Endogenous Purification Reveals GREB1 as a Key Estrogen Receptor Regulatory Factor
Open accessAbstract
Estrogen receptor-α (ER) is the driving transcription factor in most breast cancers, and its associated proteins can influence drug response, but direct methods for identifying interacting proteins have been limited. We purified endogenous ER using an approach termed RIME (rapid immunoprecipitation mass spectrometry of endogenous proteins) and discovered the interactome under agonist- and antagonist-liganded conditions in breast cancer cells, revealing transcriptional networks in breast cancer. The most estrogen-enriched ER interactor is GREB1, a potential clinical biomarker with no known function. GREB1 is shown to be a chromatin-bound ER coactivator and is essential for ER-mediated transcription, because it stabilizes interactions between ER and additional cofactors. We show a GREB1-ER interaction in three xenograft tumors, and using a directed protein-protein approach, we find GREB1-ER interactions in half of ER(+) primary breast cancers. This finding is supported by histological expression of GREB1, which shows that GREB1 is expressed in half of ER(+) cancers, and predicts good clinical outcome. These findings reveal an unexpected role for GREB1 as an estrogen-specific ER cofactor that is expressed in drug-sensitive contexts.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
While effects of individual risk SNPs are small, the results suggest that risk variants acting on several genes in the same pathway act to increase sensitivity to oestrogen and increase the risk of endometriosis.
“Moreover, GREB1 functions as an essential component of the oestrogen receptor transcription complex52, and while effects of individual risk SNPs are small, the results suggest that risk variants acting on several genes in the same pathway act to increase sensitivity to oestrogen and increase the risk of endometriosis.”
From Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism (2017) · cites this paper as [52]
GREB1 functions as an essential component of the oestrogen receptor transcription complex.
“Moreover, GREB1 functions as an essential component of the oestrogen receptor transcription complex52”
From Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism (2017) · cites this paper as [52]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
2 retracted
GREB1 Functions as a Growth Promoter and Is Modulated by IL6/STAT3 in Breast Cancer
Liu, M., Wang, G., Gomez-Fernandez, C. R., & Guo, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046410 · Cited by 34 · see citing works
RetractedRetracted: Switching of chromatin‐remodelling complexes for oestrogen receptor‐α
Okada, M., Takezawa, S., Mezaki, Y., Yamaoka, I., Takada, I., Kitagawa, H., & Kato, S. (2008) · EMBO Reports · doi:10.1038/embor.2008.55 · Cited by 27 · see citing works
RetractedFast and accurate short read alignment with Burrows-Wheeler transform
Li, H., & Durbin, R. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp324 · Cited by 58,607 · see citing works
Model-based Analysis of ChIP-Seq (MACS)
Zhang, Y., Liu, T., Meyer, C. A., Eeckhoute, J., Johnson, D. S., Bernstein, B. E., Nusbaum, C., Myers, R. M., Brown, M., Li, W., et al. (2008) · Genome Biology · doi:10.1186/gb-2008-9-9-r137 · Cited by 18,386 · see citing works
Bioconductor: open software development for computational biology and bioinformatics
Gentleman, R., Carey, V., Bates, D., Bolstad, B., Dettling, M., Dudoit, S., Ellis, B., Gautier, L., Ge, Y., Gentry, J., et al. (2004) · Genome Biology · doi:10.1186/gb-2004-5-10-r80 · Cited by 13,133 · see citing works
Fast and accurate long-read alignment with Burrows-Wheeler transform.
Li, H., & Durbin, R. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btp698 · Cited by 12,063 · see citing works
Smyth, G. K. (2004) · Statistical Applications in Genetics and Molecular Biology · doi:10.2202/1544-6115.1027 · Cited by 11,829 · see citing works
The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups
METABRIC Group, Curtis, C., Shah, S. P., Chin, S.-F., Turashvili, G., Rueda, O. M., Dunning, M. J., Speed, D., Lynch, A. G., Samarajiwa, S., et al. (2012) · Nature · doi:10.1038/nature10983 · Cited by 6,097 · see citing works
Self-citationLehmann, B. D., Bauer, J. A., Chen, X., Sanders, M. E., Chakravarthy, A. B., Shyr, Y., & Pietenpol, J. A. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45014 · Cited by 5,592 · see citing works
Tissue microarrays for high-throughput molecular profiling of tumor specimens
Kononen, J., Bubendorf, L., Kallionimeni, A., Barlund, M. T., Schraml, P., Leighton, S. B., Torhorst, J. K. H., Mihatsch, M. J., Sauter, G., & Kallionimeni, O.-P. (1998) · Nature Medicine · doi:10.1038/nm0798-844 · Cited by 4,101 · see citing works
Differential oestrogen receptor binding is associated with clinical outcome in breast cancer
Ross-Innes, C. S., Stark, R., Teschendorff, A. E., Holmes, K. A., Ali, H. R., Dunning, M., Brown, G. D., Gojiš, O., Ellis, I. O., Green, A. R., et al. (2012) · Nature · doi:10.1038/nature10730 · Cited by 2,182 · see citing works
