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Effects of Aging on Mitochondrial DNA Copy Number and Cytochromec Oxidase Gene Expression in Rat Skeletal Muscle, Liver, and Heart
Open accessAbstract
Mitochondrial DNA (mtDNA) deletions and mutations have been reported to occur with aging in various tissues. To determine the functional impact of these changes, we measured mtDNA copy number, mitochondria-encoded cytochrome c oxidase (COX) subunit I and III transcript levels, and COX enzyme activity in skeletal muscles (medial and lateral gastrocnemius and soleus), liver, and heart in 6- and 27-month-old rats. Substantial age-related reductions of mtDNA copy number occurred in skeletal muscle groups (-23-40%, p < 0.03) and liver (-50%, p < 0.01) but not in the heart. The decline in mtDNA was not associated with reduced COX transcript levels in tissues with high oxidative capacities such as red soleus muscle or liver, while transcript levels were reduced with aging in the less oxidative mixed fiber gastrocnemius muscle (-17-22%, p < 0.05). Consistent with transcript levels, COX activity also remained unchanged in aging liver and heart but declined with age in the lateral gastrocnemius (-32%, p < 0.05). Thus, the effects of aging on mitochondrial gene expression are tissue-specific. A substantial age-related decline in mtDNA copy number proportional to tissue oxidative capacities is demonstrated in skeletal muscle and liver. mtDNA levels are in contrast preserved in the aging heart muscle, presumably due to its incessant aerobic activity. Reduced mtDNA copy number has no major effects on mitochondrial encoded transcript levels and enzyme activities in various tissues under these base-line study conditions. In contrast, maintenance of mitochondrial transcript levels that may be linked to oxidative metabolism and energy demand appears to be the main determinant of mitochondrial oxidative capacity in aging tissues.
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“Age-associated alterations have been reported in skeletal muscle at both transcriptional and functional levels of mitochondrial gene expression (27).”
From Discovering pathways of sarcopenia in older adults: a role for insulin resistance on mitochondria dysfunction (2011) · cites this paper as [27]
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“Multiple groups have reported a decrease in skeletal muscle mitochondrial content and function with age.126-128”
From Hormonal and Metabolic Changes of Aging and the Influence of Lifestyle Modifications (2021) · cites this paper as [127]
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Citations
Cites
Molecular cloning: A laboratory manual
Deininger, P. L. (1990) · Analytical Biochemistry · doi:10.1016/0003-2697(90)90595-z · Cited by 84,684
tRNA punctuation model of RNA processing in human mitochondria
Ojala, D., Montoya, J., & Attardi, G. M. (1981) · Nature · doi:10.1038/290470a0 · Cited by 2,561
Adaptations of skeletal muscle to endurance exercise and their metabolic consequences
Holloszy, J. O., & Coyle, E. F. (1984) · Journal of Applied Physiology · doi:10.1152/jappl.1984.56.4.831 · Cited by 1,985
Harman, D. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.11.7124 · Cited by 1,915
Mitochondrial Genetics: A Paradigm for Aging and Degenerative Diseases?
Wallace, D. C. (1992) · Science · doi:10.1126/science.1533953 · Cited by 1,262
Muscle fiber type composition of the rat hindlimb
Armstrong, R. B., & Phelps, R. O. (1984) · American Journal of Anatomy · doi:10.1002/aja.1001710303 · Cited by 1,004
Cardiovascular regulatory mechanisms in advanced age.
