Constitutive Regulation of Cardiac Fatty Acid Metabolism through Peroxisome Proliferator-activated Receptor α Associated with Age-dependent Cardiac Toxicity

Watanabe, Kenichi; Fujii, Hiroshi; Takahashi, Toshihiro; Kodama, Makoto; Aizawa, Yoshifusa; Ohta, Yoshimi; Ono, Teruo; Hasegawa, Go; Naito, Makoto; Nakajima, Tamie; Kamijo, Yuji; Gonzalez, Frank J.; Aoyama, Toshifumi

doi:10.1074/jbc.m000248200

Constitutive Regulation of Cardiac Fatty Acid Metabolism through Peroxisome Proliferator-activated Receptor α Associated with Age-dependent Cardiac Toxicity

The peroxisome proliferator-activated receptor α (PPARα) is a member of the nuclear receptor superfamily and mediates the biological effects of peroxisome proliferators. To determine the physiological role of PPARα in cardiac fatty acid metabolism, we examined the regulation of expression of card…