in Older Women
Sheffield‐Moore, M., Paddon‐Jones, D., Casperson, S. L., Gilkison, C. R., Volpi, E., Wolf, S. E., Jiang, J., Rosenblatt, J. I., & Urban, R. J. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0588 · Cited by 61
Li, Z., Hu, M., Zong, X., Hé, Y., Wang, D., Dai, L., Dong, M., Zhou, J., Cao, H., Lv, L., et al. (2015) · Scientific Reports · doi:10.1038/srep18553 · Cited by 61
Murase, T., Haramizu, S., Ota, N., & Hase, T. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00880.2007 · Cited by 59
Sampath, H., Batra, A. K., Vartanian, V. L., Carmical, J. R., Prusak, D. J., King, I. B., Lowell, B., Earley, L. F., Wood, T. G., Marks, D. L., et al. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00387.2010 · Cited by 59
Mitochondria and the aging heart
Chaudhary, K. R., El-Sikhry, H. E., & Seubert John, M. (2011) · 老年心脏病学杂志:英文版 · doi:10.3724/sp.j.1263.2011.00159 · Cited by 57
The mitochondria in lung fibrosis: friend or foe?
Malsin, E. S., & Kamp, D. W. (2018) · Translational research · doi:10.1016/j.trsl.2018.05.005 · Cited by 56
Bioenergetics of aging and calorie restriction
Hunt, N. D., Hyun, D., Allard, J. S., Minor, R. K., Mattson, M. P., Ingram, D. K., & de Cabo, R. (2006) · Ageing Research Reviews · doi:10.1016/j.arr.2006.03.006 · Cited by 55
Mitochondrial and skeletal muscle health with advancing age
Konopka, A. R., & Nair, K. S. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.05.008 · Cited by 57
Self-citationAssociation between Risk Factors for Vascular Dementia and Adiponectin
Song, J., Lee, W. T., Park, K. A., & Lee, J. E. (2014) · BioMed Research International · doi:10.1155/2014/261672 · Cited by 58
High Rate of Large Deletions in Caenorhabditis briggsae Mitochondrial Genome Mutation Processes
Howe, D. K., Baer, C. F., & Denver, D. R. (2009) · Genome Biology and Evolution · doi:10.1093/gbe/evp055 · Cited by 52
Laubenthal, L., Hoelker, M., Frahm, J., Dänicke, S., Gerlach, K., Südekum, K., Sauerwein, H., & Häussler, S. (2015) · Journal of Dairy Science · doi:10.3168/jds.2015-9847 · Cited by 52
Age-Related Mitochondrial DNA Deletion in Rat Liver Depends on Dietary Fat Unsaturation
Quiles, J. L., Ochoa, J. J., Ramírez-Tortosa, M. C., Huertas, J. R., & Mataix, J. (2006) · The Journals of Gerontology Series A · doi:10.1093/gerona/61.2.107 · Cited by 52
Wang, H., Yang, J., Boykin, L. M., Zhao, Q., Li, Q., Wang, X., & Liu, S. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-401 · Cited by 51
Human Skeletal Muscle Aging and the Oxidative System: Cellular Events
Rossi, P., Marzani, B., Giardina, S., Negro, M., & Marzatico, F. (2008) · Current Aging Science · doi:10.2174/1874609810801030182 · Cited by 54
Changes of Mitochondrial DNA Content in the Male Offspring of Protein‐Malnourished Rats
Park, H. K., Jin, C. J., Cho, Y. M., Park, D. J., Shin, C. S., Park, K. S., KIM, S. Y., Cho, B. Y., & Lee, H. K. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1293.021 · Cited by 51
Mitochondria as the Essence of Yang Qi in the Human Body
Luo, J., Shiwei, S., Xia, J., Wang, J., & Gu, Z. (2022) · Phenomics · doi:10.1007/s43657-022-00060-3 · Cited by 52
Effect of reproductive ageing on pregnant mouse uterus and cervix
Patel, R., Moffatt, J. D., Mourmoura, E., Demaison, L., Seed, P. T., Poston, L., & Tribe, R. M. (2017) · The Journal of Physiology · doi:10.1113/jp273350 · Cited by 48
