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Inhibition of Vascular Permeability Factor/Vascular Endothelial Growth Factor-mediated Angiogenesis by the Kruppel-like Factor KLF2
Open accessAbstract
The Kruppel-like factor KLF2 was recently identified as a novel regulator of endothelial pro-inflammatory and pro-thrombotic function. Here it is shown that overexpression of KLF2 potently inhibits vascular permeability factor/vascular endothelial growth factor (VEGF-A)-mediated angiogenesis and tissue edema in the nude ear mouse model of angiogenesis. In vitro, KLF2 expression retards VEGF-mediated calcium flux, proliferation and induction of pro-inflammatory factors in endothelial cells. This effect is due to a potent inhibition of VEGFR2/KDR expression and promoter activity. These observations identify KLF2 as a regulator of VEGFR2/KDR and provide a foundation for novel approaches to regulate angiogenesis.
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Citations
Cited by
Mammalian Krüppel-Like Factors in Health and Diseases
McConnell, B. B., & Yang, V. W. (2010) · Physiological Reviews · doi:10.1152/physrev.00058.2009 · Cited by 1,018
Zeng, Z., Li, Y., Pan, Y., Lan, X., Song, F., Sun, J., Zhou, K., Liu, X., Ren, X., Wang, F., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07810-w · Cited by 992
Effects of shear stress on endothelial cells: go with the flow
Chistiakov, D. A., Orekhov, A. N., & Bobryshev, Y. V. (2017) · Acta Physiologica · doi:10.1111/apha.12725 · Cited by 431
Role of Krüppel-Like Transcription Factors in Endothelial Biology
Atkins, G. B., & Jain, M. K. (2007) · Circulation Research · doi:10.1161/01.res.0000267856.00713.0a · Cited by 419
Self-citationDekker, R. J., Boon, R. A., Rondaij, M. G., Kragt, A., Volger, O. L., Elderkamp, Y. W., Meijers, J. C. M., Voorberg, J., Pannekoek, H., & Horrevoets, A. J. G. (2006) · Blood · doi:10.1182/blood-2005-08-3465 · Cited by 353
Metadata
- Authors
- Bhattacharya, R., SenBanerjee, S., Lin, Z., Mir, S., Hamik, A., Wang, P., Mukherjee, P., Mukhopadhyay, D., & Jain, M. K.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2005-08
- Volume
- 280
- Issue
- 32
- Pages
- 28848-28851
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2058328321
- Cited by
- 174
- References
- 0
- FWCI
- 1.61
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Inhibition of Vascular Permeability Factor/Vascular Endothelial Growth Factor-mediated Angiogenesis by the Kruppel-like Factor KLF2. https://app.cochat.ai/papers/10.1074/jbc.c500200200
- The paper
- Bhattacharya, R., SenBanerjee, S., Lin, Z., Mir, S., Hamik, A., Wang, P., Mukherjee, P., Mukhopadhyay, D., & Jain, M. K. (2005). Inhibition of Vascular Permeability Factor/Vascular Endothelial Growth Factor-mediated Angiogenesis by the Kruppel-like Factor KLF2. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.c500200200
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
