Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome

Kadowaki, T.

doi:10.1172/jci29126

Cited by 2,824Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismPeroxisome Proliferator-Activated Receptors

Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome

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Kadowaki, T.·2006·Journal of Clinical Investigation

DOI 10.1172/jci29126PMC PMC1483172

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Abstract

Adiponectin is an adipokine that is specifically and abundantly expressed in adipose tissue and directly sensitizes the body to insulin. Hypoadiponectinemia, caused by interactions of genetic factors such as SNPs in the Adiponectin gene and environmental factors causing obesity, appears to play an important causal role in insulin resistance, type 2 diabetes, and the metabolic syndrome, which are linked to obesity. The adiponectin receptors, AdipoR1 and AdipoR2, which mediate the antidiabetic metabolic actions of adiponectin, have been cloned and are downregulated in obesity-linked insulin resistance. Upregulation of adiponectin is a partial cause of the insulin-sensitizing and antidiabetic actions of thiazolidinediones. Therefore, adiponectin and adiponectin receptors represent potential versatile therapeutic targets to combat obesity-linked diseases characterized by insulin resistance. This Review describes the pathophysiology of adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome.

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Reduced levels of adiponectin have also been associated with metabolic syndrome, dyslipidemia, and cardiovascular disease.
“Reduced levels of adiponectin have also been associated with metabolic syndrome, dyslipidemia, and cardiovascular disease [22].”
From Tirzepatide as monotherapy improved markers of beta-cell function and insulin sensitivity in type 2 diabetes (SURPASS-1). (2023) · cites this paper as [22]
Antidiabetic, anti-inflammatory, and antihypertensive effects have all been established to occur in response to adiponectin.
“Antidiabetic (162), anti-inflammatory (348), and antihypertensive (259) effects have all been established to occur in response to adiponectin.”
From Cardiac remodeling in obesity (2008) · cites this paper as [162]

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Blockade of the Renin-Angiotensin System Increases Adiponectin Concentrations in Patients With Essential Hypertension
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Testosterone Selectively Reduces the High Molecular Weight Form of Adiponectin by Inhibiting Its Secretion from Adipocytes
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Decreased plasma adiponectin concentration in patients with essential hypertension
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Polyunsaturated fatty acids of marine origin induce adiponectin in mice fed a high-fat diet
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Pioglitazone Ameliorates Insulin Resistance and Diabetes by Both Adiponectin-dependent and -independent Pathways
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Adiponectin and the Development of Type 2 Diabetes
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Hypoadiponectinemia is associated with visceral fat accumulation and insulin resistance in Japanese men with type 2 diabetes mellitus
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Increased β-Oxidation but No Insulin Resistance or Glucose Intolerance in Mice Lacking Adiponectin
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Genome-Wide Search for Type 2 Diabetes in Japanese Affected Sib-Pairs Confirms Susceptibility Genes on 3q, 15q, and 20q and Identifies Two New Candidate Loci on 7p and 11p
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Molecular structure of pulmonary surfactant protein D (SP-D).
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Osmotin Is a Homolog of Mammalian Adiponectin and Controls Apoptosis in Yeast through a Homolog of Mammalian Adiponectin Receptor
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Adiponectin, an Adipocyte-Derived Protein, Predicts Future Insulin Resistance: Two-Year Follow-Up Study in Japanese Population
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Comparison of Circulating Adiponectin and Proinflammatory Markers Regarding Their Association With Metabolic Syndrome in Japanese Men
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Conjugated linoleic acid enhances plasma adiponectin level and alleviates hyperinsulinemia and hypertension in Zucker diabetic fatty (fa/fa) rats
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Vascular and Metabolic Effects of Combined Therapy With Ramipril and Simvastatin in Patients With Type 2 Diabetes
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Matsuzawa, Y. (1997) · doi:10.1002/(sici)1099-0895(199703)13:1

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Authors: Kadowaki, T.
Affiliations: The University of Tokyo (JP)
Corresponding author: Kadowaki, T.
ORCID: Kadowaki, T.
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2006-07-03
Volume: 116
Issue: 7
Pages: 1784-1792
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci29126
PMC: PMC1483172
OpenAlex: W2076310317
Cited by: 2,824
References: 131
Citations by year: 2026: 64 · 2025: 72 · 2024: 98 · 2023: 97 · 2022: 92 · 2021: 166 · 2020: 137 · 2019: 130 · 2018: 139 · 2017: 137 · 2016: 159 · 2015: 162 · 2014: 198 · 2013: 214 · 2012: 197
FWCI: 18.81
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Japan Society for the Promotion of Science (10NP0201)
Topics: Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Keywords: adiponectin, adiponectin receptors, AdipoR1, AdipoR2, insulin resistance, type 2 diabetes, metabolic syndrome, hypoadiponectinemia, obesity, adipokines, thiazolidinediones, genetic polymorphism, adipose tissue
MeSH terms: Diabetes Mellitus, Type 2, Humans, Insulin Resistance, Receptors, Cell Surface, Polymorphism, Single Nucleotide, Metabolic Syndrome, Adiponectin, Receptors, Adiponectin

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Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome

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