The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Caveolin-1 Expression Inhibits Wnt/β-Catenin/Lef-1 Signaling by Recruiting β-Catenin to Caveolae Membrane Domains
Open accessAbstract
Caveolin-1 is a principal component of caveolae membranes. In NIH 3T3 cells, caveolin-1 expression is dramatically up-regulated in confluent cells and localizes at areas of cell-cell contact. However, it remains unknown whether caveolin-1 is involved in cell-cell signaling. Here, we examine the potential role of caveolin-1 in regulating beta-catenin signaling. beta-Catenin plays a dual role in the cell, linking E-cadherin to the actin cytoskeleton and in Wnt signaling by forming a complex with members of the lymphoid enhancing factor (Lef-1) family of transcription factors. We show that E-cadherin, beta-catenin, and gamma-catenin (plakoglobin) are all concentrated in caveolae membranes. Moreover, we demonstrate that activation of beta-catenin/Lef-1 signaling by Wnt-1 or by overexpression of beta-catenin itself is inhibited by caveolin-1 expression. We also show that recombinant expression of caveolin-1 in caveolin-1 negative cells is sufficient to recruit beta-catenin to caveolae membranes, thereby blocking beta-catenin-mediated transactivation. These results suggest that caveolin-1 expression can modulate Wnt/beta-catenin/Lef-1 signaling by regulating the intracellular localization of beta-catenin.
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Cites
Functional interaction of β-catenin with the transcription factor LEF-1
Behrens, J., von Kries, J. P., Kühl, M., Bruhn, L., Wedlich, D., Grosschedl, R., & Birchmeier, W. (1996) · Nature · doi:10.1038/382638a0 · Cited by 2,912
Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells
Stambolic, V., Ruel, L., & Woodgett, J. R. (1996) · Current Biology · doi:10.1016/s0960-9822(02)70790-2 · Cited by 1,321
Dissecting the Interaction between Nitric Oxide Synthase (NOS) and Caveolin
Garcı́a-Cardeña, G., Martasek, P., Masters, B. S. S., Skidd, P. M., Couet, J., Li, S., Lisanti, M. P., & Sessa, W. C. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.41.25437 · Cited by 821
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Cited by
Ligand-dependent inhibition of β-catenin/TCF signaling by androgen receptor
Chesire, D. R., & Isaacs, W. B. (2002) · Oncogene · doi:10.1038/sj.onc.1206049 · Cited by 151
Nuclear signaling from cadherin adhesion complexes
McCrea, P. D., Maher, M. T., & Gottardi, C. J. (2015) · Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2014.11.018 · Cited by 85
Rozanov, D. V., Deryugina, E. I., Monosov, E. Z., Marchenko, N. D., & Strongin, A. Y. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2003.10.006 · Cited by 64
ZHAO, D. H., HONG, J. J., GUO, S. Y., YANG, R. L., YUAN, J., WEN, C. J., ZHOU, K. Y., & LI, C. J. (2004) · Cell Research · doi:10.1038/sj.cr.7290205 · Cited by 39
Metadata
- Authors
- Galbiati, F., Volonte', D., Brown, A. M. C., Weinstein, D. E., Ben-Ze'ev, A., Pestell, R. G., & Lisanti, M. P.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2000-07
- Volume
- 275
- Issue
- 30
- Pages
- 23368-23377
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1972009876
- Cited by
- 191
- References
- 3
- FWCI
- 3.20
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Galbiati, F., Volonte', D., Brown, A. M. C., Weinstein, D. E., Ben-Ze'ev, A., Pestell, R. G., & Lisanti, M. P. (2000). Caveolin-1 Expression Inhibits Wnt/β-Catenin/Lef-1 Signaling by Recruiting β-Catenin to Caveolae Membrane Domains. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m002020200
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