Self-citationA signature motif in transcriptional co-activators mediates binding to nuclear receptors
Heery, D. M., Kalkhoven, E., Hoare, S., & Parker, M. G. (1997) · Nature · doi:10.1038/42750 · Cited by 2,128 · see citing works
Harvey, J. M., Clark, G. M., Osborne, C. K., & Allred, D. C. (1999) · Journal of Clinical Oncology · doi:10.1200/jco.1999.17.5.1474 · Cited by 2,054 · see citing works
Shultz, L. D., Lyons, B. L., Burzenski, L. M., Gott, B., Chen, X., Chaleff, S., Kotb, M., Gillies, S. D., King, M., Mangada, J., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.10.6477 · Cited by 1,736 · see citing works
Cofactor Dynamics and Sufficiency in Estrogen Receptor–Regulated Transcription
Shang, Y., Hu, X., DiRenzo, J., Lazar, M. A., & Brown, M. A. (2000) · Cell · doi:10.1016/s0092-8674(00)00188-4 · Cited by 1,647 · see citing works
AIB1, a Steroid Receptor Coactivator Amplified in Breast and Ovarian Cancer
Anzick, S. L., Kononen, J., Walker, R. L., Azorsa, D. O., Tanner, M., Guan, X., Sauter, G., Kallioniemi, O., Trent, J. M., & Meltzer, P. S. (1997) · Science · doi:10.1126/science.277.5328.965 · Cited by 1,630 · see citing works
Métivier, R., Penot, G., Hübner, M. R., Reid, G., Brand, H., Koš, M., & Gannon, F. (2003) · Cell · doi:10.1016/s0092-8674(03)00934-6 · Cited by 1,431 · see citing works
Differential Oestrogen Receptor Binding is Associated with Clinical Outcome in Breast Cancer
Stark, R. (2012) · Lecture notes in computer science · doi:10.1007/978-3-642-29627-7_30 · Cited by 1,403 · see citing works
Carroll, J. S., Liu, X. S., Brodsky, A. S., Li, W., Meyer, C. A., Szary, A. J., Eeckhoute, J., Shao, W., Hestermann, E. V., Geistlinger, T. R., et al. (2005) · Cell · doi:10.1016/j.cell.2005.05.008 · Cited by 1,384 · see citing works
Self-citationHumanized mice in translational biomedical research
Shultz, L. D., Ishikawa, F., & Greiner, D. L. (2007) · Nature reviews. Immunology · doi:10.1038/nri2017 · Cited by 1,281 · see citing works
Humanized mice in translational biomedical research
Shultz, L. (2007) · The Mouseion at the JAXlibrary (Jackson Laboratory) · Cited by 1,036 · see citing works
Endocrine-responsive breast cancer and strategies for combating resistance
Ali, S., & Coombes, R. C. (2002) · Nature reviews. Cancer · doi:10.1038/nrc721 · Cited by 867 · see citing works
ChIP-seq: Using high-throughput sequencing to discover protein–DNA interactions
Schmidt, D., Wilson, M. D., Spyrou, C., Brown, G. D., Hadfield, J., & Odom, D. T. (2009) · Methods · doi:10.1016/j.ymeth.2009.03.001 · Cited by 515 · see citing works
Self-citationbeadarray: R classes and methods for Illumina bead-based data
Dunning, M., Smith, M. L., Ritchie, M. E., & Tavaré, S. (2007) · Bioinformatics · doi:10.1093/bioinformatics/btm311 · Cited by 462 · see citing works
Analysis of the Human Endogenous Coregulator Complexome
Malovannaya, A., Lanz, R. B., Jung, S. Y., Bulynko, Y., Le, N. T., Chan, D. W., Ding, C., Shi, Y., Yucer, N., Krenciute, G., et al. (2011) · Cell · doi:10.1016/j.cell.2011.05.006 · Cited by 432 · see citing works
Torres‐Arzayus, M. I., de Mora, J. F., Yuan, J., Vázquez, F., Bronson, R. T., Rué, M., Sellers, W. R., & Brown, M. A. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.06.027 · Cited by 377 · see citing works
GATA3 acts upstream of FOXA1 in mediating ESR1 binding by shaping enhancer accessibilityPreprint
Theodorou, V., Stark, R., Menon, S., & Carroll, J. S. (2012) · Genome Research · doi:10.1101/gr.139469.112 · Cited by 367 · see citing works
Self-citationGenomic Antagonism between Retinoic Acid and Estrogen Signaling in Breast Cancer
Hua, S., Kittler, R., & White, K. P. (2009) · Cell · doi:10.1016/j.cell.2009.04.043 · Cited by 307 · see citing works
Androgen receptor driven transcription in molecular apocrine breast cancer is mediated by FoxA1
Robinson, J. L. L., MacArthur, S., Ross-Innes, C. S., Tilley, W. D., Neal, D. E., Mills, I. G., & Carroll, J. S. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.216 · Cited by 300 · see citing works
Self-citationClonogenic assay with established human tumour xenografts
Fiebig, H., Maier, A., & Burger, A. M. (2004) · European Journal of Cancer · doi:10.1016/j.ejca.2004.01.009 · Cited by 290 · see citing works
Sutherland, B. W., Toews, J., & Kast, J. (2008) · Journal of Mass Spectrometry · doi:10.1002/jms.1415 · Cited by 273 · see citing works
Cooperative interaction between retinoic acid receptor-α and estrogen receptor in breast cancerPreprint
Ross-Innes, C. S., Stark, R., Holmes, K. A., Schmidt, D., Spyrou, C., Russell, R., Massie, C. E., Vowler, S. L., Eldridge, M., & Carroll, J. S. (2010) · Genes & Development · doi:10.1101/gad.552910 · Cited by 260 · see citing works
Self-citationGREB1 is a critical regulator of hormone dependent breast cancer growth
Rae, J. M., Johnson, M. D., Scheys, J. O., Cordero, K. E., Larios, J. M., & Lippman, M. E. (2005) · Breast Cancer Research and Treatment · doi:10.1007/s10549-005-1483-4 · Cited by 251 · see citing works
PDZK1 and GREB1 are estrogen-regulated genes expressed in hormone-responsive breast cancer.
