Regulation of GREB1 Transcription by Estrogen Receptor α through a Multipartite Enhancer Spread Over 20 kb of Upstream Flanking Sequences

The nuclear receptor superfamily: the second decade

Mangelsdorf, D. J., Thummel, C., Beato, M., Herrlich, P., Schütz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90199-x · Cited by 6,964 · see citing works

Capturing Chromosome Conformation

Dekker, J., Rippe, K., Dekker, M., & Kleckner, N. (2002) · Science · doi:10.1126/science.1067799 · Cited by 3,652 · see citing works

Estrogen Receptor Null Mice: What Have We Learned and Where Will They Lead Us?

Couse, J. F., & Korach, K. S. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.3.0370 · Cited by 2,045 · see citing works

Cofactor Dynamics and Sufficiency in Estrogen Receptor–Regulated Transcription

Shang, Y., Hu, X., DiRenzo, J., Lazar, M. A., & Brown, M. A. (2000) · Cell · doi:10.1016/s0092-8674(00)00188-4 · Cited by 1,647 · see citing works

Estrogen Actions in the Central Nervous System

McEwen, B. S., & Alves, S. E. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.3.0365 · Cited by 1,483 · see citing works

Estrogen Receptor-α Directs Ordered, Cyclical, and Combinatorial Recruitment of Cofactors on a Natural Target Promoter

Métivier, R., Penot, G., Hübner, M. R., Reid, G., Brand, H., Koš, M., & Gannon, F. (2003) · Cell · doi:10.1016/s0092-8674(03)00934-6 · Cited by 1,431 · see citing works

Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1

Carroll, J. S., Liu, X. S., Brodsky, A. S., Li, W., Meyer, C. A., Szary, A. J., Eeckhoute, J., Shao, W., Hestermann, E. V., Geistlinger, T. R., et al. (2005) · Cell · doi:10.1016/j.cell.2005.05.008 · Cited by 1,384 · see citing works

Genome-wide analysis of estrogen receptor binding sites

Carroll, J. S., Meyer, C. A., Song, J. S., Li, W., Geistlinger, T., Eeckhoute, J., Brodsky, A. S., Keeton, E. K., Fertuck, K. C., Hall, G., et al. (2006) · Nature Genetics · doi:10.1038/ng1901 · Cited by 1,368 · see citing works

Estrogen receptor interaction with estrogen response elements

Klinge, C. M. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.14.2905 · Cited by 1,087 · see citing works

Estrogens, Progestogens, Normal Breast Cell Proliferation, and Breast Cancer Risk

Pike, M. C., SPICER, D. V., Dahmoush, L., & Press, M. F. (1993) · Epidemiologic Reviews · doi:10.1093/oxfordjournals.epirev.a036102 · Cited by 1,009 · see citing works

Sources of estrogen and their importance

Simpson, E. R. (2003) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(03)00360-1 · Cited by 936 · see citing works

Profiling of Estrogen Up- and Down-Regulated Gene Expression in Human Breast Cancer Cells: Insights into Gene Networks and Pathways Underlying Estrogenic Control of Proliferation and Cell Phenotype

Frasor, J. M., Danes, J. M., Komm, B. S., Chang, K. C. N., Lyttle, C. R., & Katzenellenbogen, B. S. (2003) · Endocrinology · doi:10.1210/en.2003-0567 · Cited by 875 · see citing works

Endocrine-responsive breast cancer and strategies for combating resistance

Ali, S., & Coombes, R. C. (2002) · Nature reviews. Cancer · doi:10.1038/nrc721 · Cited by 867 · see citing works

The nuclear receptor superfamily

Robinson‐Rechavi, M., Escrivá, H., & Laudet, V. (2003) · Journal of Cell Science · doi:10.1242/jcs.00247 · Cited by 588 · see citing works

c-MYC induces mammary tumorigenesis by means of a preferred pathway involving spontaneous Kras2 mutations

D'Cruz, C., Gunther, E., Boxer, R. B., Hartman, J., Sintasath, L., Moody, S., Cox, J. D., Seung, H. I., Belka, G., Golant, A., et al. (2001) · Nature Medicine · doi:10.1038/84691 · Cited by 439 · see citing works

Comparison of Fulvestrant Versus Tamoxifen for the Treatment of Advanced Breast Cancer in Postmenopausal Women Previously Untreated With Endocrine Therapy: A Multinational, Double-Blind, Randomized Trial

Howell, A., Robertson, J. F. R., Abram, P., Lichinitser, M., Elledge, R. M., Bajetta, E., Watanabe, T., Morris, C. Q., Webster, A., Dimery, I. W., et al. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.02.112 · Cited by 422 · see citing works

Genome-Wide Identification of High-Affinity Estrogen Response Elements in Human and Mouse

Bourdeau, V., Deschênes, J., Métivier, R., Nagai, Y., Nguyen, D., Bretschneider, N., Gannon, F., White, J. H., & Mader, S. (2004) · Molecular Endocrinology · doi:10.1210/me.2003-0441 · Cited by 361 · see citing works

Discovery of estrogen receptor α target genes and response elements in breast tumor cells

