The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Akt Participation in the Wnt Signaling Pathway through Dishevelled
Open accessAbstract
Inactivation of glycogen synthase kinase 3beta (GSK3beta) and the resulting stabilization of free beta-catenin are critical steps in the activation of Wnt target genes. While Akt regulates GSK3alpha/beta in the phosphatidylinositide 3-OH kinase signaling pathway, its role in Wnt signaling is unknown. Here we report that expression of Wnt or Dishevelled (Dvl) increased Akt activity. Activated Akt bound to the Axin-GSK3beta complex in the presence of Dvl, phosphorylated GSK3beta and increased free beta-catenin levels. Furthermore, in Wnt-overexpressing PC12 cells, dominant-negative Akt decreased free beta-catenin and derepressed nerve growth factor-induced differentiation. Therefore, Akt acts in association with Dvl as an important regulator of the Wnt signaling pathway.
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1 retracted
Ruel, L., Stambolic, V., Ali, A., Manoukian, A. S., & Woodgett, J. R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.31.21790 · Cited by 84
RetractedCellular survival: a play in three Akts
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A simplified system for generating recombinant adenoviruses
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Wnt signaling: a common theme in animal development
Cadigan, K. M., & Nusse, R. (1997) · Genes & Development · doi:10.1101/gad.11.24.3286 · Cited by 2,567
Mechanism of activation and function of protein kinase B
Alessi, D. R., & Cohen, P. (1998) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(98)80062-2 · Cited by 743
Serine Phosphorylation-regulated Ubiquitination and Degradation of β-Catenin
Orford, K., Crockett, C., Jensen, J. P., Weissman, A. M., & Byers, S. W. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.40.24735 · Cited by 714
Protein Kinase B/Akt Participates in GLUT4 Translocation by Insulin in L6 Myoblasts
Wang, Q., Somwar, R., Bilan, P. J., Liu, Z., Jin, J., Woodgett, J. R., & Klip, A. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.6.4008 · Cited by 592
Mitogen inactivation of glycogen synthase kinase-3 β in intact cells via serine 9 phosphorylation
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Differential Regulation of Glycogen Synthase Kinase 3β by Insulin and Wnt Signaling
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Cited by
PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer
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The protein kinase B/Akt signalling pathway in human malignancy
Nicholson, K. M., & Anderson, N. G. (2002) · Cellular Signalling · doi:10.1016/s0898-6568(01)00271-6 · Cited by 1,639
The Hair Follicle as a Dynamic Miniorgan
Schneider, M. R., Schmidt-Ullrich, R., & Paus, R. (2009) · Current Biology · doi:10.1016/j.cub.2008.12.005 · Cited by 1,119
Fibroblasts in fibrosis: novel roles and mediators
Kendall, R. T., & Feghali-Bostwick, C. A. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00123 · Cited by 1,082
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Metadata
- Authors
- Fukumoto, S., Hsieh, C.-M., Maemura, K., Layne, M. D., Yet, S.-F., Lee, K.-H., Matsui, T., Rosenzweig, A., Taylor, W. G., Rubin, J. S., Perrella, M. A., & Lee, M.-E.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2001-05
- Volume
- 276
- Issue
- 20
- Pages
- 17479-17483
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2137395552
- Cited by
- 334
- References
- 35
- FWCI
- 5.21
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Fukumoto, S., Hsieh, C.-M., Maemura, K., Layne, M. D., Yet, S.-F., Lee, K.-H., Matsui, T., Rosenzweig, A., Taylor, W. G., Rubin, J. S., Perrella, M. A., & Lee, M.-E. (2001). Akt Participation in the Wnt Signaling Pathway through Dishevelled. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.c000880200
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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