Ghosh, M., Thompson, D. A., & Weigel, R. J. (2000) · PubMed · Cited by 243 · see citing works
Protein interaction screening by quantitative immunoprecipitation combined with knockdown (QUICK)
Selbach, M., & Mann, M. (2006) · Nature Methods · doi:10.1038/nmeth972 · Cited by 240 · see citing works
PBX1 Genomic Pioneer Function Drives ERα Signaling Underlying Progression in Breast Cancer
Magnani, L., Ballantyne, E. B., Zhang, X., & Lupien, M. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002368 · Cited by 193 · see citing works
AP‐2γ regulates oestrogen receptor‐mediated long‐range chromatin interaction and gene transcription
Tan, S. K., Lin, Z. H., Chang, C. W., Varang, V., Chng, K. R., Pan, Y. F., Yong, E., Sung, W.-K. K., & Cheung, E. C. W. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.151 · Cited by 156 · see citing works
Dunbier, A. K., Anderson, H., Ghazoui, Z. F., Folkerd, E. J., A’Hern, R., Crowder, R. J., Hoog, J., Smith, I. E., Osin, P., Nerurkar, A. Y., et al. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.23.9616 · Cited by 120 · see citing works
Stossi, F., Likhite, V. S., Katzenellenbogen, J. A., & Katzenellenbogen, B. S. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m513405200 · Cited by 118 · see citing works
Streamlined analysis schema for high-throughput identification of endogenous protein complexes
Malovannaya, A., Li, Y., Bulynko, Y. A., Jung, S. Y., Wang, Y., Lanz, R. B., O’Malley, B. W., & Qin, J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912599106 · Cited by 118 · see citing works
Zwart, W. T., Theodorou, V., Kok, M., Canisius, S., Linn, S. C., & Carroll, J. S. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.368 · Cited by 115 · see citing works
Self-citationShevchenko, A., & Shevchenko, A. (2001) · Analytical Biochemistry · doi:10.1006/abio.2001.5321 · Cited by 113 · see citing works
GREB1 is a novel androgen‐regulated gene required for prostate cancer growth
Rae, J. M., Johnson, M. D., Cordero, K. E., Scheys, J. O., Larios, J. M., Gottardis, M. M., Pienta, K. J., & Lippman, M. E. (2006) · The Prostate · doi:10.1002/pros.20403 · Cited by 87 · see citing works
BASH: a tool for managing BeadArray spatial artefacts
Cairns, J., Dunning, M., Ritchie, M. E., Russell, R. B., & Lynch, A. G. (2008) · Bioinformatics · doi:10.1093/bioinformatics/btn557 · Cited by 71 · see citing works
Oyama, M., Nagashima, T., Suzuki, T., Kozuka‐Hata, H., Yumoto, N., Shiraishi, Y., Ikeda, K., Kuroki, Y., Gotoh, N., Ishida, T., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.156877 · Cited by 51 · see citing works
Holmes, K. A., Hurtado, A., Brown, G. D., Launchbury, R., Ross-Innes, C. S., Hadfield, J., Odom, D. T., & Carroll, J. S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1018863108 · Cited by 50 · see citing works
Self-citationShen, C., Huang, Y., Liu, Y., Wang, G., Zhao, Y., Wang, Z. P., Teng, M., Wang, Y., Flockhart, D. A., Skaar, T. C., et al. (2011) · BMC Systems Biology · doi:10.1186/1752-0509-5-67 · Cited by 31 · see citing works
Hnatyszyn, H. J., Liu, M., Hilger, A., Herbert, L. M., Gomez-Fernandez, C. R., Jordà, M., Thomas, D. G., Rae, J. M., El‐Ashry, D., & Lippman, M. E. (2009) · Breast Cancer Research and Treatment · doi:10.1007/s10549-009-0584-x · Cited by 28 · see citing works
McCune, K. R., Bhat‐Nakshatri, P., Thorat, M. A., Nephew, K. P., Badve, S., & Nakshatri, H. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-1530 · Cited by 23 · see citing works
Flagged first, then by citations
1 of the 50 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Progesterone receptor modulates ERα action in breast cancer
Mohammed, H., Russell, I. A., Stark, R., Rueda, O. M., Hickey, T. E., Tarulli, G. A., Sérandour, A. A., Birrell, S. N., Bruna, A., Saadi, A., et al. (2015) · Nature · doi:10.1038/nature14583 · Cited by 661 · see citing works
Self-citationResponse and resistance to BET bromodomain inhibitors in triple-negative breast cancer
Shu, S., Lin, C. Y., He, H. H., Witwicki, R. M., Tabassum, D. P., Roberts, J. M., Janiszewska, M., Jin Huh, S., Liang, Y., Ryan, J., et al. (2016) · Nature · doi:10.1038/nature16508 · Cited by 632 · see citing works
Self-citationThe DREAM complex: master coordinator of cell cycle-dependent gene expression
Sadasivam, S., & DeCaprio, J. A. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3556 · Cited by 524 · see citing works
Arnal, J., Lenfant, F., Métivier, R., Flouriot, G., Henrion, D., Adlanmérini, M., Fontaine, C., Gourdy, P., Chambon, P., Katzenellenbogen, B. S., et al. (2017) · Physiological Reviews · doi:10.1152/physrev.00024.2016 · Cited by 428 · see citing works
Mohammed, H., Taylor, C., Brown, G. D., Papachristou, E., Carroll, J., & D'Santos, C. (2016) · Nature Protocols · doi:10.1038/nprot.2016.020 · Cited by 316 · see citing works
Self-citationSapkota, Y., Steinthorsdottir, V., Morris, A. P., Fassbender, A., Rahmioglu, N., De Vivo, I., Buring, J. E., Zhang, F., Edwards, T. L., Jones, S., et al. (2017) · Nature Communications · doi:10.1038/ncomms15539 · Cited by 344 · see citing works