Liegro, C. M. D., Bellafiore, M., Izquierdo, J. M., RANTANEN, A., & Cuezva, J. M. (2000) · Biochemical Journal · doi:10.1042/0264-6021:3520109 · Cited by 48
Long-term cadmium exposure accelerates age-related mitochondrial changes in renal epithelial cells
Takaki, A., Jimi, S., Segawa, M., Hisano, S., Takebayashi, S., & Iwasaki, H. (2004) · Toxicology · doi:10.1016/j.tox.2004.06.005 · Cited by 47
Toda, K., Takeda, S., Hitoe, S., Nakamura, S., Matsuda, H., & Shimoda, H. (2015) · Journal of Natural Medicines · doi:10.1007/s11418-015-0948-y · Cited by 46
Chen, Q., Thompson, J., Hu, Y., & Lesnefsky, E. J. (2021) · Aging · doi:10.18632/aging.202858 · Cited by 45
McComsey, G. A., Libutti, D. E., O’Riordan, M., Shelton, J. M., Storer, N. J., Ganz, J. C., Jasper, J. J., Harrill, D., & Gerschenson, M. (2008) · Antiviral Therapy · doi:10.1177/135965350801300511 · Cited by 45
Aging-associated changes in cardiac gene expression
Volkova, M. V., Garg, R., DICK, S., & Boheler, K. R. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.11.016 · Cited by 44
Picca, A., Pesce, V., Fracasso, F., Joseph, A.-M., Leeuwenburgh, C., & Lezza, A. M. S. (2014) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2014.03.004 · Cited by 44
Effects of aging on basal fat oxidation in obese humans
Solomon, T. P. J., Marchetti, C. M., Krishnan, R. K., González, F., & Kirwan, J. P. (2008) · Metabolism · doi:10.1016/j.metabol.2008.03.021 · Cited by 44
The contradictory role of branched-chain amino acids in lifespan and insulin resistance
He, Y., Li, K., Wei, J., Lin, Y., & Liu, Y. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1189982 · Cited by 46
Memon, A. A., Sundquist, J., Hedelius, A., Palmér, K., Wang, X., & Sundquist, K. (2021) · Scientific Reports · doi:10.1038/s41598-021-84132-w · Cited by 44
Regulation of Skeletal Muscle Mitochondrial Content During Aging
Lyons, C. N., Mathieu-Costello, O. A., & Moyes, C. D. (2006) · The Journals of Gerontology Series A · doi:10.1093/gerona/61.1.3 · Cited by 43
Is defective electron transport at the hub of aging?
Maklashina, E., & Ackrell, B. A. C. (2003) · Aging Cell · doi:10.1111/j.1474-9728.2003.00078.x · Cited by 43
Mitochondrial Dysfunction in Cardiovascular Aging
Hoppel, C. L., Lesnefsky, E. J., Chen, Q., & Tandler, B. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-55330-6_24 · Cited by 44
Age-dependent Bupivacaine-induced Muscle Toxicity during Continuous Peripheral Nerve Block in Rats
Nouette‐Gaulain, K., Dadure, C., Morau, D., Pertuiset, C., Galbès, O., Hayot, M., Mercier, J. G., Sztark, F., Rossignol, R., & Capdevila, X. (2009) · Anesthesiology · doi:10.1097/aln.0b013e3181bbc949 · Cited by 41
An alternate form of Ku80 is required for DNA end-binding activity in mammalian mitochondria
Coffey, G. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.19.3793 · Cited by 41
Cardiac ageing: from hallmarks to therapeutic opportunities
Hastings, M. H., Zhou, Q., Wu, C., Shabani, P., Huang, S., Yu, X., Singh, A. P., Guseh, J. S., Li, H., Lerchenmüller, C., et al. (2024) · Cardiovascular Research · doi:10.1093/cvr/cvae124 · Cited by 42
Bharadwaj, M. S., Tyrrell, D. J., Leng, I., Demons, J. L., Lyles, M. F., Carr, J. J., Nicklas, B. J., & Molina, A. J. A. (2015) · BMC Obesity · doi:10.1186/s40608-015-0070-4 · Cited by 41
The variability of the mitochondrial genome in human aging: a key for life and death?