Lin, C., Ström, A., Vega, V. B., Kong, S. L., Yeo, A. L., Thomsen, J. S., Chan, W. C., Doray, B., Bangarusamy, D. K., Ramasamy, A., et al. (2004) · Genome biology · doi:10.1186/gb-2004-5-9-r66 · Cited by 303 · see citing works

GREB1 is a critical regulator of hormone dependent breast cancer growth

Rae, J. M., Johnson, M. D., Scheys, J. O., Cordero, K. E., Larios, J. M., & Lippman, M. E. (2005) · Breast Cancer Research and Treatment · doi:10.1007/s10549-005-1483-4 · Cited by 251 · see citing works

Downstream targets of growth factor and oestrogen signalling and endocrine resistance: the potential roles of c-Myc, cyclin D1 and cyclin E

Butt, A. J., McNeil, C. M., Musgrove, E. A., & Sutherland, R. L. (2005) · Endocrine Related Cancer · doi:10.1677/erc.1.00993 · Cited by 244 · see citing works

PDZK1 and GREB1 are estrogen-regulated genes expressed in hormone-responsive breast cancer.

Ghosh, M., Thompson, D. A., & Weigel, R. J. (2000) · PubMed · Cited by 243 · see citing works

Diversity in the mechanisms of gene regulation by estrogen receptors

Sánchez, R., Nguyen, D., Rocha, W., White, J. H., & Mader, S. (2002) · BioEssays · doi:10.1002/bies.10066 · Cited by 200 · see citing works

The evolution of tamoxifen therapy in breast cancer: selective oestrogen-receptor modulators and downregulators

O'Regan, R. M., & Jordan, V. C. (2002) · The Lancet Oncology · doi:10.1016/s1470-2045(02)00711-8 · Cited by 126 · see citing works

Defining a minimal estrogen receptor DNA binding domain

Mader, S., Chambon, P., & White, J. H. (1993) · Nucleic Acids Research · doi:10.1093/nar/21.5.1125 · Cited by 123 · see citing works

3C Technology: Analyzing the Spatial Organization of Genomic Loci In Vivo

Splinter, E., Grosveld, F. G., & de Laat, W. L. (2003) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(03)75030-7 · Cited by 121 · see citing works

c-Myc Suppresses p21WAF1/CIP1 Expression during Estrogen Signaling and Antiestrogen Resistance in Human Breast Cancer Cells

Mukherjee, S., & Conrad, S. E. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502278200 · Cited by 117 · see citing works

BRCA1 expression is not directly responsive to estrogen

Marks, J. R., Hüper, G., Vaughn, J. P., Davis, P. L., Norris, J. D., McDonnell, D. P., Wiseman, R. W., Futreal, P. A., & Iglehart, J. D. (1997) · Oncogene · doi:10.1038/sj.onc.1200808 · Cited by 116 · see citing works

Identification of novel oestrogen receptor target genes in human ZR75-1 breast cancer cells by expression profiling

Soulez, M., & Parker, M. (2001) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0270259 · Cited by 111 · see citing works

Constitutive overexpression of cyclin D1 but not cyclin E confers acute resistance to antiestrogens in T-47D breast cancer cells.

Hui, R., Finney, G. L., Carroll, J. S., Lee, C. S. L., Musgrove, E. A., & Sutherland, R. L. (2002) · PubMed · Cited by 110 · see citing works

A genomic view of estrogen actions in human breast cancer cells by expression profiling of the hormone-responsive transcriptome

Cicatiello, L., Scafoglio, C., Altucci, L., Cancemi, M., Natoli, G., Facchiano, A. M., Iazzetti, G., Calogero, R., Biglia, N., Bortoli, M. D., et al. (2004) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0320719 · Cited by 92 · see citing works

Multiplatform genome-wide identification and modeling of functional human estrogen receptor binding sites

Vega, V. B., Lin, C., Lai, K. S., Kong, S. L., Xie, M., Su, X., Teh, H. F., Thomsen, J. S., Yeo, A. L., Sung, W.-K. K., et al. (2006) · Genome biology · doi:10.1186/gb-2006-7-9-r82 · Cited by 53 · see citing works

Estrogen, Selective Estrogen Receptor Modulation, and Coronary Heart Disease: Something or Nothing

Jordan, V. C. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.1.2 · Cited by 24 · see citing works

Opposite Effects of Histone Deacetylase Inhibitors on Glucocorticoid and Estrogen Signaling in Human Endometrial Ishikawa Cells

Rocha, W., Sánchez, R., Deschênes, J., Auger, A., Hébert, E., White, J. H., & Mader, S. (2005) · Molecular Pharmacology · doi:10.1124/mol.105.014514 · Cited by 19 · see citing works

PPARγ and the global map of adipogenesis and beyond

Lefterova, M. I., Haakonsson, A. K., Lazar, M. A., & Mandrup, S. (2014) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2014.04.001 · Cited by 629 · see citing works

ChIP‐Seq of ERα and RNA polymerase II defines genes differentially responding to ligands

Welboren, W.-J., van Driel, M. A., Janssen‐Megens, E. M., van Heeringen, S. J., Sweep, F. C. G. J., Span, P. N., & Stunnenberg, H. G. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.88 · Cited by 395 · see citing works

Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism

Sapkota, Y., Steinthorsdottir, V., Morris, A. P., Fassbender, A., Rahmioglu, N., De Vivo, I., Buring, J. E., Zhang, F., Edwards, T. L., Jones, S., et al. (2017) · Nature Communications · doi:10.1038/ncomms15539 · Cited by 344 · see citing works

Genomic actions of estrogen receptor α: what are the targets and how are they regulated?