Estrogen Signaling in Endometrial Cancer: a Key Oncogenic Pathway with Several Open Questions
Rodriguez, A. C., Blanchard, Z., Maurer, K. A., & Gertz, J. (2019) · Hormones and Cancer · doi:10.1007/s12672-019-0358-9 · Cited by 291 · see citing works
Prince, D. J., O'Rourke, S. M., Thompson, T., Ali, O. A., Lyman, H. S., Saglam, I. K., Hotaling, T. J., Spidle, A., & Miller, M. R. (2016) · Science Advances · doi:10.1126/sciadv.1603198 · Cited by 221 · see citing works
Topoisomerase II beta interacts with cohesin and CTCF at topological domain borders
Uusküla-Reimand, L., Hou, H., Samavarchi‐Tehrani, P., Rudan, M. V., Liang, M., Medina-Rivera, A., Mohammed, H., Schmidt, D., Schwalie, P. C., Young, E. J., et al. (2016) · Genome biology · doi:10.1186/s13059-016-1043-8 · Cited by 251 · see citing works
Self-citationIansante, V., Choy, P. M., Fung, S. W., Liu, Y., Chai, J.-G., Dyson, J., Río, A. D., D’Santos, C. S., Williams, R. L., Chokshi, S., et al. (2015) · Nature Communications · doi:10.1038/ncomms8882 · Cited by 234 · see citing works
Self-citationSpliceosomal disruption of the non-canonical BAF complex in cancer
Inoue, D., Chew, G.-L., Liu, B., Michel, B. C., Pangallo, J., D’Avino, A. R., Hitchman, T. D., North, K., Lee, S. C.-W., Bitner, L. E., et al. (2019) · Nature · doi:10.1038/s41586-019-1646-9 · Cited by 229 · see citing works
Enhancer Activation Requires trans-Recruitment of a Mega Transcription Factor Complex
Liu, Z., Merkurjev, D., Yang, F., Li, W., Oh, S., Friedman, M. J., Song, X., Zhang, F., Ma, Q., Ohgi, K. A., et al. (2014) · Cell · doi:10.1016/j.cell.2014.08.027 · Cited by 218 · see citing works
Shu, S., Wu, H., Ge, J. Y., Zeid, R., Harris, I. S., Jovanović, B., Murphy, K. C., Wang, B., Qiu, X., Endress, J. E., et al. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.04.027 · Cited by 205 · see citing works
Self-citationTigan, A.-S., Bellutti, F., Kollmann, K., Tebb, G., & Sexl, V (2016) · Oncogene · doi:10.1038/onc.2015.407 · Cited by 204 · see citing works
GIGGLE: a search engine for large-scale integrated genome analysis
Layer, R. M., Pedersen, B. S., DiSera, T., Marth, G., Gertz, J., & Quinlan, A. R. (2018) · Nature Methods · doi:10.1038/nmeth.4556 · Cited by 197 · see citing works
Nagarajan, S., Rao, S. V., Sutton, J., Cheeseman, D., Dunn, S., Papachristou, E. K., Prada, J.-E. G., Couturier, D., Kumar, S. S., Kishore, K., et al. (2020) · Nature Genetics · doi:10.1038/s41588-019-0541-5 · Cited by 181 · see citing works
Self-citationMaintaining and reprogramming genomic androgen receptor activity in prostate cancer
Mills, I. G. (2014) · Nature reviews. Cancer · doi:10.1038/nrc3678 · Cited by 172 · see citing works
FOXA1 Directs H3K4 Monomethylation at Enhancers via Recruitment of the Methyltransferase MLL3
Jozwik, K. M., Chernukhin, I. V., Sérandour, A. A., Nagarajan, S., & Carroll, J. S. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.11.028 · Cited by 164 · see citing works
Self-citationMurat, P., Marsico, G., Herdy, B., Ghanbarian, A. T., Portella, G., & Balasubramanian, S. (2018) · Genome biology · doi:10.1186/s13059-018-1602-2 · Cited by 166 · see citing works
Hess, J. E., Zendt, J. S., Matala, A. R., & Narum, S. R. (2016) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2015.3064 · Cited by 164 · see citing works
Papachristou, E. K., Kishore, K., Holding, A. N., Harvey, K., Roumeliotis, T. I., Chilamakuri, C. S. R., Omarjee, S., Chia, K. M., Swarbrick, A., Lim, E., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04619-5 · Cited by 148 · see citing works
Self-citationMartin, L., Ribas, R., Simigdala, N., Schuster, E. F., Pancholi, S., Tenev, T., Gellert, P., Buluwela, L., Harrod, A., Thornhill, A. M., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01864-y · Cited by 156 · see citing works
Self-citationCooperative Dynamics of AR and ER Activity in Breast Cancer
D’Amato, N. C., Gordon, M. A., Babbs, B. L., Spoelstra, N. S., Butterfield, K., Torkko, K. C., Phan, V. T., Barton, V. N., Rogers, T. J., Sartorius, C. A., et al. (2016) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-16-0167 · Cited by 154 · see citing works
Transcriptional landscape of the human cell cycle
Liu, Y., Chen, S., Wang, S., Soares, F., Fischer, M., Meng, F., Du, Z., Lin, C. Y., Meyer, C. A., DeCaprio, J. A., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1617636114 · Cited by 150 · see citing works
KMT2C mediates the estrogen dependence of breast cancer through regulation of ERα enhancer function
Gala, K. P., Li, Q., Sinha, A., Razavi, P., Dorso, M. A., Sánchez-Vega, F., Chung, Y. R., Hendrickson, R. C., Hsieh, J. J.-D., Berger, M. F., et al. (2018) · Oncogene · doi:10.1038/s41388-018-0273-5 · Cited by 133 · see citing works
Iyer, L. M., Zhang, D., Burroughs, A. M., & Aravind, L. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt573 · Cited by 133 · see citing works
Myc and its interactors take shape
