The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Increased β-Oxidation but No Insulin Resistance or Glucose Intolerance in Mice Lacking Adiponectin
Open accessAbstract
Previous reports showed that recombinant fragments of adiponectin (adipo) displayed pharmacological effects when injected into rodents, but the relevance of these observations to the physiological function of adipo is unclear. We generated Adipo(-/-) mice by gene targeting. Adipo(-/-) mice are fertile with normal body and fat pad weights. Plasma glucose and insulin levels of Adipo(-/-) and Adipo(+/+) mice are similar under fasting conditions and during an intraperitoneal glucose tolerance test (GTT). Insulin tolerance test (ITT) also produces similar plasma glucose and insulin levels in the two groups of mice. Hyperinsulinemic-euglycemic clamp analysis showed that Adipo(-/-) and Adipo(+/+) mice have similar glucose infusion rates to maintain a similar serum glucose. High-fat diet feeding for 7 months led to similar weight gain and similar GTT and ITT responses. We next measured beta-oxidation and found it to be significantly increased in muscle and liver of Adipo(-/-) mice. In conclusion, our study indicates that absence of adipo causes increased beta-oxidation but does not cause glucose intolerance or insulin resistance in mice.
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Weyer, C., Funahashi, T., Tanaka, S., Hotta, K., Matsuzawa, Y., Pratley, R. E., & Tataranni, P. A. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.5.7463 · Cited by 3,541
The adipocyte-secreted protein Acrp30 enhances hepatic insulin action
Berg, A. H., Combs, T. P., Du, X., Brownlee, M., & Scherer, P. E. (2001) · Nature Medicine · doi:10.1038/90992 · Cited by 2,526
Havel, P. J. (2002) · Current Opinion in Lipidology · doi:10.1097/00041433-200202000-00008 · Cited by 575
Malonyl-CoA and the regulation of fatty acid oxidation in soleus muscle
ALAM, N., & SAGGERSON, E. D. (1998) · Biochemical Journal · doi:10.1042/bj3340233 · Cited by 141
Cited by
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Kadowaki, T. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29126 · Cited by 2,824
Adiponectin and Adiponectin Receptors
Kadowaki, T., & Yamauchi, T. (2005) · Endocrine Reviews · doi:10.1210/er.2005-0005 · Cited by 2,634
Adipocytes as regulators of energy balance and glucose homeostasis
Rosen, E. D., & Spiegelman, B. M. (2006) · Nature · doi:10.1038/nature05483 · Cited by 2,170
Adiponectin as an anti-inflammatory factor
Ouchi, N., & Walsh, K. (2007) · Clinica Chimica Acta · doi:10.1016/j.cca.2007.01.026 · Cited by 872
Inflammatory mechanisms in the regulation of insulin resistance
Tilg, H., & Moschen, A. R. (2008) · Molecular Medicine · doi:10.2119/2007-00119.tilg · Cited by 779
Metadata
- Authors
- Ma, K., Cabrero, A., Saha, P. K., Kojima, H., Li, L., Chang, B. H.-J., Paul, A., & Chan, L.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2002-09
- Volume
- 277
- Issue
- 38
- Pages
- 34658-34661
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2043419594
- Cited by
- 287
- References
- 4
- FWCI
- 13.07
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Ma, K., Cabrero, A., Saha, P. K., Kojima, H., Li, L., Chang, B. H.-J., Paul, A., & Chan, L. (2002). Increased β-Oxidation but No Insulin Resistance or Glucose Intolerance in Mice Lacking Adiponectin. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.c200362200
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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