Lakatta, E. G. (1993) · Physiological Reviews · doi:10.1152/physrev.1993.73.2.413 · Cited by 791
Decline in skeletal muscle mitochondrial respiratory chain function: possible factor in ageing
Trounce, I., Byrne, E., & Marzuki, S. (1989) · The Lancet · doi:10.1016/s0140-6736(89)92143-0 · Cited by 730
Effect of age on in vivo rates of mitochondrial protein synthesis in human skeletal muscle
Rooyackers, O. E., Adey, D. B., Ades, P. A., & Nair, K. S. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.26.15364 · Cited by 564
Self-citationKarlson, P. (1974) · Biochemical Education · doi:10.1016/0307-4412(74)90015-6 · Cited by 541
Research works printed but not linked: 4
- Murakami, 1994, Am. J. Physiol., 267, E388
- Ji, 1990, Am. J. Physiol., 258, R918
- Ji, 1991, Am. J. Physiol., 261, R386
- Fu, 1998, Am. J. Physiol., 275, E1023
Cited by
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MacKrell, J. G., Arias, E. B., & Cartee, G. D. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/gls194 · Cited by 25
Mao, P., Gallagher, P., Nedungadi, S., Mańczak, M., Shirendeb, U. P., Kohama, S. G., Ferguson, B. M., Park, B. S., & Reddy, P. H. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.10.014 · Cited by 26
Historical perspective of matrix metalloproteases
Pulkoski-Gross, A. E. (2015) · Frontiers in Bioscience-Scholar · doi:10.2741/s429 · Cited by 24
Samiullah, S., Roberts, J. R., & Wu, S. (2017) · Scientific Reports · doi:10.1038/s41598-017-06527-y · Cited by 23
Constantin‐Teodosiu, D., Constantin, D., Pelsers, M. M. A. L., Verdijk, L. B., van Loon, L. J. C., & Greenhaff, P. L. (2019) · International Journal of Obesity · doi:10.1038/s41366-019-0473-2 · Cited by 22
Gonzalez-Armenta, J. L., Li, N., Lee, R.-L., Lu, B., & Molina, A. J. A. (2020) · The Journals of Gerontology Series A · doi:10.1093/gerona/glaa299 · Cited by 23
Colom, B., Oliver, J., & García-Palmer, F. (2014) · The Journals of Gerontology Series A · doi:10.1093/gerona/glu014 · Cited by 22
Pansarasa, O., Felzani, G., Vecchiet, J., & Marzatico, F. (2002) · Experimental Gerontology · doi:10.1016/s0531-5565(02)00085-2 · Cited by 26
Chimienti, G., Picca, A., Fracasso, F., Russo, F., Orlando, A., Riezzo, G., Leeuwenburgh, C., Pesce, V., & Lezza, A. M. S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041665 · Cited by 24
Increased transcription of mitochondrial genes for Complex I in human platelets during ageing
Pich, M. M., Raule, N., Catani, L., Fagioli, M. E., Faenza, I., Cocco, L., & Lenaz, G. (2004) · FEBS Letters · doi:10.1016/s0014-5793(03)01520-5 · Cited by 22
The “fast” and the “slow” modes of mitochondrial DNA degradation
Shokolenko, I. N., Wilson, G. L., & ALEXEYEV, M. F. (2014) · Mitochondrial DNA Part A · doi:10.3109/19401736.2014.905829 · Cited by 22
Effects of hydrogen peroxide on mitochondrial gene expression of intestinal epithelial cells
Li, J. (2002) · World Journal of Gastroenterology · doi:10.3748/wjg.v8.i6.1117 · Cited by 22
Bioenergetics of the aging heart and skeletal muscles: Modern concepts and controversies
Tepp, K., Timohhina, N., Puurand, M., Klepinin, A., Chekulayev, V., Shevchuk, I., & Kaambre, T. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.04.001 · Cited by 21
Lopez-Bellón, S., Rodríguez-López, S., González-Reyes, J. A., Burón, M. I., de Cabo, R., & Villalba, J. M. (2022) · GeroScience · doi:10.1007/s11357-022-00574-8 · Cited by 19
Effect of aerobic exercise on mitochondrial DNA and aging
Eluamai, A., & Brooks, K. A. (2013) · Journal of Exercise Science & Fitness · doi:10.1016/j.jesf.2013.03.003 · Cited by 20
Vesco, A. P. D., Gasparino, E., Neto, A. R. O., Rossi, R. M., Soares, M. A. M., & da Silva, S. C. C. (2012) · Livestock Science · doi:10.1016/j.livsci.2012.11.005 · Cited by 20
The Association of Mitochondrial Content with Prevalent and Incident Type 2 Diabetes
Reiling, E., Ling, C., Uitterlinden, A. G., Riet, E. V. ‘., Welschen, L. M. C., Ladenvall, C., Almgren, P., Lyssenko, V., Nijpels, G., van Hove, E. C., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1775 · Cited by 20
Bioenergetic Changes during Differentiation of Human Embryonic Stem Cells along the Hepatic Lineage
