Rtt106p is a histone chaperone involved in heterochromatin-mediated silencing

Huang, Shengbing; Zhou, Hui; Katzmann, David; Hochstrasser, Mark; Atanasova, Elena; Zhang, Zhiguo

doi:10.1073/pnas.0506176102

Cited by 130Genomics and Chromatin DynamicsNuclear Structure and FunctionEpigenetics and DNA Methylation

Rtt106p is a histone chaperone involved in heterochromatin-mediated silencing

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Huang, Shengbing, Zhou, Hui, Katzmann, David, Hochstrasser, Mark, Atanasova, Elena, Zhang, Zhiguo·2005·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.0506176102PMC PMC1224646

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Abstract

Epigenetic inheritance of heterochromatin structure is an important cellular process whose mechanism remains elusive. In this article, we describe the identification of nine enhancers of the silencing defect of a Saccharomyces cerevisiae -PCNA mutant by screening a library of ≈4,700 viable yeast deletion mutants. Of the nine mutants identified, six ( hir1 , hir3 , sas2 , sas4 , sas5 , and sir1 ) were previously known to reduce silencing synergistically with a mutation in Cac1p, the large subunit of chromatin assembly factor 1 (CAF-1). The predicted gene products that are affected in three other mutants ( nam7 , msh2 , and rtt106 ) have not been implicated previously in silencing. Characterization of the rtt106 Δ allele revealed that it synergistically reduced heterochromatin silencing when combined with a mutation in Cac1p but not with a mutation in Asf1p (a histone H3 and H4 chaperone). Moreover, Rtt106p interacted with histones H3 and H4 both in vitro and in vivo , and it displayed a nucleosome assembly activity in vitro . Furthermore, Rtt106p interacts with CAF-1 physically through Cac1p. These biochemical and genetic data indicate that Rtt106p is a previously uncharacterized histone chaperone connecting S phase to epigenetic inheritance.

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Loss of Rtt106 causes aberrant 'cryptic' transcription initiation within gene bodies and compromised silencing at the mating loci and telomeres, likely due to defective nucleosome assembly.
“Loss of Rtt106 causes aberrant ‘cryptic’ transcription initiation within gene bodies26 and compromised silencing at the mating loci and telomeres27,28, likely due to defective nucleosome assembly26,27,29.”
From SWI/SNF and the histone chaperone Rtt106 drive expression of the Pleiotropic Drug Resistance network genes (2022) · cites this paper as [28]

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Self-citation

Authors: Huang, S., Zhou, H., Katzmann, D., Hochstrasser, M., Atanasova, E., & Zhang, Z.
Affiliations: Mayo Clinic (US)
ORCID: Zhou, Hui
Katzmann, David
Hochstrasser, Mark
Zhang, Zhiguo
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2005-09-12
Volume: 102
Issue: 38
Pages: 13410-13415
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.0506176102
PMC: PMC1224646
OpenAlex: W2031481332
Cited by: 130
References: 64
Citations by year: 2026: 3 · 2025: 2 · 2024: 4 · 2023: 3 · 2022: 5 · 2021: 9 · 2020: 4 · 2019: 5 · 2018: 6 · 2017: 8 · 2016: 8 · 2015: 5 · 2014: 6 · 2013: 7 · 2012: 7
FWCI: 2.13
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Cancer Research UK
University of Toronto
National Institutes of Health
National Institute of General Medical Sciences (R01GM046904, R37GM046904, GM-46904)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Keywords: histone chaperone, heterochromatin silencing, epigenetic inheritance, CAF-1, nucleosome assembly, histone H3, histone H4, S phase, Saccharomyces cerevisiae, Sir proteins
MeSH terms: Histones, Ribonucleases, Saccharomyces cerevisiae, Gene Expression Regulation, Fungal, S Phase, Gene Deletion, Proliferating Cell Nuclear Antigen, Molecular Chaperones, Gene Silencing, Saccharomyces cerevisiae Proteins, Chromatin Assembly and Disassembly, Epigenesis, Genetic

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

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Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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Rtt106p is a histone chaperone involved in heterochromatin-mediated silencing

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