Welboren, W.-J., Sweep, F. C. G. J., Span, P. N., & Stunnenberg, H. G. (2009) · Endocrine Related Cancer · doi:10.1677/erc-09-0086 · Cited by 154 · see citing works

Estrogen Receptor Regulation of Carbonic Anhydrase XII through a Distal Enhancer in Breast Cancer

Barnett, D., Sheng, S., Charn, T. H., Waheed, A., Sly, W. S., Lin, C., Liu, E. T., & Katzenellenbogen, B. S. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-6151 · Cited by 153 · see citing works

Chromosome crosstalk in three dimensions

Göndör, A., & OHLSSON, R. I. (2009) · Nature · doi:10.1038/nature08453 · Cited by 151 · see citing works

Mechanisms of primary and secondary estrogen target gene regulation in breast cancer cells

Bourdeau, V., Deschênes, J., Laperrière, D., Aid, M., White, J. H., & Mader, S. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm945 · Cited by 143 · see citing works

Derailed estrogen signaling and breast cancer: an authentic couple.

Manavathi, B., Dey, O., Gajulapalli, V. N. R., Bhatia, R., Bugide, S., & Kumar, R. (2013) · Endocrine reviews · doi:10.1210/er.2011-1057 · Cited by 123 · see citing works

Histone H3 lysine 4 acetylation and methylation dynamics define breast cancer subtypes

Messier, T., Gordon, J. A. R., Boyd, J. R., Tye, C. E., Browne, G., Stein, J. L., Lian, J. B., & Stein, G. S. (2016) · Oncotarget · doi:10.18632/oncotarget.6922 · Cited by 125 · see citing works

Estrogen Signaling Drives Ciliogenesis in Human Endometrial Organoids

Haider, S., Gamperl, M., Burkard, T. R., Kunihs, V., Kaindl, U., Junttila, S., Fiala, C., Schmidt, K., Mendjan, S., Knöfler, M., et al. (2019) · Endocrinology · doi:10.1210/en.2019-00314 · Cited by 115 · see citing works

Mutations in GREB1L Cause Bilateral Kidney Agenesis in Humans and Mice

Tomasi, L. D., David, P., Humbert, C., Silbermann, F., Arrondel, C., Torès, F., Fouquet, S., Desgrange, A., Niel, O., Bôle‐Feysot, C., et al. (2017) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2017.09.026 · Cited by 111 · see citing works

Estrogen Stimulates Degradation of β-Amyloid Peptide by Up-regulating Neprilysin

Liang, K., Yang, L., Yin, C., Xiao, Z., Zhang, J., Liu, Y., & Huang, J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.051664 · Cited by 108 · see citing works

Progesterone Receptor Transcriptome and Cistrome in Decidualized Human Endometrial Stromal Cells

Mazur, E. C., Vasquez, Y. M., Li, X., Kommagani, R., Jiang, L., Chen, R., Lanz, R. B., Kovanci, E., Gibbons, W. E., & DeMayo, F. J. (2015) · Endocrinology · doi:10.1210/en.2014-1566 · Cited by 106 · see citing works

Nonallelic transvection of multiple imprinted loci is organized by the H19 imprinting control region during germline developmentPreprint

Sandhu, K. S., Shi, C., Sjölinder, M., Zhao, Z., Göndör, A., Liu, L., Tiwari, V. K., Guibert, S., Emilsson, L., Imreh, M. P., et al. (2009) · Genes & Development · doi:10.1101/gad.552109 · Cited by 93 · see citing works

Genetic, Epigenetic, and Steroidogenic Modulation Mechanisms in Endometriosis

Zubrzycka, A., Zubrzycki, M., Perdas, E., & Zubrzycka, M. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9051309 · Cited by 97 · see citing works

Long noncoding RNA expression profiles in gut tissues constitute molecular signatures that reflect the types of microbes

Liang, L., Ai, L., Qian, J., Fang, J., & Xu, J. (2015) · Scientific Reports · doi:10.1038/srep11763 · Cited by 92 · see citing works

AKT Alters Genome-Wide Estrogen Receptor α Binding and Impacts Estrogen Signaling in Breast Cancer

Bhat‐Nakshatri, P., Wang, G., Appaiah, H. N., Luktuke, N., Carroll, J. S., Geistlinger, T., Brown, M. A., Badve, S., Liu, Y., & Nakshatri, H. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00799-08 · Cited by 89 · see citing works

Genome-Wide Progesterone Receptor Binding: Cell Type-Specific and Shared Mechanisms in T47D Breast Cancer Cells and Primary Leiomyoma Cells