Hopkinson, B. M., Desler, C., Kalisz, M., Vestentoft, P. S., Rasmussen, L. J., & Bisgaard, H. C. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/5080128 · Cited by 20
A ketogenic diet impacts markers of mitochondrial mass in a tissue specific manner in aged mice
Zhou, Z., Hagopian, K., López-Domínguez, J. A., Kim, K., Jasoliya, M., Roberts, M. N., Cortopassi, G. A., Showalter, M. R., Roberts, B. S., González-Reyes, J. A., et al. (2021) · Aging · doi:10.18632/aging.202834 · Cited by 19
Ridge, P. G., Maxwell, T. J., Foutz, S. J., Bailey, M. H., Corcoran, C. D., Tschanz, J. T., Norton, M. C., Munger, R. G., O’Brien, E., Kerber, R. A., et al. (2014) · BMC Bioinformatics · doi:10.1186/1471-2105-15-s7-s6 · Cited by 19
Fu, H., Shan, D., Li, J., Swallah, M. S., Yang, X., Ji, L., Wang, S., Gong, H., Lyu, B., & Yu, H. (2022) · Food & Function · doi:10.1039/d2fo02869g · Cited by 19
Mitochondrial biogenesis in organismal senescence and neurodegeneration
Daskalaki, I., & Tavernarakis, N. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111345 · Cited by 18
The Aging Athlete: Part 1, ???Boomeritis??? of the Lower Extremity
Prescott, J. W., & Yu, J. S. (2012) · American Journal of Roentgenology · doi:10.2214/ajr.12.8912 · Cited by 19
Tan, M. H., Gan, H. M., Bracken‐Grissom, H. D., Chan, T., Grandjean, F., & Austin, C. M. (2021) · Journal of Crustacean Biology · doi:10.1093/jcbiol/ruab009 · Cited by 18
Age and Diet Affect Gene Expression Profile in Canine Skeletal Muscle
Middelbos, I. S., Vester, B. M., Karr‐Lilienthal, L. K., Schook, L. B., & Swanson, K. S. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004481 · Cited by 18
Barazzoni, R., Zanetti, M., Bosutti, A., Stebel, M., Cattin, L., Biolo, G., & Guarnieri, G. (2004) · Clinical Nutrition · doi:10.1016/j.clnu.2004.06.007 · Cited by 18
Self-citationThe Mitochondrial Proteomic Signatures of Human Skeletal Muscle Linked to Insulin Resistance
Kruse, R., Sahebekhtiari, N., & Højlund, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155374 · Cited by 19
Wang, Q., Paunesku, T., & Woloschak, G. E. (2010) · Radiation and Environmental Biophysics · doi:10.1007/s00411-010-0270-8 · Cited by 17
Engeham, S., Mdaki, K. S., Jewell, K., Austin, R., Lehner, A. N., & Langley‐Evans, S. C. (2012) · Journal of Nutrition and Metabolism · doi:10.1155/2012/989037 · Cited by 17
Reijne, A. C., Čiapaitė, J., van Dijk, T. H., Havinga, R., van der Zee, E. A., Groen, A. K., Reijngoud, D., Bakker, B. M., & van Dijk, G. (2016) · PLoS ONE · doi:10.1371/journal.pone.0149419 · Cited by 17
Li, R., Zou, H., Jia, Y., & Zhao, R. (2013) · BMC Veterinary Research · doi:10.1186/1746-6148-9-87 · Cited by 16
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Gureev, A. P., Andrianova, N. V., Pevzner, I. B., Zorova, L. D., Chernyshova, E. V., Sadovnikova, I. S., Chistyakov, D. V., Popkov, V. A., Semenovich, D. S., Babenko, V. A., et al. (2022) · FEBS Journal · doi:10.1111/febs.16451 · Cited by 16
Hao, Z., Xu, G., Yuan, M., Tan, R., Xia, Y., Liu, Y., & Yin, X. (2022) · Nutrients · doi:10.3390/nu14183856 · Cited by 17
Quantitative changes in mitochondrial DNA copy number in various tissues of pigs during growth
Xie, Y., Jin, L. G., Chen, X. J., He, M., Wang, Y., Liu, R., Li, M., & Li, X. W. (2015) · Genetics and Molecular Research · doi:10.4238/2015.march.6.12 · Cited by 16
Li, C., White-Springer, S. H., Warren, L. K., & Wohlgemuth, S. E. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.11.022 · Cited by 16
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Zhang, R., Du, J., Xiao, Z., Jiang, Y., Jin, L., & Weng, Q. (2022) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-022-04801-0 · Cited by 17
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Wagatsuma, A., & Sakuma, K. (2012) · Journal of Aging Research · doi:10.1155/2012/768304 · Cited by 15
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Błasiak, J. (2010) · Frontiers in bioscience · doi:10.2741/3789 · Cited by 15
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Wang, P., Castellani, C. A., Yao, J., Huan, T., Bielak, L. F., Zhao, W., Haessler, J., Joehanes, R., Sun, X., Guo, X., et al. (2021) · Human Molecular Genetics · doi:10.1093/hmg/ddab240 · Cited by 12
