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Pharmacologic Targeting or Genetic Deletion of Mitochondrial Cyclophilin D Protects from NSAID-Induced Small Intestinal Ulceration in Mice

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Post-Injury Treatment with NIM811 Promotes Recovery of Function in Adult Female Rats after Spinal Cord Contusion: A Dose-Response Study

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Mitochondrion as a Target of Astaxanthin Therapy in Heart Failure

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Matrix metalloproteinase inhibition protects CyPD knockout mice independently of RISK/mPTP signalling: a parallel pathway to protection

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The 18-kDa Translocator Protein Inhibits Vascular Cell Adhesion Molecule-1 Expression via Inhibition of Mitochondrial Reactive Oxygen Species

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Investigating the Mitochondrial Permeability Transition Pore in Disease Phenotypes and Drug Screening

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ABT-737 sensitizes curcumin-induced anti-melanoma cell activity through facilitating mPTP death pathway

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AICAR induces AMPK-independent programmed necrosis in prostate cancer cells

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Cyclophilin D Is Involved in the Regulation of Autophagy and Affects the Lifespan of P. anserina in Response to Mitochondrial Oxidative Stress

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Commentary: SPG7 is an essential and conserved component of the mitochondrial permeability transition pore

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Cyclosporine before PCI in Acute Myocardial Infarction

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Cell death induced by acute renal injury: a perspective on the contributions of accidental and programmed cell death

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The Importance of Humanized Yeast to Better Understand the Role of Bcl-2 Family in Apoptosis: Finding of Novel Therapeutic Opportunities

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Targeting Mitochondria to Control Ageing and Senescence

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Effects of permeability transition inhibition and decrease in cytochrome c content on doxorubicin toxicity in K562 cells

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Pharmacological screening and enzymatic assays for apoptosis

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A Calcineurin-Independent Mechanism of Angiogenesis Inhibition by a Nonimmunosuppressive Cyclosporin A Analog

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Dose and timing of injections for effective cyclosporine A pretreatment before renal ischemia reperfusion in mice

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Continuous Infusion of Phenelzine, Cyclosporine A, or Their Combination: Evaluation of Mitochondrial Bioenergetics, Oxidative Damage, and Cytoskeletal Degradation following Severe Controlled Cortical Impact Traumatic Brain Injury in Rats

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Interplay between NAD+ and acetyl‑CoA metabolism in ischemia-induced mitochondrial pathophysiology

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Slow activation of fast mitochondrial Ca2+ uptake by cytosolic Ca2+

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Heat shock protein 60 regulates yolk sac erythropoiesis in mice

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Dephosphorylation of the Rieske iron–sulfur protein after induction of the mitochondrial permeability transition

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Fatty Liver and Ischemia/Reperfusion: Are there Drugs Able to Mitigate Injury?

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Deregulation of mitochondrial functions provoked by long‐chain fatty acid accumulating in long‐chain 3‐hydroxyacyl‐CoA dehydrogenase and mitochondrial permeability transition deficiencies in rat heart – mitochondrial permeability transition pore opening as a potential contributing pathomechanism of cardiac alterations in these disorders

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Thyroid Stimulating Hormone Triggers Hepatic Mitochondrial Stress through Cyclophilin D Acetylation

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Opposite and tissue-specific effects of coenzyme Q2 on mPTP opening and ROS production between heart and liver mitochondria: Role of complex I

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Modulation of the matrix redox signaling by mitochondrial Ca2+

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Metabolite accumulation in VLCAD deficiency markedly disrupts mitochondrial bioenergetics and Ca2+ homeostasis in the heart

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Knockout of cyclophilin D in Ppif−/− mice increases stability of brain mitochondria against Ca2+ stress

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Immunophilin deficiency augments Ca2+-dependent glutamate release from mouse cortical astrocytes

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C0818, a novel curcumin derivative, induces ROS-dependent cytotoxicity in human hepatocellular carcinoma cells in vitro via disruption of Hsp90 function

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Effect of progesterone and its synthetic analogues on the activity of mitochondrial permeability transition pore in isolated rat liver mitochondria

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Uncoupling, metabolic inhibition and induction of mitochondrial permeability transition in rat liver mitochondria caused by the major long-chain hydroxyl monocarboxylic fatty acids accumulating in LCHAD deficiency

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Role of the permeability transition pore complex in lethal inter-organelle crosstalk

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Cyclophilin D promotes tubular cell damage and the development of interstitial fibrosis in the obstructed kidney

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Disease Outcome and Brain Metabolomics of Cyclophilin-D Knockout Mice in Sepsis

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Drug delivery platforms for neonatal brain injury

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Cyclophilin D in Mitochondrial Dysfunction: A Key Player in Neurodegeneration?

