The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Human and Mouse Fas (APO-1/CD95) Death Receptor Genes Each Contain a p53-responsive Element That Is Activated by p53 Mutants Unable to Induce Apoptosis
Open accessAbstract
p53 is a tumor suppressor protein that induces apoptosis at least in part through its ability to act as a sequence-specific transactivator. This work reports that intron 1 of the mouse Fas death receptor gene contains a p53-responsive element (p53RE) that matches the p53 consensus sequence and that is located between nucleotides +1704 and +1723 from the transcription initiation site. This element is specifically bound by p53 and functions as a p53-dependent enhancer in mammalian or in yeast reporter gene assays. Contrary to bax, another known pro-apoptotic p53-target gene, both mouse and human FAS p53REs are still activated by the discriminatory p53 mutants Pro-175 and Ala-143, a class of mutants unable to induce apoptosis. We propose that p53-dependent up-regulation of Fas does not induce apoptosis per se but sensitizes the cell to other pro-apoptotic signal(s). The functional conservation of p53-dependent Fas up-regulation argues strongly in favor of its biological importance and suggests that murine models may be used to study further the in vivo role of Fas in the p53 response.
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“TNF receptors include the p53-induced targets FAS47, 48, 49 and TNFRSF10A–D;38, 39 these can be activated by external stimuli such as binding with FASL or TNF-α, thereby leading to caspase-dependent apoptosis.178”
From Census and evaluation of p53 target genes (2017) · cites this paper as [48]
Citations
Cites
Molecular cloning: A laboratory manual
Deininger, P. L. (1990) · Analytical Biochemistry · doi:10.1016/0003-2697(90)90595-z · Cited by 84,684
WAF1, a potential mediator of p53 tumor suppression
El-Deiry, W. S., Tokino, T., Velculescu, V. E., Levy, D. B., Parsons, R., Trent, J. M., Lin, D., Mercer, W. E., Kinzler, K. W., & Vogelstein, B. (1993) · Cell · doi:10.1016/0092-8674(93)90500-p · Cited by 8,321
Transformation of intact yeast cells treated with alkali cations
Ito, H., Fukuda, Y., Murata, K., & Kimura, A. (1983) · Journal of Bacteriology · doi:10.1128/jb.153.1.163-168.1983 · Cited by 7,518
Lane, D. P. (1992) · Nature · doi:10.1038/358015a0 · Cited by 5,138
Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
Toshiyuki, M., & Reed, J. C. (1995) · Cell · doi:10.1016/0092-8674(95)90412-3 · Cited by 4,063
Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.
Greenblatt, M. S., Bennett, W. P., Hollstein, M., & Harris, C. C. (1994) · PubMed · Cited by 3,463
Gietz, R. D., & Sugino, A. (1988) · Gene · doi:10.1016/0378-1119(88)90185-0 · Cited by 2,901
Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations
Cho, Y., Gorina, S., Jeffrey, P. D., & Pavletich, N. P. (1994) · Science · doi:10.1126/science.8023157 · Cited by 2,559
A model for p53-induced apoptosis
Polyak, K., Xia, Y., Zweier, J. L., Kinzler, K. W., & Vogelstein, B. (1997) · Nature · doi:10.1038/38525 · Cited by 2,500
Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
Deng, C., Zhang, P., Wade Harper, J., Elledge, S. J., & Leder, P. (1995) · Cell · doi:10.1016/0092-8674(95)90039-x · Cited by 2,113
Flagged first, then by citations
Research works printed but not linked: 6
- Greenblatt, 1994, Cancer Res., 54, 4855
- Gottlieb, 1996, Biochim. Biophys. Acta, 1287, 77
- Waldman, 1995, Cancer Res., 55, 5187
- Fuchs, 1997, Cancer Res., 57, 2550
- May, 1989, Oncogene, 4, 1037
- Sheikh, 1998, Cancer Res., 58, 1593
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Items 101–131 of 131
Elevated levels of oxidative DNA damage activate p53 and caspases in brain of ayu with aging
Nagasaka, R., Okamoto, N., & Ushio, H. (2006) · Journal of Applied Ichthyology · doi:10.1111/j.1439-0426.2006.00740.x · Cited by 6
Sreedhar, A. S., Pardhasaradhi, B. V. V., Khar, A., & Srinivas, U. K. (2002) · Oncogene · doi:10.1038/sj.onc.1205504 · Cited by 5
Wu, R. T. Y., & Cheng, W. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-418680-4.00021-x · Cited by 4
Wang, H., Xu, Y., Lin, J., & Huang, Y. (2024) · Cancer Control · doi:10.1177/10732748241262190 · Cited by 2
Sun, M., Zheng, S., & Zhao, J. (2009) · Cited by 2
Silencing Ubiquitin-Specific Peptidase 10 Alleviates Persistent Corneal Epithelial Defect in Mice
Banerjee, A., Shaik, M. A., Tilstra-Smith, C., Castro, N., Reynoso-García, J., Zuber, M. E., & Bernstein, A. M. (2025) · American Journal Of Pathology · doi:10.1016/j.ajpath.2025.10.006 · Cited by 1