Population-level expression variability of mitochondrial DNA-encoded genes in humans
Wang, G., Yang, E., Mandhan, I., Brinkmeyer‐Langford, C., & Cai, J. J. (2014) · European Journal of Human Genetics · doi:10.1038/ejhg.2013.293 · Cited by 13
Gianotti, T. F., Castaño, G. O., Gemma, C., Burgueño, A. L., Rosselli, M. S., Pirola, C. J., & Sookoian, S. C. (2011) · Metabolism · doi:10.1016/j.metabol.2010.12.008 · Cited by 13
Role of Akirin1 in the regulation of skeletal muscle fiber‐type switch
Rao, V. V., Sangiah, U., Mary, K. A., Akira, S., & Mohanty, A. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.28406 · Cited by 13
Mohamed, A. A. (2020) · Current Rheumatology Reviews · doi:10.2174/1573397116666200429113226 · Cited by 13
Long-term cycles of hypoxia and normoxia increase the contents of liver mitochondrial DNA in rats
Luo, Y., Guoshou, L., Chen, Y., Liu, F., Xu, G., Yin, J., & Gao, Y. (2012) · European Journal of Applied Physiology · doi:10.1007/s00421-012-2414-9 · Cited by 13
Chow, L. S., & Nair, K. S. (2005) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2005.07.007 · Cited by 13
Self-citationBajracharya, R., & Ballard, J. W. O. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.10.003 · Cited by 13
Pesce, V., Fracasso, F., Musicco, C., Lezza, A. M. S., Cantatore, P., & Gadaleta, M. N. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1297.077 · Cited by 13
Aging and diabetes: Mitochondrial dysfunction
Irving, B. A., & Nair, K. S. (2007) · Current Diabetes Reports · doi:10.1007/s11892-007-0039-x · Cited by 13
Self-citationAssociation of mitochondrial DNA copy number with self-rated health status
Takahashi, P. Y., Jenkins, G. D., Welkie, B. P., McDonnell, S. K., Evans, J. M., Cerhan, J. R., Olson, J. E., Thibodeau, S. N., Cicek, M. S., & Ryu, E. (2018) · The Application of Clinical Genetics · doi:10.2147/tacg.s167640 · Cited by 13
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Lee, H. K. (2001) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(01)00336-9 · Cited by 13
Ren, Y., & Zhu, S. (2022) · Frontiers in Plant Science · doi:10.3389/fpls.2022.970303 · Cited by 12
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Walrand, S., Short, K. R., Heemstra, L. A., Novak, C. M., Levine, J. A., Coenen-Schimke, J. M., & Nair, K. S. (2013) · The FASEB Journal · doi:10.1096/fj.13-239806 · Cited by 12
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D’Aquila, P., Rango, F. D., Guarasci, F., Mandalà, M., Corsonello, A., Bellizzi, D., & Passarino, G. (2020) · Nutrients · doi:10.3390/nu12020460 · Cited by 12
He, Y., Chen, X., Yan, D., Xiao, F., Lin, R., Liao, X.-P., Liu, Y.-W., Pu, S.-Y., Yu, Q., Sun, H., et al. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.07.026 · Cited by 12
Alzahrani, K., Licknack, T. J., Watson, D. L., Anthony, N. B., & Rhoads, D. D. (2019) · PLoS ONE · doi:10.1371/journal.pone.0205480 · Cited by 12
Heiby, J. C., & Ori, A. (2022) · Current Opinion in Systems Biology · doi:10.1016/j.coisb.2022.100416 · Cited by 11
Liu, C., Wu, X., Yang, H., Yu, L., & Zhang, Y. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.1054769 · Cited by 10
Houshmand, M., Zeinali, V., Hosseini, A., Seifi, A., Danaei, B., & Kamfar, S. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1203019 · Cited by 11
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Herbst, A. J., Hoang, A. N., Kim, C., Aiken, J. M., McKenzie, D. I., Goldwater, D. S., & Wanagat, J. (2021) · Rejuvenation Research · doi:10.1089/rej.2021.0052 · Cited by 10
Wu, S., Wu, Y., Chen, J., Zhuang, P., Zhang, Y., & Jiao, J. (2022) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2022.109202 · Cited by 12
Paula, D. P., & Andow, D. A. (2022) · Neotropical Entomology · doi:10.1007/s13744-022-01011-3 · Cited by 10
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Park, J. E., Kim, M. J., Ha, S. K., Hong, S. G., Oh, H. J., Kim, G. A., Park, E., Kang, J. T., Saadeldin, I. M., Jang, G., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041256 · Cited by 9
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Sadeesh, E. M., & Malik, A. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-09815-9 · Cited by 8