Tu, W. B., Helander, S., Pilstål, R., Hickman, K. A., Lourenco, C., Jurišica, I., Raught, B., Wallner, B., Sunnerhagen, M., & Penn, L. Z. (2014) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2014.06.002 · Cited by 125 · see citing works
Tavera-Mendoza, L. E., Westerling, T., Libby, E., Marusyk, A., Cato, L., Cassani, R., Cameron, L., Ficarro, S. B., Marto, J. A., Klawitter, J., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1615015114 · Cited by 124 · see citing works
Montaudon, É., Nikitorowicz-Buniak, J., Sourd, L., Morisset, L., Botty, R. E., Huguet, L., Dahmani, A., Painsec, P., Némati, F., Vacher, S., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17697-1 · Cited by 122 · see citing works
Proteomic Analysis of Coregulators Bound to ERα on DNA and Nucleosomes Reveals Coregulator Dynamics
Foulds, C. E., Feng, Q. F., Chen, D., Bailey, S., Hunsaker, T. L., Malovannaya, A., Hamilton, R. A., Gates, L. A., Zhang, Z., Li, C., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.06.007 · Cited by 119 · see citing works
Barfeld, S. J., Urbanucci, A., Itkonen, H. M., Fazli, L., Hicks, J. L., Thiede, B., Rennie, P. S., Yegnasubramanian, S., Marzo, A. M. D., & Mills, I. G. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.04.006 · Cited by 114 · see citing works
Tamoxifen Resistance in Breast Cancer Is Regulated by the EZH2–ERα–GREB1 Transcriptional Axis
Wu, Y.-M., Zhang, Z., Cenciarini, M. E., Proietti, C. J., Amasino, M., Hong, T., Yang, M., Liao, Y., Chiang, H.-C., Kaklamani, V., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-1327 · Cited by 111 · see citing works
Nelson, A. W., Groen, A. J., Miller, J. L., Warren, A. Y., Holmes, K. A., Tarulli, G. A., Tilley, W. D., Katzenellenbogen, B. S., Hawse, J. R., Gnanapragasam, V. J., et al. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.11.016 · Cited by 116 · see citing works
Self-citationEmbryonic transcription factor SOX9 drives breast cancer endocrine resistance
Jeselsohn, R. M., Cornwell, M., Pun, M. J., Buchwalter, G., Nguyen, M., Bango, C., Huang, Y., Kuang, Y., Paweletz, C. P., Fu, X., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1620993114 · Cited by 112 · see citing works
Self-citationLatos, P. A., Gonçalves, Â., Oxley, D., Mohammed, H., Turro, E., & Hemberger, M. (2015) · Nature Communications · doi:10.1038/ncomms8776 · Cited by 111 · see citing works
Self-citationIntron retention is regulated by altered MeCP2-mediated splicing factor recruitment
Wong, J. J. L., Gao, D., Nguyen, T. V., Kwok, C., van Geldermalsen, M., Middleton, R., Pinello, N., Thoeng, A., Nagarajah, R., Holst, J., et al. (2017) · Nature Communications · doi:10.1038/ncomms15134 · Cited by 110 · see citing works
XL-MS: protein cross-linking coupled with mass spectrometry
Holding, A. N. (2015) · Methods · doi:10.1016/j.ymeth.2015.06.010 · Cited by 107 · see citing works
Global Transcriptome Abnormalities of the Eutopic Endometrium from Women with Adenomyosis
Herndon, C. N., Aghajanova, L., Balayan, S., Erikson, D., Barragan, F., Goldfien, G., Vo, K. C., Hawkins, S., & Giudice, L. C. (2016) · Reproductive Sciences · doi:10.1177/1933719116650758 · Cited by 106 · see citing works
Yang, Y., Lu, H., Chen, C. O., Lyu, Y., Cole, R. N., & Semenza, G. L. (2022) · Nature Communications · doi:10.1038/s41467-021-27944-8 · Cited by 103 · see citing works
Progesterone Receptor Regulation of Uterine Adaptation for Pregnancy
Wu, S., Li, R., & DeMayo, F. J. (2018) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2018.04.001 · Cited by 102 · see citing works
Robinson, J. L. L., Hickey, T. E., Warren, A. Y., Vowler, S. L., Carroll, T., Lamb, A. D. G., Papoutsoglou, N., Neal, D. E., Tilley, W. D., & Carroll, J. S. (2013) · Oncogene · doi:10.1038/onc.2013.508 · Cited by 99 · see citing works
Self-citationEnhancer-Mediated Oncogenic Function of the Menin Tumor Suppressor in Breast Cancer
Dreijerink, K. M. A., Groner, A. C., Vos, E. S. M., Font‐Tello, A., Gu, L., Chi, D., Reyes, J. M., Cook, J., Lim, E., Lin, C. Y., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.02.025 · Cited by 92 · see citing works
Genetic, Epigenetic, and Steroidogenic Modulation Mechanisms in Endometriosis
Zubrzycka, A., Zubrzycki, M., Perdas, E., & Zubrzycka, M. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9051309 · Cited by 97 · see citing works
Stirzaker, C., Song, J. Z., Ng, W., Du, Q., Armstrong, N. J., Locke, W. J., Statham, A. L., French, H. J., Pidsley, R., Valdés‐Mora, F., et al. (2016) · Oncogene · doi:10.1038/onc.2016.297 · Cited by 88 · see citing works
Nassa, G., Salvati, A., Tarallo, R., Gigantino, V., Alexandrova, E., Memoli, D., Sellitto, A., Rizzo, F. M., Malanga, D., Mirante, T., et al. (2019) · Science Advances · doi:10.1126/sciadv.aav5590 · Cited by 90 · see citing works
Brophy, P. D., Rasmussen, M. B., Parida, M., Bonde, G., Darbro, B. W., Hong, X., Clarke, J. C., Peterson, K. A., Denegre, J. M., Schneider, M., et al. (2017) · Genetics · doi:10.1534/genetics.117.1125 · Cited by 89 · see citing works