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Novel insights into the mitochondrial permeability transition

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Oxidative Stress and Inflammation in the Liver

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Infarct size reduction by cyclosporine A at reperfusion involves inhibition of the mitochondrial permeability transition pore but does not improve mitochondrial respiration

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The Haves and Have-Nots: The Mitochondrial Permeability Transition Pore across Species

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Postconditioning in Acute Myocardial Infarction Patients

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Mitochondrial Regulation of Plant Programmed Cell Death

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Impact of adenosine nucleotide translocase (ANT) proline isomerization on Ca2+-induced cysteine relative mobility/mitochondrial permeability transition pore

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The role of Cyclophilin D in learning and memory

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Discovery of non-peptidic small molecule inhibitors of cyclophilin D as neuroprotective agents in Aβ-induced mitochondrial dysfunction

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Carbon monoxide (CO) modulates hydrogen peroxide (H 2 O 2 )-mediated cellular dysfunction by targeting mitochondria in rabbit lens epithelial cells

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Divergent Effects of Cyclophilin-D Inhibition on the Female Rat Heart: Acute Versus Chronic Post-Myocardial Infarction

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Cyclophilin D Contributes to Anesthesia Neurotoxicity in the Developing Brain

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Role of arachidonic acid, lipoxygenase, and mitochondrial depolarization in reperfusion arrhythmias

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ATG7-enhanced impaired autophagy exacerbates acute pancreatitis by promoting regulated necrosis via the miR-30b-5p/CAMKII pathway

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Photo-Induction and Automated Quantification of Reversible Mitochondrial Permeability Transition Pore Opening in Primary Mouse Myotubes

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Probing the molecular mechanisms of neuronal degeneration: importance of mitochondrial dysfunction and calcineurin activation

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cis-4-Decenoic and decanoic acids impair mitochondrial energy, redox and Ca 2+ homeostasis and induce mitochondrial permeability transition pore opening in rat brain and liver: Possible implications for the pathogenesis of MCAD deficiency

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Lack of cyclophilin D protects against the development of acute lung injury in endotoxemia

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An Approach to Experimental Synaptic Pathology Using Green Fluorescent Protein-Transgenic Mice and Gene Knockout Mice to Show Mitochondrial Permeability Transition Pore-Driven Excitotoxicity in Interneurons and Motoneurons

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Mitochondrial Flashes: Elemental Signaling Events in Eukaryotic Cells

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Genetic deletion of p66shc and/or cyclophilin D results in decreased pulmonary vascular tone

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Cyclophilin D regulation of the mitochondrial permeability transition pore

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Absence of Ca2+-Induced Mitochondrial Permeability Transition but Presence of Bongkrekate-Sensitive Nucleotide Exchange in C. crangon and P. serratus

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Cell Death Pathways

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Cyclosporin A aggravates hydrogen peroxide-induced cell death in kidney proximal tubule epithelial cells

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Mitochondrial Calcium Signaling in Pancreatic β-Cell

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Protective effects of cyclosporine A and hypothermia on neuronal mitochondria in a rat asphyxial cardiac arrest model

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The effect of mitochondrial calcium uniporter and cyclophilin D knockout on resistance of brain mitochondria to Ca2+-induced damage

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Lipid droplets, autophagy, and ER stress as key (survival) pathways during ischemia‐reperfusion of transplanted grafts

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The Role of Cyclosporine in the Treatment of Myocardial Reperfusion Injury

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The yeast mitochondrial permeability transition is regulated by reactive oxygen species, endogenous Ca2+ and Cpr3, mediating cell death

Kamei, Y., Koushi, M., Aoyama, Y., & Asakai, R. (2018) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2018.07.004 · Cited by 19

Antioxidant and mitochondrial protective effects of oxidized metabolites of oltipraz

Choi, S. H., Kim, Y. M., Lee, J. M., & Kim, S. G. (2010) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425250903427972 · Cited by 18

Role of Mitochondria in Drug-Induced Cholestatic Injury

Kass, G. E. N., & Price, S. C. (2008) · Clinics in Liver Disease · doi:10.1016/j.cld.2007.11.005 · Cited by 19

Cardioprotection in the Clinical Setting

Ivanés, F., Mewton, N., Rioufol, G., Piot, C. A., Elbaz, M., Revel, D., Croisille, P., & Ovize, M. (2010) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-010-6243-y · Cited by 18

Role of Mitochondria in Neonatal Hypoxic-Ischemic Brain Injury.