Yin, P., Roqueiro, D., Huang, L., Owen, J. K., Xie, A., Navarro, A., Monsivais, D., Coon, J. S., Kim, J. J., Dai, Y. D., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029021 · Cited by 87 · see citing works

Genomic Analyses of Hormone Signaling and Gene Regulation

Cheung, E. C. W., & Kraus, W. L. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135840 · Cited by 85 · see citing works

GREB1 is an estrogen receptor-regulated tumour promoter that is frequently expressed in ovarian cancer

Hodgkinson, K. M., Forrest, L. A., Vuong, N., Garson, K., Djordjevic, B., & Vanderhyden, B. C. (2018) · Oncogene · doi:10.1038/s41388-018-0377-y · Cited by 87 · see citing works

Cistromics of hormone-dependent cancer

Lupien, M., & Brown, M. A. (2009) · Endocrine Related Cancer · doi:10.1677/erc-09-0038 · Cited by 83 · see citing works

Location analysis for the estrogen receptor-α reveals binding to diverse ERE sequences and widespread binding within repetitive DNA elements

Mason, C. E., Shu, F., Wang, C., Session, R. M., Kallen, R. G., Sidell, N., Yu, T., Liu, M. H., Cheung, E. C. W., & Kallen, C. B. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkp1188 · Cited by 76 · see citing works

Harnessing intestinal tryptophan catabolism to relieve atherosclerosis in mice

Chajadine, M., Laurans, L., Radecke, T., Mouttoulingam, N., Al-Rifai, R., Bacquer, E., Delaroque, C., Rytter, H., Bredon, M., Knosp, C. A., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-50807-x · Cited by 76 · see citing works

Estrogen regulation of X-box binding protein-1 and its role in estrogen induced growth of breast and endometrial cancer cells

Sengupta, S., Sharma, C. G. N., & Jordan, V. C. (2010) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci.2010.025 · Cited by 74 · see citing works

Coactivator Function Defines the Active Estrogen Receptor Alpha Cistrome

Lupien, M., Eeckhoute, J., Meyer, C. A., Krum, S. A., Rhodes, D. R., Liu, X., & Brown, M. A. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00020-09 · Cited by 74 · see citing works

Identifying the Biological Basis of GWAS Hits for Endometriosis1

Fung, J. N., Rogers, P. A. W., & Montgomery, G. W. (2015) · Biology of Reproduction · doi:10.1095/biolreprod.114.126458 · Cited by 69 · see citing works

A co-ordinated interaction between CTCF and ER in breast cancer cells

Ross-Innes, C. S., Brown, G. D., & Carroll, J. S. (2011) · BMC Genomics · doi:10.1186/1471-2164-12-593 · Cited by 66 · see citing works

The Orphan Nuclear Receptor LRH-1 and ERα Activate GREB1 Expression to Induce Breast Cancer Cell Proliferation

Chand, A. L., Wijayakumara, D., Knower, K. C., Herridge, K. A., Howard, T. L., Lazarus, K. A., & Clyne, C. D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031593 · Cited by 65 · see citing works

Urolithin A suppresses the proliferation of endometrial cancer cells by mediating estrogen receptor‐α‐dependent gene expression

Zhang, W., Chen, J., Aguilera‐Barrantes, I., Shiau, C., Sheng, X., Wang, L., Stoner, G. D., & Huang, Y. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600048 · Cited by 64 · see citing works

Positive Regulation of Estrogen Receptor Alpha in Breast Tumorigenesis

Porras, L., Ismail, H., & Mader, S. (2021) · Cells · doi:10.3390/cells10112966 · Cited by 62 · see citing works

Single-cell profiling reveals that eRNA accumulation at enhancer–promoter loops is not required to sustain transcription

Rahman, S., Zorca, C. E., Traboulsi, T., Noutahi, E., Krause, M. R., Mader, S., & Zenklusen, D. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw1220 · Cited by 62 · see citing works

A statistical model of ChIA-PET data for accurate detection of chromatin 3D interactions

Paulsen, J., Rødland, E. A., Holden, L., Holden, M., & Hovig, E. J. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku738 · Cited by 61 · see citing works

Role for Growth Regulation by Estrogen in Breast Cancer 1 (GREB1) in Hormone-Dependent Cancers

Cheng, M., Michalski, S., & Kommagani, R. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092543 · Cited by 59 · see citing works

Biotransformation of Bisphenol AF to Its Major Glucuronide Metabolite Reduces Estrogenic Activity

Li, M., Yang, Y., Yang, Y. Q., Yin, J., Zhang, J., Feng, Y., & Shao, B. (2013) · PLoS ONE · doi:10.1371/journal.pone.0083170 · Cited by 58 · see citing works

Major transcriptome re-organisation and abrupt changes in signalling, cell cycle and chromatin regulation at neural differentiationin vivo

Olivera-Martínez, I., Schurch, N., Li, R. A., Song, J., Halley, P. A., Das, R. M., Burt, D. W., Barton, G. J., & Storey, K. G. (2014) · Development · doi:10.1242/dev.112623 · Cited by 53 · see citing works