Rose, G., Passarino, G., Franceschi, C., & BENEDICTIS, G. D. (2002) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(02)00042-0 · Cited by 40
Barazzoni, R., Zanetti, M., Bosutti, A., Biolo, G., Serdoz, L. V., Stebel, M., & Guarnieri, G. (2004) · Endocrinology · doi:10.1210/en.2004-1396 · Cited by 42
Self-citationQi, Z., He, J., Su, Y., He, Q., Liu, J., Yu, L., Al-Attas, O. S., Hussain, T., Ding, S., Ji, L., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021140 · Cited by 40
Aging is a deprivation syndrome driven by a germ–soma conflict
Heininger, K. (2002) · Ageing Research Reviews · doi:10.1016/s1568-1637(02)00015-6 · Cited by 40
de Oliveira, B. L., & Niederer, S. (2016) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1005214 · Cited by 37
Skeletal Muscle in Hypoxia and Inflammation: Insights on the COVID-19 Pandemic
Girolamo, F. G. D., Fiotti, N., Sisto, U. G., Nunnari, A., Colla, S., Mearelli, F., Vinci, P., Schincariol, P., & Biolo, G. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.865402 · Cited by 42
PCR-Based Determination of Mitochondrial DNA Copy Number in Multiple Species
Leuthner, T. C., Hartman, J. H., Ryde, I. T., & Meyer, J. N. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1433-4_8 · Cited by 32
Pesce, V., Cormio, A., Fracasso, F., Lezza, A. M. S., Cantatore, P., & Gadaleta, M. N. (2005) · The Journals of Gerontology Series A · doi:10.1093/gerona/60.6.715 · Cited by 36
Lund, K. C., & Wallace, K. B. (2004) · Cardiovascular Toxicology · doi:10.1385/ct:4:3:217 · Cited by 36
The role of DNA ‐ PK in aging and energy metabolism
Chung, J. H. (2018) · FEBS Journal · doi:10.1111/febs.14410 · Cited by 34
Pesce, V., Fracasso, F., Cassano, P., Lezza, A. M. S., Cantatore, P., & Gadaleta, M. N. (2010) · Rejuvenation Research · doi:10.1089/rej.2009.0955 · Cited by 35
Mitochondrial DNA Content in Human Omental Adipose Tissue
Lindinger, A., Peterli, R., Peters, T. T. A., Kern, B. E., von Flüe, M., Calame‐Christe, M., Hoch, M., Eberlé, A. N., & Lindinger, P. W. (2009) · Obesity Surgery · doi:10.1007/s11695-009-9987-3 · Cited by 35
Hawkins, T. D., Hagemeyer, J. C. G., Hoadley, K. D., Marsh, A. G., & Warner, M. E. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00128 · Cited by 35
Effect of Aging and Caloric Restriction on the Mitochondrial Proteome
Chang, J. H., Cornell, J. E., Remmen, H. V., Hakala, K., Ward, W. F., & Richardson, A. (2007) · The Journals of Gerontology Series A · doi:10.1093/gerona/62.3.223 · Cited by 35
Aging of Stem and Progenitor Cells: Mechanisms, Impact on Therapeutic Potential, and Rejuvenation
Nurković, J., Volarević, V., Lako, M., Armstrong, L., Arsenijević, N., & Stojković, M. (2015) · Rejuvenation Research · doi:10.1089/rej.2015.1676 · Cited by 34
When S -Nitrosylation Gets to Mitochondria: From Signaling to Age-Related Diseases
Montagna, C., Cirotti, C., Rizza, S., & Filomeni, G. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2019.7872 · Cited by 35
Lebrecht, D., Kirschner, J., Geist, A., Haberstroh, J., & Walker, U. A. (2009) · Cardiovascular Pathology · doi:10.1016/j.carpath.2009.06.006 · Cited by 34
Skeletal muscle mitochondrial protein metabolism and function in ageing and type 2 diabetes
Barazzoni, R. (2003) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-200401000-00015 · Cited by 34
