The Rtt106 Histone Chaperone Is Functionally Linked to Transcription Elongation and Is Involved in the Regulation of Spurious Transcription from Cryptic Promoters in Yeast*♦
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Rtt106 is a histone chaperone that has been suggested to play a role in heterochromatin-mediated silencing in Saccharomyces cerevisiae. It interacts physically and functionally with the chromatin assembly factor-1 (CAF-1), which is associated with replication-coupled nucleosomal deposition. In this work, we have taken several approaches to study Rtt106 in greater detail and have identified a previously unknown function of Rtt106. We found genetic interactions between rtt106Delta and mutations in genes encoding transcription elongation factors, including Spt6, TFIIS, and members of the PAF and yeast DSIF complexes. In addition, chromatin immunoprecipitation analysis indicates that Rtt106 is associated with transcribed regions of active genes. Furthermore, our results show that Rtt106 is required for the repression of transcription from a cryptic promoter within a coding region. This observation strongly suggests that Rtt106 is involved in the regulation of chromatin structure of transcribed regions. Finally, we provide evidence that Rtt106 plays a role in regulating the levels of histone H3 transcription-coupled deposition over transcribed regions. Taken together, our results indicate a direct link for Rtt106 with transcription elongation and the chromatin dynamics associated with RNA polymerase II passage.
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Rtt106, a fungal-specific histone chaperone, functions in histone deposition during DNA replication and transcription elongation in S. cerevisiae, and preferentially binds H3K56-acetylated histone H3-H4.
“Rtt106, a fungal-specific histone chaperone, functions in histone deposition during DNA replication and transcription elongation in S. cerevisiae, and preferentially binds H3K56-acetylated histone H3-H424–26.”
From SWI/SNF and the histone chaperone Rtt106 drive expression of the Pleiotropic Drug Resistance network genes (2022) · cites this paper as [26]
Loss of Rtt106 causes aberrant 'cryptic' transcription initiation within gene bodies and compromised silencing at the mating loci and telomeres, likely due to defective nucleosome assembly.
“Loss of Rtt106 causes aberrant ‘cryptic’ transcription initiation within gene bodies26 and compromised silencing at the mating loci and telomeres27,28, likely due to defective nucleosome assembly26,27,29.”
From SWI/SNF and the histone chaperone Rtt106 drive expression of the Pleiotropic Drug Resistance network genes (2022) · cites this paper as [26]
The increased mRNA in rtt106Δ may reflect increased transcription initiation caused by defective histone deposition or increased nucleosome spacing.
“This may reflect increased transcription initiation that could be caused by defective histone deposition or increased nucleosome spacing in rtt106Δ26,27,29.”
From SWI/SNF and the histone chaperone Rtt106 drive expression of the Pleiotropic Drug Resistance network genes (2022) · cites this paper as [26]
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- Authors
- Imbeault, D., Gamar, L., Rufiange, A., Paquet, E., & Nourani, A.
- Affiliations
- Centre hospitalier universitaire de Québec (CA)
- Corresponding author
- Nourani, Amine
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2008-10
- Volume
- 283
- Issue
- 41
- Pages
- 27350-27354
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2046705884
- Cited by
- 66
- References
- 16
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 4 · 2022: 4 · 2021: 2 · 2020: 1 · 2019: 3 · 2018: 1 · 2017: 3 · 2015: 2 · 2014: 5 · 2013: 9 · 2012: 6
- FWCI
- 3.01
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- histone chaperone, transcription elongation, cryptic promoter, cryptic transcription, transcriptional repression, chromatin structure, CAF-1, Spt6, TFIIS, PAF complex, RNA polymerase II, heterochromatin silencing, Saccharomyces cerevisiae
- MeSH terms
- Chromosomal Proteins, Non-Histone, DNA-Binding Proteins, Histones, Mutation, Nuclear Proteins, Nucleosomes, Promoter Regions, Genetic, RNA Polymerase II, Saccharomyces cerevisiae, Transcription, Genetic, Molecular Chaperones, Gene Silencing, Saccharomyces cerevisiae Proteins, Transcriptional Elongation Factors, Histone Chaperones, Chromatin Assembly Factor-1
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