The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Direct Functional Interactions between Insulin-like Growth Factor-binding Protein-3 and Retinoid X Receptor-α Regulate Transcriptional Signaling and Apoptosis
Open accessAbstract
Insulin-like growth factor-binding protein (IGFBP)-3 regulates apoptosis in an IGF-independent fashion and has been shown to localize to nuclei. We cloned the nuclear receptor retinoid X receptor-alpha(RXR-alpha) as an IGFBP-3 protein partner in a yeast two-hybrid screen. Multiple methodologies showed that IGFBP-3 and RXR-alpha bind each other within the nucleus. IGFBP-3-induced apoptosis was abolished in RXR-alpha-knockout cells. IGFBP-3 and RXR ligands were additive in inducing apoptosis in prostate cancer cells. IGFBP-3 enhanced RXR response element and inhibited RARE signaling. Thus, RXR-alpha-IGFBP-3 interaction leads to modulation of the transcriptional activity of RXR-alpha and is essential for mediating the effects of IGFBP-3 on apoptosis.
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The casein kinase 1 family: participation in multiple cellular processes in eukaryotes
Knippschild, U., Gocht, A., Wolff, S., Huber, N., Löhler, J., & Stöter, M. (2005) · Cellular Signalling · doi:10.1016/j.cellsig.2004.12.011 · Cited by 601
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Insulin Growth Factor Binding Protein 7 (IGFBP7)-Related Cancer and IGFBP3 and IGFBP7 Crosstalk
Jin, L., Shen, F., Weinfeld, M., & Sergi, C. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00727 · Cited by 123
Impaired glucose homeostasis in insulin-like growth factor-binding protein-3-transgenic mice
Silha, J. V., Gui, Y., & Murphy, L. J. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00014.2002 · Cited by 96
Insulin-like growth factor binding protein-3 leads to insulin resistance in adipocytes
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Metadata
- Authors
- Liu, B., Lee, H.-Y., Weinzimer, S. A., Powell, D. R., Clifford, J. L., Kurie, J. M., & Cohen, P.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2000-10
- Volume
- 275
- Issue
- 43
- Pages
- 33607-33613
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2027454234
- Cited by
- 326
- References
- 41
- FWCI
- 15.32
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Direct Functional Interactions between Insulin-like Growth Factor-binding Protein-3 and Retinoid X Receptor-α Regulate Transcriptional Signaling and Apoptosis. https://app.cochat.ai/papers/10.1074/jbc.m002547200
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- Liu, B., Lee, H.-Y., Weinzimer, S. A., Powell, D. R., Clifford, J. L., Kurie, J. M., & Cohen, P. (2000). Direct Functional Interactions between Insulin-like Growth Factor-binding Protein-3 and Retinoid X Receptor-α Regulate Transcriptional Signaling and Apoptosis. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m002547200
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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