Self-citationDigital PCR Quantitation of Muscle Mitochondrial DNA: Age, Fiber Type, and Mutation-Induced Changes
Herbst, A. J., Widjaja, K., Nguy, B., Lushaj, E. B., Moore, T. M., Hevener, A. L., McKenzie, D. I., Aiken, J. M., & Wanagat, J. (2017) · The Journals of Gerontology Series A · doi:10.1093/gerona/glx058 · Cited by 33
Sun, J., Longchamps, R. J., Piggott, D. A., Castellani, C. A., Sumpter, J. A., Brown, T. T., Mehta, S. H., Arking, D. E., & Kirk, G. D. (2018) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiy658 · Cited by 33
Haga, H., Matsuo, K., Yabuki, Y., Zhang, C., Han, F., & Fukunaga, K. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.104492 · Cited by 33
Mitochondrial-nuclear Cross-talk in the Aging and Failing Heart
Marín-García, J., Pi, Y., & Goldenthal, M. J. (2006) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-006-0584-6 · Cited by 33
Rat liver mitochondrial proteome: Changes associated with aging and acetyl-L-carnitine treatment
Musicco, C., Capelli, V., Pesce, V., Timperio, A. M., Calvani, M., Mosconi, L., Cantatore, P., & Gadaleta, M. N. (2011) · Journal of Proteomics · doi:10.1016/j.jprot.2011.05.041 · Cited by 31
Boudina, S. (2013) · Current Pharmaceutical Design · doi:10.2174/1381612811319320004 · Cited by 32
Branched-Chain Amino Acids: Metabolism, Physiological Function, and Application
Cynober, L., & Harris, R. A. (2006) · Cited by 32
Bakala, H., Ladouce, R., Baraibar, M. A., & Friguet, B. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.07.015 · Cited by 34
Kim, M., Haroon, S., Chen, G., Ding, D., Wanagat, J., Liu, L., Zhang, Y., White, K., Park, H.-J., Han, C. J., et al. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.110675 · Cited by 31
Zhao, L., Hu, Y., Liu, W. Y., Wu, H. W., Xiao, J., Zhang, C. M., Zhang, H., Zhang, X., Liu, J., Lu, X., et al. (2020) · Food Chemistry · doi:10.1016/j.foodchem.2020.126538 · Cited by 31
Visioli, F., Ingram, A., Beckman, J. S., Magnusson, K. R., & Hagen, T. M. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.12.008 · Cited by 31
Drew, B., & Leeuwenburgh, C. (2004) · Acta Physiologica Scandinavica · doi:10.1111/j.1365-201x.2004.01371.x · Cited by 32
Skeletal muscle mitochondrial dysfunction & diabetes.
Raghavakaimal, S., & Nair, K. S. (2007) · PubMed · Cited by 31
Self-citationFujisawa, Y., Napoli, E., Wong, S., Song, G., Yamaguchi, R., Matsui, T., Nagasaki, K., Ogata, T., & Giulivi, C. (2014) · BBA Clinical · doi:10.1016/j.bbacli.2014.12.003 · Cited by 30
Jin, C. J., Park, H. K., Cho, Y. M., Pak, Y. K., Lee, K., Kim, M., Friso, S., Choi, S., Park, K. S., & Lee, H. K. (2007) · Journal of Nutrition · doi:10.1093/jn/137.2.339 · Cited by 30
Ethanol feeding enhances age-related deterioration of the rat hepatic mitochondrion
Cahill, A., Hershman, S. H., Davies, A. M., & Sýkora, P. (2005) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00193.2005 · Cited by 30
de Cavanagh, E. M. V., Flores, I., Ferder, M., Inserra, F., & Ferder, L. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.08.007 · Cited by 30
Mechanisms of altered protein turnover in chronic diseases: a review of human kinetic studies
Biolo, G., Antonione, R., Barazzoni, R., Zanetti, M., & Guarnieri, G. (2003) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-200301000-00009 · Cited by 30
Self-citationDoes Aging Adversely Affect Muscle Mitochondrial Function?