Characterization of Beryllium as a Novel Agent to Study Cell Cycle Arrest and Cellular Senescence
Gorjala, P. (2020) · Digital Scholarship - UNLV (University of Nevada Reno) · doi:10.34917/4332720 · Cited by 1
Bourdon, J., & Lane, D. P. (2007) · Wiley eBooks · doi:10.1002/9780470025079.chap223 · Cited by 1
Self-citationMutant IDH uncouples p53 from target gene regulation to disable tumor suppressionPreprint
Martin, C. P., Sullivan, W. B., Brinkman, J. A., Scoville, D. M., Yashinskie, J. J., Tian, S., Mezzadra, R., Ho, Y.-J., Koche, R. P., Baslan, T., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.30.615916 · Cited by 1
TRIM22/Staf50 - a novel target gene of the tumor suppressor p53
Obad, S. (2007) · Lund University Publications (Lund University) · Cited by 1
Chandrasekaran, Y. (2005) · Texas ScholarWorks (Texas Digital Library)
Relationship of Fas, FasL, p53 and bcl-2 expressions in human non-small cell lung carcinomas
Li, Y., Jiang, D., Zhao, J., Ge, J.-F., & Zheng, S. (2010) · International Conference on Biomedical Engineering and Informatics (BMEI) · doi:10.1109/bmei.2010.5639972
DNA damage-induced cell death : The role of caspase-2
Vakifahmetoglu, H. (2009) · Figshare
Fanucchi, S. (2011) · University of the Witwatersrand, Johannesburg Institutional Repository on DSpace (University of the Witwatersrand, Johannesburg)
Relationship of Fas FasL p53 and bcl-2 expressions in non-small cell lung carcinomas
Sun, M., Jiang, D., Zheng, S., & Zhao, J. (2009) · International Conference on Future BioMedical Information Engineering · doi:10.1109/fbie.2009.5405898
Targeting MDM2, the antagonist of the tumor suppressor p53
Sriraman, A. (2018) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-7056
The MDM2 oncoprotein antagonizes Poly(ADP-ribosyl)ation
Giansanti, C. (2023) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-9741
Rho, J. K., Choi, Y., Ryoo, B., Na, I. I., Yang, S. H., Kim, C. H., & Lee, J. C. (2023) · doi:10.1158/0008-5472.c.6495159
Rho, J. K., Choi, Y., Ryoo, B., Na, I. I., Yang, S. H., Kim, C. H., & Lee, J. C. (2023) · doi:10.1158/0008-5472.c.6495159.v1
Kontny, U., & Kovar, H. (2005) · Humana Press eBooks · doi:10.1385/1-59259-851-x:163
Qin, K., Helei, H., Liang, Y., & Zhang, X. (2020) · Figshare · doi:10.6084/m9.figshare.12144525
Qin, K., Helei, H., Liang, Y., & Zhang, X. (2020) · Figshare · doi:10.6084/m9.figshare.12144495
Qin, K., Helei, H., Liang, Y., & Zhang, X. (2020) · Figshare · doi:10.6084/m9.figshare.12144510
Qin, K., Helei, H., Liang, Y., & Zhang, X. (2020) · Figshare · doi:10.6084/m9.figshare.12144483
Qin, K., Helei, H., Liang, Y., & Zhang, X. (2020) · Figshare · doi:10.6084/m9.figshare.12144501
Qin, K., Helei, H., Liang, Y., & Zhang, X. (2020) · Figshare · doi:10.6084/m9.figshare.12144486
Qin, K., Helei, H., Liang, Y., & Zhang, X. (2020) · Figshare · doi:10.6084/m9.figshare.12144480
Qin, K., Helei, H., Liang, Y., & Zhang, X. (2020) · Figshare · doi:10.6084/m9.figshare.12144489
Qin, K., Hou, H., Liang, Y., & Zhang, X. (2020) · Figshare · doi:10.6084/m9.figshare.12144498
Qin, K., Hou, H., Liang, Y., & Zhang, X. (2020) · Figshare · doi:10.6084/m9.figshare.12144474
Qin, K., Hou, H., Liang, Y., & Zhang, X. (2020) · Figshare · doi:10.6084/m9.figshare.12144516
Metadata
- Authors
- Munsch, D., Watanabe-Fukunaga, R., Bourdon, J.-C., Nagata, S., May, E., Yonish-Rouach, E., & Reisdorf, P.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- The University of Osaka (JP)
- Corresponding author
- Reisdorf, Philippe
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2000-02
- Volume
- 275
- Issue
- 6
- Pages
- 3867-3872
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2022923458
- Cited by
- 131
- References
- 53
- Citations by year
- 2025: 1 · 2024: 5 · 2023: 3 · 2022: 2 · 2021: 1 · 2020: 14 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 1 · 2015: 3 · 2014: 2 · 2012: 3
- FWCI
- 6.92
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Discovery Research Portal (University of Dundee) (submittedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
- Keywords
- Fas, p53 response elements, p53, intron 1, mutant p53, apoptosis sensitization, Bax, tumor suppressor
- MeSH terms
- Animals, Cell Line, Humans, Mutation, Promoter Regions, Genetic, Protein Binding, Transfection, Transcriptional Activation, Tumor Suppressor Protein p53, Apoptosis, Genes, Reporter, fas Receptor, Mice
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