Ji, Z., Mohammed, H., Webber, A., Ridsdale, J., Han, N., Carroll, J. S., & Sharrocks, A. D. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku274 · Cited by 89 · see citing works
Self-citationVälimäki, N., Kuisma, H., Pasanen, A. M., Heikinheimo, O., Sjöberg, J., Bützow, R. C., Sarvilinna, N. S., Heinonen, H.-R., Tolvanen, J., Bramante, S., et al. (2018) · eLife · doi:10.7554/elife.37110 · Cited by 88 · see citing works
Hodgkinson, K. M., Forrest, L. A., Vuong, N., Garson, K., Djordjevic, B., & Vanderhyden, B. C. (2018) · Oncogene · doi:10.1038/s41388-018-0377-y · Cited by 87 · see citing works
Williams, C., & Lin, C. (2016) · ecancermedicalscience · doi:10.3332/ecancer.2013.370 · Cited by 87 · see citing works
Genomic study of severe fetal anomalies and discovery of GREB1L mutations in renal agenesis
Boissel, S., Fallet‐Bianco, C., Chitayat, D. A., Kremer, V., Nassif, C., Rypens, F., Delrue, M., Soglio, D. B. D., Oligny, L. L., Patey, N., et al. (2017) · Genetics in Medicine · doi:10.1038/gim.2017.173 · Cited by 84 · see citing works
Modulating transcription factor activity: Interfering with protein-protein interaction networks
François, M., Donovan, P., & Fontaine, F. R. (2018) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2018.07.019 · Cited by 80 · see citing works
Lee, C., Kao, Y., Lee, W.-R., Hsiao, Y.-W., Lu, T., Chu, C.-Y., Lin, Y., Huang, H.-Y., Hsieh, T., Liu, Y., et al. (2019) · The American Journal of Surgical Pathology · doi:10.1097/pas.0000000000001265 · Cited by 82 · see citing works
Opposing roles of nuclear receptor HNF4α isoforms in colitis and colitis-associated colon cancer
Chellappa, K., Deol, P., Evans, J. R., Vuong, L. M., Chen, G., Briançon, N., Bolotin, E., Lytle, C. Y., Nair, M. G., & Sladek, F. M. (2016) · eLife · doi:10.7554/elife.10903 · Cited by 80 · see citing works
Lempiäinen, J. K., Niskanen, E. A., Launonen, K., Lampinen, R., Göös, H., Varjosalo, M. T., & Palvimo, J. J. (2017) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m117.067488 · Cited by 78 · see citing works
Campbell, T. M., Castro, M. A. A., de Oliveira, K. G., Ponder, B. A. J., & Meyer, K. B. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-1153 · Cited by 78 · see citing works
Pathogenesis of Endometriosis and Endometriosis-Associated Cancers
Adilbayeva, A., & Kunz, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147624 · Cited by 88 · see citing works
Narum, S. R., Genova, A. D., Micheletti, S. J., & Maass, A. (2018) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2018.0935 · Cited by 74 · see citing works
Estrogen receptor-α signaling in post-natal mammary development and breast cancers
Rusidzé, M., Adlanmérini, M., Chantalat, É., Raymond‐Letron, I., Cayre, S., Arnal, J., Deugnier, M., & Lenfant, F. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03860-4 · Cited by 73 · see citing works
Progesterone receptor isoforms, agonists and antagonists differentially reprogram estrogen signaling
Singhal, H., Greene, M. E., Zarnke, A. L., Lainé, M., Abosy, R. A., Chang, Y.-F., Dembo, A. G., Schoenfelt, K. Q., Vadhi, R., Qiu, X., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.21378 · Cited by 73 · see citing works
BET Bromodomain Proteins as Cancer Therapeutic Targets
Shu, S., & Polyak, K. (2016) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2016.81.030908 · Cited by 72 · see citing works
Hevener, A. L., Zhou, Z., Moore, T. M., Drew, B. G., & Ribas, V. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.06.013 · Cited by 72 · see citing works
TRPS1 Is a Lineage-Specific Transcriptional Dependency in Breast Cancer
Witwicki, R. M., Ekram, M. B., Qiu, X., Janiszewska, M., Shu, S., Kwon, M., Trinh, A. C., Frias, E., Ramadan, N., Hoffman, G., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.10.023 · Cited by 70 · see citing works
An HDAC3-PROX1 corepressor module acts on HNF4α to control hepatic triglycerides
Armour, S. M., Remsberg, J. R., Damle, M., Sidoli, S., Ho, W. Y., Li, Z., Garcia, B. A., & Lazar, M. A. (2017) · Nature Communications · doi:10.1038/s41467-017-00772-5 · Cited by 69 · see citing works
Gonzalez, T. L., Hancock, M., Sun, S., Gersch, C. L., Larios, J. M., David, W. S., Hu, J., Hayes, D. F., Wang, S., & Rae, J. M. (2020) · Breast Cancer Research and Treatment · doi:10.1007/s10549-020-05564-y · Cited by 69 · see citing works
Mortlock, S., Corona, R. I., Kho, P. F., Pharoah, P. D. P., Seo, J.-H., Freedman, M. L., Gayther, S. A., Siedhoff, M. T., Rogers, P. A. W., Leuchter, R., et al. (2022) · Cell Reports Medicine · doi:10.1016/j.xcrm.2022.100542 · Cited by 71 · see citing works
Comparing the rules of engagement of androgen and glucocorticoid receptors
Claessens, F., Joniau, S., & Helsen, C. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2467-3 · Cited by 69 · see citing works
Machacek, M. E., Saunders, H. I., Zhang, Z., Tan, E. P., Li, J., Li, T., Villar, M. T., Artigues, A., Lydic, T. A., Cork, G. K., et al. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.008373 · Cited by 68 · see citing works