Short, K. R., & Nair, K. S. (2001) · Exercise and Sport Sciences Reviews · doi:10.1097/00003677-200107000-00006 · Cited by 30
Self-citationTissue-Specific Effect of Age and Caloric Restriction Diet on Mitochondrial DNA Content
Cassano, P., Sciancalepore, A. G., Lezza, A. M. S., Leeuwenburgh, C., Cantatore, P., & Gadaleta, M. N. (2006) · Rejuvenation Research · doi:10.1089/rej.2006.9.211 · Cited by 29
Eya, J. C., Ashame, M. F., Pomeroy, C. F., Manning, B. B., & Peterson, B. C. (2012) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2012.05.019 · Cited by 28
Zhang, J., Block, E. R., & Patel, J. M. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(02)00075-1 · Cited by 28
Pilot study of mitochondrial bioenergetics in subjects with acute porphyrias
Dixon, N., Li, T., Marion, B., Faust, D., Dozier, S., Molina, A. J. A., Rudnick, S., & Bonkovsky, H. L. (2019) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2019.05.010 · Cited by 28
Effect of Creatine Supplementation Dosing Strategies on Aging Muscle Performance
Chami, J., & Candow, D. G. (2019) · The Journal of nutrition, health and aging · doi:10.1007/s12603-018-1148-8 · Cited by 27
Mitochondria and the Repurposing of Diabetes Drugs for Off-Label Health Benefits
Yip, J., Chiang, G. S. H., Lee, I. C. J., Lehming-Teo, R., Dai, K., Dongol, L., Wang, L. Y.-T., Teo, D. W. X., Seah, G. T., & Lehming, N. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26010364 · Cited by 30
Mitochondrial function, mitochondrial DNA and ageing: a reappraisal
Passarino, G., Rose, G., & Bellizzi, D. (2010) · Biogerontology · doi:10.1007/s10522-010-9294-3 · Cited by 26
Polydatin alleviates parkinsonism in MPTP-model mice by enhancing glycolysis in dopaminergic neurons
Zhang, S., Wang, S., Shi, X., & Feng, X. (2020) · Neurochemistry International · doi:10.1016/j.neuint.2020.104815 · Cited by 27
Differential expression and clinical significance of COX6C in human diseases.
Tian, B., Sun, W., Wang, S.-H., Liu, P., & Wang, Y. (2021) · Europe PMC (PubMed Central) · Cited by 26
Tissue-specific expression atlas of murine mitochondrial tRNAs
He, Q., He, X., Xiao, Y., Zhao, Q., Ye, Z., Cui, L., Chen, Y., & Guan, M. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100960 · Cited by 25
Chen, J., Zheng, Q., Peiffer, L. B., Hicks, J. L., Haffner, M. C., Rosenberg, A. Z., Levi, M., Wang, X. X., Özbek, B., Valle, J. A. B.-D., et al. (2020) · American Journal Of Pathology · doi:10.1016/j.ajpath.2020.03.018 · Cited by 26
Quantitative assessment of mitochondrial DNA copies from whole genome sequencing
Chu, H., Hsiao, W., Tsao, T. T.-H., Chang, C., Liu, Y.-W., Fan, C.-C., Lin, H., Chang, H.-H., Yeh, T.-J., Chen, J., et al. (2012) · BMC Genomics · doi:10.1186/1471-2164-13-s7-s5 · Cited by 26
Minet, A. D., & Gaster, M. (2012) · Biogerontology · doi:10.1007/s10522-012-9372-9 · Cited by 25
Metadata
- Authors
- Barazzoni, R., Short, K. R., & Nair, K. S.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Nair, K.Sreekumaran
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2000-02
- Volume
- 275
- Issue
- 5
- Pages
- 3343-3347
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2011919513
- Cited by
- 367
- References
- 37
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 7 · 2023: 8 · 2022: 18 · 2021: 18 · 2020: 13 · 2019: 15 · 2018: 11 · 2017: 12 · 2016: 12 · 2015: 11 · 2014: 17 · 2013: 17 · 2012: 20
- FWCI
- 4.70
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- ArTS Archivio della ricerca di Trieste (University of Trieste https://www.units.it/) (submittedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (R0 AG 09531, R01AG009531)
- National Center for Research Resources (RR-00585, M01RR000585)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- aging, mitochondrial DNA copy number, cytochrome c oxidase, mitochondrial gene expression, skeletal muscle, liver, heart, oxidative capacity, tissue-specific aging, gastrocnemius, soleus muscle
- MeSH terms
- Aging, Animals, Electron Transport Complex IV, DNA, Mitochondrial, Heart, Liver, Male, Rats, Inbred F344, Gene Expression, Muscle, Skeletal, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review