Predictive features of ligand‐specific signaling through the estrogen receptor

Nwachukwu, J. C., Srinivasan, S., Zheng, Y., Wang, S., Min, J., Dong, C., Liao, Z., Nowak, J., Wright, N. A., Houtman, R., et al. (2016) · Molecular Systems Biology · doi:10.15252/msb.20156701 · Cited by 53 · see citing works

Functional evaluation of genetic variants associated with endometriosis near GREB1

Fung, J. N., Holdsworth-Carson, S. J., Sapkota, Y., Zhao, Z. Z., Jones, L., Girling, J. E., Paiva, P., Healey, M., Nyholt, D. R., Rogers, P. A. W., et al. (2015) · Human Reproduction · doi:10.1093/humrep/dev051 · Cited by 46 · see citing works

TET2 is a component of the estrogen receptor complex and controls 5mC to 5hmC conversion at estrogen receptor cis-regulatory regions

Broome, R., Chernukhin, I. V., Jamieson, S., Kishore, K., Papachristou, E. K., Mao, S.-Q., Tejedo, C. G., Mahtey, A., Theodorou, V., Groen, A. J., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108776 · Cited by 50 · see citing works

Molecular characterization of corona radiata cells from patients with diminished ovarian reserve using microarray and microfluidic-based gene expression profiling

May‐Panloup, P., Ferré-L’Hôtellier, V., Morinière, C., Marcaillou, C., Lemerle, S., Malinge, M., Coutolleau, A., Lucas, N., Reynier, P., Descamps, P., et al. (2012) · Human Reproduction · doi:10.1093/humrep/der431 · Cited by 49 · see citing works

H2A.Z-dependent crosstalk between enhancer and promoter regulates Cyclin D1 expression

Dalvai, M., Bellucci, L., Fleury, L., Lavigne, A.-C., Moutahir, F., & Bystricky, K. (2012) · Oncogene · doi:10.1038/onc.2012.442 · Cited by 49 · see citing works

Estrogen Receptor α, Fos-Related Antigen-2, and c-Jun Coordinately Regulate Human UDP Glucuronosyltransferase 2B15 and 2B17 Expression in Response to 17β-Estradiol in MCF-7 Cells

Hu, D. G., & Mackenzie, P. I. (2009) · Molecular Pharmacology · doi:10.1124/mol.109.057380 · Cited by 48 · see citing works

17β‐estradiol upregulates GREB1 and accelerates ovarian tumor progression in vivo

Laviolette, L. A., Hodgkinson, K. M., Minhas, N., Perez‐Iratxeta, C., & Vanderhyden, B. C. (2014) · International Journal of Cancer · doi:10.1002/ijc.28741 · Cited by 47 · see citing works

RNA Sequencing of MCF-7 Breast Cancer Cells Identifies Novel Estrogen-Responsive Genes with Functional Estrogen Receptor-Binding Sites in the Vicinity of Their Transcription Start Sites

Yamaga, R., Ikeda, K., Horie‐Inoue, K., Ouchi, Y., Suzuki, Y., & Inoue, S. (2013) · Hormones and Cancer · doi:10.1007/s12672-013-0140-3 · Cited by 46 · see citing works

E2‐mediated cathepsin D (CTSD) activation involves looping of distal enhancer elements

Bretschneider, N., Kangaspeska, S., Seifert, M., Reid, G., Gannon, F., & Denger, S. (2008) · Molecular Oncology · doi:10.1016/j.molonc.2008.05.004 · Cited by 45 · see citing works

TIP48/Reptin and H2A.Z Requirement for Initiating Chromatin Remodeling in Estrogen-Activated Transcription

Dalvai, M., Fleury, L., Bellucci, L., Kocanova, S., & Bystricky, K. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003387 · Cited by 41 · see citing works

Tumor necrosis factor-α activates estrogen signaling pathways in endometrial epithelial cells via estrogen receptor α

Gori, I., Pellegrini, C., Staedler, D., Russell, R., Jan, C., & Canny, G. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.06.043 · Cited by 40 · see citing works

Estrogen receptor-mediated long-range chromatin interactions and transcription in breast cancer

Liu, M. H., & Cheung, E. C. W. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.09.019 · Cited by 39 · see citing works

Determining the endocrine disruption potential of industrial chemicals using an integrative approach: Public databases, in vitro exposure, and modeling receptor interactions

Alofe, O., Kisanga, E. P., Inayat‐Hussain, S. H., Fukumura, M., García-Milian, R., Perera, L., Vasiliou, V., & Whirledge, S. (2019) · Environment International · doi:10.1016/j.envint.2019.104969 · Cited by 38 · see citing works

The genomic landscape of estrogen receptor α binding sites in mouse mammary gland

Palaniappan, M., Nguyen, L., Grimm, S. L., Xi, Y., Xia, Z., Li, W., & Coarfa, C. (2019) · PLoS ONE · doi:10.1371/journal.pone.0220311 · Cited by 37 · see citing works

Theoretical analysis of the role of chromatin interactions in long-range action of enhancers and insulators

Mukhopadhyay, S., Schedl, P. D., Studitsky, V. M., & Sengupta, A. M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1103845108 · Cited by 35 · see citing works