Liu, R.-F., Huang, X., Sun, Q., Hou, Z., Yang, W., Zhang, J., Zhang, P., Huang, L., Lu, Y., & Fu, Q. (2022) · Animals · doi:10.3390/ani12131706 · Cited by 8
Amino acid and protein metabolism in chronic renal failure
Nair, K. S. (2005) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2004.09.026 · Cited by 8
Self-citationSung, B., Jung, K. J., Song, H. S., Son, M. J., Yu, B. P., & Chung, H. Y. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.03.009 · Cited by 8
Murata, M., Miwa, Y., & Sato, I. (2009) · Okajimas Folia Anatomica Japonica · doi:10.2535/ofaj.86.93 · Cited by 8
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Park, H. K., Jin, C. J., Cho, Y. M., Park, D. J., Shin, C. S., Park, K. S., Kim, S. Y., Cho, B. Y., & Lee, H. K. (2004) · Springer eBooks · doi:10.1007/978-3-662-41088-2_21 · Cited by 8
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Witte, S., Boshnakovska, A., Özdemir, M., Chowdhury, A., Rehling, P., & Aich, A. (2023) · Biology Open · doi:10.1242/bio.059844 · Cited by 7
Li, Z. H., Zhang, P., Ma, H. K., Xu, W., Sun, J., Yan, B. L., Zhang, Q. Q., & Gao, H. (2018) · Crustaceana · doi:10.1163/15685403-00003816 · Cited by 7
Matsubara, Y., Miyama, Y., Imai, R., Oizumi, H., Miyazaki, S., Haneda, E., Mizuno, K., Omiya, Y., Ikeda, Y., & Mizoguchi, K. (2022) · Bioscience Biotechnology and Biochemistry · doi:10.1093/bbb/zbac052 · Cited by 8
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Santos, A. L., & Sinha, S. (2023) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-031-26576-1_15 · Cited by 8
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Damirchi, A., Babaei, P., Gholamali, M., & Ranjbar, K. (2012) · InTech eBooks · doi:10.5772/48411 · Cited by 7
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Münch, D., & Amdam, G. V. (2013) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-415823-8.00037-x · Cited by 7
Barazzoni, R., Zanetti, M., Sturnega, M., Stebel, M., Semolic, A., Pirulli, A., Vinci, P., Zentilin, L., Giacca, M., Cattin, L., et al. (2010) · Clinical Nutrition · doi:10.1016/j.clnu.2010.11.001 · Cited by 7
Self-citationSpadafora, D., Kozhukhar, N., & ALEXEYEV, M. F. (2016) · PLoS ONE · doi:10.1371/journal.pone.0152705 · Cited by 7
Gonzalez-Armenta, J. L., Bergstrom, J., Lee, J., Furdui, C. M., Nicklas, B. J., & Molina, A. J. A. (2023) · GeroScience · doi:10.1007/s11357-023-00855-w · Cited by 6
Direct quantification of mitochondrial DNA and its 4.9-kb common deletion without DNA purification
Peinnequin, A., Poyot, T., Dib, A., Aubourg, A., Mouret, C., & Demeilliers, C. (2010) · Analytical Biochemistry · doi:10.1016/j.ab.2010.10.010 · Cited by 6
Marcus, R. L., Westlen-Boyer, K., & LaStayo, P. C. (2011) · Elsevier eBooks · doi:10.1016/b978-0-323-02948-3.00023-7 · Cited by 6
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Metadata
- Authors
- Barazzoni, R., Short, K. R., & Nair, K. S.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Nair, K.Sreekumaran
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2000-02
- Volume
- 275
- Issue
- 5
- Pages
- 3343-3347
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2011919513
- Cited by
- 367
- References
- 37
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 7 · 2023: 8 · 2022: 18 · 2021: 18 · 2020: 13 · 2019: 15 · 2018: 11 · 2017: 12 · 2016: 12 · 2015: 11 · 2014: 17 · 2013: 17 · 2012: 20
- FWCI
- 4.70
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- ArTS Archivio della ricerca di Trieste (University of Trieste https://www.units.it/) (submittedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (R0 AG 09531, R01AG009531)
- National Center for Research Resources (RR-00585, M01RR000585)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- aging, mitochondrial DNA copy number, cytochrome c oxidase, mitochondrial gene expression, skeletal muscle, liver, heart, oxidative capacity, tissue-specific aging, gastrocnemius, soleus muscle
- MeSH terms
- Aging, Animals, Electron Transport Complex IV, DNA, Mitochondrial, Heart, Liver, Male, Rats, Inbred F344, Gene Expression, Muscle, Skeletal, Rats
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