Lu, Y., Tucker, D., Dong, Y., Zhao, N., Zhuo, X., & Zhang, Q. (2015) · PubMed · Cited by 18

Mitochondrial DNA: a molecular switch driving sterile neuroinflammation

Jauhari, A., Singh, T., Carlisle, D. L., & Friedlander, R. M. (2026) · Translational Neurodegeneration · doi:10.1186/s40035-026-00540-w · Cited by 20

Phosphate is not an absolute requirement for the inhibitory effects of cyclosporin A or cyclophilin D deletion on mitochondrial permeability transition

McGee, A. M., & Baines, C. P. (2012) · Biochemical Journal · doi:10.1042/bj20111881 · Cited by 17

Impaired F1Fo-ATP-Synthase Dimerization Leads to the Induction of Cyclophilin D-Mediated Autophagy-Dependent Cell Death and Accelerated Aging

Warnsmann, V., Marschall, L., & Osiewacz, H. D. (2021) · Cells · doi:10.3390/cells10040757 · Cited by 18

Developmental Changes of the Sensitivity of Cardiac and Liver Mitochondrial Permeability Transition Pore to Calcium Load and Oxidative Stress

Drahota, Z., Milerová, M., Endlicher, R., Rychtrmoc, D., Červinková, Z., & Ošťádal, B. (2012) · Physiological Research · doi:10.33549/physiolres.932377 · Cited by 17

Chloride channel blocker IAA-94 increases myocardial infarction by reducing calcium retention capacity of the cardiac mitochondria

Ponnalagu, D., Hussain, A. T., Thanawala, R., Meka, J., Bednarczyk, P., Feng, Y., Szewczyk, A. M., Rao, S. G., Bopassa, J. C., Khan, M., et al. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116841 · Cited by 17

Mitochondrial DNA Mutations, Apoptosis, and the Misfolded Protein Response

Mott, J. L., Zhang, D., & Zassenhaus, H. P. (2005) · Rejuvenation Research · doi:10.1089/rej.2005.8.216 · Cited by 16

The cyclophilin repertoire of the fission yeastSchizosaccharomyces pombe

Pemberton, T. J., & Kay, J. E. (2005) · Yeast · doi:10.1002/yea.1288 · Cited by 18

Down‐regulation of miRNA‐27b‐3p suppresses keratinocytes apoptosis in oral lichen planus

Chen, J., Wang, Y., Du, G., Zhang, W., Cao, T., Shi, L., Wang, Y., Mi, J., & Tang, G. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14324 · Cited by 16

Evaluation of (-)-epigallocatechin-3-gallate (EGCG)-induced cytotoxicity on astrocytes: A potential mechanism of calcium overloading-induced mitochondrial dysfunction

Miao, Y., Sun, X., Gao, G., Jia, X., Wu, H., Chen, Y., & Huang, L. (2019) · Toxicology in Vitro · doi:10.1016/j.tiv.2019.104592 · Cited by 16

Cyclophilin D participates in the inhibitory effect of high‐fat diet on the expression of steroidogenic acute regulatory protein

Su, X., Lin, D. X., Luo, D., Sun, M., Wang, X., Ye, J., Zhang, M., Zhang, Y., Xu, X., Yu, C., et al. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14569 · Cited by 16

Genetic Approach to Elucidate the Role of Cyclophilin D in Traumatic Brain Injury Pathology

Readnower, R. D., Hubbard, W. B., Kalimon, O. J., Geddes, J. W., & Sullivan, P. G. (2021) · Cells · doi:10.3390/cells10020199 · Cited by 15

The Role of Cyclophilins in Inflammatory Bowel Disease and Colorectal Cancer

Liang, L., Lin, R.-X., Xie, Y., Lin, H., Shao, F., Rui, W., & Chen, H. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.58671 · Cited by 17

Therapeutic strategies to protect the immature newborn myocardium during resuscitation following asphyxia

Gill, R. S., Pelletier, J., LaBossière, J., Bigam, D. L., & Cheung, P. (2012) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y2012-041 · Cited by 17

Electrophysiological characterization of the Cyclophilin D-deleted mitochondrial permeability transition pore

Marchi, U. D., Basso, E., Szabó, I., & Zoratti, M. (2006) · Molecular Membrane Biology · doi:10.1080/09687860600907644 · Cited by 53

Genetic Dissection of the Permeability Transition Pore

Forte, M. A., & Bernardi, P. (2005) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-005-6565-9 · Cited by 79

Untersuchungen zur Aktivität der mitochondrialen Permeabilitätstransitionspore in der Cyclophilin-D-Knock-out-Maus (Ppif-/-)

Ziemer, M. (2015) · Digitalen Hochschulbibliothek Sachsen-Anhalt (Universitäts- und Landesbibliothek Sachsen-Anhalt) · doi:10.25673/4298

Phosphate Is Essential for Inhibition of the Mitochondrial Permeability Transition Pore by Cyclosporin A and by Cyclophilin D Ablation

Basso, E., Petronilli, V., Forte, M. A., & Bernardi, P. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.c800132200 · Cited by 177

Cyclophilin D regulation of the mitochondrial permeability transition pore

Murphy, E. (2022) · Current Opinion in Physiology · doi:10.1016/j.cophys.2022.100486 · Cited by 19