The Estrogen-Regulated Transcription Factor PITX1 Coordinates Gene-Specific Regulation by Estrogen Receptor-Alpha in Breast Cancer Cells

Stender, J. D., Stossi, F., Funk, C. C., Charn, T. H., Barnett, D., & Katzenellenbogen, B. S. (2011) · Molecular Endocrinology · doi:10.1210/me.2011-0102 · Cited by 35 · see citing works

HMGN1 Modulates Estrogen-Mediated Transcriptional Activation through Interactions with Specific DNA-Binding Transcription Factors

Zhu, N., & Hansen, U. M. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01724-07 · Cited by 26 · see citing works

Expression of Genomic Functional Estrogen Receptor 1 in Mouse Sertoli Cells

Lin, J., Zhu, J., Li, X., Li, S., Lan, Z., Ko, C. J., & Lei, Z. M. (2014) · Reproductive Sciences · doi:10.1177/1933719114527355 · Cited by 24 · see citing works

Two Estrogen Response Element Sequences Near the PCNA Gene Are Not Responsible for Its Estrogen-Enhanced Expression in MCF7 Cells

Wang, C., Yu, J., & Kallen, C. B. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003523 · Cited by 23 · see citing works

Consideration of GREB1 as a potential therapeutic target for hormone-responsive or endocrine-resistant cancers

Hodgkinson, K. M., & Vanderhyden, B. C. (2014) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2014.936382 · Cited by 22 · see citing works

Long-range gene regulation in hormone-dependent cancer

Tettey, T. T., Rinaldi, L., & Hager, G. L. (2023) · Nature reviews. Cancer · doi:10.1038/s41568-023-00603-4 · Cited by 21 · see citing works

GATA2 and Progesterone Receptor Interaction in Endometrial Stromal Cells Undergoing Decidualization

Kohlmeier, A., Sison, C., Yilmaz, B. D., Coon, J. S., Dyson, M. T., & Bulun, S. E. (2020) · Endocrinology · doi:10.1210/endocr/bqaa070 · Cited by 22 · see citing works

Chromatin interaction networks and higher order architectures of eukaryotic genomes

Sandhu, K. S., Li, G., Sung, W.-K. K., & Ruan, Y. (2011) · Journal of Cellular Biochemistry · doi:10.1002/jcb.23155 · Cited by 20 · see citing works

The Estrogen Receptor α-Cistrome Beyond Breast Cancer

Droog, M., Mensink, M., & Zwart, W. T. (2016) · Molecular Endocrinology · doi:10.1210/me.2016-1062 · Cited by 20 · see citing works

GREB1 isoforms regulate proliferation independent of ERα co-regulator activities in breast cancer

Haines, C. N., Braunreiter, K. M., Mo, X. M., & Burd, C. J. (2018) · Endocrine Related Cancer · doi:10.1530/erc-17-0496 · Cited by 20 · see citing works

β-Catenin Is a Positive Regulator of Estrogen Receptor-α Function in Breast Cancer Cells

Gupta, N. V., Schmitt, F., Grebhardt, S., & Mayer, D. (2011) · Cancers · doi:10.3390/cancers3032990 · Cited by 20 · see citing works

An H2A histone isotype regulates estrogen receptor target genes by mediating enhancer-promoter-3′-UTR interactions in breast cancer cells

Su, C.-H., Tzeng, T., Cheng, C., & Hsu, M. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt1341 · Cited by 19 · see citing works

The transcriptional co-activator NCOA6 promotes estrogen-induced GREB1 transcription by recruiting ERα and enhancing enhancer–promoter interactions

Tong, Z., Liu, Y., Yu, X., Martinez, J. D., & Xu, J. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.010704 · Cited by 18 · see citing works

Chromatin immunoprecipitation: advancing analysis of nuclear hormone signaling

Vinckevicius, A., & Chakravarti, D. (2012) · Journal of Molecular Endocrinology · doi:10.1530/jme-12-0016 · Cited by 18 · see citing works

Janus kinase 2 — A novel negative regulator of estrogen receptor α function

Gupta, N. V., Grebhardt, S., & Mayer, D. (2011) · Cellular Signalling · doi:10.1016/j.cellsig.2011.08.016 · Cited by 18 · see citing works

Resolvin D2 Supports MCF-7 Cell Proliferation via Activation of Estrogen Receptor

Al-Zaubai, N., Johnstone, C. N., Leong, M. M., Li, J., Rizzacasa, M. A., & Stewart, A. G. (2014) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.114.214403 · Cited by 16 · see citing works

The tri-nucleotide spacer sequence between estrogen response element half-sites is conserved and modulates ERα-mediated transcriptional responses

Shu, F., Sidell, N., Yang, D., & Kallen, C. B. (2010) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2010.04.009 · Cited by 16 · see citing works

Effects of Pubertal Exposure to Dietary Soy on Estrogen Receptor Activity in the Breast of Cynomolgus Macaques

Dewi, F. N., Wood, C. E., Willson, C. J., Register, T. C., Lees, C. J., Howard, T. D., Huang, Z., Murphy, S. K., Tooze, J. A., Chou, J. W., et al. (2016) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-15-0165 · Cited by 15 · see citing works