FOXM1 binds directly to non-consensus sequences in the human genome
Sanders, D. A., Gormally, M. V., Marsico, G., Beraldi, D., Tannahill, D., & Balasubramanian, S. (2015) · Genome biology · doi:10.1186/s13059-015-0696-z · Cited by 68 · see citing works
Endocrine therapy resistance in estrogen receptor (ER)-positive breast cancer
Marchi, T. D., Foekens, J. A., Umar, A., & Martens, J. W. M. (2016) · Drug Discovery Today · doi:10.1016/j.drudis.2016.05.012 · Cited by 68 · see citing works
Giulianelli, S., Riggio, M., Guillardoy, T., Piñero, C. P., Gorostiaga, M. A., Sequeira, G. R., Pataccini, G., Abascal, M. F., de Toledo, M. F. P., Jacobsen, B. M., et al. (2019) · International Journal of Cancer · doi:10.1002/ijc.32252 · Cited by 67 · see citing works
Finlay-Schultz, J., Gillen, A. E., Brechbuhl, H. M., Ivie, J., Matthews, S. B., Jacobsen, B. M., Bentley, D. L., Kabos, P., & Sartorius, C. A. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-3541 · Cited by 66 · see citing works
Proteomics to study DNA-bound and chromatin-associated gene regulatory complexes
Wierer, M., & Mann, M. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddw208 · Cited by 66 · see citing works
Visualizing the Architectures and Interactions of Nuclear Receptors
Khorasanizadeh, S., & Rastinejad, F. (2016) · Endocrinology · doi:10.1210/en.2016-1559 · Cited by 64 · see citing works
Xie, G., Liu, X., Zhang, Y., Li, W., Liu, S., Chen, Z., Xu, B., Yang, J.-Y., He, L., Zhang, Z., et al. (2017) · Oncogene · doi:10.1038/onc.2017.157 · Cited by 67 · see citing works
Enhancer RNAs stimulate Pol II pause release by harnessing multivalent interactions to NELF
Gorbovytska, V., Kim, S.-K., Kuybu, F., Götze, M., Um, D., Kang, K., Pittroff, A., Brennecke, T., Schneider, L.-M., Leitner, A., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-29934-w · Cited by 67 · see citing works
Pharmacological targeting of the transcription factor SOX18 delays breast cancer in mice
Overman, J. P., Fontaine, F. R., Moustaqil, M. D., Mittal, D., Sierecki, E., Sacilotto, N., Zuegg, J., Robertson, A. A. B., Holmes, K. A., Salim, A. A., et al. (2017) · eLife · doi:10.7554/elife.21221 · Cited by 63 · see citing works
Self-citationCottu, P. H., Bièche, I., Assayag, F., Botty, R. E., Château‐Joubert, S., Thuleau, A., Bagarre, T., Albaud, B., Rapinat, A., Gentien, D., et al. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-3230 · Cited by 61 · see citing works
The dark side of ZNF217, a key regulator of tumorigenesis with powerful biomarker value
Cohen, P. A., Donini, C. F., Nguyen, N. T., Lincet, H., & Vendrell, J. A. (2015) · Oncotarget · doi:10.18632/oncotarget.5893 · Cited by 60 · see citing works
Chiang, I. K., Fritzsche, M., Pichol-Thievend, C., Neal, A., Holmes, K. A., Lagendijk, A. K., Overman, J. P., D'Angelo, D., Omini, A., Hermkens, D. M. A., et al. (2017) · Development · doi:10.1242/dev.146241 · Cited by 61 · see citing works
Self-citationSalt-Inducible Kinase 2 Regulates Mitotic Progression and Transcription in Prostate Cancer
Bon, H., Wadhwa, K., Schreiner, A., Osborne, M., Carroll, T. D., Ramos‐Montoya, A., Ross‐Adams, H., Visser, M., Hoffmann, R., Ahmed, A. A., et al. (2014) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-13-0182-t · Cited by 60 · see citing works
Role for Growth Regulation by Estrogen in Breast Cancer 1 (GREB1) in Hormone-Dependent Cancers
Cheng, M., Michalski, S., & Kommagani, R. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092543 · Cited by 59 · see citing works
Characterizing Endogenous Protein Complexes with Biological Mass Spectrometry
Rogawski, R., & Sharon, M. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00217 · Cited by 58 · see citing works
Bullard, W. L., da Rosa, J. L., Liu, S., Wang, Y., & Sabatini, R. S. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.579821 · Cited by 57 · see citing works
Structure and decay of a proto-Y region in Tilapia, Oreochromis niloticus
Gammerdinger, W., Conte, M. A., Acquah, E. A., Roberts, R. B., & Kocher, T. D. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-975 · Cited by 58 · see citing works
Estrogen-independent molecular actions of mutant estrogen receptor 1 in endometrial cancerPreprint
Blanchard, Z., Vahrenkamp, J. M., Berrett, K. C., Arnesen, S., & Gertz, J. (2019) · Genome Research · doi:10.1101/gr.244780.118 · Cited by 57 · see citing works
Application of Metabolomics in Drug Resistant Breast Cancer Research
Shajahan‐Haq, A. N., Cheema, M., & Clarke, R. C. (2015) · Metabolites · doi:10.3390/metabo5010100 · Cited by 55 · see citing works
CTCF modulates Estrogen Receptor function through specific chromatin and nuclear matrix interactions
Fiorito, E., Sharma, Y., Gilfillan, S., Wang, S., Singh, S. K., Satheesh, S. V., Katika, M. R., Urbanucci, A., Thiede, B., Mills, I. G., et al. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw785 · Cited by 53 · see citing works