Induction of UDP-Glucuronosyltransferase 2B15 Gene Expression by the Major Active Metabolites of Tamoxifen, 4-Hydroxytamoxifen and Endoxifen, in Breast Cancer Cells

Chanawong, A., Hu, D. G., Meech, R., Mackenzie, P. I., & McKinnon, R. A. (2015) · Drug Metabolism and Disposition · doi:10.1124/dmd.114.062935 · Cited by 15 · see citing works

The challenge of modeling nuclear receptor regulatory networks in mammalian cells

Jagannathan, V., & Robinson‐Rechavi, M. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.06.012 · Cited by 13 · see citing works

Insights into ectopic estrogen receptor expression, nucleocytoplasmic distribution and interaction with chromatin obtained with new antibodies to estrogen receptors α and β

Chantzi, Ν. Ι., Meligova, A. K., Dhimolea, E., Petrou, C. C., Mitsiou, D. J., Magafa, V., Pechtelidou, A., Florentin, I., Kitraki, E., Cordopatis, P. A., et al. (2011) · Steroids · doi:10.1016/j.steroids.2011.05.010 · Cited by 12 · see citing works

From Influenza Virus Infections to Lupus: Synchronous Estrogen Receptor α and RNA Polymerase II Binding Within the Immunoglobulin Heavy Chain Locus

Jones, B. G., Sealy, R. E., Penkert, R. R., Surman, S. L., Birshtein, B. K., Xu, B., Neale, G. A. M., Maul, R. W., Gearhart, P. J., & Hurwitz, J. L. (2020) · Viral Immunology · doi:10.1089/vim.2019.0144 · Cited by 12 · see citing works

Editor’s Highlight: Development of anIn vitroAssay Measuring Uterine-Specific Estrogenic Responses for Use in Chemical Safety Assessment

Miller, M. M., Alyea, R. A., Sommer, C., Doheny, D. L., Rowley, S. M., Childs, K. M., Balbuena, P., Ross, S. M., Dong, J., Sun, B., et al. (2016) · Toxicological Sciences · doi:10.1093/toxsci/kfw152 · Cited by 11 · see citing works

Estradiol-independent modulation of breast cancer transcript profile by 17beta-hydroxysteroid dehydrogenase type 1

Aka, J. A., Calvo, E.-L., & Lin, S. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.08.026 · Cited by 11 · see citing works

Physiologically Relevant Estrogen Receptor Alpha Pathway Reporters for Single-Cell Imaging-Based Carcinogenic Hazard Assessment of Estrogenic Compounds

Duijndam, B., Goudriaan, A., van den Hoorn, T., van der Stel, W., Dévédec, S. E. L., Bouwman, P., van der Laan, J. W., & van de Water, B. (2021) · Toxicological Sciences · doi:10.1093/toxsci/kfab037 · Cited by 10 · see citing works

Polyamine Oxidase Expression Is Downregulated by 17β-Estradiol via Estrogen Receptor 2 in Human MCF-7 Breast Cancer Cells

Kim, J. H., & Lee, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147521 · Cited by 8 · see citing works

SEdb 3.0: a comprehensive super-enhancer database across multiple species

Song, S., Liu, L., Feng, C., Xie, L., Zhang, G., Zhang, Y., Gao, Y., Yin, M., Tang, X., Pei, W., et al. (2025) · Nucleic Acids Research · doi:10.1093/nar/gkaf1294 · Cited by 8 · see citing works

Unique Transcriptomic Changes Underlie Hormonal Interactions During Mammary Histomorphogenesis in Female Pigs

Trott, J. F., Schennink, A., Horigan, K. C., Lemay, D. G., Cohen, J. R., Famula, T. R., Dragon, J. A., & Hovey, R. C. (2021) · Endocrinology · doi:10.1210/endocr/bqab256 · Cited by 6 · see citing works

Chromatin Immunoprecipitation with Estrogen Receptor 1 and the Promoter of Greb1 in TM4 Sertoli Cells

Lin, J., & Lei, Z. M. (2015) · Methods in molecular biology · doi:10.1007/978-1-4939-3127-9_7 · Cited by 6 · see citing works

Nuclear Receptors, Ligands and the Mammalian B Cell

Jones, B. G., Penkert, R. R., Surman, S. L., Sealy, R. E., & Hurwitz, J. L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144997 · Cited by 5 · see citing works

The genetic architecture of cervical length is shared with spontaneous preterm birth risk

Wolf, H. M., Webb, B. T., Strauss, J. F., Tarca, A., Romero, R., Hassan, S., Latendresse, S. J., Chaiworapongsa, T., Berry, S. M., Gomez-Lopez, N., et al. (2024) · Communications Medicine · doi:10.1038/s43856-025-01078-0 · Cited by 3 · see citing works

Single nucleus multi-omics regulatory atlas of the murine pituitaryPreprint

Ruf-Zamojski, F. M., Zhang, Z., Zamojski, M., Smith, G. R., Mendelev, N., Liu, H., Nudelman, G., Moriwaki, M., Pinças, H., Castanon, R., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.06.06.138024 · Cited by 3 · see citing works

Case report: 16-yr life history and genomic evolution of an ER+ HER2− breast cancerPreprint

Xu, B., Amallraja, A., Swaminathan, P., Elsey, R. J., Davis, C. M., Theel, S., Viet, S., Petersen, J. L., Krie, A. K., Davies, G., et al. (2020) · Molecular Case Studies · doi:10.1101/mcs.a005629 · Cited by 3 · see citing works

Nursing Genetic Research: New Insights Linking Breast Cancer Genetics and Bone Density

Sanchez-Fernandez, A., Roncero‐Martín, R., Morán, J. M., García, J. M. L., Puerto-Parejo, L. M., López‐Espuela, F., Aliaga, I. J., & Pedrera-Canal, M. (2020) · Healthcare · doi:10.3390/healthcare8020172 · Cited by 2 · see citing works

The Role of Steroid Hormones, GREB1, and Reproductive Status in Ovarian Cancer Progression

Hodgkinson, K. M. (2016) · uO Research (University of Ottawa) · doi:10.20381/ruor-5777 · Cited by 1 · see citing works

ACTIVATION OF ESTROGEN RECEPTOR ALPHA, ARYL HYDROCARBON RECEPTOR, AND NUCLEAR FACTOR ERYTHROID-2 LIKE 2 IN HUMAN BREAST CANCER CELLS

Lo, R. (2014) · TSpace (University of Toronto) · Cited by 1 · see citing works

NETWORKS IN EPIGENETICS

Sandhu, K. S. (2010) · Figshare

Identification in silico d’éléments de réponse de récepteurs nucléaires impliqués dans le cancer du sein

Laperrière, D. (2008) · doi:10.71781/25843

Molecular Mechanisms of Aryl Hydrocarbon Receptor Transactivation and Crosstalk with Estrogen Receptor alpha

Ahmed, S. (2012) · TSpace (University of Toronto)

The Regulation of TiPARP by the Aryl Hydrocarbon Receptor, the Platelet-derived Growth Factor Receptor, and the Estrogen Receptor Alpha

Rajendra, S. (2013) · TSpace (University of Toronto)

The Role of Androgen Receptor Signalling in Endocrine Resistant Breast Cancer

Bryan, R. A. (2018) · Open Access at Essex (University of Essex)

Identification and characterization of estrogen receptor-regulated gene expression programs

Barnett, D. (2010) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)

Prédiction de boucles de régulation associant microARN et gènes régulés par le récepteur de l'acide rétinoïque dans le cancer du sein

Boufaden, A. (2011) · doi:10.71781/30526

Chayote leaves display seasonal variation in phytoestrogenic activities and phenolic content

Marquez, C. M., Dante, R. A. S., Carag, H. M., Cruz, J. C. D., Quiming, N. S., Nicolas, M. G., & Velarde, M. C. (2023) · SciEnggJ · doi:10.54645/2023161qfv-33

Inducible estrogen receptor alpha in normal breast epithelial cells demonstrate estrogen receptor-dependent DNA damagePreprint

Majhi, P. D., Black, A. L., Sharma, A., Phadkar, J., Roberts, A. L., Singh, P., Kane, J. J., O’Dare, K., van Eijk, P., Reed, S. H., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.13.643100

TOX3 – A candidate breast cancer predisposition gene

Schmidt, X. (2011) · doi:10.70675/db4a6d31z3401z4ca4zbffaz3e0ea19675bd

Identification and implication of novel genes in the pathogenesis of congenital abnormalities of the kidney and urinary tract

Tomasi, L. D. (2018) · doi:10.70675/ea3a51afz9fd6z47c9za7f4z1b6605b3a2f6

Long-Range Activation of GREB1 by Estrogen Receptor via Three Distal Consensus Estrogen-Responsive Elements in Breast Cancer Cells

Sun, J., Nawaz, Z., & Slingerland, J. M. (2007) · Molecular Endocrinology · doi:10.1210/me.2007-0082 · Cited by 83 · see citing works

Transcriptional Regulation of Promoters Containing Different Estrogen Response Elements

Wood, J. R. (2000) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)

Endogenous Purification Reveals GREB1 as a Key Estrogen Receptor Regulatory Factor

Mohammed, H., D’Santos, C., Serandour, A. A., Ali, H. R., Brown, G. D., Atkins, A., Rueda, O. M., Holmes, K. A., Theodorou, V., Robinson, J. L. L., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.01.010 · Cited by 400 · see citing works

Estrogen response element-dependent regulation of transcriptional activation of estrogen receptors α and β by coactivators and corepressors

Klinge, C., Jernigan, S. C., Mattingly, K., Risinger, K. E., & Zhang, J. (2004) · Journal of Molecular Endocrinology · doi:10.1677/jme.1.01541 · Cited by 186 · see citing works

Abstract P5-05-13: Quantitative combinatory indexed ChIP-seq reveals distinct transcriptional complexes containing estrogen receptor and GREB1 at chromatin in breast cancer cells

Sun, J. J., & Lippman, M. (2019) · Cancer Research · doi:10.1158/1538-7445.sabcs18-p5-05-13