Mao, C., Livezey, M. R., Kim, J. E., & Shapiro, D. J. (2016) · Scientific Reports · doi:10.1038/srep34753 · Cited by 55 · see citing works
Dong, P., Yu, B., Pan, L., Tian, X., & Liu, F. (2018) · BioMed Research International · doi:10.1155/2018/2760918 · Cited by 52 · see citing works
Androgen receptor: A promising therapeutic target in breast cancer
Vasiliou, S. K., & Diamandis, E. P. (2019) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2019.1575643 · Cited by 52 · see citing works
Mathe, A., Wong‐Brown, M. W., Locke, W. J., Stirzaker, C., Braye, S. G., Forbes, J., Clark, S. J., Avery‐Kiejda, K. A., & Scott, R. J. (2016) · Scientific Reports · doi:10.1038/srep33435 · Cited by 52 · see citing works
RNF8 identified as a co-activator of estrogen receptor α promotes cell growth in breast cancer
Wang, S., Luo, H., Wang, C., Sun, H., Sun, G., Sun, N., Zeng, K., Song, H., Zou, R., Zhou, T., et al. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.02.011 · Cited by 50 · see citing works
Burris, T. P., de Vera, I. M. S., Côté, I., Flaveny, C. A., Wanninayake, U. S., Chatterjee, A., Walker, J. K., Steinauer, N., Zhang, J., Coons, L. A., et al. (2023) · Pharmacological Reviews · doi:10.1124/pharmrev.121.000436 · Cited by 53 · see citing works
Global transcriptional analysis identifies a novel role for SOX4 in tumor-induced angiogenesis
Vervoort, S. J., de Jong, O. G., Roukens, M. G., Frederiks, C. L., Vermeulen, J. F., Lourenço, A. R., Bella, L., Vidaković, A. T., Sandoval, J. L., Moelans, C. B., et al. (2018) · eLife · doi:10.7554/elife.27706 · Cited by 50 · see citing works
Self-citationFunctional evaluation of genetic variants associated with endometriosis near GREB1
Fung, J. N., Holdsworth-Carson, S. J., Sapkota, Y., Zhao, Z. Z., Jones, L., Girling, J. E., Paiva, P., Healey, M., Nyholt, D. R., Rogers, P. A. W., et al. (2015) · Human Reproduction · doi:10.1093/humrep/dev051 · Cited by 46 · see citing works
Broome, R., Chernukhin, I. V., Jamieson, S., Kishore, K., Papachristou, E. K., Mao, S.-Q., Tejedo, C. G., Mahtey, A., Theodorou, V., Groen, A. J., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108776 · Cited by 50 · see citing works
Self-citationProgesterone Receptor Attenuates STAT1-Mediated IFN Signaling in Breast Cancer
Goodman, M. L., Trinca, G. M., Walter, K. R., Papachristou, E. K., D’Santos, C. S., Li, T., Liu, Q., Lai, Z., Chalise, P., Madan, R., et al. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1801152 · Cited by 48 · see citing works
Self-citationMechanistic Drivers of Müllerian Duct Development and Differentiation Into the Oviduct
González, L. S., Rota, I. A., Artibani, M., Morotti, M., Hu, Z., Wietek, N. C., Alsaadi, A., Albukhari, A., Sauka‐Spengler, T., & Ahmed, A. A. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.605301 · Cited by 49 · see citing works
Hagan, C. R., Knutson, T. P., & Lange, C. A. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt706 · Cited by 48 · see citing works
- Authors
- Mohammed, H., D’Santos, C., Serandour, A. A., Ali, H. R., Brown, G. D., Atkins, A., Rueda, O. M., Holmes, K. A., Theodorou, V., Robinson, J. L. L., Zwart, W., Saadi, A., Ross-Innes, C. S., Chin, S.-F., Menon, S., Stingl, J., Palmieri, C., Caldas, C., & Carroll, J. S.
- Affiliations
- Cancer Research UK (GB)
- Thermo Fisher Scientific (United Kingdom) (GB)
- Imperial College Healthcare NHS Trust (GB)
- University of Cambridge (GB)
- Corresponding author
- Carroll, Jason S.
- ORCID
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2013-02
- Volume
- 3
- Issue
- 2
- Pages
- 342-349
- ISSN
- 2211-1247 (ISSN-L)
- PMC
- PMC7116645
- OpenAlex
- W2135060880
- Cited by
- 400
- References
- 50
- Citations by year
- 2026: 22 · 2025: 20 · 2024: 25 · 2023: 40 · 2022: 28 · 2021: 28 · 2020: 29 · 2019: 42 · 2018: 37 · 2017: 40 · 2016: 35 · 2015: 26 · 2014: 18 · 2013: 10
- FWCI
- 19.68
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cell Reports (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Apollo (University of Cambridge) (submittedVersion, cc-by-nc-nd)
- Apollo
- Funders
- Cancer Research UK (A20411, 10208, 15602, 22310)
- National Institute for Health and Care Research (CL-2013-14-006)
- Imperial College London
- Imperial College Healthcare NHS Trust
- Hutchison Whampoa Limited
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- GREB1, estrogen receptor alpha, protein-protein interaction, breast cancer, estrogen receptor coactivator, transcriptional regulation, Rime, estrogen receptor-positive breast cancer, clinical biomarkers, drug response
- MeSH terms
- Animals, Breast Neoplasms, Chromatin, Female, Humans, Neoplasm Proteins, Transcription, Genetic, Transplantation, Heterologous, Gene Expression Regulation, Neoplastic, Mice, SCID, RNA Interference, RNA, Small Interfering, Cell Line, Tumor, Chromatin Immunoprecipitation, Estrogen Receptor alpha, Mice, Protein Interaction Maps, MCF-7 Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review